Pediatric Cancer Predisposition and Surveillance: An Overview, and a Tribute to Alfred G. Knudson Jr

by Brodeur, Garrett M, Nichols, Kim E, Plon, Sharon E, Schiffman, Joshua D, Malkin, David
Published in Clinical cancer research

Signatures of copy number alterations in human cancer

by Steele, Christopher D, Abbasi, Ammal, Islam, S M Ashiqul, Bowes, Amy L, Khandekar, Azhar, Haase, Kerstin, Hames-Fathi, Shadi, Ajayi, Dolapo, Verfaillie, Annelien, Dhami, Pawan, McLatchie, Alex, Lechner, Matt, Light, Nicholas, Shlien, Adam, Malkin, David, Feber, Andrew, Proszek, Paula, Lesluyes, Tom, Mertens, Fredrik, Flanagan, Adrienne M, Tarabichi, Maxime, Van Loo, Peter, Alexandrov, Ludmil B, Pillay, Nischalan
Published in Nature (London)

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies

by Schultz, Kris Ann P, Williams, Gretchen M, Kamihara, Junne, Stewart, Douglas R, Harris, Anne K, Bauer, Andrew J, Turner, Joyce, Shah, Rachana, Schneider, Katherine, Schneider, Kami Wolfe, Carr, Ann Garrity, Harney, Laura A, Baldinger, Shari, Frazier, A Lindsay, Orbach, Daniel, Schneider, Dominik T, Malkin, David, Dehner, Louis P, Messinger, Yoav H, Hill, D Ashley
Published in Clinical cancer research

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study

by Villani, Anita, MD, Shore, Ari, BScH, Wasserman, Jonathan D, MD, Stephens, Derek, MSc, Kim, Raymond H, MD, Druker, Harriet, MSc, Gallinger, Bailey, MSc, Naumer, Anne, MS, Kohlmann, Wendy, MS, Novokmet, Ana, BA, Tabori, Uri, MD, Tijerin, Marta, MD, Greer, Mary-Louise C, MBBS, Finlay, Jonathan L, Prof, Schiffman, Joshua D, MD, Malkin, David, Prof
Published in The lancet oncology

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

by Waszak, Sebastian M, Northcott, Paul A, Buchhalter, Ivo, Robinson, Giles W, Sutter, Christian, Groebner, Susanne, Grund, Kerstin B, Brugières, Laurence, Jones, David T W, Pajtler, Kristian W, Morrissy, A Sorana, Kool, Marcel, Sturm, Dominik, Chavez, Lukas, Ernst, Aurelie, Brabetz, Sebastian, Hain, Michael, Zichner, Thomas, Segura-Wang, Maia, Weischenfeldt, Joachim, Rausch, Tobias, Mardin, Balca R, Zhou, Xin, Baciu, Cristina, Lawerenz, Christian, Chan, Jennifer A, Varlet, Pascale, Guerrini-Rousseau, Lea, Fults, Daniel W, Grajkowska, Wiesława, Hauser, Peter, Jabado, Nada, Ra, Young-Shin, Zitterbart, Karel, Shringarpure, Suyash S, De La Vega, Francisco M, Bustamante, Carlos D, Ng, Ho-Keung, Perry, Arie, MacDonald, Tobey J, Hernáiz Driever, Pablo, Bendel, Anne E, Bowers, Daniel C, McCowage, Geoffrey, Chintagumpala, Murali M, Cohn, Richard, Hassall, Timothy, Fleischhack, Gudrun, Eggen, Tone, Wesenberg, Finn, Feychting, Maria, Lannering, Birgitta, Schüz, Joachim, Johansen, Christoffer, Andersen, Tina V, Röösli, Martin, Kuehni, Claudia E, Grotzer, Michael, Kjaerheim, Kristina, Monoranu, Camelia M, Archer, Tenley C, Duke, Elizabeth, Pomeroy, Scott L, Shelagh, Redmond, Frank, Stephan, Sumerauer, David, Scheurlen, Wolfram, Ryzhova, Marina V, Milde, Till, Kratz, Christian P, Samuel, David, Zhang, Jinghui, Solomon, David A, Marra, Marco, Eils, Roland, Bartram, Claus R, von Hoff, Katja, Rutkowski, Stefan, Ramaswamy, Vijay, Gilbertson, Richard J, Korshunov, Andrey, Taylor, Michael D, Lichter, Peter, Malkin, David, Gajjar, Amar, Korbel, Jan O, Pfister, Stefan M
Published in The lancet oncology

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study

by Villani, Anita, MD, Tabori, Uri, MD, Schiffman, Joshua, MD, Shlien, Adam, PhD, Beyene, Joseph, PhD, Druker, Harriet, MSc, Novokmet, Ana, BA, Finlay, Jonathan, Prof, Malkin, David, Prof
Published in The lancet oncology

Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction

by Das, Bikul, Tsuchida, Rika, Malkin, David, Koren, Gideon, Baruchel, Sylvain, Yeger, Herman
Published in Stem cells (Dayton, Ohio)

p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis

by Fischer, Nicholas W, Prodeus, Aaron, Malkin, David, Gariépy, Jean
Published in Cell cycle (Georgetown, Tex.)

Heath policy guiding the identification, analysis and management of secondary findings for individuals undergoing genomic sequencing: a systematic review protocol

by Majeed, Safa, Mighton, Chloe, Malkin, David, Bombard, Yvonne
Published in BMJ open

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

by Capaci, Valeria, Bascetta, Lorenzo, Fantuz, Marco, Beznoussenko, Galina V, Sommaggio, Roberta, Cancila, Valeria, Bisso, Andrea, Campaner, Elena, Mironov, Alexander A, Wiśniewski, Jacek R, Ulloa Severino, Luisa, Scaini, Denis, Bossi, Fleur, Lees, Jodi, Alon, Noa, Brunga, Ledia, Malkin, David, Piazza, Silvano, Collavin, Licio, Rosato, Antonio, Bicciato, Silvio, Tripodo, Claudio, Mantovani, Fiamma, Del Sal, Giannino
Published in Nature communications

Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

by Hayes, Madeline N., McCarthy, Karin, Jin, Alexander, Oliveira, Mariana L., Iyer, Sowmya, Garcia, Sara P., Sindiri, Sivasish, Gryder, Berkley, Motala, Zainab, Nielsen, G. Petur, Borg, Jean-Paul, van de Rijn, Matt, Malkin, David, Khan, Javed, Ignatius, Myron S., Langenau, David M.
Published in Cell stem cell

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

by Castelo-Branco, Pedro, PhD, Choufani, Sanaa, PhD, Mack, Stephen, BSc, Gallagher, Denis, PhD, Zhang, Cindy, MSc, Lipman, Tatiana, MSc, Zhukova, Nataliya, MD, Walker, Erin J, PhD, Martin, Dianna, PhD, Merino, Diana, MSc, Wasserman, Jonathan D, MD, Elizabeth, Cynthia, MSc, Alon, Noa, BSc, Zhang, Libo, PhD, Hovestadt, Volker, MSc, Kool, Marcel, PhD, Jones, David TW, PhD, Zadeh, Gelareh, MD, Croul, Sidney, Prof, Hawkins, Cynthia, MD, Hitzler, Johann, MD, Wang, Jean CY, MD, Baruchel, Sylvain, Prof, Dirks, Peter B, Prof, Malkin, David, Prof, Pfister, Stefan, MD, Taylor, Michael D, MD, Weksberg, Rosanna, Prof, Tabori, Uri, Dr
Published in The lancet oncology

Inherited TP53 Mutations and the Li-Fraumeni Syndrome

by Guha, Tanya, Malkin, David
Published in Cold Spring Harbor perspectives in medicine

Li-fraumeni syndrome

by Malkin, David
Published in Genes & cancer

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

by Leroy, Bernard, Ballinger, Mandy L, Baran-Marszak, Fanny, Bond, Gareth L, Braithwaite, Antony, Concin, Nicole, Donehower, Lawrence A, El-Deiry, Wafik S, Fenaux, Pierre, Gaidano, Gianluca, Langerød, Anita, Hellstrom-Lindberg, Eva, Iggo, Richard, Lehmann-Che, Jacqueline, Mai, Phuong L, Malkin, David, Moll, Ute M, Myers, Jeffrey N, Nichols, Kim E, Pospisilova, Sarka, Ashton-Prolla, Patricia, Rossi, Davide, Savage, Sharon A, Strong, Louise C, Tonin, Patricia N, Zeillinger, Robert, Zenz, Thorsten, Fraumeni, Jr, Joseph F, Taschner, Peter E M, Hainaut, Pierre, Soussi, Thierry
Published in Cancer research (Chicago, Ill.)

Germ-line and somatic DICER1 mutations in pineoblastoma

by de Kock, Leanne, Sabbaghian, Nelly, Druker, Harriet, Weber, Evan, Hamel, Nancy, Miller, Suzanne, Choong, Catherine S., Gottardo, Nicholas G., Kees, Ursula R., Rednam, Surya P., van Hest, Liselotte P., Jongmans, Marjolijn C., Jhangiani, Shalini, Lupski, James R., Zacharin, Margaret, Bouron-Dal Soglio, Dorothée, Huang, Annie, Priest, John R., Perry, Arie, Mueller, Sabine, Albrecht, Steffen, Malkin, David, Grundy, Richard G., Foulkes, William D.
Published in Acta neuropathologica

Congenital midline spinal hamartoma in an infant with DICER1 syndrome: A case report

by Hammad, Rawan, Lo, Winnie, Chen, Haiying, Shroff, Manohar, Malkin, David, Villani, Anita, Denburg, Avram
Published in Frontiers in oncology

A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis

by Cheung, Yee Him, Gayden, Tenzin, Campeau, Philippe M., LeDuc, Charles A., Russo, Donna, Nguyen, Van-Hung, Guo, Jiancheng, Qi, Ming, Guan, Yanfang, Albrecht, Steffen, Moroz, Brenda, Eldin, Karen W., Lu, James T., Schwartzentruber, Jeremy, Malkin, David, Berghuis, Albert M., Emil, Sherif, Gibbs, Richard A., Burk, David L., Vanstone, Megan, Lee, Brendan H., Orchard, David, Boycott, Kym M., Chung, Wendy K., Jabado, Nada
Published in American journal of human genetics

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

by Light, Nicholas, Layeghifard, Mehdi, Attery, Ayush, Subasri, Vallijah, Zatzman, Matthew, Anderson, Nathaniel D, Hatkar, Rupal, Blay, Sasha, Chen, David, Novokmet, Ana, Fuligni, Fabio, Tran, James, de Borja, Richard, Agarwal, Himanshi, Waldman, Larissa, Abegglen, Lisa M, Albertson, Daniel, Finlay, Jonathan L, Hansford, Jordan R, Behjati, Sam, Villani, Anita, Gerstung, Moritz, Alexandrov, Ludmil B, Somers, Gino R, Schiffman, Joshua D, Rotter, Varda, Malkin, David, Shlien, Adam
Published in Nature communications

Recurrent Focal Copy-Number Changes and Loss of Heterozygosity Implicate Two Noncoding RNAs and One Tumor Suppressor Gene at Chromosome 3q13.31 in Osteosarcoma

by PASIC, Ivan, SHLIEN, Adam, DURBIN, Adam D, STAVROPOULOS, Dimitrios J, BASKIN, Berivan, RAY, Peter N, NOVOKMET, Ana, MALKIN, David
Published in Cancer research (Chicago, Ill.)