Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

by Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca
Published in Nature communications

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

by Läll, Kristi, Mägi, Reedik, Morris, Andrew, Metspalu, Andres, Fischer, Krista
Published in Genetics in medicine

Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions

by Reisberg, Sulev, Krebs, Kristi, Lepamets, Maarja, Kals, Mart, Mägi, Reedik, Metsalu, Kristjan, Lauschke, Volker M, Vilo, Jaak, Milani, Lili
Published in Genetics in medicine

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

by Patxot, Marion, Banos, Daniel Trejo, Kousathanas, Athanasios, Orliac, Etienne J, Ojavee, Sven E, Moser, Gerhard, Holloway, Alexander, Sidorenko, Julia, Kutalik, Zoltan, Mägi, Reedik, Visscher, Peter M, Rönnegård, Lars, Robinson, Matthew R
Published in Nature communications

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

by Läll, Kristi, Lepamets, Maarja, Palover, Marili, Esko, Tõnu, Metspalu, Andres, Tõnisson, Neeme, Padrik, Peeter, Mägi, Reedik, Fischer, Krista
Published in BMC cancer

Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia

by Alver, Maris, Palover, Marili, Saar, Aet, Läll, Kristi, Zekavat, Seyedeh Maryam, Tõnisson, Neeme, Leitsalu, Liis, Reigo, Anu, Nikopensius, Tiit, Ainla, Tiia, Kals, Mart, Mägi, Reedik, Gabriel, Stacey B, Eha, Jaan, Lander, Eric S, Irs, Alar, Philippakis, Anthony, Marandi, Toomas, Natarajan, Pradeep, Metspalu, Andres, Kathiresan, Sekar, Esko, Tõnu
Published in Genetics in medicine

Improving GWAS discovery and genomic prediction accuracy in biobank data

by Orliac, Etienne J, Trejo Banos, Daniel, Ojavee, Sven E, Läll, Kristi, Mägi, Reedik, Visscher, Peter M, Robinson, Matthew R
Published in Proceedings of the National Academy of Sciences - PNAS

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank

by James, Glen, Reisberg, Sulev, Lepik, Kaido, Galwey, Nicholas, Avillach, Paul, Kolberg, Liis, Mägi, Reedik, Esko, Tõnu, Alexander, Myriam, Waterworth, Dawn, Loomis, A Katrina, Vilo, Jaak
Published in PloS one

Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

by Lee, Arthur S, Rusch, Jannette, Lima, Ana C, Usmani, Abul, Huang, Ni, Lepamets, Maarja, Vigh-Conrad, Katinka A, Worthington, Ronald E, Mägi, Reedik, Wu, Xiaobo, Aston, Kenneth I, Atkinson, John P, Carrell, Douglas T, Hess, Rex A, O'Bryan, Moira K, Conrad, Donald F
Published in Nature communications

Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery

by Mägi, Reedik, Manning, Sean, Yousseif, Ahmed, Pucci, Andrea, Santini, Ferruccio, Karra, Efthimia, Querci, Giorgia, Pelosini, Caterina, McCarthy, Mark I, Lindgren, Cecilia M, Batterham, Rachel L
Published in PloS one

MARV: a tool for genome-wide multi-phenotype analysis of rare variants

by Kaakinen, Marika, Mägi, Reedik, Fischer, Krista, Heikkinen, Jani, Järvelin, Marjo-Riitta, Morris, Andrew P, Prokopenko, Inga
Published in BMC bioinformatics

Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays

by Krjutškov, Kaarel, Andreson, Reidar, Mägi, Reedik, Nikopensius, Tiit, Khrunin, Andrey, Mihailov, Evelin, Tammekivi, Veronika, Sork, Helena, Remm, Maido, Metspalu, Andres
Published in Nucleic acids research

Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations

by Mueller, Jakob C., Lõhmussaar, Elin, Mägi, Reedik, Remm, Maido, Bettecken, Thomas, Lichtner, Peter, Biskup, Saskia, Illig, Thomas, Pfeufer, Arne, Luedemann, Jan, Schreiber, Stefan, Pramstaller, Peter, Pichler, Irene, Romeo, Giovanni, Gaddi, Anthony, Testa, Alessandra, Wichmann, Heinz-Erich, Metspalu, Andres, Meitinger, Thomas
Published in American journal of human genetics

Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry

by Burns, Kharis, Mullin, Benjamin H, Moolhuijsen, Loes M E, Laisk, Triin, Tyrmi, Jaakko S, Cui, Jinrui, Actkins, Ky'Era V, Louwers, Yvonne V, Davis, Lea K, Dudbridge, Frank, Azziz, Ricardo, Goodarzi, Mark O, Laivuori, Hannele, Mägi, Reedik, Visser, Jenny A, Laven, Joop S E, Wilson, Scott G, Day, Felix R, Stuckey, Bronwyn G A
Published in BMC genomics

Evolution of the Pygmy Phenotype: Evidence of Positive Selection from Genome-wide Scans in African, Asian, and Melanesian Pygmies

by Migliano, Andrea Bamberg, Romero, Irene Gallego, Metspalu, Mait, Leavesley, Matthew, Pagani, Luca, Antao, Tiago, Huang, Da-Wei, Sherman, Brad T., Siddle, Katharine, Scholes, Clarissa, Hudjashov, Georgi, Kaitokai, Elton, Babalu, Avis, Belatti, Maggie, Cagan, Alex, Hopkinshaw, Bryony, Shaw, Colin, Nelis, Mari, Metspalu, Ene, Mägi, Reedik, Lempicki, Richard A., Villems, Richard, Lahr, Marta Mirazon, Kivisild, Toomas
Published in Human biology

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

by Pasman, Joëlle A, Verweij, Karin J H, Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L, Abdellaoui, Abdel, Nivard, Michel G, Baselmans, Bart M L, Ong, Jue-Sheng, Ip, Hill F, van der Zee, Matthijs D, Bartels, Meike, Day, Felix R, Fontanillas, Pierre, Elson, Sarah L, de Wit, Harriet, Davis, Lea K, MacKillop, James, Derringer, Jaime L, Branje, Susan J T, Hartman, Catharina A, Heath, Andrew C, van Lier, Pol A C, Madden, Pamela A F, Mägi, Reedik, Meeus, Wim, Montgomery, Grant W, Oldehinkel, A J, Pausova, Zdenka, Ramos-Quiroga, Josep A, Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P M, Bell, Jordana T, Spector, Tim D, Gelernter, Joel, Boomsma, Dorret I, Martin, Nicholas G, MacGregor, Stuart, Perry, John R B, Palmer, Abraham A, Posthuma, Danielle, Munafò, Marcus R, Gillespie, Nathan A, Derks, Eske M, Vink, Jacqueline M
Published in Nature neuroscience

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

by Shungin, Dmitry, Deng, Wei Q, Varga, Tibor V, Luan, Jian'an, Mihailov, Evelin, Metspalu, Andres, Morris, Andrew P, Forouhi, Nita G, Lindgren, Cecilia, Magnusson, Patrik K E, Pedersen, Nancy L, Hallmans, Göran, Chu, Audrey Y, Justice, Anne E, Graff, Mariaelisa, Winkler, Thomas W, Rose, Lynda M, Langenberg, Claudia, Cupples, L Adrienne, Ridker, Paul M, Wareham, Nicholas J, Ong, Ken K, Loos, Ruth J F, Chasman, Daniel I, Ingelsson, Erik, Kilpeläinen, Tuomas O, Scott, Robert A, Mägi, Reedik, Paré, Guillaume, Franks, Paul W
Published in PLoS genetics

Extent, causes, and consequences of small RNA expression variation in human adipose tissue

by Parts, Leopold, Hedman, Åsa K, Keildson, Sarah, Knights, Andrew J, Abreu-Goodger, Cei, van de Bunt, Martijn, Guerra-Assunção, José Afonso, Bartonicek, Nenad, van Dongen, Stijn, Mägi, Reedik, Nisbet, James, Barrett, Amy, Rantalainen, Mattias, Nica, Alexandra C, Quail, Michael A, Small, Kerrin S, Glass, Daniel, Enright, Anton J, Winn, John, Deloukas, Panos, Dermitzakis, Emmanouil T, McCarthy, Mark I, Spector, Timothy D, Durbin, Richard, Lindgren, Cecilia M
Published in PLoS genetics

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

by Walsh, Kyle M, Codd, Veryan, Rice, Terri, Nelson, Christopher P, Smirnov, Ivan V, McCoy, Lucie S, Hansen, Helen M, Elhauge, Edward, Ojha, Juhi, Francis, Stephen S, Madsen, Nils R, Bracci, Paige M, Pico, Alexander R, Molinaro, Annette M, Tihan, Tarik, Berger, Mitchel S, Chang, Susan M, Prados, Michael D, Jenkins, Robert B, Wiemels, Joseph L, Samani, Nilesh J, Wiencke, John K, Wrensch, Margaret R
Published in Oncotarget

Rare coding variants and X-linked loci associated with age at menarche

by Lunetta, Kathryn L, Day, Felix R, Sulem, Patrick, Ruth, Katherine S, Tung, Joyce Y, Hinds, David A, Esko, Tõnu, Elks, Cathy E, Altmaier, Elisabeth, He, Chunyan, Huffman, Jennifer E, Mihailov, Evelin, Porcu, Eleonora, Robino, Antonietta, Rose, Lynda M, Schick, Ursula M, Stolk, Lisette, Teumer, Alexander, Thompson, Deborah J, Traglia, Michela, Wang, Carol A, Yerges-Armstrong, Laura M, Antoniou, Antonis C, Barbieri, Caterina, Coviello, Andrea D, Cucca, Francesco, Demerath, Ellen W, Dunning, Alison M, Gandin, Ilaria, Grove, Megan L, Gudbjartsson, Daniel F, Hocking, Lynne J, Hofman, Albert, Huang, Jinyan, Jackson, Rebecca D, Karasik, David, Kriebel, Jennifer, Lange, Ethan M, Lange, Leslie A, Langenberg, Claudia, Li, Xin, Luan, Jian'an, Mägi, Reedik, Morrison, Alanna C, Padmanabhan, Sandosh, Pirie, Ailith, Polasek, Ozren, Porteous, David, Reiner, Alex P, Rivadeneira, Fernando, Rudan, Igor, Sala, Cinzia F, Schlessinger, David, Scott, Robert A, Stöckl, Doris, Visser, Jenny A, Völker, Uwe, Vozzi, Diego, Wilson, James G, Zygmunt, Marek, Boerwinkle, Eric, Buring, Julie E, Crisponi, Laura, Easton, Douglas F, Hayward, Caroline, Hu, Frank B, Liu, Simin, Metspalu, Andres, Pennell, Craig E, Ridker, Paul M, Strauch, Konstantin, Streeten, Elizabeth A, Toniolo, Daniela, Uitterlinden, André G, Ulivi, Sheila, Völzke, Henry, Wareham, Nicholas J, Wellons, Melissa, Franceschini, Nora, Chasman, Daniel I, Thorsteinsdottir, Unnur, Murray, Anna, Stefansson, Kari, Murabito, Joanne M, Ong, Ken K, Perry, John R B
Published in Nature communications