Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

by Guièze, Romain, Liu, Vivian M., Rosebrock, Daniel, Jourdain, Alexis A., Hernández-Sánchez, María, Martinez Zurita, Aina, Sun, Jing, Ten Hacken, Elisa, Baranowski, Kaitlyn, Thompson, Philip A., Heo, Jin-Mi, Cartun, Zachary, Aygün, Ozan, Iorgulescu, J. Bryan, Zhang, Wandi, Notarangelo, Giulia, Livitz, Dimitri, Li, Shuqiang, Davids, Matthew S., Biran, Anat, Fernandes, Stacey M., Brown, Jennifer R., Lako, Ana, Ciantra, Zoe B., Lawlor, Matthew A., Keskin, Derin B., Udeshi, Namrata D., Wierda, William G., Livak, Kenneth J., Letai, Anthony G., Neuberg, Donna, Harper, J. Wade, Carr, Steven A., Piccioni, Federica, Ott, Christopher J., Leshchiner, Ignaty, Johannessen, Cory M., Doench, John, Mootha, Vamsi K., Getz, Gad, Wu, Catherine J.
Published in Cancer cell

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

by Kale, Justin, Kutuk, Ozgur, Brito, Glauber Costa, Andrews, Tallulah S, Leber, Brian, Letai, Anthony, Andrews, David W
Published in EMBO reports

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

by Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Published in Cell

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

by Burger, Jan A, Landau, Dan A, Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M, Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J, Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R, Abruzzo, Lynne V, Carter, Scott L, Keating, Michael J, Davids, Matthew S, Wierda, William G, Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Dal Cin, Paola, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O'Brien, Susan, Letai, Anthony, Weitz, David A, Nowak, Martin A, Getz, Gad, Wu, Catherine J
Published in Nature communications

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

by Sarosiek, Kristopher A., Chi, Xiaoke, Bachman, John A., Sims, Joshua J., Montero, Joan, Patel, Luv, Flanagan, Annabelle, Andrews, David W., Sorger, Peter, Letai, Anthony
Published in Molecular cell

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer

by Potter, Danielle S, Du, Ruochen, Bhola, Patrick, Bueno, Raphael, Letai, Anthony
Published in Cell death & disease

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer

by Lal, Jessica Castrillon, Townsend, Madeline G, Mehta, Anita K, Oliwa, Madisson, Miller, Eric, Sotayo, Alaba, Cheney, Emily, Mittendorf, Elizabeth A, Letai, Anthony, Guerriero, Jennifer L
Published in Breast cancer research : BCR

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

by Ariës, Ingrid M, Bodaar, Kimberly, Karim, Salmaan A, Chonghaile, Triona Ni, Hinze, Laura, Burns, Melissa A, Pfirrmann, Maren, Degar, James, Landrigan, Jack T, Balbach, Sebastian, Peirs, Sofie, Menten, Björn, Isenhart, Randi, Stevenson, Kristen E, Neuberg, Donna S, Devidas, Meenakshi, Loh, Mignon L, Hunger, Stephen P, Teachey, David T, Rabin, Karen R, Winter, Stuart S, Dunsmore, Kimberly P, Wood, Brent L, Silverman, Lewis B, Sallan, Stephen E, Van Vlierberghe, Pieter, Orkin, Stuart H, Knoechel, Birgit, Letai, Anthony G, Gutierrez, Alejandro
Published in The Journal of experimental medicine

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

by Zoeller, Jason J, Vagodny, Aleksandr, Daniels, Veerle W, Taneja, Krishan, Tan, Benjamin Y, DeRose, Yoko S, Fujita, Maihi, Welm, Alana L, Letai, Anthony, Leverson, Joel D, Blot, Vincent, Bronson, Roderick T, Dillon, Deborah A, Brugge, Joan S
Published in Breast cancer research : BCR

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins

by Alcon, Clara, Gómez Tejeda Zañudo, Jorge, Albert, Reka, Wagle, Nikhil, Scaltriti, Maurizio, Letai, Anthony, Samitier, Josep, Montero, Joan
Published in Cells (Basel, Switzerland)

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

by DiNardo, Courtney D., Pratz, Keith, Pullarkat, Vinod, Jonas, Brian A., Arellano, Martha, Becker, Pamela S., Frankfurt, Olga, Konopleva, Marina, Wei, Andrew H., Kantarjian, Hagop M., Xu, Tu, Hong, Wan-Jen, Chyla, Brenda, Potluri, Jalaja, Pollyea, Daniel A., Letai, Anthony
Published in Blood

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

by Guerriero, Jennifer L, Sotayo, Alaba, Ponichtera, Holly E, Castrillon, Jessica A, Pourzia, Alexandra L, Schad, Sara, Johnson, Shawn F, Carrasco, Ruben D, Lazo, Suzan, Bronson, Roderick T, Davis, Scott P, Lobera, Mercedes, Nolan, Michael A, Letai, Anthony
Published in Nature (London)

Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia

by Konopleva, Marina, Pollyea, Daniel A, Potluri, Jalaja, Chyla, Brenda, Hogdal, Leah, Busman, Todd, McKeegan, Evelyn, Salem, Ahmed Hamed, Zhu, Ming, Ricker, Justin L, Blum, William, DiNardo, Courtney D, Kadia, Tapan, Dunbar, Martin, Kirby, Rachel, Falotico, Nancy, Leverson, Joel, Humerickhouse, Rod, Mabry, Mack, Stone, Richard, Kantarjian, Hagop, Letai, Anthony
Published in Cancer discovery

Priming BCL-2 to kill: the combination therapy of tamoxifen and ABT-199 in ER+ breast cancer

by Deng, Jing, Letai, Anthony
Published in Breast cancer research : BCR

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL

by Bojarczuk, Kamil, Wienand, Kirsty, Ryan, Jeremy A., Chen, Linfeng, Villalobos-Ortiz, Mariana, Mandato, Elisa, Stachura, Joanna, Letai, Anthony, Lawton, Lee N., Chapuy, Bjoern, Shipp, Margaret A.
Published in Blood

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

by Chonghaile, Triona Ni, Sarosiek, Kristopher A., Vo, Thanh-Trang, Ryan, Jeremy A., Tammareddi, Anupama, Del Gaizo Moore, Victoria, Deng, Jing, Anderson, Kenneth C., Richardson, Paul, Tai, Yu-Tzu, Mitsiades, Constantine S., Matulonis, Ursula A., Drapkin, Ronny, Stone, Richard, DeAngelo, Daniel J., McConkey, David J., Sallan, Stephen E., Silverman, Lewis, Hirsch, Michelle S., Carrasco, Daniel Ruben, Letai, Anthony
Published in Science (American Association for the Advancement of Science)

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance

by Togami, Katsuhiro, Pastika, Timothy, Stephansky, Jason, Ghandi, Mahmoud, Christie, Amanda L, Jones, Kristen L, Johnson, Carl A, Lindsay, Ross W, Brooks, Christopher L, Letai, Anthony, Craig, Jeffrey W, Pozdnyakova, Olga, Weinstock, David M, Montero, Joan, Aster, Jon C, Johannessen, Cory M, Lane, Andrew A
Published in The Journal of clinical investigation

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

by Townsend, Elizabeth C., Murakami, Mark A., Christodoulou, Alexandra, Christie, Amanda L., Köster, Johannes, DeSouza, Tiffany A., Morgan, Elizabeth A., Kallgren, Scott P., Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E., Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K., Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A., Cooke, Vesselina G., Davids, Matthew S., DeAngelo, Daniel J., Dorfman, David M., Eaton, Hilary, Ebert, Benjamin L., Etchin, Julia, Firestone, Brant, Fisher, David C., Freedman, Arnold S., Galinsky, Ilene A., Gao, Hui, Garcia, Jacqueline S., Garnache-Ottou, Francine, Graubert, Timothy A., Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H., Herbert, Zachary T., Horwitz, Steven M., Inghirami, Giorgio, Intlekofer, Andrew M., Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D., Jacobson, Caron A., Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A., Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M., Kung, Andrew L., Kupper, Thomas S., LeBoeuf, Nicole R., LaCasce, Ann S., Lees, Emma, Li, Loretta S., Look, A. Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y., Odejide, Oreofe O., Orkin, Stuart H., Paquette, Rachel R., Place, Andrew E., Roderick, Justine E., Ryan, Jeremy A., Sallan, Stephen E., Shoji, Brent, Silverman, Lewis B., Soiffer, Robert J., Steensma, David P., Stegmaier, Kimberly, Stone, Richard M., Tamburini, Jerome, Thorner, Aaron R., van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P., Wuerthner, Jens U., Williams, David A., Wollison, Bruce M., Lane, Andrew A., Letai, Anthony, Bertagnolli, Monica M., Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C., Shipp, Margaret A., Griffin, James D., Weinstock, David M.
Published in Cancer cell

Cell Line-Specific Network Models of ER + Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations

by Gómez Tejeda Zañudo, Jorge, Mao, Pingping, Alcon, Clara, Kowalski, Kailey, Johnson, Gabriela N, Xu, Guotai, Baselga, Jose, Scaltriti, Maurizio, Letai, Anthony, Montero, Joan, Albert, Réka, Wagle, Nikhil
Published in Cancer research (Chicago, Ill.)

Potent and Specific Peptide Inhibitors of Human Pro-Survival Protein Bcl-xL

by Dutta, Sanjib, Ryan, Jeremy, Chen, T. Scott, Kougentakis, Christos, Letai, Anthony, Keating, Amy E.
Published in Journal of molecular biology