Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

by Messner, Christoph B., Demichev, Vadim, Wendisch, Daniel, Michalick, Laura, White, Matthew, Freiwald, Anja, Textoris-Taube, Kathrin, Vernardis, Spyros I., Egger, Anna-Sophia, Kreidl, Marco, Ludwig, Daniela, Kilian, Christiane, Agostini, Federica, Zelezniak, Aleksej, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, von Kalle, Christof, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Langenberg, Claudia, Lilley, Kathryn S., Kuebler, Wolfgang M., Mülleder, Michael, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Kurth, Florian, Sander, Leif Erik, Ralser, Markus
Published in Cell Systems

Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure

by Piedrafita, Gabriel, Varma, Sreejith J, Castro, Cecilia, Messner, Christoph B, Szyrwiel, Lukasz, Griffin, Julian L, Ralser, Markus
Published in PLoS biology

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

by Yu, Jason S L, Heineike, Benjamin M, Hartl, Johannes, Aulakh, Simran K, Correia-Melo, Clara, Lehmann, Andrea, Lemke, Oliver, Agostini, Federica, Lee, Cory T, Demichev, Vadim, Messner, Christoph B, Mülleder, Michael, Ralser, Markus
Published in PLoS biology

Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts

by Zelezniak, Aleksej, Vowinckel, Jakob, Capuano, Floriana, Messner, Christoph B., Demichev, Vadim, Polowsky, Nicole, Mülleder, Michael, Kamrad, Stephan, Klaus, Bernd, Keller, Markus A., Ralser, Markus
Published in Cell systems

Global analysis of cytosine and adenine DNA modifications across the tree of life

by Varma, Sreejith Jayasree, Calvani, Enrica, Grüning, Nana-Maria, Messner, Christoph B, Grayson, Nicholas, Capuano, Floriana, Mülleder, Michael, Ralser, Markus
Published in eLife

Ultra-fast proteomics with Scanning SWATH

by Messner, Christoph B, Demichev, Vadim, Bloomfield, Nic, Yu, Jason S L, White, Matthew, Kreidl, Marco, Egger, Anna-Sophia, Freiwald, Anja, Ivosev, Gordana, Wasim, Fras, Zelezniak, Aleksej, Jürgens, Linda, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Lilley, Kathryn S, Mülleder, Michael, Tate, Stephen, Ralser, Markus
Published in Nature biotechnology

The proteomic landscape of genome-wide genetic perturbations

by Messner, Christoph B., Demichev, Vadim, Muenzner, Julia, Aulakh, Simran K., Barthel, Natalie, Röhl, Annika, Herrera-Domínguez, Lucía, Egger, Anna-Sophia, Kamrad, Stephan, Hou, Jing, Tan, Guihong, Lemke, Oliver, Calvani, Enrica, Szyrwiel, Lukasz, Mülleder, Michael, Lilley, Kathryn S., Boone, Charles, Kustatscher, Georg, Ralser, Markus
Published in Cell

Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice

by Messner, Christoph B., Driscoll, Paul C., Piedrafita, Gabriel, De Volder, Michael F. L., Ralser, Markus
Published in Proceedings of the National Academy of Sciences - PNAS

A time-resolved proteomic and prognostic map of COVID-19

by Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Thibeault, Charlotte, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T., Stubbemann, Paula, Lippert, Lena J., Grüning, Nana-Maria, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Tancevski, Ivan, Witzenrath, Martin, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Kleinschmidt, Malte, Heim, Katrin M., Meyer-Arndt, Lil, Hübner, Ralf H., Andermann, Tim, Doehn, Jan M., Opitz, Bastian, Sawitzki, Birgit, Schürmann, Mariana, Zoller, Thomas, Alius, Florian, Knape, Philipp, Breitbart, Astrid, Pergantis, Panagiotis, Schürmann, Dirk, Temmesfeld-Wollbrück, Bettina, Wendisch, Daniel, Brumhard, Sophia, Haenel, Sascha S., Conrad, Claudia, Georg, Philipp, Eckardt, Kai-Uwe, Lehner, Lukas, Kruse, Jan M., Ferse, Carolin, Körner, Roland, Spies, Claudia, Edel, Andreas, Weber-Carstens, Steffen, Krannich, Alexander, Li, Linna, Behrens, Uwe, Schmidt, Sein, Rönnefarth, Maria, Dang-Heine, Chantip, Röhle, Robert, Lieker, Emma, Kretzler, Lucie, Wirsching, Isabelle, Wollboldt, Christian, Wu, Yinan, Schwanitz, Georg, Hillus, David, Kasper, Stefanie, Horn, Alexandra, Briesemeister, Dana, Treue, Denise, Hummel, Michael, Corman, Victor M., Drosten, Christian, von Kalle, Christof, Kurth, Florian
Published in Cell systems

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

by Correia-Melo, Clara, Kamrad, Stephan, Tengölics, Roland, Messner, Christoph B., Trebulle, Pauline, Townsend, StJohn, Jayasree Varma, Sreejith, Freiwald, Anja, Heineike, Benjamin M., Campbell, Kate, Herrera-Dominguez, Lucía, Kaur Aulakh, Simran, Szyrwiel, Lukasz, Yu, Jason S.L., Zelezniak, Aleksej, Demichev, Vadim, Mülleder, Michael, Papp, Balázs, Alam, Mohammad Tauqeer, Ralser, Markus
Published in Cell

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

by Cervia-Hasler, Carlo, Brüningk, Sarah C, Hoch, Tobias, Fan, Bowen, Muzio, Giulia, Thompson, Ryan C, Ceglarek, Laura, Meledin, Roman, Westermann, Patrick, Emmenegger, Marc, Taeschler, Patrick, Zurbuchen, Yves, Pons, Michele, Menges, Dominik, Ballouz, Tala, Cervia-Hasler, Sara, Adamo, Sarah, Merad, Miriam, Charney, Alexander W, Puhan, Milo, Brodin, Petter, Nilsson, Jakob, Aguzzi, Adriano, Raeber, Miro E, Messner, Christoph B, Beckmann, Noam D, Borgwardt, Karsten, Boyman, Onur
Published in Science (American Association for the Advancement of Science)

Combined Ab Initio Computational and Infrared Spectroscopic Study of the cis- and trans-Bis(glycinato)copper(II) Complexes in Aqueous Environment

by Lutz, Oliver M. D, Messner, Christoph B, Hofer, Thomas S, Glätzle, Matthias, Huck, Christian W, Bonn, Günther K, Rode, Bernd M
Published in The journal of physical chemistry letters

Erbium(III) in Aqueous Solution: An Ab Initio Molecular Dynamics Study

by Canaval, Lorenz R, Sakwarathorn, Theerathad, Rode, Bernd M, Messner, Christoph B, Lutz, Oliver M. D, Bonn, Günther K
Published in The journal of physical chemistry. B

Computational study of the hafnium (IV) ion in aqueous solution

by Messner, Christoph B., Hofer, Thomas S., Randolf, Bernhard R., Rode, Bernd M.
Published in Chemical physics letters

Structure and Dynamics of Chromatographically Relevant Fe(III)-Chelates

by Messner, Christoph B, Lutz, Oliver M. D, Rainer, Matthias, Huck, Christian W, Hofer, Thomas S, Rode, Bernd M, Bonn, Günther K
Published in The journal of physical chemistry. B

1H-NMR as implemented in several origin of life studies artificially implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed

by Keller, Markus A., Driscoll, Paul C., Messner, Christoph B., Ralser, Markus
Published in Wellcome open research

Computational Vibrational Spectroscopy of glycine in aqueous solution – Fundamental considerations towards feasible methodologies

by Lutz, Oliver M.D., Messner, Christoph B., Hofer, Thomas S., Canaval, Lorenz R., Bonn, Guenther K., Huck, Christian W.
Published in Chemical physics

A proteomic survival predictor for COVID-19 patients in intensive care

by Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J. Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J. Lippert, Elisa T. Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B. Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J. Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S. Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B. Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A. Keller, Ivan Tancevski, John F. Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Florian Kurth, Markus Ralser
Published in PLOS digital health

Primordial Krebs-cycle-like non-enzymatic reactions detected by mass spectrometry and nuclear magnetic resonance

by Keller, Markus A., Driscoll, Paul C., Messner, Christoph B., Ralser, Markus
Published in Wellcome open research

The Proteomic Landscape of Genome-Wide Genetic Perturbations

by Messner, Christoph B, Demichev, Vadim, Muenzner, Julia, Aulakh, Simran, Röhl, Annika, Herrera-Domínguez, Lucía, Egger, Anna-Sophia, Kamrad, Stephan, Lemke, Oliver, Calvani, Enrica, Mülleder, Michael, Lilley, Kathryn S, Kustatscher, Georg, Ralser, Markus
Published in bioRxiv