Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

by Munroe, Patricia B, Smith, Albert V, Verwoert, Germaine C, Amin, Najaf, Teumer, Alexander, Zhao, Jing Hua, Parsa, Afshin, Dehghan, Abbas, Peden, John F, Rudan, Igor, Chambers, John C, Fox, Ervin R, Alexander, Myriam, Tabara, Yasuharu, Seielstad, Mark, Kuznetsova, Tatiana, Ludwig, Barbara, Tomaszewski, Maciej, O'Connell, Jeffrey R, Kardia, Sharon L, Hingorani, Aroon D, Lawlor, Debbie A, Lawrence, Robert W, Clarke, Robert, Ongen, Halit, Li, Yali, Adair, Linda S, Lee, Nanette R, Bolton, Judith A Hoffman, Chaturvedi, Nish, Islam, Muhammad, Kulkarni, Smita R, Groop, Leif, Voight, Benjamin F, Guarrera, Simonetta, Plump, Andrew, Barroso, Inês, Vartiainen, Erkki, Burton, Paul R, Dong, Yanbin, Wang, Xiaoling, Lohman, Kurt K, Smith, Nicholas L, Kinra, Sanjay, Prabhakaran, Dorairaj, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A, Kita, Yoshikuni, Wichmann, H-Erich, Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Wong, Andrew, Raffel, Leslie J, Yao, Jie, Schwartz, Stephen M, Ikram, M Arfan, Rasheed, Asif, Watkins, Hugh, Bakker, Stephan J L, van Gilst, Wiek H, Janipalli, Charles S, Rivadeneira, Fernando, Ala-Korpela, Mika, Soininen, Pasi, Völzke, Henry, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Zhai, Guangju, Nalls, Michael A, Terzic, Janos, Kumar, M V Kranthi, Charchar, Fadi J, Schwarz, Peter E H, Guo, Xiuqing, Bots, Michiel L, Samani, Nilesh J, Palmer, Lyle J, Casas, Juan P, Vineis, Paolo, Raitakari, Olli, Wong, Tien Y, Tai, E Shyong, Cooper, Richard S, Rao, Dabeeru C, Harris, Tamara B, Morris, Richard W, Kivimaki, Mika, Coresh, Josef, Navis, Gerjan, Han, Bok-Ghee, Melander, Olle, Gyllensten, Ulf B, Rettig, Rainer, Uda, Manuela, Psaty, Bruce M, Abecasis, Gonçalo R
Published in Nature (London)

Cardiovascular Risk Estimation and Eligibility for Statins in Primary Prevention Comparing Different Strategies

by Nanchen, David, MD, Chiolero, Arnaud, MD, MSc, Cornuz, Jacques, MD, MPH, Marques-Vidal, Pedro-Manuel, MD, PhD, Firmann, Mathieu, MD, Mooser, Vincent, MD, Paccaud, Fred, MD, MSc, Waeber, Gérard, MD, Vollenweider, Peter, MD, Rodondi, Nicolas, MD, MAS
Published in The American journal of cardiology

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

by Voight, Benjamin F, PhD, Peloso, Gina M, PhD, Orho-Melander, Marju, PhD, Frikke-Schmidt, Ruth, DMSc, Jensen, Majken K, PhD, Hólm, Hilma, MD, Johnson, Toby, PhD, Schunkert, Heribert, Prof, Samani, Nilesh J, Prof, Hopewell, Jemma C, PhD, Thompson, John F, Prof, Li, Mingyao, PhD, Newton-Cheh, Christopher, MD, Musunuru, Kiran, MD, Saleheen, Danish, MBBS, Chen, Li, MSc, Stewart, Alexandre FR, PhD, Schillert, Arne, PhD, Thorsteinsdottir, Unnur, PhD, Thorgeirsson, Gudmundur, MD, Engert, James C, PhD, Morgan, Thomas, MD, Spertus, John, Prof, Stoll, Monika, Prof, Berger, Klaus, Prof, Girelli, Domenico, Prof, Patterson, Christopher C, PhD, Devaney, Joseph, PhD, Burnett, Mary-Susan, PhD, Mooser, Vincent, MD, Ripatti, Samuli, PhD, Sinisalo, Juha, MD, Lokki, Marja-Liisa, PhD, Havulinna, Aki, PhD, de Faire, Ulf, Prof, Gigante, Bruna, MD, Ingelsson, Erik, PhD, Wild, Philipp, MD, de Bakker, Paul I W, Prof, Maitland-van der Zee, Anke-Hilse, PhD, Grobbee, Diederick E, Prof, Kamphuisen, Pieter W, PhD, Deneer, Vera H M, PhD, Elbers, Clara C, PhD, Onland-Moret, N Charlotte, PhD, Hofker, Marten H, Prof, Wijmenga, Cisca, Prof, Verschuren, WM Monique, PhD, Rasheed, Asif, Frossard, Philippe, Demissie, Serkalem, PhD, Willer, Cristen, PhD, Do, Ron, PhD, Ordovas, Jose M, Prof, Abecasis, Gonçalo R, Prof, Boehnke, Michael, Prof, Mohlke, Karen L, PhD, Daly, Mark J, PhD, Guiducci, Candace, BS, Surti, Aarti, BS, Gonzalez, Elena, BS, Purcell, Shaun, PhD, Gabriel, Stacey, PhD, Marrugat, Jaume, PhD, Peden, John, PhD, Diemert, Patrick, MD, Willenborg, Christina, MSc, König, Inke R, PhD, Fischer, Marcus, MD, Ziegler, Andreas, PhD, Buysschaert, Ian, MD, Lambrechts, Diether, PhD, Van de Werf, Frans, Prof, Fox, Keith A, Prof, El Mokhtari, Nour Eddine, MD, Rubin, Diana, MD, Schreiber, Stefan, Prof, Schäfer, Arne, PhD, Danesh, John, Prof, Roberts, Robert, Prof, McPherson, Ruth, Prof, Watkins, Hugh, Prof, Hall, Alistair S, Prof, Rimm, Eric, ScD, Boerwinkle, Eric, PhD, Cupples, L Adrienne, Prof, Reilly, Muredach P, MD, Melander, Olle, Prof, Mannucci, Pier M, Prof, Ardissino, Diego, Prof, Siscovick, David, Prof, Elosua, Roberto, PhD, Stefansson, Kari, MD, O'Donnell, Christopher J, MD, Salomaa, Veikko, Prof, Rader, Daniel J, Prof, Peltonen, Leena, Prof, Schwartz, Stephen M, Prof, Altshuler, David, Prof, Kathiresan, Sekar, Dr MD
Published in The Lancet (British edition)

Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia

by Yu, Yi, Wyszynski, Diego F, Waterworth, Dawn M, Wilton, Steven D, Barter, Philip J, Kesaniemi, Y. Antero, Mahley, Robert W, McPherson, Ruth, Waeber, Gerard, Bersot, Thomas P, Ma, Qianli, Sharma, Sanjay S, Montgomery, Douglas S, Middleton, Lefkos T, Sundseth, Scott S, Mooser, Vincent, Grundy, Scott M, Farrer, Lindsay A
Published in Journal of lipid research

Protecting Privacy and Security of Genomic Data in i2b2 with Homomorphic Encryption and Differential Privacy

by Raisaro, Jean Louis, Choi, Gwangbae, Pradervand, Sylvain, Colsenet, Raphael, Jacquemont, Nathalie, Rosat, Nicolas, Mooser, Vincent, Hubaux, Jean-Pierre
Published in IEEE/ACM transactions on computational biology and bioinformatics

Biological, clinical and population relevance of 95 loci for blood lipids

by Caulfield, Mark J, Ordovas, Jose M, Kuzawa, Christopher W, Samani, Nilesh J, Crawford, Gabriel, Lokki, Marja-Liisa, Magnusson, Patrik K. E, Wilson, James G, Ricketts, Sally L, Pedersen, Nancy L, Döring, Angela, Hicks, Andrew A, Twee-Hee Ong, Rick, McPherson, Ruth, Martin, Nicholas G, Chambers, John, Burtt, Noel P, Bonnycastle, Lori L, Seielstad, Mark, Koseki, Masahiro, Kaprio, Jaakko, Rieder, Mark, Khaw, Kay-Tee, Zee, Robert Y. L, Campbell, Harry, Havulinna, Aki S, Sandhu, Manjinder S, Orho-Melander, Marju, Reilly, Muredach P, Taylor Jr, Herman A, Uitterlinden, Andre G, Musunuru, Kiran, Willer, Cristen J, Stefansson, Kari, Smit, Johannes H, Kathiresan, Sekar, Borecki, Ingrid B, Gyllensten, Ulf, Munroe, Patricia B, Pramstaller, Peter P, McArdle, Wendy, Tall, Alan R, Oostra, Ben A, Waterworth, Dawn M, Luan, Jian'an, Zhang, Weihua, Boomsma, Dorret I, Wright, Alan F, Vitart, Veronique, Cecile J. W. Janssens, A, Jin Go, Min, Erdmann, Jeanette, Abecasis, Gonçalo R, Launer, Lenore J, Hua Zhao, Jing, Ejebe, Kenechi G, Assimes, Themistocles L, Sabatti, Chiara, Waeber, Gérard, Aulchenko, Yurii S, Lange, Leslie A, Pirruccello, James P, Boerwinkle, Eric, Rudan, Igor, Ballantyne, Christie M, Groop, Leif C, Lakatta, Edward G, Schadt, Eric E, Scuteri, Angelo, Pattaro, Cristian, Schunkert, Heribert, Ferrucci, Luigi, Li, Xiaohui, Marroni, Fabio, Johansen, Christopher T, Bandinelli, Stefania, Feitosa, Mary F, Sanna, Serena, Rader, Daniel J, Loos, Ruth J. F, Igl, Wilmar, Vollenweider, Peter, Whitfield, John B, Salomaa, Veikko, Gieger, Christian, Hegele, Robert A, Wong, Tien Y, Demissie, Serkalem, Hayward, Caroline, Kastelein, John J.P, Nieminen, Markku S, Lucas, Gavin, Guiducci, Candace, Wilson, James F, Ingelsson, Erik, Wareham, Nicholas J, Boekholdt, S. Matthijs, Rose, Lynda M, Chen, Yii-der I, König, Inke R
Published in Nature (London)

Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease

by Elliott, Paul, Chambers, John C, Zhang, Weihua, Clarke, Robert, Hopewell, Jemma C, Peden, John F, Erdmann, Jeanette, Braund, Peter, Engert, James C, Bennett, Derrick, Coin, Lachlan, Ashby, Deborah, Tzoulaki, Ioanna, Brown, Ian J, Mt-Isa, Shahrul, McCarthy, Mark I, Peltonen, Leena, Freimer, Nelson B, Farrall, Martin, Ruokonen, Aimo, Hamsten, Anders, Lim, Noha, Froguel, Philippe, Waterworth, Dawn M, Vollenweider, Peter, Waeber, Gerard, Jarvelin, Marjo-Riitta, Mooser, Vincent, Scott, James, Hall, Alistair S, Schunkert, Heribert, Anand, Sonia S, Collins, Rory, Samani, Nilesh J, Watkins, Hugh, Kooner, Jaspal S
Published in JAMA : the journal of the American Medical Association

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

by Povysil, Gundula, Butler-Laporte, Guillaume, Shang, Ning, Wang, Chen, Khan, Atlas, Alaamery, Manal, Nakanishi, Tomoko, Zhou, Sirui, Forgetta, Vincenzo, Eveleigh, Robert J.M
Published in The Journal of clinical investigation

The neuro genomics partnership: A new consortium dedicated to a fully open patient to patient (P2P) integrative R&D approach

by Degroot, Clotilde, Taylor, Kirsten, Mooser, Vincent, Rouleau, Guy, Gan-Or, Ziv, Sharp, Madeleine, Durcan, Thomas, Postuma, Ronald, Doyon, Julien, Kustermann, Thomas, Jagasia, Ravi, Taylor, Caitlin, Lussier, Marc, Fon, Edward
Published in Journal of the neurological sciences

Genetic and functional association of FAM5C with myocardial infarction

by Connelly, Jessica J, Shah, Svati H, Doss, Jennifer F, Gadson, Shera, Nelson, Sarah, Crosslin, David R, Hale, A Brent, Lou, Xuemei, Wang, Ty, Haynes, Carol, Seo, David, Crossman, David C, Mooser, Vincent, Granger, Christopher B, Jones, Christopher J H, Kraus, William E, Hauser, Elizabeth R, Gregory, Simon G
Published in BMC medical genetics

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

by JACQUEMONT, Sébastien, REYMOND, Alexandre, THORLEIFSSON, Gudmar, BELFIORE, Marco, BOUQUILLON, Sonia, CAMPION, Dominique, DE LEEUW, Nicole, DE VRIES, Bert B. A, ESKO, Tõnu, FERNANDEZ, Bridget A, FERNANDEZ-ARANDA, Fernando, FERNANDEZ-REAL, José Manuel, ZUFFEREY, Flore, GRATACOS, Mònica, GUILMATRE, Audrey, HOYER, Juliane, JARVELIN, Marjo-Riitta, FRANK KOOY, R, KURG, Ants, LE CAIGNEC, Cédric, MÄNNIK, Katrin, PLATT, Orah S, SANLAVILLE, Damien, HAREWOOD, Louise, VAN HAELST, Mieke M, VILLATORO GOMEZ, Sergi, WALHA, Faida, WU, Bai-Lin, YU, Yongguo, ABOURA, Azzedine, ADDOR, Marie-Claude, ALEMBIK, Yves, ANTONARAKIS, Stylianos E, ARVEILER, Benoît, WALTERS, Robin G, BARTH, Magalie, BEDNAREK, Nathalie, BENA, Frédérique, BERGMANN, Sven, BERI, Mylène, BERNARDINI, Laura, BLAUMEISER, Bettina, BONNEAU, Dominique, BOTTANI, Armand, BOUTE, Odile, KUTALIK, Zoltán, BRUNNER, Han G, CAILLEY, Dorothee, CALLIER, Patrick, CHIESA, Jean, CHRAST, Jacqueline, COIN, Lachlan, COUTTON, Charles, CUISSET, Jean-Marie, CUVELLIER, Jean-Christophe, DAVID, Albert, MARTINET, Danielle, YIPING SHEN, VALSESIA, Armand, BECKMANN, Noam D
Published in Nature (London)

The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)

by Abderrahmani, Amar, Steinmann, Myriam, Plaisance, Valérie, Niederhauser, Guy, Haefliger, Jacques-Antoine, Mooser, Vincent, Bonny, Christophe, Nicod, Pascal, Waeber, Gérard
Published in Molecular and Cellular Biology

Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study

by Hauser, Elizabeth R., Mooser, Vincent, Crossman, David C., Haines, Jonathan L., Jones, Christopher H., Winkelmann, Bernhard R., Schmidt, Silke, Scott, William K., Roses, Allen D., Pericak-Vance, Margaret A., Granger, Christopher B., Kraus, William E.
Published in The American heart journal

Rational drug repositioning by medical genetics

by Wang, Zhong-Yi, Zhang, Hong-Yu
Published in Nature biotechnology

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

by Cousminer, Diana L, Berry, Diane J, Timpson, Nicholas J, Ang, Wei, Thiering, Elisabeth, Byrne, Enda M, Taal, H Rob, Huikari, Ville, Bradfield, Jonathan P, Kerkhof, Marjan, Groen-Blokhuis, Maria M, Kreiner-Møller, Eskil, Marinelli, Marcella, Holst, Claus, Leinonen, Jaakko T, Perry, John R B, Surakka, Ida, Pietiläinen, Olli, Kettunen, Johannes, Anttila, Verneri, Kaakinen, Marika, Sovio, Ulla, Pouta, Anneli, Das, Shikta, Lagou, Vasiliki, Power, Chris, Prokopenko, Inga, Evans, David M, Kemp, John P, St Pourcain, Beate, Ring, Susan, Palotie, Aarno, Kajantie, Eero, Osmond, Clive, Lehtimäki, Terho, Viikari, Jorma S, Kähönen, Mika, Warrington, Nicole M, Lye, Stephen J, Palmer, Lyle J, Tiesler, Carla M T, Flexeder, Claudia, Montgomery, Grant W, Medland, Sarah E, Hofman, Albert, Hakonarson, Hakon, Guxens, Mònica, Bartels, Meike, Salomaa, Veikko, Murabito, Joanne M, Kaprio, Jaakko, Sørensen, Thorkild I A, Ballester, Ferran, Bisgaard, Hans, Boomsma, Dorret I, Koppelman, Gerard H, Grant, Struan F A, Jaddoe, Vincent W V, Martin, Nicholas G, Heinrich, Joachim, Pennell, Craig E, Raitakari, Olli T, Eriksson, Johan G, Smith, George Davey, Hyppönen, Elina, Järvelin, Marjo-Riitta, McCarthy, Mark I, Ripatti, Samuli, Widén, Elisabeth
Published in Human molecular genetics

Pharmacogenetics-guided dalcetrapib therapy after an acute coronary syndrome: the dal-GenE trial

by Tardif, Jean Claude, Pfeffer, Marc A, Kouz, Simon, Koenig, Wolfgang, Maggioni, Aldo P, McMurray, John J V, Mooser, Vincent, Waters, David D, Grégoire, Jean C, L’Allier, Philippe L, Wouter Jukema, J, White, Harvey D., Heinonen, Therese, Black, Donald M, Laghrissi-Thode, Fouzia, Levesque, Sylvie, Guertin, Marie Claude, Dubé, Marie Pierre
Published in European heart journal

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

by O'DONNELL, Christopher J, KAVOUSI, Maryam, HOFFMANN, Udo, BIELAK, Lawrence F, QUNYUAN ZHANG, EIRIKSDOTTIR, Gudny, VAN DUIJN, Cornelia M, FOX, Caroline S, DE ANDRADE, Mariza, KRAJA, Aldi T, SIGURDSSON, Sigurdur, ELIAS-SMALE, Suzette E, SMITH, Albert V, MURABITO, Joanne M, LAUNER, Lenore J, VAN DER LUGT, Aad, KATHIRESAN, Sekar, KRESTIN, Gabriel P, HERRINGTON, David M, HOWARD, Timothy D, YONGMEI LIU, POST, Wendy, MITCHELL, Braxton D, KARDIA, Sharon L. R, O'CONNELL, Jeffrey R, HAIQING SHEN, SHULDINER, Alan R, ALTSHULER, David, ELOSUA, Roberto, SALOMAA, Veikko, SCHWARTZ, Stephen M, SISCOVICK, David S, VOIGHT, Benjamin F, BIS, Joshua C, FEITOSA, Mary F, GLAZER, Nicole L, PSATY, Bruce M, BOERWINKLE, Eric, HEISS, Gerardo, BLANKENBERG, Stefan, ZELLER, Tanja, WILD, Philipp S, SCHNABEL, Renate B, SCHILLERT, Arne, ZIEGLER, Andreas, HWANG, Shih-Jen, MIINZEL, Thomas F, WHITE, Charles C, ROTTER, Jerome I, NAILS, Michael, OUDKERK, Matthijs, JOHNSON, Andrew D, NEWMAN, Anne B, UITTERLINDEN, Andre G, MASSARO, Joseph M, CUNNINGHAM, Julie, SUN, Yan V, PROVINCE, Michael A, ASPELUND, Thor, DEHGHAN, Abbas
Published in Circulation (New York, N.Y.)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

by Fox, Caroline S, Liu, Yongmei, White, Charles C, Feitosa, Mary, Smith, Albert V, Heard-Costa, Nancy, Lohman, Kurt, Johnson, Andrew D, Foster, Meredith C, Greenawalt, Danielle M, Griffin, Paula, Ding, Jinghong, Newman, Anne B, Tylavsky, Fran, Miljkovic, Iva, Kritchevsky, Stephen B, Launer, Lenore, Garcia, Melissa, Eiriksdottir, Gudny, Carr, J Jeffrey, Gudnason, Vilmunder, Harris, Tamara B, Cupples, L Adrienne, Borecki, Ingrid B
Published in PLoS genetics

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

by Schumann, Gunter, Coin, Lachlan J, Lourdusamy, Anbarasu, Charoen, Pimphen, Berger, Karen H, Stacey, David, Desrivières, Sylvane, Aliev, Fazil A, Khan, Anokhi A, Aulchenko, Yurii S, Bakalkin, Georgy, Bakker, Stephan J, Balkau, Beverley, Beulens, Joline W, Bilbao, Ainhoa, de Boer, Rudolf A, Beury, Delphine, Bots, Michiel L, Cauchi, Stéphane, Cavalcanti-Proença, Christine, Chambers, John C, Clarke, Toni-Kim, Dahmen, Norbert, de Geus, Eco J, Dick, Danielle, Ducci, Francesca, Easton, Alanna, Esk, Tõnu, Foroud, Tatiana, Freimer, Nelson B, Girault, Jean-Antoine, Grobbee, Diederick E, Guarrera, Simonetta, Gudbjartsson, Daniel F, Hartikainen, Anna-Liisa, Heath, Andrew C, Hesselbrock, Victor, Hottenga, Jouke-Jan, Kaprio, Jaakko, Khaw, Kay-Tee, Kuehnel, Brigitte, Laitinen, Jaana, Luan, Jian'an, Mangino, Massimo, Maroteaux, Matthieu, Matullo, Giuseppe, Mueller, Christian, Navis, Gerjan, Numans, Mattijs E, Núñez, Alejandro, Nyholt, Dale R, Onland-Moret, Charlotte N, Oostra, Ben A, O'Reilly, Paul F, Palkovits, Miklos, Penninx, Brenda W, Polidoro, Silvia, Pouta, Anneli, Prokopenko, Inga, Ricceri, Fulvio, Santos, Eugenio, Smit, Johannes H, Soranzo, Nicole, Song, Kijoung, Sovio, Ulla, Stumvoll, Michael, Surakk, Ida, Thorgeirsson, Thorgeir E, Thorsteinsdottir, Unnur, Troakes, Claire, Tyrfingsson, Thorarinn, Tönjes, Anke, Uiterwaal, Cuno S, Uitterlinden, Andre G, van der Harst, Pim, van der Schouw, Yvonne T, Staehlin, Oliver, Waeber, Gerard, Wareham, Nicholas J, Wichmann, Erich H, Witteman, Jacqueline C, Yuan, Xin, Zhai, Guangju, Zhao, Jing H, Zhang, Weihua, Martin, Nicholas G, Metspalu, Andres, Doering, Angela, Scott, James, Spector, Tim D, Loos, Ruth J, Boomsma, Dorret I, Peltonen, Leena, van Duijn, Cornelia M, Vineis, Paolo, Kooner, Jaspal S, Spanagel, Rainer, Heberlein, Ulrike A, Jarvelin, Marjo-Riitta, Elliott, Paul
Published in Proceedings of the National Academy of Sciences - PNAS

Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib

by Tardif, Jean-Claude, Dubé, Marie-Pierre, Pfeffer, Marc A., Waters, David D., Koenig, Wolfgang, Maggioni, Aldo P., McMurray, John J.V., Mooser, Vincent, White, Harvey D., Heinonen, Therese, Black, Donald M., Guertin, Marie-Claude
Published in The American heart journal