Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair by Haradhvala, N J, Kim, J, Maruvka, Y E, Polak, P, Rosebrock, D, Livitz, D, Hess, J M, Leshchiner, I, Kamburov, A, Mouw, K W, Lawrence, M S, Getz, G

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Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes by Yakneen, Sergei, Waszak, Sebastian M, Gertz, Michael, Korbel, Jan O

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Abstract PD9-02: Evolutionary analysis of 462 serial metastatic biopsies from 208 patients with estrogen receptor-positive (ER+) metastatic breast cancer (MBC) using whole exome se... by Cohen, O, Buendia-Buendia, J, Wander, S, Nayar, U, Mao, P, Waks, A, Kim, D, Freeman, S, Adalsteinsson, V, Helvie, K, Livitz, D, Rosebrock, D, Leshchiner, I, Dellostritto, L, Garrido-Castro, A, Jain, E, Periyasamy, S, Mackichan, C, Lloyd, M, Marini, L, Krop, I, Garraway, L, Getz, G, Winer, E, Lin, N, Wagle, N

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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes by Dentro, Stefan C., Leshchiner, Ignaty, Haase, Kerstin, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Vázquez-García, Ignacio, Kleinheinz, Kortine, Livitz, Dimitri G., Malikic, Salem, Donmez, Nilgun, Sengupta, Subhajit, Anur, Pavana, Jolly, Clemency, Rosebrock, Daniel, Schumacher, Steven E., Fittall, Matthew, Drews, Ruben M., Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Zhu, Hongtu, Adams, David J., McGranahan, Nicholas, Swanton, Charles, Getz, Gad, Boutros, Paul C., Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S. Cenk, Ji, Yuan, Peifer, Martin, Martincorena, Inigo, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Gerstung, Moritz, Spellman, Paul T., Wang, Wenyi, Wedge, David C., Dentro, Stefan C., Leshchiner, Ignaty, Gerstung, Moritz, Jolly, Clemency, Haase, Kerstin, Tarabichi, Maxime, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Rubanova, Yulia, Macintyre, Geoff, Demeulemeester, Jonas, Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D., Cao, Shaolong, Cmero, Marek, Cun, Yupeng, Dawson, Kevin J., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew, Getz, Gad, Ha, Gavin, Imielinski, Marcin, Ji, Yuan, Kleinheinz, Kortine, Lee, Juhee, Lee-Six, Henry, Livitz, Dimitri G., Malikic, Salem, Markowetz, Florian, Martincorena, Inigo, Mustonen, Ville, Oesper, Layla, Peifer, Martin, Peto, Myron, Raphael, Benjamin J., Rosebrock, Daniel, Salcedo, Adriana, Schumacher, Steven E., Sengupta, Subhajit, Shi, Ruian, Spiro, Oliver, Vázquez-García, Ignacio, Vembu, Shankar, Wheeler, David A., Yao, Xiaotong, Yuan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Van Loo, Peter

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Resistance to checkpoint blockade therapy through inactivation of antigen presentation by Sade-Feldman, Moshe, Jiao, Yunxin J, Chen, Jonathan H, Rooney, Michael S, Barzily-Rokni, Michal, Eliane, Jean-Pierre, Bjorgaard, Stacey L, Hammond, Marc R, Vitzthum, Hans, Blackmon, Shauna M, Frederick, Dennie T, Hazar-Rethinam, Mehlika, Nadres, Brandon A, Van Seventer, Emily E, Shukla, Sachet A, Yizhak, Keren, Ray, John P, Rosebrock, Daniel, Livitz, Dimitri, Adalsteinsson, Viktor, Getz, Gad, Duncan, Lyn M, Li, Bo, Corcoran, Ryan B, Lawrence, Donald P, Stemmer-Rachamimov, Anat, Boland, Genevieve M, Landau, Dan A, Flaherty, Keith T, Sullivan, Ryan J, Hacohen, Nir

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A community effort to create standards for evaluating tumor subclonal reconstruction by Salcedo, Adriana, Tarabichi, Maxime, Espiritu, Shadrielle Melijah G, Deshwar, Amit G, David, Matei, Wilson, Nathan M, Dentro, Stefan, Wintersinger, Jeff A, Liu, Lydia Y, Ko, Minjeong, Sivanandan, Srinivasan, Zhang, Hongjiu, Zhu, Kaiyi, Ou Yang, Tai-Hsien, Chilton, John M, Buchanan, Alex, Lalansingh, Christopher M, P'ng, Christine, Anghel, Catalina V, Umar, Imaad, Lo, Bryan, Zou, William, Simpson, Jared T, Stuart, Joshua M, Anastassiou, Dimitris, Guan, Yuanfang, Ewing, Adam D, Ellrott, Kyle, Wedge, David C, Morris, Quaid, Van Loo, Peter, Boutros, Paul C

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The evolutionary history of 2,658 cancers by Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C, Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J, Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vázquez-García, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G, Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C, Bowtell, David D, Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D, Spellman, Paul T, Wedge, David C, Van Loo, Peter

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Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma by Hruban, Ralph H., Moffitt, Richard A., Gupta, Manaswi, Getz, Gad, Gabriel, Stacey B., Meyerson, Matthew, Laird, Peter W., Loher, Phillipe, Rigoutsos, Isidore, Telonis, Aristeidis G., Mezlini, Aziz M., Hoadley, Katherine A., Murray, Bradley A., Hess, Julian, Zhang, Hailei, Tiao, Grace, Schumacher, Steven E., Noble, Michael S., Gehlenborg, Nils, Lawrence, Michael S., Bowlby, Reanne, Birol, Inanc, Weinstein, John N., Spellman, Paul T., Liu, Yuexin, Paul, Drwiega, Smyrk, Thomas, Gerken, Mark, Lau, Kevin, Renkel, Jeremy, Wise, Lisa, Yena, Peggy, Zmuda, Erik, Shih, Juliann, Balasundaram, Miruna, Chu, Andy, Chuah, Eric, Dhalla, Noreen, Mungall, Andrew J., Thiessen, Nina, Brooks, Denise, Balu, Saianand, Jefferys, Stuart R., Jones, Corbin D., Mose, Lisle E., Shi, Yan, Simons, Janae V., Soloway, Matthew G., Tan, Donghui, Chaffee, Kari, Oberg, Ann, Wheeler, David A., Bartlett, John, Stephen, Yeager, Howard, Zaren, Breggia, Anne, Shroff, Rachna T., Liu, Jia, Lolla, Laxmi, Pihl, Todd, Roggin, Kevin, Becker, Karl-Friedrich, Boice, Lori, Pretti da Cunha Tirapelli, Daniela, Huelsenbeck-Dill, Lori, Jenkins, Roger, Kemp, Rafael, Lyadov, Vladimir, Maithel, Shishir, Manikhas, Georgy, Montgomery, Eric, Noushmehr, Houtan, Owonikoko, Taofeek, Rieger-Christ, Kimberly, Sica, Gabriel, Su, Tao, Sullivan, Travis, Tarvin, Katherine, Urbanski, Stefan, Curley, Erin, Gardner, Johanna, Shelton, Candace, Bathe, Oliver, Hibshoosh, Hanina, Radenbaugh, Amie, Berrios, Mario, Bootwalla, Moiz S., Maglinte, Dennis T., Triche, Timothy J., Weisenberger, Daniel J., Kucherlapati, Melanie, Meier, Sam, Tempero, Margaret, Bailey, Peter, Gill, Anthony, Kench, James, Demchok, John A., Ferguson, Martin L., Tarnuzzer, Roy, Wang, Zhining

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Two-dimensional gas chromatography/mass spectrometry, physical property modeling and automated production of component maps to assess the weathering of pollutants by Antle, Patrick M., Zeigler, Christian D., Livitz, Dimitri G., Robbat, Albert

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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies by Guièze, Romain, Liu, Vivian M., Rosebrock, Daniel, Jourdain, Alexis A., Hernández-Sánchez, María, Martinez Zurita, Aina, Sun, Jing, Ten Hacken, Elisa, Baranowski, Kaitlyn, Thompson, Philip A., Heo, Jin-Mi, Cartun, Zachary, Aygün, Ozan, Iorgulescu, J. Bryan, Zhang, Wandi, Notarangelo, Giulia, Livitz, Dimitri, Li, Shuqiang, Davids, Matthew S., Biran, Anat, Fernandes, Stacey M., Brown, Jennifer R., Lako, Ana, Ciantra, Zoe B., Lawlor, Matthew A., Keskin, Derin B., Udeshi, Namrata D., Wierda, William G., Livak, Kenneth J., Letai, Anthony G., Neuberg, Donna, Harper, J. Wade, Carr, Steven A., Piccioni, Federica, Ott, Christopher J., Leshchiner, Ignaty, Johannessen, Cory M., Doench, John, Mootha, Vamsi K., Getz, Gad, Wu, Catherine J.

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Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors by Adalsteinsson, Viktor A, Ha, Gavin, Freeman, Samuel S, Choudhury, Atish D, Stover, Daniel G, Parsons, Heather A, Gydush, Gregory, Reed, Sarah C, Rotem, Denisse, Rhoades, Justin, Loginov, Denis, Livitz, Dimitri, Rosebrock, Daniel, Leshchiner, Ignaty, Kim, Jaegil, Stewart, Chip, Rosenberg, Mara, Francis, Joshua M, Zhang, Cheng-Zhong, Cohen, Ofir, Oh, Coyin, Ding, Huiming, Polak, Paz, Lloyd, Max, Mahmud, Sairah, Helvie, Karla, Merrill, Margaret S, Santiago, Rebecca A, O'Connor, Edward P, Jeong, Seong H, Leeson, Rachel, Barry, Rachel M, Kramkowski, Joseph F, Zhang, Zhenwei, Polacek, Laura, Lohr, Jens G, Schleicher, Molly, Lipscomb, Emily, Saltzman, Andrea, Oliver, Nelly M, Marini, Lori, Waks, Adrienne G, Harshman, Lauren C, Tolaney, Sara M, Van Allen, Eliezer M, Winer, Eric P, Lin, Nancy U, Nakabayashi, Mari, Taplin, Mary-Ellen, Johannessen, Cory M, Garraway, Levi A, Golub, Todd R, Boehm, Jesse S, Wagle, Nikhil, Getz, Gad, Love, J Christopher, Meyerson, Matthew

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Framework for quality assessment of whole genome cancer sequences by Whalley, Justin P, Buchhalter, Ivo, Rheinbay, Esther, Raine, Keiran M, Stobbe, Miranda D, Kleinheinz, Kortine, Werner, Johannes, Beltran, Sergi, Gut, Marta, Hübschmann, Daniel, Hutter, Barbara, Livitz, Dimitri, Perry, Marc D, Rosenberg, Mara, Saksena, Gordon, Trotta, Jean-Rémi, Eils, Roland, Gerhard, Daniela S, Campbell, Peter J, Schlesner, Matthias, Gut, Ivo G

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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig by Rubanova, Yulia, Shi, Ruian, Harrigan, Caitlin F, Li, Roujia, Wintersinger, Jeff, Sahin, Nil, Deshwar, Amit G, Morris, Quaid D

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Author Correction: The evolutionary history of 2,658 cancers by Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Dentro, Stefan C, Gonzalez, Santiago, Rosebrock, Daniel, Mitchell, Thomas J, Rubanova, Yulia, Anur, Pavana, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vázquez-García, Ignacio, Haase, Kerstin, Jerman, Lara, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G, Cmero, Marek, Demeulemeester, Jonas, Schumacher, Steven, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C, Bowtell, David D, Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Yuan, Ke, Wang, Wenyi, Morris, Quaid D, Spellman, Paul T, Wedge, David C, Van Loo, Peter

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Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig by Rubanova, Yulia, Shi, Ruian, Harrigan, Caitlin F, Li, Roujia, Wintersinger, Jeff, Sahin, Nil, Deshwar, Amit G, Morris, Quaid D

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Abstract LB-225: Liquid biopsies identify trunk mutations and reflect multiple tumors in a patient by Freeman, Samuel S., Lin, Ziao, Ha, Gavin, Leshchiner, Ignaty, Rhoades, Justin, Livitz, Dimitri, Rosebrock, Daniel, Reed, Sarah C., Gydush, Gregory, Lo, Christopher, Rotem, Denisse, Choudhury, Atish D., Stover, Daniel G., Parsons, Heather A., Boehm, Jesse S., Love, J Christopher, Meyerson, Matthew, Grandgenett, Paul, Hollingsworth, Michael A., Adalsteinsson, Viktor A., Getz, Gad

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Abstract LB-257: Liquid biopsy versus tissue biopsy to assess acquired resistance and tumor heterogeneity in gastrointestinal cancers by Parikh, Aparna R., Leshchiner, Ignaty, Elagina, Liudmila, Goyal, Lipika, Levovitz, Chaya, Siravegna, Giulia, Livitz, Dimitri, Rhrissorrakrai, Kahn, Martin, Liz, Seventer, Emily E. Van, Hanna, Megan, Slowik, Kara, Utro, Filippo, Pinto, Christopher J., Wong, Alicia, Danysh, Brian P., Cruz, Ferran Fece de la, Fetter, Isobel J., Nadres, Brandon, Shahzade, Heather A., Allen, Jill N., Blaszkowsky, Lawrence S., Clark, Jeffrey W., Giantonio, Bruce, Murphy, Janet E., Nipp, Ryan D., Roeland, Eric, Ryan, David P., Weekes, Colin D., Kwak, Eunice L., Faris, Jason E., Aguet, Francois, Guha, Ipsita, Hazar-Rethinam, Mehlika, Dias-Santagata, Dora, Ting, David T., Zhu, Andrew X., Hong, Theodore S., Golub, Todd R., Iafrate, A J., Adalsteinsson, Viktor, Bardelli, Alberto, Parida, Laxmi, Juric, Dejan, Getz, Gad, Corcoran, Ryan B.

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Abstract 218: The evolutionary history of 2,658 cancers by Jolly, Clemency, Gerstung, Moritz, Leshchiner, Ignaty, Dentro, Stefan C., Gonzalez, Santiago, Mitchell, Thomas J., Rubanova, Yulia, Anur, Pavana, Rosebrock, Daniel, Yu, Kaixian, Tarabichi, Maxime, Deshwar, Amit, Wintersinger, Jeff, Kleinheinz, Kortine, Vásquez-García, Ignacio, Haase, Kerstin, Sengupta, Subhajit, Macintyre, Geoff, Malikic, Salem, Donmez, Nilgun, Livitz, Dimitri G., Cmero, Mark, Demeulemeester, Jonas, Schumacher, Steve, Fan, Yu, Yao, Xiaotong, Lee, Juhee, Schlesner, Matthias, Boutros, Paul C., Bowtell, David D., Zhu, Hongtu, Getz, Gad, Imielinski, Marcin, Beroukhim, Rameen, Sahinalp, S Cenk, Ji, Yuan, Peifer, Martin, Markowetz, Florian, Mustonen, Ville, Juan, Ke, Wang, Wenyi, Morris, Quaid D., Spellman, Paul T., Wedge, David C., Loo, Peter Van

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Genetically-Defined Diffuse Large B-Cell Lymphoma Subsets Arise By Distinct Pathogenetic Mechanisms and Predict Outcome by Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew, Kim, Jaegil, Kamburow, Atanas, Redd, Robert A., Lawrence, Michael, Roemer, Margaretha G.M., Li, Amy, Ziepert, Marita, Staiger, Annette M., Wala, Jeremiah, Ducar, Matthew D., Leshchiner, Ignaty, Rheinbay, Esther, Taylor-Weiner, Amaro, Coughlin, Caroline, Hess, Julian, Pedamallu, Chandra, Livitz, Dimitri, Rosebrock, Daniel, Rosenberg, Mara, Tracy, Adam, Horn, Heike, van Hummelen, Paul, Feldman, Andrew L, Link, Brian K, Novak, Anne J, Cerhan, James R., Habermann, Thomas M, Siebert, Reiner, Rosenwald, Andreas, Thorner, Aaron R., Meyerson, Matthew, Golub, Todd R., Beroukhim, Rameen, Wulf, Gerald, Ott, German, Rodig, Scott J., Monti, Stefano, Neuberg, Donna S., Loeffler, Markus, Pfreundschuh, Michael, Trümper, Lorenz, Getz, Gad, Shipp, Margaret A.

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Abstract LB-136: High concordance of whole-exome sequencing of cell-free DNA and matched biopsies enables genomic discovery in metastatic cancer by Adalsteinsson, Viktor A., Ha, Gavin, Freeman, Sam, Choudhury, Atish D., Stover, Daniel G., Parsons, Heather A., Gydush, Gregory, Reed, Sarah, Loginov, Denis, Livitz, Dimitri, Rosebrock, Daniel, Leshchiner, Ignat, Cohen, Ofir, Oh, Coyin, Kim, Jaegil, Stewart, Chip, Rosenberg, Mara, Ding, Huiming, Lloyd, Maxwell R., Mahmud, Sairah, Helvie, Karla E., Merrill, Margaret S., Santiago, Rebecca A., O’Connor, Edward P., Jeong, Seong H., Kramkowski, Joseph F., Lohr, Jens G., Polacek, Laura, Oliver, Nelly, Marini, Lori, Francis, Joshua, Harshman, Lauren C., Van Allen, Eliezer M., Winer, Eric P., Lin, Nancy U., Nakabayashi, Mari, Taplin, Mary-Ellen, Garraway, Levi A., Golub, Todd R., Boehm, Jesse S., Wagle, Nikhil, Getz, Gad, Meyerson, Matthew, Love, Christopher J.

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