Deciphering the Emerging Complexities of Molecular Mechanisms at GWAS Loci

by Cannon, Maren E., Mohlke, Karen L.
Published in American journal of human genetics

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

by Laakso, Markku, Kuusisto, Johanna, Stančáková, Alena, Kuulasmaa, Teemu, Pajukanta, Päivi, Lusis, Aldons J., Collins, Francis S., Mohlke, Karen L., Boehnke, Michael
Published in Journal of lipid research

GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach

by Schmidt, Ellen M, Zhang, Ji, Zhou, Wei, Chen, Jin, Mohlke, Karen L, Chen, Y Eugene, Willer, Cristen J
Published in Bioinformatics

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits

by Freund, Malika Kumar, Burch, Kathryn S., Shi, Huwenbo, Mancuso, Nicholas, Kichaev, Gleb, Garske, Kristina M., Pan, David Z., Miao, Zong, Mohlke, Karen L., Laakso, Markku, Pajukanta, Päivi, Pasaniuc, Bogdan, Arboleda, Valerie A.
Published in American journal of human genetics

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

by Civelek, Mete, Wu, Ying, Pan, Calvin, Raulerson, Chelsea K., Ko, Arthur, He, Aiqing, Tilford, Charles, Saleem, Niyas K., Stančáková, Alena, Scott, Laura J., Fuchsberger, Christian, Stringham, Heather M., Jackson, Anne U., Narisu, Narisu, Chines, Peter S., Small, Kerrin S., Kuusisto, Johanna, Parks, Brian W., Pajukanta, Päivi, Kirchgessner, Todd, Collins, Francis S., Gargalovic, Peter S., Boehnke, Michael, Laakso, Markku, Mohlke, Karen L., Lusis, Aldons J.
Published in American journal of human genetics

The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

by Miao, Zong, Alvarez, Marcus, Ko, Arthur, Bhagat, Yash, Rahmani, Elior, Jew, Brandon, Heinonen, Sini, Muñoz-Hernandez, Linda Liliana, Herrera-Hernandez, Miguel, Aguilar-Salinas, Carlos, Tusie-Luna, Teresa, Mohlke, Karen L, Laakso, Markku, Pietiläinen, Kirsi H, Halperin, Eran, Pajukanta, Päivi
Published in PLoS genetics

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

by Perrin, Hannah J, Currin, Kevin W, Vadlamudi, Swarooparani, Pandey, Gautam K, Ng, Kenneth K, Wabitsch, Martin, Laakso, Markku, Love, Michael I, Mohlke, Karen L
Published in PLoS genetics

Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus

by Fogarty, Marie P, Cannon, Maren E, Vadlamudi, Swarooparani, Gaulton, Kyle J, Mohlke, Karen L
Published in PLoS genetics

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

by Spracklen, Cassandra N, Wang, Xu, Li, Shengxu, Wu, Ying, Wang, Ya Xing, Takeuchi, Fumihiko, Wu, Jer-Yuarn, Jung, Keum-Ji, Hu, Cheng, Akiyama, Koichi, Zhang, Yonghong, Moon, Sanghoon, Johnson, Todd A, Li, Huaixing, Dorajoo, Rajkumar, He, Meian, Cannon, Maren E, Roman, Tamara S, Lin, Keng-Hung, Guo, Xiuqing, Sheu, Wayne H H, Absher, Devin, Adair, Linda S, Assimes, Themistocles L, Aung, Tin, Cai, Qiuyin, Chang, Li-Ching, Chen, Chien-Hsiun, Chien, Li-Hsin, Chuang, Lee-Ming, Chuang, Shu-Chun, Du, Shufa, Fan, Qiao, Fann, Cathy S J, Feranil, Alan B, Friedlander, Yechiel, Gordon-Larsen, Penny, Gu, Dongfeng, Gui, Lixuan, Guo, Zhirong, Heng, Chew-Kiat, Hixson, James, Hou, Xuhong, Hwang, Mi Yeong, Hwu, Chii-Min, Isono, Masato, Juang, Jyh-Ming Jimmy, Khor, Chiea-Chuen, Koh, Woon-Puay, Lee, I-Te, Lee, Sun-Ju, Lee, Wen-Jane, Lim, Blanche, Lim, Sing-Hui, Liu, Jianjun, Nabika, Toru, Pan, Wen-Harn, Peng, Hao, Quertermous, Thomas, Sabanayagam, Charumathi, Sandow, Kevin, Shi, Jinxiu, Sun, Liang, Tan, Pok Chien, Tan, Shu-Pei, Taylor, Kent D, Teo, Yik-Ying, Toh, Sue-Anne, van Dam, Rob M, Wang, Aili, Wang, Feijie, Wang, Jie, Wei, Wen Bin, Xiang, Yong-Bing, Yao, Jie, Yuan, Jian-Min, Zhang, Rong, Zhao, Wanting, Rich, Stephen S, Rotter, Jerome I, Wang, Tzung-Dau, Wu, Tangchun, Lin, Xu, Han, Bok-Ghee, Tanaka, Toshihiro, Katsuya, Tomohiro, Jia, Weiping, Jee, Sun-Ha, Chen, Yuan-Tsong, Kato, Norihiro, Jonas, Jost B, Cheng, Ching-Yu, Shu, Xiao-Ou, He, Jiang, Zheng, Wei, Wong, Tien-Yin, Kim, Bong-Jo, Tai, E-Shyong, Mohlke, Karen L, Sim, Xueling
Published in Human molecular genetics

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

by Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick Th, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Cho, Myeong-Chan, Hwu, Chii-Min, Absher, Devin, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, Gu, Dongfeng, Mo, Zengnan, Wu, Jer-Yuarn, Lin, Xu, Miki, Tetsuro, Tai, E Shyong, Lee, Jong-Young, Kato, Norihiro, Shu, Xiao-Ou, Tanaka, Toshihiro
Published in Human molecular genetics

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

by Spracklen, Cassandra N, Shi, Jinxiu, Vadlamudi, Swarooparani, Wu, Ying, Zou, Meng, Raulerson, Chelsea K, Davis, James P, Zeynalzadeh, Monica, Jackson, Kayla, Yuan, Wentao, Wang, Haifeng, Shou, Weihua, Wang, Ying, Luo, Jingchun, Lange, Leslie A, Lange, Ethan M, Popkin, Barry M, Gordon-Larsen, Penny, Du, Shufa, Huang, Wei, Mohlke, Karen L
Published in PLoS genetics

INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis

by Liu, Yan, Sanoff, Hanna K, Cho, Hyunsoon, Burd, Christin E, Torrice, Chad, Mohlke, Karen L, Ibrahim, Joseph G, Thomas, Nancy E, Sharpless, Norman E
Published in PloS one

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

by Pan, David Z, Garske, Kristina M, Alvarez, Marcus, Bhagat, Yash V, Boocock, James, Nikkola, Elina, Miao, Zong, Raulerson, Chelsea K, Cantor, Rita M, Civelek, Mete, Glastonbury, Craig A, Small, Kerrin S, Boehnke, Michael, Lusis, Aldons J, Sinsheimer, Janet S, Mohlke, Karen L, Laakso, Markku, Pajukanta, Päivi, Ko, Arthur
Published in Nature communications

A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell

by Kulzer, Jennifer R., Stitzel, Michael L., Morken, Mario A., Huyghe, Jeroen R., Fuchsberger, Christian, Kuusisto, Johanna, Laakso, Markku, Boehnke, Michael, Collins, Francis S., Mohlke, Karen L.
Published in American journal of human genetics

Pla2g12b drives expansion of triglyceride-rich lipoproteins

by Thierer, James H, Foresti, Ombretta, Yadav, Pradeep Kumar, Wilson, Meredith H, Moll, Tabea O C, Shen, Meng-Chieh, Busch-Nentwich, Elisabeth M, Morash, Margaret, Mohlke, Karen L, Rawls, John F, Malhotra, Vivek, Hussain, M Mahmood, Farber, Steven A
Published in Nature communications

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

by Davis, James P, Huyghe, Jeroen R, Locke, Adam E, Jackson, Anne U, Sim, Xueling, Stringham, Heather M, Teslovich, Tanya M, Welch, Ryan P, Fuchsberger, Christian, Narisu, Narisu, Chines, Peter S, Kangas, Antti J, Soininen, Pasi, Ala-Korpela, Mika, Kuusisto, Johanna, Collins, Francis S, Laakso, Markku, Boehnke, Michael, Mohlke, Karen L
Published in PLoS genetics

Recent advances in understanding the genetic architecture of type 2 diabetes

by Mohlke, Karen L, Boehnke, Michael
Published in Human molecular genetics

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

by Spracklen, Cassandra N, Iyengar, Apoorva K, Vadlamudi, Swarooparani, Raulerson, Chelsea K, Jackson, Anne U, Brotman, Sarah M, Wu, Ying, Cannon, Maren E, Davis, James P, Crain, Aaron T, Currin, Kevin W, Perrin, Hannah J, Narisu, Narisu, Stringham, Heather M, Fuchsberger, Christian, Locke, Adam E, Welch, Ryan P, Kuusisto, Johanna K, Pajukanta, Päivi, Scott, Laura J, Li, Yun, Collins, Francis S, Boehnke, Michael, Laakso, Markku, Mohlke, Karen L
Published in PLoS genetics

Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans

by Schick, Ursula M., Jain, Deepti, Hodonsky, Chani J., Morrison, Jean V., Davis, James P., Brown, Lisa, Sofer, Tamar, Conomos, Matthew P., Schurmann, Claudia, McHugh, Caitlin P., Nelson, Sarah C., Vadlamudi, Swarooparani, Stilp, Adrienne, Plantinga, Anna, Baier, Leslie, Bien, Stephanie A., Gogarten, Stephanie M., Laurie, Cecelia A., Taylor, Kent D., Liu, Yongmei, Auer, Paul L., Franceschini, Nora, Szpiro, Adam, Rice, Ken, Kerr, Kathleen F., Rotter, Jerome I., Hanson, Robert L., Papanicolaou, George, Rich, Stephen S., Loos, Ruth J.F., Browning, Brian L., Browning, Sharon R., Weir, Bruce S., Laurie, Cathy C., Mohlke, Karen L., North, Kari E., Thornton, Timothy A., Reiner, Alex P.
Published in American journal of human genetics

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

by Roman, Tamara S., Marvelle, Amanda F., Fogarty, Marie P., Vadlamudi, Swarooparani, Gonzalez, Arlene J., Buchkovich, Martin L., Huyghe, Jeroen R., Fuchsberger, Christian, Jackson, Anne U., Wu, Ying, Civelek, Mete, Lusis, Aldons J., Gaulton, Kyle J., Sethupathy, Praveen, Kangas, Antti J., Soininen, Pasi, Ala-Korpela, Mika, Kuusisto, Johanna, Collins, Francis S., Laakso, Markku, Boehnke, Michael, Mohlke, Karen L.
Published in American journal of human genetics