The evolutionary history of lethal metastatic prostate cancer

by Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B, Tubio, Jose M C, Papaemmanuil, Elli, Brewer, Daniel S, Kallio, Heini M L, Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J, Isaacs, William, Emmert-Buck, Michael R, Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C, Neal, David E, Cooper, Colin S, Eeles, Rosalind A, Visakorpi, Tapio, Campbell, Peter J, McDermott, Ultan, Wedge, David C, Bova, G Steven
Published in Nature (London)

Transparency and reproducibility in artificial intelligence

by Haibe-Kains, Benjamin, Adam, George Alexandru, Hosny, Ahmed, Khodakarami, Farnoosh, Waldron, Levi, Wang, Bo, McIntosh, Chris, Goldenberg, Anna, Kundaje, Anshul, Greene, Casey S, Broderick, Tamara, Hoffman, Michael M, Leek, Jeffrey T, Korthauer, Keegan, Huber, Wolfgang, Brazma, Alvis, Pineau, Joelle, Tibshirani, Robert, Hastie, Trevor, Ioannidis, John P A, Quackenbush, John, Aerts, Hugo J W L
Published in Nature (London)

Human metabolic individuality in biomedical and pharmaceutical research

by SUHRE, Karsten, SHIN, So-Youn, HAMMOND, Christopher J, HRABE DEANGELIS, Martin, KASTENMÜLLER, Gabi, KÖTTGEN, Anna, KRONENBERG, Florian, MANGINO, Massimo, MEISINGER, Christa, MEITINGER, Thomas, MEWES, Hans-Werner, MILBURN, Michael V, PETERSEN, Ann-Kristin, PREHN, Cornelia, RAFFLER, Johannes, RIED, Janina S, RÖMISCH-MARG, Werner, SAMANI, Nilesh J, SMALL, Kerrin S, WICHMANN, H.-Erich, GUANGJUZHAI, ILLIG, Thomas, SPECTOR, Tim D, MOHNEY, Robert P, ADAMSKI, Jerzy, SORANZO, Nicole, GIEGER, Christian, MEREDITH, David, WÄGELE, Brigitte, ALTMAIER, Elisabeth, DELOUKAS, Panos, ERDMANN, Jeanette, GRUNDBERG, Elin
Published in Nature (London)

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

by Meng, Bo, Abdullahi, Adam, Ferreira, Isabella A T M, Goonawardane, Niluka, Saito, Akatsuki, Kimura, Izumi, Yamasoba, Daichi, Gerber, Pehuén Pereyra, Fatihi, Saman, Rathore, Surabhi, Zepeda, Samantha K, Papa, Guido, Kemp, Steven A, Ikeda, Terumasa, Toyoda, Mako, Tan, Toong Seng, Kuramochi, Jin, Mitsunaga, Shigeki, Ueno, Takamasa, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Brevini, Teresa, Mallery, Donna L, Charles, Oscar J, Bowen, John E, Joshi, Anshu, Walls, Alexandra C, Jackson, Laurelle, Martin, Darren, Smith, Kenneth G C, Bradley, John, Briggs, John A G, Choi, Jinwook, Madissoon, Elo, Meyer, Kerstin B, Mlcochova, Petra, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Teichmann, Sarah A, Fisher, Andrew J, Pizzuto, Matteo S, de Marco, Anna, Corti, Davide, Hosmillo, Myra, Lee, Joo Hyeon, James, Leo C, Thukral, Lipi, Veesler, David, Sigal, Alex, Sampaziotis, Fotios, Goodfellow, Ian G, Matheson, Nicholas J, Sato, Kei, Gupta, Ravindra K
Published in Nature (London)

A structural variation reference for medical and population genetics

by Collins, Ryan L, Brand, Harrison, Karczewski, Konrad J, Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C, Khera, Amit V, Lowther, Chelsea, Gauthier, Laura D, Wang, Harold, Watts, Nicholas A, Solomonson, Matthew, O'Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W, Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R, Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M, Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D, Lin, Henry J, Rich, Stephen S, Post, Wendy S, Chen, Yii-Der Ida, Rotter, Jerome I, Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M, Kathiresan, Sekar, Daly, Mark J, Banks, Eric, MacArthur, Daniel G, Talkowski, Michael E
Published in Nature (London)

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

by Erdmann, Jeanette, Stark, Klaus, Esslinger, Ulrike B, Rumpf, Philipp Moritz, Koesling, Doris, de Wit, Cor, Kaiser, Frank J, Braunholz, Diana, Medack, Anja, Fischer, Marcus, Zimmermann, Martina E, Tennstedt, Stephanie, Graf, Elisabeth, Eck, Sebastian, Aherrahrou, Zouhair, Nahrstaedt, Janja, Willenborg, Christina, Bruse, Petra, Brænne, Ingrid, Nöthen, Markus M, Hofmann, Per, Braund, Peter S, Mergia, Evanthia, Reinhard, Wibke, Burgdorf, Christof, Schreiber, Stefan, Balmforth, Anthony J, Hall, Alistair S, Bertram, Lars, Steinhagen-Thiessen, Elisabeth, Li, Shu-Chen, März, Winfried, Reilly, Muredach, Kathiresan, Sekar, McPherson, Ruth, Walter, Ulrich, Ott, Jurg, Samani, Nilesh J, Strom, Tim M, Meitinger, Thomas, Hengstenberg, Christian, Schunkert, Heribert
Published in Nature (London)

Genomic analyses identify molecular subtypes of pancreatic cancer

by Bailey, Peter, Nones, Katia, Johns, Amber L, Patch, Ann-Marie, Gingras, Marie-Claude, Miller, David K, Christ, Angelika N, Bruxner, Tim J C, Quinn, Michael C, Nourse, Craig, Murtaugh, L Charles, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourbakhsh, Ehsan, Wani, Shivangi, Fink, Lynn, Holmes, Oliver, Chin, Venessa, Anderson, Matthew J, Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Xu, Qinying, Wilson, Peter J, Cloonan, Nicole, Kassahn, Karin S, Taylor, Darrin, Quek, Kelly, Robertson, Alan, Pantano, Lorena, Mincarelli, Laura, Sanchez, Luis N, Evers, Lisa, Wu, Jianmin, Pinese, Mark, Cowley, Mark J, Jones, Marc D, Colvin, Emily K, Nagrial, Adnan M, Humphrey, Emily S, Mawson, Amanda, Humphris, Jeremy, Chou, Angela, Pajic, Marina, Scarlett, Christopher J, Pinho, Andreia V, Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S, Kench, James G, Lovell, Jessica A, Merrett, Neil D, Toon, Christopher W, Epari, Krishna, Nguyen, Nam Q, Barbour, Andrew, Zeps, Nikolajs, Moran-Jones, Kim, Jamieson, Nigel B, Graham, Janet S, Duthie, Fraser, Oien, Karin, Hair, Jane, Grützmann, Robert, Maitra, Anirban, Iacobuzio-Donahue, Christine A, Wolfgang, Christopher L, Morgan, Richard A, Lawlor, Rita T, Corbo, Vincenzo, Bassi, Claudio, Rusev, Borislav, Capelli, Paola, Salvia, Roberto, Tortora, Giampaolo, Mukhopadhyay, Debabrata, Petersen, Gloria M, Munzy, Donna M, Fisher, William E, Karim, Saadia A, Eshleman, James R, Hruban, Ralph H, Pilarsky, Christian, Morton, Jennifer P, Sansom, Owen J, Scarpa, Aldo, Musgrove, Elizabeth A, Bailey, Ulla-Maja Hagbo, Hofmann, Oliver, Sutherland, Robert L, Wheeler, David A, Gill, Anthony J, Gibbs, Richard A, Pearson, John V, Waddell, Nicola, Biankin, Andrew V, Grimmond, Sean M
Published in Nature (London)

Whole genomes redefine the mutational landscape of pancreatic cancer

by Waddell, Nicola, Pajic, Marina, Patch, Ann-Marie, Chang, David K, Kassahn, Karin S, Bailey, Peter, Johns, Amber L, Miller, David, Nones, Katia, Quek, Kelly, Quinn, Michael C J, Robertson, Alan J, Fadlullah, Muhammad Z H, Bruxner, Tim J C, Christ, Angelika N, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Wilson, Peter J, Markham, Emma, Cloonan, Nicole, Anderson, Matthew J, Fink, J Lynn, Holmes, Oliver, Kazakoff, Stephen H, Leonard, Conrad, Newell, Felicity, Poudel, Barsha, Song, Sarah, Taylor, Darrin, Waddell, Nick, Wood, Scott, Xu, Qinying, Wu, Jianmin, Pinese, Mark, Cowley, Mark J, Lee, Hong C, Jones, Marc D, Nagrial, Adnan M, Humphris, Jeremy, Chantrill, Lorraine A, Chin, Venessa, Steinmann, Angela M, Mawson, Amanda, Humphrey, Emily S, Colvin, Emily K, Chou, Angela, Scarlett, Christopher J, Pinho, Andreia V, Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S, Kench, James G, Pettitt, Jessica A, Merrett, Neil D, Toon, Christopher, Epari, Krishna, Nguyen, Nam Q, Barbour, Andrew, Zeps, Nikolajs, Jamieson, Nigel B, Graham, Janet S, Niclou, Simone P, Bjerkvig, Rolf, Grützmann, Robert, Aust, Daniela, Hruban, Ralph H, Maitra, Anirban, Iacobuzio-Donahue, Christine A, Wolfgang, Christopher L, Morgan, Richard A, Lawlor, Rita T, Corbo, Vincenzo, Bassi, Claudio, Falconi, Massimo, Zamboni, Giuseppe, Tortora, Giampaolo, Tempero, Margaret A, Gill, Anthony J, Eshleman, James R, Pilarsky, Christian, Scarpa, Aldo, Musgrove, Elizabeth A, Pearson, John V, Biankin, Andrew V, Grimmond, Sean M
Published in Nature (London)

Transcript expression-aware annotation improves rare variant interpretation

by Cummings, Beryl B, Karczewski, Konrad J, Kosmicki, Jack A, Seaby, Eleanor G, Watts, Nicholas A, Singer-Berk, Moriel, Mudge, Jonathan M, Karjalainen, Juha, Satterstrom, F Kyle, O'Donnell-Luria, Anne H, Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J, MacArthur, Daniel G
Published in Nature (London)

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

by Burton, Paul R, Clayton, David G, Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, McCarthy, Mark I, Ouwehand, Willem H, Samani, Nilesh J, Todd, John A, Donnelly, Peter, Barrett, Jeffrey C
Published in Nature

Evaluating drug targets through human loss-of-function genetic variation

by Minikel, Eric Vallabh, Karczewski, Konrad J, Martin, Hilary C, Cummings, Beryl B, Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C, van Heel, David A, Daly, Mark J, Schreiber, Stuart L, MacArthur, Daniel G
Published in Nature (London)

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

by Lloyd-Price, Jason, Arze, Cesar, Ananthakrishnan, Ashwin N, Schirmer, Melanie, Avila-Pacheco, Julian, Poon, Tiffany W, Andrews, Elizabeth, Ajami, Nadim J, Bonham, Kevin S, Brislawn, Colin J, Casero, David, Courtney, Holly, Gonzalez, Antonio, Graeber, Thomas G, Hall, A Brantley, Lake, Kathleen, Landers, Carol J, Mallick, Himel, Plichta, Damian R, Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Shungin, Dmitry, Vázquez-Baeza, Yoshiki, White, 3rd, Richard A, Braun, Jonathan, Denson, Lee A, Jansson, Janet K, Knight, Rob, Kugathasan, Subra, McGovern, Dermot P B, Petrosino, Joseph F, Stappenbeck, Thaddeus S, Winter, Harland S, Clish, Clary B, Franzosa, Eric A, Vlamakis, Hera, Xavier, Ramnik J, Huttenhower, Curtis
Published in Nature (London)

Proteogenomics connects somatic mutations to signalling in breast cancer

by Mertins, Philipp, Mani, D R, Ruggles, Kelly V, Gillette, Michael A, Clauser, Karl R, Wang, Pei, Wang, Xianlong, Qiao, Jana W, Cao, Song, Petralia, Francesca, Kawaler, Emily, Mundt, Filip, Krug, Karsten, Tu, Zhidong, Lei, Jonathan T, Gatza, Michael L, Wilkerson, Matthew, Perou, Charles M, Yellapantula, Venkata, Huang, Kuan-lin, Lin, Chenwei, McLellan, Michael D, Yan, Ping, Davies, Sherri R, Townsend, R Reid, Skates, Steven J, Wang, Jing, Zhang, Bing, Kinsinger, Christopher R, Mesri, Mehdi, Rodriguez, Henry, Ding, Li, Paulovich, Amanda G, Fenyö, David, Ellis, Matthew J, Carr, Steven A
Published in Nature (London)

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

by Lucas, Carolina, Vogels, Chantal B F, Yildirim, Inci, Rothman, Jessica E, Lu, Peiwen, Monteiro, Valter, Gehlhausen, Jeff R, Campbell, Melissa, Silva, Julio, Tabachnikova, Alexandra, Peña-Hernandez, Mario A, Muenker, M Catherine, Breban, Mallery I, Fauver, Joseph R, Mohanty, Subhasis, Huang, Jiefang, Shaw, Albert C, Ko, Albert I, Omer, Saad B, Grubaugh, Nathan D, Iwasaki, Akiko
Published in Nature (London)

Using DNA sequencing data to quantify T cell fraction and therapy response

by Bentham, Robert, Litchfield, Kevin, Watkins, Thomas B K, Lim, Emilia L, Rosenthal, Rachel, Martínez-Ruiz, Carlos, Hiley, Crispin T, Bakir, Maise Al, Salgado, Roberto, Moore, David A, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Published in Nature (London)

The mutational constraint spectrum quantified from variation in 141,456 humans

by Karczewski, Konrad J, Francioli, Laurent C, Tiao, Grace, Cummings, Beryl B, Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L, Laricchia, Kristen M, Ganna, Andrea, Birnbaum, Daniel P, Gauthier, Laura D, Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A, Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M, Seaby, Eleanor G, Kosmicki, Jack A, Walters, Raymond K, Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X, Samocha, Kaitlin E, Pierce-Hoffman, Emma, Zappala, Zachary, O'Donnell-Luria, Anne H, Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S, Vittal, Christopher, Armean, Irina M, Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M, Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E, Neale, Benjamin M, Daly, Mark J, MacArthur, Daniel G
Published in Nature (London)

Suppressing quantum errors by scaling a surface code logical qubit

by Acharya, Rajeev, Aleiner, Igor, Arute, Frank, Asfaw, Abraham, Bardin, Joseph C., Basso, Joao, Bengtsson, Andreas, Bortoli, Gina, Bourassa, Alexandre, Bovaird, Jenna, Broughton, Michael, Buell, David A., Burger, Tim, Burkett, Brian, Chen, Yu, Chiaro, Ben, Collins, Roberto, Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Faoro, Lara, Flores Burgos, Leslie, Forati, Ebrahim, Foxen, Brooks, Giang, William, Gidney, Craig, Gilboa, Dar, Gross, Jonathan A., Habegger, Steve, Hamilton, Michael C., Harrigan, Matthew P., Harrington, Sean D., Hoffmann, Markus, Hong, Sabrina, Huang, Trent, Huff, Ashley, Huggins, William J., Ioffe, Lev B., Isakov, Sergei V., Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Kafri, Dvir, Kechedzhi, Kostyantyn, Kieferová, Mária, Kim, Seon, Klots, Andrey R., Korotkov, Alexander N., Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Lee, Joonho, Lee, Kenny, Locharla, Aditya, Lucero, Erik, Malone, Fionn D., Martin, Orion, McCourt, Trevor, McEwen, Matt, Megrant, Anthony, Meurer Costa, Bernardo, Mohseni, Masoud, Montazeri, Shirin, Mount, Emily, Mruczkiewicz, Wojciech, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Murray, Niu, Murphy Yuezhen, O’Brien, Thomas E., Opremcak, Alex, Petukhov, Andre, Quintana, Chris, Roushan, Pedram, Rubin, Nicholas C., Saei, Negar, Sank, Daniel, Sankaragomathi, Kannan, Shearn, Michael J., Shorter, Aaron, Shvarts, Vladimir, Skruzny, Jindra, Smelyanskiy, Vadim, Smith, W. Clarke, Sterling, George, Strain, Doug, Szalay, Marco, Xing, Cheng, Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng
Published in Nature (London)

The repertoire of mutational signatures in human cancer

by Alexandrov, Ludmil B, Kim, Jaegil, Haradhvala, Nicholas J, Huang, Mi Ni, Tian Ng, Alvin Wei, Wu, Yang, Boot, Arnoud, Covington, Kyle R, Gordenin, Dmitry A, Bergstrom, Erik N, Islam, S M Ashiqul, Lopez-Bigas, Nuria, Klimczak, Leszek J, McPherson, John R, Morganella, Sandro, Sabarinathan, Radhakrishnan, Wheeler, David A, Mustonen, Ville, Getz, Gad, Rozen, Steven G, Stratton, Michael R
Published in Nature (London)

Pan-cancer analysis of whole genomes

by Campbell, Peter J, Getz, Gad, Korbel, Jan O, Stuart, Joshua M, Jennings, Jennifer L, Stein, Lincoln D, Perry, Marc D
Published in Nature (London)

Mapping the human genetic architecture of COVID-19

by Niemi, Mari E. K, Karjalainen, Juha, Liao, Rachel G, Neale, Benjamin M, Daly, Mark, Ganna, Andrea
Published in Nature (London)