Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

by Coakley, Kristen M, Shannon, Kevin, Li, Qing, Warner, Kegan, Przybranowski, Sally, Akagi, Keiko, Krisman, Kimberly, Kogan, Scott C, Parada, Luis, Diaz-Flores, Ernesto, Gorman, Matthew, Roose, Jeroen P, Kim, Doris, Bonifas, Jeannette M, Crone, Michael, Jenkins, Nancy A, Wolff, Linda, Lauchle, Jennifer O, Copeland, Neal G, Sebolt-Leopold, Judith, Tran, Mary, Le, Doan T
Published in Nature

Iron-silica interaction at extreme conditions and the electrically conducting layer at the base of Earth's mantle

by Dubrovinsky, L, Dubrovinskaia, N, Langenhorst, F, Dobson, D, Rubie, D, Geßmann, C, Abrikosov, I. A, Johansson, B, Baykov, V. I, Vitos, L, Bihan, T. Le, Crichton, W. A, Dmitriev, V, Weber, H.-P
Published in Nature (London)

Structural variants drive context-dependent oncogene activation in cancer

by Xu, Zhichao, Lee, Dong-Sung, Chandran, Sahaana, Le, Victoria T, Bump, Rosalind, Yasis, Jean, Dallarda, Sofia, Marcotte, Samantha, Clock, Benjamin, Haghani, Nicholas, Cho, Chae Yun, Akdemir, Kadir C, Tyndale, Selene, Futreal, P Andrew, McVicker, Graham, Wahl, Geoffrey M, Dixon, Jesse R
Published in Nature (London)

Measurement of the axial vector form factor from antineutrino-proton scattering

by Cai, T, Moore, M L, Olivier, A, Akhter, S, Dar, Z Ahmad, Ansari, V, Ascencio, M V, Bashyal, A, Bercellie, A, Betancourt, M, Bodek, A, Bonilla, J L, Bravar, A, Budd, H, Caceres, G, Carneiro, M F, Díaz, G A, da Motta, H, Felix, J, Fields, L, Filkins, A, Fine, R, Gago, A M, Gallagher, H, Gilligan, S M, Gran, R, Granados, E, Harris, D A, Henry, S, Jena, D, Jena, S, Kleykamp, J, Klustová, A, Kordosky, M, Last, D, Le, T, Lozano, A, Lu, X-G, Maher, E, Manly, S, Mann, W A, Mauger, C, McFarland, K S, Messerly, B, Miller, J, Moreno, O, Morfín, J G, Naples, D, Nelson, J K, Nguyen, C, Paolone, V, Perdue, G N, Plows, K-J, Ramírez, M A, Ransome, R D, Ray, H, Ruterbories, D, Schellman, H, Salinas, C J Solano, Su, H, Sultana, M, Syrotenko, V S, Valencia, E, Vaughan, N H, Waldron, A V, Wascko, M O, Wret, C, Yaeggy, B, Zazueta, L
Published in Nature (London)

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

by Perrouault, L, Asseline, U, Rivalle, Christian, Thuong, N. T, Bisagni, E, Giovannangeli, C, Doan, T. Le, Hélène, C
Published in Nature (London)

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

by Le Voyer, Tom, Gervais, Adrian, Rosain, Jérémie, Rinchai, Darawan, Hancioglu, Gonca, Ghillani-Dalbin, Pascale, Charuel, Jean-Luc, Philippot, Quentin, Gueye, Mame Sokhna, Maglorius Renkilaraj, Majistor Raj Luxman, Ogishi, Masato, Soudée, Camille, Migaud, Mélanie, Rozenberg, Flore, Momenilandi, Mana, Delmonte, Ottavia M, Müller, Gabriele, Keller, Baerbel, Franco Gallego, William Alexander, Rubin, Tamar, Emiroglu, Melike, Parvaneh, Nima, Aranda-Guillen, Maribel, Berrios, David I, Vong, Linda, Katelaris, Constance H, Mustillo, Peter, Raedler, Johannes, Bohlen, Jonathan, Winter, Sarah, McLean, Catriona, Guffroy, Aurélien, DeRisi, Joseph L, Yu, David, Miller, Corey, Feng, Yi, Béziat, Vivien, Bustamante, Jacinta, Pan-Hammarström, Qiang, Holland, Steve M, Bosticardo, Marita, Kenney, Heather, Slade, Charlotte A, Boztuğ, Kaan, Mahlaoui, Nizar, Abraham, Roshini S, Lougaris, Vassilios, Hauck, Fabian, Sediva, Anna, Atschekzei, Faranaz, Poli, M Cecilia, Slatter, Mary A, Palterer, Boaz, Suan, Daniel, Wong, Melanie, Kane, Alisa, Ma, Cindy, Grombiříková, Hana, Dalal, Ilan, Aladjidi, Nathalie, Hie, Miguel, Lazaro, Estibaliz, Franco, Jose, Keles, Sevgi, Malphettes, Marion, Pasquet, Marlene, Maccari, Maria Elena, Meinhardt, Andrea, Shahrooei, Mohammad, Goodnow, Christopher C, Gray, Paul E, Belot, Alexandre, Kuehn, Hye Sun, Rosenzweig, Sergio D, Miyara, Makoto, Licciardi, Francesco, Servettaz, Amélie, Le Guenno, Guillaume, Herrmann, Vera-Maria, Sarrot-Reynauld, Françoise, Schuetz, Catharina, Cunningham-Rundles, Charlotte, Tangye, Stuart G, Sobacchi, Cristina, Grimbacher, Bodo, Fieschi, Claire, Berteloot, Laureline, Trouillet Assant, Sophie, Neven, Benedicte, Abel, Laurent, Cobat, Aurélie, Jouanguy, Emmanuelle, Kampe, Olle, Bastard, Paul, Roifman, Chaim M, Landegren, Nils, Notarangelo, Luigi D, Anderson, Mark S, Casanova, Jean-Laurent, Puel, Anne
Published in Nature (London)

Autoantibodies against type I IFNs in humans with alternative NF-.B pathway deficiency

by Le Voyer, T, Parent, AV, Liu, X, Gervais, A, Nguyen, T, Lorenzo, MP, Rackaityte, E, Zhang, P, Bizien, L, Hancioglu, G, Gueye, MS, Renkilaraj, MRLM, Ogishi, M, Soudee, C, Migaud, M, Rozenberg, F, Momenilandi, M, Riller, Q, Imberti, L, Delmonte, OM, Muller, G, Keller, B, Orrego, J, Gallego, WAF, Rubin, T, Emiroglu, M, Parvaneh, N, Eriksson, D, Aranda-Guillen, M, Vong, L, Katelaris, CH, Mustillo, P, Raedler, J, Bohlen, J, Celik, JB, Astudillo, C, Guffroy, A, DeRisi, JL, Miller, C, Guichard, A, Pan-Hammarstrom, Q, Zhang, Y, Rosen, LB, Holland, SM, Bosticardo, M, Kenney, H, Slade, CA, Abraham, RS, Lougaris, V, Hauck, F, Sediva, A, Poli, MC, Palterer, B, Keller, MD, Sullivan, A, Suan, D, Wong, M, Ma, C, Ciznar, P, Aladjidi, N, Hie, M, Lazaro, E, Franco, J, Keles, S, Malphettes, M, Meinhardt, A, Ikinciogullari, A, Shahrooei, M, Celmeli, F, Goodnow, CC, Gray, PE, Belot, A, Kuehn, HS, Rosenzweig, SD, Miyara, M, Licciardi, F, Barlogis, V, Le Guenno, G, Kuijpers, T, Ducoux, G, Sarrot-Reynauld, F, Cunningham-Rundles, C, Rieux-Laucat, F, Tangye, SG, Sobacchi, C, Doffinger, R, Grimbacher, B, Fieschi, C, Bryant, VL, Assant, ST, Su, H, Neven, B, Abel, L, Zhang, Q, Boisson, B, Cobat, A, Kampe, O, Landegren, N, Notarangelo, LD, Puel, A
Published in Nature (London)

Lysyl oxidase is essential for hypoxia-induced metastasis

by Giaccia, Amato J, Erler, Janine T, Bennewith, Kevin L, Nicolau, Monica, Dornhöfer, Nadja, Kong, Christina, Le, Quynh-Thu, Chi, Jen-Tsan Ashley, Jeffrey, Stefanie S
Published in Nature

A saturated map of common genetic variants associated with human height

by Yengo, Loïc, Karaderi, Tugce, Vrieze, Scott, Alvarez, Marcus, Arbeeva, Liubov, Bhaskar, Seema, Brody, Jennifer A, Burgdorf, Kristoffer S, Cai, Qiuyin, Chang, Li-Ching, Couture, Christian, Dietl, Alexander, Giannakopoulou, Olga, Gjesing, Anette P, Havulinna, Aki S, Hindy, George, Johansson, Ingegerd, Jørgensen, Torben, Kanoni, Stavroula, Kim, Han-Na, Le, Phuong, Lin, Shih-Yi, Liu, Jun, Long, Jirong, Mavarani, Laven, Nakatochi, Masahiro, Nethander, Maria, Pandit, Anita, Christofidou, Paraskevi, Pyarajan, Saiju, Rakugi, Hiromi, Rasheed, Asif, Raven, Dennis, Riveros, Carlos, Sendamarai, Anoop, Sitlani, Colleen M, Taylor, Kent D, Tayo, Bamidele O, Theusch, Elizabeth, Vaccargiu, Simona, van der Laan, Sander W, Verma, Shefali S, Veturi, Yogasudha, Wang, Chaolong, Bin Wei, Wen, Wu, Yang, Xia, Rui, Zimmermann, Martina E, Zoledziewska, Magdalena, Åsvold, Bjørn Olav, Biino, Ginevra, Boomsma, Dorret I, Brumpton, Ben, Chambers, John C, Ciullo, Marina, Janaka de Silva, H, Dedoussis, George V, Feitosa, Mary F, Ford, Ian, Hewitt, Alex W, Huang, Paul L, Jukema, J Wouter, Kang, Kui Dong, Kessler, Thorsten, Koh, Woon-Puay, Lieb, Wolfgang, Lye, Stephen J, McGarrah, Robert W, Mellström, Dan, Mucci, Lorelei A, Orozco, Lorena, Qu, Jia, Rader, Daniel J, Rallidis, Loukianos S, Rao, Dabeeru C, Rhee, Sang Youl, Rudan, Igor, Schmidt, Börge, Schmidt, Helena, Schulze, Matthias B, Simonsick, Eleanor M, Singleton, Andrew B, Stampfer, Meir J, 't Hart, Leen M, Timpson, Nicholas J, Tremblay, Angelo, Tusié-Luna, Maria-Teresa, van der Harst, Pim, van Schoor, Natasja M, Widen, Elisabeth, Willemsen, Gonneke, Willett, Walter C, Wilson, James F, Yuan, Jian-Min, Zhu, Xiaofeng, O'Donnell, Christopher J, Sun, Yan V, Justice, Anne E, Winkler, Thomas W, Willer, Cristen J
Published in Nature (London)

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

by Perrouault, L, Asseline, U, Rivalle, C, Thuong, N T, Bisagni, E, Giovannangeli, C, Le Doan, T, Hélène, C
Published in Nature (London)

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

by Carvelli, Julien, Demaria, Olivier, Vély, Frédéric, Batista, Luciana, Chouaki Benmansour, Nassima, Fares, Joanna, Carpentier, Sabrina, Thibult, Marie-Laure, Morel, Ariane, Remark, Romain, André, Pascale, Represa, Agnès, Piperoglou, Christelle, Cordier, Pierre Yves, Le Dault, Erwan, Guervilly, Christophe, Simeone, Pierre, Gainnier, Marc, Morel, Yannis, Ebbo, Mikael, Schleinitz, Nicolas, Vivier, Eric
Published in Nature (London)

Dietary intervention impact on gut microbial gene richness

by Cotillard, Aurélie, Kennedy, Sean P, Kong, Ling Chun, Prifti, Edi, Pons, Nicolas, Le Chatelier, Emmanuelle, Almeida, Mathieu, Quinquis, Benoit, Levenez, Florence, Galleron, Nathalie, Gougis, Sophie, Rizkalla, Salwa, Batto, Jean-Michel, Renault, Pierre, Doré, Joel, Zucker, Jean-Daniel, Clément, Karine, Ehrlich, Stanislav Dusko
Published in Nature (London)

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

by Meng, Bo, Abdullahi, Adam, Ferreira, Isabella A T M, Goonawardane, Niluka, Saito, Akatsuki, Kimura, Izumi, Yamasoba, Daichi, Gerber, Pehuén Pereyra, Fatihi, Saman, Rathore, Surabhi, Zepeda, Samantha K, Papa, Guido, Kemp, Steven A, Ikeda, Terumasa, Toyoda, Mako, Tan, Toong Seng, Kuramochi, Jin, Mitsunaga, Shigeki, Ueno, Takamasa, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Brevini, Teresa, Mallery, Donna L, Charles, Oscar J, Bowen, John E, Joshi, Anshu, Walls, Alexandra C, Jackson, Laurelle, Martin, Darren, Smith, Kenneth G C, Bradley, John, Briggs, John A G, Choi, Jinwook, Madissoon, Elo, Meyer, Kerstin B, Mlcochova, Petra, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Teichmann, Sarah A, Fisher, Andrew J, Pizzuto, Matteo S, de Marco, Anna, Corti, Davide, Hosmillo, Myra, Lee, Joo Hyeon, James, Leo C, Thukral, Lipi, Veesler, David, Sigal, Alex, Sampaziotis, Fotios, Goodfellow, Ian G, Matheson, Nicholas J, Sato, Kei, Gupta, Ravindra K
Published in Nature (London)

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

by Collier, Dami A, Ferreira, Isabella A T M, Kotagiri, Prasanti, Datir, Rawlings P, Lim, Eleanor Y, Touizer, Emma, Meng, Bo, Abdullahi, Adam, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, Le Gresley, Emma, Caputo, Daniela, Bergamaschi, Laura, Smith, Kenneth G C, Bradley, John R, Ceron-Gutierrez, Lourdes, Cortes-Acevedo, Paulina, Barcenas-Morales, Gabriela, Linterman, Michelle A, McCoy, Laura E, Davis, Chris, Thomson, Emma, Lyons, Paul A, McKinney, Eoin, Doffinger, Rainer, Wills, Mark, Gupta, Ravindra K
Published in Nature (London)

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

by Grant, Rogan A, Morales-Nebreda, Luisa, Markov, Nikolay S, Swaminathan, Suchitra, Querrey, Melissa, Guzman, Estefany R, Abbott, Darryl A, Donnelly, Helen K, Donayre, Alvaro, Goldberg, Isaac A, Klug, Zasu M, Borkowski, Nicole, Lu, Ziyan, Kihshen, Hermon, Politanska, Yuliya, Sichizya, Lango, Kang, Mengjia, Shilatifard, Ali, Qi, Chao, Lomasney, Jon W, Argento, A Christine, Kruser, Jacqueline M, Malsin, Elizabeth S, Pickens, Chiagozie O, Smith, Sean B, Walter, James M, Pawlowski, Anna E, Schneider, Daniel, Nannapaneni, Prasanth, Abdala-Valencia, Hiam, Bharat, Ankit, Gottardi, Cara J, Budinger, G R Scott, Misharin, Alexander V, Singer, Benjamin D, Wunderink, Richard G
Published in Nature (London)

Neoantigen-directed immune escape in lung cancer evolution

by Rosenthal, Rachel, Cadieux, Elizabeth Larose, Salgado, Roberto, Bakir, Maise Al, Moore, David A, Hiley, Crispin T, Lund, Tom, Tanić, Miljana, Reading, James L, Joshi, Kroopa, Henry, Jake Y, Ghorani, Ehsan, Wilson, Gareth A, Birkbak, Nicolai J, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Szallasi, Zoltan, Loi, Sherene, Hellmann, Matthew D, Feber, Andrew, Chain, Benny, Herrero, Javier, Quezada, Sergio A, Demeulemeester, Jonas, Van Loo, Peter, Beck, Stephan, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London)

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

by Vieira-Silva, Sara, Falony, Gwen, Belda, Eugeni, Nielsen, Trine, Aron-Wisnewsky, Judith, Chakaroun, Rima, Forslund, Sofia K, Assmann, Karen, Valles-Colomer, Mireia, Nguyen, Thi Thuy Duyen, Proost, Sebastian, Prifti, Edi, Tremaroli, Valentina, Pons, Nicolas, Le Chatelier, Emmanuelle, Andreelli, Fabrizio, Bastard, Jean-Phillippe, Coelho, Luis Pedro, Galleron, Nathalie, Hansen, Tue H, Hulot, Jean-Sébastien, Lewinter, Christian, Pedersen, Helle K, Quinquis, Benoit, Rouault, Christine, Roume, Hugo, Salem, Joe-Elie, Søndertoft, Nadja B, Touch, Sothea, Dumas, Marc-Emmanuel, Ehrlich, Stanislav Dusko, Galan, Pilar, Gøtze, Jens P, Hansen, Torben, Holst, Jens J, Køber, Lars, Letunic, Ivica, Nielsen, Jens, Oppert, Jean-Michel, Stumvoll, Michael, Vestergaard, Henrik, Zucker, Jean-Daniel, Bork, Peer, Pedersen, Oluf, Bäckhed, Fredrik, Clément, Karine, Raes, Jeroen
Published in Nature (London)

Proteogenomics connects somatic mutations to signalling in breast cancer

by Mertins, Philipp, Mani, D R, Ruggles, Kelly V, Gillette, Michael A, Clauser, Karl R, Wang, Pei, Wang, Xianlong, Qiao, Jana W, Cao, Song, Petralia, Francesca, Kawaler, Emily, Mundt, Filip, Krug, Karsten, Tu, Zhidong, Lei, Jonathan T, Gatza, Michael L, Wilkerson, Matthew, Perou, Charles M, Yellapantula, Venkata, Huang, Kuan-lin, Lin, Chenwei, McLellan, Michael D, Yan, Ping, Davies, Sherri R, Townsend, R Reid, Skates, Steven J, Wang, Jing, Zhang, Bing, Kinsinger, Christopher R, Mesri, Mehdi, Rodriguez, Henry, Ding, Li, Paulovich, Amanda G, Fenyö, David, Ellis, Matthew J, Carr, Steven A
Published in Nature (London)

Lung adenocarcinoma promotion by air pollutants

by Hill, William, Lim, Emilia L, Weeden, Clare E, Lee, Claudia, Augustine, Marcellus, Chen, Kezhong, Kuan, Feng-Che, Marongiu, Fabio, Evans, Jr, Edward J, Moore, David A, Rodrigues, Felipe S, Pich, Oriol, Bakker, Bjorn, Cha, Hongui, Myers, Renelle, van Maldegem, Febe, Boumelha, Jesse, Veeriah, Selvaraju, Rowan, Andrew, Naceur-Lombardelli, Cristina, Karasaki, Takahiro, Sivakumar, Monica, De, Swapnanil, Caswell, Deborah R, Nagano, Ai, Black, James R M, Martínez-Ruiz, Carlos, Ryu, Min Hyung, Huff, Ryan D, Li, Shijia, Favé, Marie-Julie, Magness, Alastair, Suárez-Bonnet, Alejandro, Priestnall, Simon L, Lüchtenborg, Margreet, Lavelle, Katrina, Pethick, Joanna, Hardy, Steven, McRonald, Fiona E, Lin, Meng-Hung, Troccoli, Clara I, Ghosh, Moumita, Miller, York E, Merrick, Daniel T, Keith, Robert L, Al Bakir, Maise, Bailey, Chris, Hill, Mark S, Saal, Lao H, Chen, Yilun, George, Anthony M, Abbosh, Christopher, Kanu, Nnennaya, Lee, Se-Hoon, McGranahan, Nicholas, Berg, Christine D, Sasieni, Peter, Houlston, Richard, Turnbull, Clare, Lam, Stephen, Awadalla, Philip, Grönroos, Eva, Downward, Julian, Jacks, Tyler, Carlsten, Christopher, Malanchi, Ilaria, Hackshaw, Allan, Litchfield, Kevin, DeGregori, James, Jamal-Hanjani, Mariam, Swanton, Charles
Published in Nature (London)

High-throughput discovery of novel developmental phenotypes

by Dickinson, Mary E, Flenniken, Ann M, Ji, Xiao, Teboul, Lydia, Wong, Michael D, White, Jacqueline K, Meehan, Terrence F, Weninger, Wolfgang J, Westerberg, Henrik, Adissu, Hibret, Baker, Candice N, Bower, Lynette, Brown, James M, Caddle, L Brianna, Chiani, Francesco, Clary, Dave, Cleak, James, Daly, Mark J, Denegre, James M, Doe, Brendan, Dolan, Mary E, Edie, Sarah M, Fuchs, Helmut, Gailus-Durner, Valerie, Galli, Antonella, Gambadoro, Alessia, Gallegos, Juan, Guo, Shiying, Horner, Neil R, Hsu, Chih-Wei, Johnson, Sara J, Kalaga, Sowmya, Keith, Lance C, Lanoue, Louise, Lawson, Thomas N, Lek, Monkol, Mark, Manuel, Marschall, Susan, Mason, Jeremy, McElwee, Melissa L, Newbigging, Susan, Nutter, Lauryl M J, Peterson, Kevin A, Ramirez-Solis, Ramiro, Rowland, Douglas J, Ryder, Edward, Samocha, Kaitlin E, Seavitt, John R, Selloum, Mohammed, Szoke-Kovacs, Zsombor, Tamura, Masaru, Trainor, Amanda G, Tudose, Ilinca, Wakana, Shigeharu, Warren, Jonathan, Wendling, Olivia, West, David B, Wong, Leeyean, Yoshiki, Atsushi, MacArthur, Daniel G, Tocchini-Valentini, Glauco P, Gao, Xiang, Flicek, Paul, Bradley, Allan, Skarnes, William C, Justice, Monica J, Parkinson, Helen E, Moore, Mark, Wells, Sara, Braun, Robert E, Svenson, Karen L, de Angelis, Martin Hrabe, Herault, Yann, Mohun, Tim, Mallon, Ann-Marie, Henkelman, R Mark, Brown, Steve D M, Adams, David J, Lloyd, K C Kent, McKerlie, Colin, Beaudet, Arthur L, Bućan, Maja, Murray, Stephen A
Published in Nature (London)