Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor

by Ahn, Seungkirl, Kim, Jihee, Lucaveche, Carmen L., Reedy, Mary C., Luttrell, Louis M., Lefkowitz, Robert J., Daaka, Yehia
Published in The Journal of biological chemistry

Synthetic nanobodies as angiotensin receptor blockers

by McMahon, Conor, Staus, Dean P., Wingler, Laura M., Wang, Jialu, Skiba, Meredith A., Elgeti, Matthias, Hubbell, Wayne L., Rockman, Howard A., Kruse, Andrew C., Lefkowitz, Robert J.
Published in Proceedings of the National Academy of Sciences - PNAS

β-Arrestin-Mediated Localization of Smoothened to the Primary Cilium

by Kovacs, Jeffrey J, Whalen, Erin J, Liu, Renshui, Xiao, Kunhong, Kim, Jihee, Chen, Minyong, Wang, Jiangbo, Chen, Wei, Lefkowitz, Robert J
Published in Science (American Association for the Advancement of Science)

The Kinase Grk2 Regulates Nedd4/Nedd4-2-Dependent Control of Epithelial Na+Channels

by Dinudom, Anuwat, Fotia, Andrew B., Lefkowitz, Robert J., Young, John A., Kumar, Sharad, Cook, David I., Giebisch, Gerhard
Published in Proceedings of the National Academy of Sciences - PNAS

β-arrestins: traffic cops of cell signaling

by Lefkowitz, Robert J, Whalen, Erin J
Published in Current opinion in cell biology

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

by Kahsai, Alem W, Shah, Kunal S, Shim, Paul J, Lee, Mason A, Shreiber, Bowie N, Schwalb, Allison M, Zhang, Xingdong, Kwon, Henry Y, Huang, Li-Yin, Soderblom, Erik J, Ahn, Seungkirl, Lefkowitz, Robert J
Published in Proceedings of the National Academy of Sciences - PNAS

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

by Ahn, Seungkirl, Shenoy, Sudha K, Wei, Huijun, Lefkowitz, Robert J
Published in The Journal of biological chemistry

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

by Walters, Robert W, Shukla, Arun K, Kovacs, Jeffrey J, Violin, Jonathan D, DeWire, Scott M, Lam, Christopher M, Chen, J Ruthie, Muehlbauer, Michael J, Whalen, Erin J, Lefkowitz, Robert J
Published in The Journal of clinical investigation

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

by Ahn, Seungkirl, Kim, Jihee, Hara, Makoto R., Ren, Xiu-Rong, Lefkowitz, Robert J.
Published in The Journal of biological chemistry

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

by Strachan, Ryan T., Sun, Jin-peng, Rominger, David H., Violin, Jonathan D., Ahn, Seungkirl, Rojas Bie Thomsen, Alex, Zhu, Xiao, Kleist, Andrew, Costa, Tommaso, Lefkowitz, Robert J.
Published in The Journal of biological chemistry

β-Arrestin-biased Agonism at the β2-Adrenergic Receptor

by Drake, Matthew T., Violin, Jonathan D., Whalen, Erin J., Wisler, James W., Shenoy, Sudha K., Lefkowitz, Robert J.
Published in The Journal of biological chemistry

G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans

by Fukuto, Hana S, Ferkey, Denise M, Apicella, Alfonso J, Lans, Hannes, Sharmeen, Tahira, Chen, Wei, Lefkowitz, Robert J, Jansen, Gert, Schafer, William R, Hart, Anne C
Published in Neuron (Cambridge, Mass.)

Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice

by Gainetdinov, Raul R, Bohn, Laura M, Walker, Julia K.L, Laporte, Stéphane A, Macrae, Alexander D, Caron, Marc G, Lefkowitz, Robert J, Premont, Richard T
Published in Neuron (Cambridge, Mass.)

Seven transmembrane receptors—A brief personal retrospective

by Lefkowitz, Robert J.
Published in Biochimica et biophysica acta. Biomembranes

N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of Arrestins

by Vines, Charlotte M., Revankar, Chetana M., Maestas, Diane C., LaRusch, Leah L., Cimino, Daniel F., Kohout, Trudy A., Lefkowitz, Robert J., Prossnitz, Eric R.
Published in The Journal of biological chemistry

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

by Beaulieu, Jean-Martin, Marion, Sébastien, Rodriguiz, Ramona M., Medvedev, Ivan O., Sotnikova, Tatyana D., Ghisi, Valentina, Wetsel, William C., Lefkowitz, Robert J., Gainetdinov, Raul R., Caron, Marc G.
Published in Cell

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4

by Shukla, Arun K, Kim, Jihee, Ahn, Seungkirl, Xiao, Kunhong, Shenoy, Sudha K, Liedtke, Wolfgang, Lefkowitz, Robert J
Published in The Journal of biological chemistry

Seven-transmembrane-spanning receptors and heart function

by Rockman, Howard A, Koch, Walter J, Lefkowitz, Robert J
Published in Nature (London)

Conformation Guides Molecular Efficacy in Docking Screens of Activated β‑2 Adrenergic G Protein Coupled Receptor

by Weiss, Dahlia R, Ahn, SeungKirl, Sassano, Maria F, Kleist, Andrew, Zhu, Xiao, Strachan, Ryan, Roth, Bryan L, Lefkowitz, Robert J, Shoichet, Brian K
Published in ACS chemical biology

β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics

by Violin, Jonathan D., DiPilato, Lisa M., Yildirim, Necmettin, Elston, Timothy C., Zhang, Jin, Lefkowitz, Robert J.
Published in The Journal of biological chemistry