HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

by Jacobsen, A V, Lowes, K N, Tanzer, M C, Lucet, I S, Hildebrand, J M, Petrie, E J, van Delft, M F, Liu, Z, Conos, S A, Zhang, J-G, Huang, D C S, Silke, J, Lessene, G, Murphy, J M
Published in Cell death & disease

Upregulation of lymphotoxin β expression in liver progenitor (oval) cells in chronic hepatitis C

by Lowes, K N, Croager, E J, Abraham, L J, Olynyk, J K, Yeoh, G C T
Published in Gut

Engineering a multimodal nerve conduit for repair of injured peripheral nerve

by Quigley, A F, Bulluss, K J, Kyratzis, I L B, Gilmore, K, Mysore, T, Schirmer, K S U, Kennedy, E L, O'Shea, M, Truong, Y B, Edwards, S L, Peeters, G, Herwig, P, Razal, J M, Campbell, T E, Lowes, K N, Higgins, M J, Moulton, S E, Murphy, M A, Cook, M J, Clark, G M, Wallace, G G, Kapsa, R M I
Published in Journal of neural engineering

Upregulation of lymphotoxin   expression in liver progenitor (oval) cells in chronic hepatitis C

by Lowes, K N
Published in Gut

DNA electroporation in vivo targets mature fibres in dystrophic mdx muscle

by Wong, Sharon H.A., Lowes, Kym N., Quigley, Anita F., Marotta, Rosetta, Kita, Magdalena, Byrne, Edward, Kornberg, Andrew J., Cook, Mark J., Kapsa, Robert M.I.
Published in Neuromuscular disorders : NMD

Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation

by Mertens, K., Lowes, D.A., Webster, N.R., Talib, J., Hall, L., Davies, M.J., Beattie, J.H., Galley, H.F.
Published in British journal of anaesthesia : BJA

A prospective one-year natural history study of mucopolysaccharidosis types IIIA and IIIB: Implications for clinical trial design

by Truxal, K.V., Fu, H., McCarty, D.M., McNally, K.A., Kunkler, K.L., Zumberge, N.A., Martin, L., Aylward, S.C., Alfano, L.N., Berry, K.M., Lowes, L.P., Corridore, M., McKee, C., McBride, K.L., Flanigan, K.M.
Published in Molecular genetics and metabolism

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

by Mendell, Jerry R, Sahenk, Zarife, Malik, Vinod, Gomez, Ana M, Flanigan, Kevin M, Lowes, Linda P, Alfano, Lindsay N, Berry, Katherine, Meadows, Eric, Lewis, Sarah, Braun, Lyndsey, Shontz, Kim, Rouhana, Maria, Clark, Kelly Reed, Rosales, Xiomara Q, Al-Zaidy, Samiah, Govoni, Alessandra, Rodino-Klapac, Louise R, Hogan, Mark J, Kaspar, Brian K
Published in Molecular therapy

Development of Duchenne Video Assessment scorecards to evaluate ease of movement among those with Duchenne muscular dystrophy

by Contesse, Marielle G, Lowes, Linda P, White, Michelle K, Dalle Pazze, Laura, McSherry, Christine, Alfano, Lindsay N, Iammarino, Megan, Reash, Natalie, Bonarrigo, Kelly, Kiefer, Michael, Laubscher, Katie, McIntyre, Melissa, Mockler, Shelley, Nelson, Leslie, Vogel, Leslie, Leffler, Mindy G
Published in PloS one

Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes

by Mendell, Jerry R., Sahenk, Zarife, Al-Zaidy, Samiah, Rodino-Klapac, Louise R., Lowes, Linda P., Alfano, Lindsay N., Berry, Katherine, Miller, Natalie, Yalvac, Mehmet, Dvorchik, Igor, Moore-Clingenpeel, Melissa, Flanigan, Kevin M., Church, Kathleen, Shontz, Kim, Curry, Choumpree, Lewis, Sarah, McColly, Markus, Hogan, Mark J., Kaspar, Brian K.
Published in Molecular therapy

A prospective study of patients with low back pain attending a Canadian emergency department: Why they came and what happened?

by Kawchuk, Gregory N, Aaskov, Jacob, Mohler, Matthew, Lowes, Justin, Kruhlak, Maureen, Couperthwaite, Stephanie, Yang, Esther H, Villa-Roel, Cristina, Rowe, Brian H
Published in PloS one

QUEST: A New Frontiers Uranus orbiter mission concept study

by Jarmak, S., Leonard, E., Akins, A., Dahl, E., Cremons, D.R., Cofield, S., Curtis, A., Dong, C., Dunham, E.T., Journaux, B., Murakami, D., Ng, W., Piquette, M., Girija, A. Pradeepkumar, Rink, K., Schurmeier, L., Stein, N., Tallarida, N., Telus, M., Lowes, L., Budney, C., Mitchell, K.L.
Published in Acta astronautica

Remote Delivery of Motor Function Assessment and Training for Clinical Trials in Neuromuscular Disease: A Response to the COVID-19 Global Pandemic

by James, Meredith K., Rose, Kristy, Alfano, Lindsay N., Reash, Natalie F., Eagle, Michelle, Lowes, Linda P.
Published in Frontiers in genetics

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

by Nachbur, Ueli, Stafford, Che A, Bankovacki, Aleksandra, Zhan, Yifan, Lindqvist, Lisa M, Fiil, Berthe K, Khakham, Yelena, Ko, Hyun-Ja, Sandow, Jarrod J, Falk, Hendrik, Holien, Jessica K, Chau, Diep, Hildebrand, Joanne, Vince, James E, Sharp, Phillip P, Webb, Andrew I, Jackman, Katherine A, Mühlen, Sabrina, Kennedy, Catherine L, Lowes, Kym N, Murphy, James M, Gyrd-Hansen, Mads, Parker, Michael W, Hartland, Elizabeth L, Lew, Andrew M, Huang, David C S, Lessene, Guillaume, Silke, John
Published in Nature communications

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

by Pierotti, Catia L, Jacobsen, Annette V, Grohmann, Christoph, Dempsey, Ruby K, Etemadi, Nima, Hildebrand, Joanne M, Fitzgibbon, Cheree, Young, Samuel N, Davies, Katherine A, Kersten, Wilhelmus J A, Silke, John, Lowes, Kym N, Jousset Sabroux, Hélène, Huang, David C S, van Delft, Mark F, Murphy, James M, Lessene, Guillaume
Published in Biochemical journal

S11 Long-term follow-up of the phase 1 START trial of onasemnogene abeparvovec gene therapy in spinal muscular atrophy type 1

by Mendell, JR, Shell, R, Lehman, KJ, McColly, M, Lowes, LP, Alfano, LN, Miller, NF, Iammarino, MA, Church, K, Kausar, I, Reyna, SP, Meriggioli, M, Kleyn, A, Al-Zaidy, S
Published in Thorax

Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

by McDonald, Craig M, Campbell, Craig, Torricelli, Ricardo Erazo, Finkel, Richard S, Flanigan, Kevin M, Goemans, Nathalie, Heydemann, Peter, Kaminska, Anna, Kirschner, Janbernd, Muntoni, Francesco, Osorio, Andrés Nascimento, Schara, Ulrike, Sejersen, Thomas, Shieh, Perry B, Sweeney, H Lee, Topaloglu, Haluk, Tulinius, Már, Vilchez, Juan J, Voit, Thomas, Wong, Brenda, Elfring, Gary, Kroger, Hans, Luo, Xiaohui, McIntosh, Joseph, Ong, Tuyen, Riebling, Peter, Souza, Marcio, Spiegel, Robert J, Peltz, Stuart W, Mercuri, Eugenio, Alfano, Lindsay N, Eagle, Michelle, James, Meredith K, Lowes, Linda, Mayhew, Anna, Mazzone, Elena S, Nelson, Leslie, Rose, Kristy J, Abdel-Hamid, Hoda Z, Apkon, Susan D, Barohn, Richard J, Bertini, Enrico, Bloetzer, Clemens, de Vaud, Lausanne Canton, Butterfield, Russell J, Chabrol, Brigitte, Chae, Jong-Hee, Jongno-gu, Daehak-ro, Comi, Giacomi Pietro, Darras, Basil T, Dastgir, Jahannaz, Desguerre, Isabelle, Escobar, Raul G, Finanger, Erika, Guglieri, Michela, Hughes, Imelda, Iannaccone, Susan T, Jones, Kristi J, Karachunski, Peter, Kudr, Martin, Lotze, Timothy, Mah, Jean K, Mathews, Katherine, Nevo, Yoram, Parsons, Julie, Péréon, Yann, de Queiroz Campos Araujo, Alexandra Prufer, Renfroe, J Ben, de Resende, Maria Bernadete Dutra, Ryan, Monique, Selby, Kathryn, Tennekoon, Gihan, Vita, Giuseppe
Published in The Lancet (British edition)

Consensus Guidelines for Improving Quality of Assessment and Training for Neuromuscular Diseases

by Duong, Tina, Krosschell, Kristin J., James, Meredith K., Nelson, Leslie, Alfano, Lindsay N., Eichinger, Katy, Mazzone, Elena, Rose, Kristy, Lowes, Linda P., Mayhew, Anna, Florence, Julaine, King, Wendy, Senesac, Claudia R., Eagle, Michelle
Published in Frontiers in genetics

Validation of the North Star Assessment for Limb-Girdle Type Muscular Dystrophies

by James, Meredith K, Alfano, Lindsay N, Muni-Lofra, Robert, Reash, Natalie F, Sodhi, Jassi, Iammarino, Megan A, Moat, Dionne, Shannon, Kianna, McCallum, Michelle, Richardson, Mark, Eagle, Michelle, Straub, Volker, Marini-Bettolo, Chiara, Lowes, Linda P, Mayhew, Anna G
Published in Physical therapy

Stratification of asthma phenotypes by airway proteomic signatures

by Burg, Dominic, Nicholas, Ben, Strazzeri, Fabio, Staykova, Doroteya, Bansal, Aruna T., Xian, Yang, Corfield, Julie, Wilson, Susan, Ward, Jonathan, Lutter, Rene, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Sven-Erik, Fowler, Stephen J., Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sandström, Thomas, Sun, Kai, Riley, John, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Sterk, Peter J., Djukanović, Ratko, Ahmed, H., Badorrek, P., Ballereau, S., Baribaud, F., Behndig, A.F., Berglind, A., Berton, A., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bush, A., Casaulta, C., Chaiboonchoe, A., Davison, T., De Meulder, B., Delin, I., El Hadjam, L., Erzen, D., Faulenbach, C., Fitch, N., Formaggio, E., Gahlemann, M., Garissi, D., Garret, T., Gent, J., Guillmant-Farry, E., Henriksson, E., James, A., Johnson, K., Jullian, N., Kerry, G., Klüglich, M., Knowles, R., Konradsen, J.R., Kretsos, K., Lantz, A.-S., Larminie, C., Latzin, P., Lefaudeux, D., Lemonnier, N., Lowe, L.A., Lutter, R., Mazein, A., McEvoy, L., Mores, N., Murray, C.S., Nething, K., Nordlund, B., Nsubuga, S., Pellet, J., Pison, C., Praticò, G., Valls, M. Puig, Rossios, C., Santini, G., Saqi, M., Sehgal, N., Söderman, P., Sogbesan, A., Spycher, F., Stephan, S., Stokholm, J., Sunther, M., Szentkereszty, M., Tamasi, L., Valente, S., van Aalderen, W.M., van Drunen, C.M., Van Eyll, J., Vyas, A., Yu, W., Zwinderman, A.H.
Published in Journal of allergy and clinical immunology