DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

by Lokk, Kaie, Modhukur, Vijayachitra, Rajashekar, Balaji, Märtens, Kaspar, Mägi, Reedik, Kolde, Raivo, Koltšina, Marina, Nilsson, Torbjörn K, Vilo, Jaak, Salumets, Andres, Tõnisson, Neeme
Published in Genome Biology

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

by Patxot, Marion, Banos, Daniel Trejo, Kousathanas, Athanasios, Orliac, Etienne J, Ojavee, Sven E, Moser, Gerhard, Holloway, Alexander, Sidorenko, Julia, Kutalik, Zoltan, Mägi, Reedik, Visscher, Peter M, Rönnegård, Lars, Robinson, Matthew R
Published in Nature communications

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

by Läll, Kristi, Lepamets, Maarja, Palover, Marili, Esko, Tõnu, Metspalu, Andres, Tõnisson, Neeme, Padrik, Peeter, Mägi, Reedik, Fischer, Krista
Published in BMC cancer

Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis

by Ojavee, Sven E, Kousathanas, Athanasios, Trejo Banos, Daniel, Orliac, Etienne J, Patxot, Marion, Läll, Kristi, Mägi, Reedik, Fischer, Krista, Kutalik, Zoltan, Robinson, Matthew R
Published in Nature communications

Improving GWAS discovery and genomic prediction accuracy in biobank data

by Orliac, Etienne J, Trejo Banos, Daniel, Ojavee, Sven E, Läll, Kristi, Mägi, Reedik, Visscher, Peter M, Robinson, Matthew R
Published in Proceedings of the National Academy of Sciences - PNAS

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank

by James, Glen, Reisberg, Sulev, Lepik, Kaido, Galwey, Nicholas, Avillach, Paul, Kolberg, Liis, Mägi, Reedik, Esko, Tõnu, Alexander, Myriam, Waterworth, Dawn, Loomis, A Katrina, Vilo, Jaak
Published in PloS one

Rare copy-number variants as modulators of common disease susceptibility

by Auwerx, Chiara, Jõeloo, Maarja, Sadler, Marie C, Tesio, Nicolò, Ojavee, Sven, Clark, Charlie J, Mägi, Reedik, Reymond, Alexandre, Kutalik, Zoltán
Published in Genome medicine

A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations

by Clemente, Florian J., Cardona, Alexia, Inchley, Charlotte E., Peter, Benjamin M., Jacobs, Guy, Pagani, Luca, Lawson, Daniel J., Antão, Tiago, Vicente, Mário, Mitt, Mario, DeGiorgio, Michael, Faltyskova, Zuzana, Xue, Yali, Ayub, Qasim, Szpak, Michal, Mägi, Reedik, Eriksson, Anders, Manica, Andrea, Raghavan, Maanasa, Rasmussen, Morten, Rasmussen, Simon, Willerslev, Eske, Vidal-Puig, Antonio, Tyler-Smith, Chris, Villems, Richard, Nielsen, Rasmus, Metspalu, Mait, Malyarchuk, Boris, Derenko, Miroslava, Kivisild, Toomas
Published in American journal of human genetics

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

by Guo, Michael H., Nandakumar, Satish K., Ulirsch, Jacob C., Zekavat, Seyedeh M., Buenrostro, Jason D., Natarajan, Pradeep, Salem, Rany M., Chiarle, Roberto, Mitt, Mario, Kals, Mart, Pärn, Kalle, Fischer, Krista, Milani, Lili, Mägi, Reedik, Palta, Priit, Gabriel, Stacey B., Metspalu, Andres, Lander, Eric S., Kathiresan, Sekar, Hirschhorn, Joel N., Esko, Tõnu, Sankaran, Vijay G.
Published in Proceedings of the National Academy of Sciences - PNAS

A cross-disorder dosage sensitivity map of the human genome

by Collins, Ryan L., Glessner, Joseph T., Porcu, Eleonora, Lepamets, Maarja, Brandon, Rhonda, Lauricella, Christopher, Han, Lide, Morley, Theodore, Niestroj, Lisa-Marie, Ulirsch, Jacob, Everett, Selin, Howrigan, Daniel P., Boone, Philip M., Fu, Jack, Karczewski, Konrad J., Kellaris, Georgios, Lowther, Chelsea, Lucente, Diane, Mohajeri, Kiana, Nõukas, Margit, Nuttle, Xander, Samocha, Kaitlin E., Trinh, Mi, Ullah, Farid, Võsa, Urmo, Metspalu, Andres, Mägi, Reedik, Nelis, Mari, Milani, Lili, Esko, Tõnu, Hurles, Matthew E., Aradhya, Swaroop, Davis, Erica E., Finucane, Hilary, Gusella, James F., Janze, Aura, Katsanis, Nicholas, Matyakhina, Ludmila, Neale, Benjamin M., Sanders, David, Warren, Stephanie, Hodge, Jennelle C., Lal, Dennis, Ruderfer, Douglas M., Meck, Jeanne, Mägi, Reedik, Esko, Tõnu, Reymond, Alexandre, Kutalik, Zoltán, Hakonarson, Hakon, Sunyaev, Shamil, Brand, Harrison, Talkowski, Michael E.
Published in Cell

Distribution and medical impact of loss-of-function variants in the Finnish founder population

by Lim, Elaine T, Würtz, Peter, Havulinna, Aki S, Palta, Priit, Tukiainen, Taru, Rehnström, Karola, Esko, Tõnu, Mägi, Reedik, Inouye, Michael, Lappalainen, Tuuli, Chan, Yingleong, Salem, Rany M, Lek, Monkol, Flannick, Jason, Sim, Xueling, Manning, Alisa, Ladenvall, Claes, Bumpstead, Suzannah, Hämäläinen, Eija, Aalto, Kristiina, Maksimow, Mikael, Salmi, Marko, Blankenberg, Stefan, Ardissino, Diego, Shah, Svati, Horne, Benjamin, McPherson, Ruth, Hovingh, Gerald K, Reilly, Muredach P, Watkins, Hugh, Goel, Anuj, Farrall, Martin, Girelli, Domenico, Reiner, Alex P, Stitziel, Nathan O, Kathiresan, Sekar, Gabriel, Stacey, Barrett, Jeffrey C, Lehtimäki, Terho, Laakso, Markku, Groop, Leif, Kaprio, Jaakko, Perola, Markus, McCarthy, Mark I, Boehnke, Michael, Altshuler, David M, Lindgren, Cecilia M, Hirschhorn, Joel N, Metspalu, Andres, Freimer, Nelson B, Zeller, Tanja, Jalkanen, Sirpa, Koskinen, Seppo, Raitakari, Olli, Durbin, Richard, MacArthur, Daniel G, Salomaa, Veikko, Ripatti, Samuli, Daly, Mark J, Palotie, Aarno
Published in PLoS genetics

Copy Number Variations and Cognitive Phenotypes in Unselected Populations

by Männik, Katrin, Mägi, Reedik, Macé, Aurélien, Cole, Ben, Guyatt, Anna L, Shihab, Hashem A, Maillard, Anne M, Alavere, Helene, Kolk, Anneli, Reigo, Anu, Mihailov, Evelin, Leitsalu, Liis, Ferreira, Anne-Maud, Nõukas, Margit, Teumer, Alexander, Salvi, Erika, Cusi, Daniele, McGue, Matt, Iacono, William G, Gaunt, Tom R, Beckmann, Jacques S, Jacquemont, Sébastien, Kutalik, Zoltán, Pankratz, Nathan, Timpson, Nicholas, Metspalu, Andres, Reymond, Alexandre
Published in JAMA : the journal of the American Medical Association

Improved polygenic prediction by Bayesian multiple regression on summary statistics

by Lloyd-Jones, Luke R, Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E, Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R, Goddard, Michael E, Yang, Jian, Visscher, Peter M
Published in Nature communications

Genetic structure of Europeans: a view from the North-East

by Nelis, Mari, Esko, Tõnu, Mägi, Reedik, Zimprich, Fritz, Zimprich, Alexander, Toncheva, Draga, Karachanak, Sena, Piskácková, Tereza, Balascák, Ivan, Peltonen, Leena, Jakkula, Eveliina, Rehnström, Karola, Lathrop, Mark, Heath, Simon, Galan, Pilar, Schreiber, Stefan, Meitinger, Thomas, Pfeufer, Arne, Wichmann, H-Erich, Melegh, Béla, Polgár, Noémi, Toniolo, Daniela, Gasparini, Paolo, D'Adamo, Pio, Klovins, Janis, Nikitina-Zake, Liene, Kucinskas, Vaidutis, Kasnauskiene, Jūrate, Lubinski, Jan, Debniak, Tadeusz, Limborska, Svetlana, Khrunin, Andrey, Estivill, Xavier, Rabionet, Raquel, Marsal, Sara, Julià, Antonio, Antonarakis, Stylianos E, Deutsch, Samuel, Borel, Christelle, Attar, Homa, Gagnebin, Maryline, Macek, Milan, Krawczak, Michael, Remm, Maido, Metspalu, Andres
Published in PloS one

Evolution of the Pygmy Phenotype: Evidence of Positive Selection from Genome-wide Scans in African, Asian, and Melanesian Pygmies

by Migliano, Andrea Bamberg, Romero, Irene Gallego, Metspalu, Mait, Leavesley, Matthew, Pagani, Luca, Antao, Tiago, Huang, Da-Wei, Sherman, Brad T., Siddle, Katharine, Scholes, Clarissa, Hudjashov, Georgi, Kaitokai, Elton, Babalu, Avis, Belatti, Maggie, Cagan, Alex, Hopkinshaw, Bryony, Shaw, Colin, Nelis, Mari, Metspalu, Ene, Mägi, Reedik, Lempicki, Richard A., Villems, Richard, Lahr, Marta Mirazon, Kivisild, Toomas
Published in Human biology

Mapping the genetic architecture of gene regulation in whole blood

by Schramm, Katharina, Marzi, Carola, Schurmann, Claudia, Carstensen, Maren, Reinmaa, Eva, Biffar, Reiner, Eckstein, Gertrud, Gieger, Christian, Grabe, Hans-Jörgen, Homuth, Georg, Kastenmüller, Gabriele, Mägi, Reedik, Metspalu, Andres, Mihailov, Evelin, Peters, Annette, Petersmann, Astrid, Roden, Michael, Strauch, Konstantin, Suhre, Karsten, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Wang-Sattler, Rui, Waldenberger, Melanie, Meitinger, Thomas, Illig, Thomas, Herder, Christian, Grallert, Harald, Prokisch, Holger
Published in PloS one

Genomic analyses inform on migration events during the peopling of Eurasia

by Pagani, Luca, Lawson, Daniel John, Jagoda, Evelyn, Mörseburg, Alexander, Eriksson, Anders, Mitt, Mario, Clemente, Florian, Hudjashov, Georgi, DeGiorgio, Michael, Saag, Lauri, Wall, Jeffrey D, Cardona, Alexia, Mägi, Reedik, Wilson Sayres, Melissa A, Kaewert, Sarah, Inchley, Charlotte, Scheib, Christiana L, Järve, Mari, Karmin, Monika, Jacobs, Guy S, Antao, Tiago, Iliescu, Florin Mircea, Kushniarevich, Alena, Ayub, Qasim, Tyler-Smith, Chris, Xue, Yali, Yunusbayev, Bayazit, Tambets, Kristiina, Mallick, Chandana Basu, Saag, Lehti, Pocheshkhova, Elvira, Andriadze, George, Muller, Craig, Westaway, Michael C, Lambert, David M, Zoraqi, Grigor, Turdikulova, Shahlo, Dalimova, Dilbar, Sabitov, Zhaxylyk, Sultana, Gazi Nurun Nahar, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Isakova, Jainagul, Damba, Larisa D, Gubina, Marina, Nymadawa, Pagbajabyn, Evseeva, Irina, Atramentova, Lubov, Utevska, Olga, Ricaut, François-Xavier, Brucato, Nicolas, Sudoyo, Herawati, Letellier, Thierry, Cox, Murray P, Barashkov, Nikolay A, Skaro, Vedrana, Mulahasanovic, Lejla, Primorac, Dragan, Sahakyan, Hovhannes, Mormina, Maru, Eichstaedt, Christina A, Lichman, Daria V, Abdullah, Syafiq, Chaubey, Gyaneshwer, Wee, Joseph T S, Mihailov, Evelin, Karunas, Alexandra, Litvinov, Sergei, Khusainova, Rita, Ekomasova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Marjanović, Damir, Yepiskoposyan, Levon, Behar, Doron M, Balanovska, Elena, Metspalu, Andres, Derenko, Miroslava, Malyarchuk, Boris, Voevoda, Mikhail, Fedorova, Sardana A, Osipova, Ludmila P, Lahr, Marta Mirazón, Gerbault, Pascale, Leavesley, Matthew, Migliano, Andrea Bamberg, Petraglia, Michael, Balanovsky, Oleg, Khusnutdinova, Elza K, Metspalu, Ene, Thomas, Mark G, Manica, Andrea, Nielsen, Rasmus, Villems, Richard, Willerslev, Eske, Kivisild, Toomas, Metspalu, Mait
Published in Nature (London)

Population-Specific Imputation Reference Panel as a Tool for GWAS Analysis

by Kals, Mart, Palta, Priit, Mägi, Reedik
Published in Human heredity

Cerebral small vessel disease genomics and its implications across the lifespan

by Sargurupremraj, Muralidharan, Suzuki, Hideaki, Jian, Xueqiu, Sarnowski, Chloé, Evans, Tavia E, Bis, Joshua C, Eiriksdottir, Gudny, Sakaue, Saori, Terzikhan, Natalie, Habes, Mohamad, Zhao, Wei, Armstrong, Nicola J, Yanek, Lisa R, Hagenaars, Saskia P, Kumar, Rajan B, van den Akker, Erik B, McWhirter, Rebekah E, Saba, Yasaman, Satizabal, Claudia L, Beaudet, Gregory, Petit, Laurent, Tsuchida, Ami, Zago, Laure, Schilling, Sabrina, Sigurdsson, Sigurdur, Gottesman, Rebecca F, Lewis, Cora E, Aggarwal, Neelum T, Lopez, Oscar L, Smith, Jennifer A, Valdés Hernández, Maria C, Wright, Margaret J, Knol, Maria J, Dörr, Marcus, Thomson, Russell J, Bordes, Constance, Le Grand, Quentin, Duperron, Marie-Gabrielle, Smith, Albert V, Knopman, David S, Schreiner, Pamela J, Evans, Denis A, Rotter, Jerome I, Beiser, Alexa S, Beekman, Marian, Vernooij, Meike W, Wittfeld, Katharina, Niessen, Wiro J, Soumaré, Aicha, Boerwinkle, Eric, Sidney, Stephen, Turner, Stephen T, Davies, Gail, Thalamuthu, Anbupalam, Völker, Uwe, van Buchem, Mark A, Dupuis, Josée, Bastin, Mark E, Ames, David, Teumer, Alexander, Amouyel, Philippe, Kwok, John B, Deary, Ian J, Schofield, Peter R, Brodaty, Henry, Jiang, Jiyang, Tabara, Yasuharu, Miyamoto, Susumu, Yoshida, Kazumichi, Nagata, Manabu, Kamatani, Yoichiro, Matsuda, Fumihiko, Psaty, Bruce M, Bennett, David A, De Jager, Philip L, Mosley, Thomas H, Sachdev, Perminder S, Schmidt, Reinhold, Warren, Helen R, Trégouët, David-Alexandre, Ikram, Mohammad A, DeCarli, Charles, Srikanth, Velandai K, Jukema, J Wouter, Slagboom, Eline P, Kardia, Sharon L R, Okada, Yukinori, Mazoyer, Bernard, Wardlaw, Joanna M, Nyquist, Paul A, Mather, Karen A, Grabe, Hans J, Schmidt, Helena, Gudnason, Vilmundur, Longstreth, Jr, William T, Launer, Lenore J, Seshadri, Sudha, Tzourio, Christophe, Fornage, Myriam, Debette, Stéphanie
Published in Nature communications

Polygenic Risk Score Predicts Modified Risk in IBRCA1/I Pathogenic Variant c.4035del and c.5266dup Carriers in Breast Cancer Patients

by Berga-Švītiņa, Egija, Maksimenko, Jeļena, Miklaševičs, Edvīns, Fischer, Krista, Vilne, Baiba, Mägi, Reedik
Published in Cancers