Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis by Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

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Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic by Smith, Amos B., Chen, Kwunmin, Robinson, Darius J., Laakso, Leif M., Hale, Karl J.

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FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)–C(34) fragment of FK-506, FR-900520, and FR-900523 by Smith, Amos B., Hale, Karl J., Laakso, Leif M., Chen, Kwunmin, Riéra, Antoni

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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism by Fadista, João, Vikman, Petter, Laakso, Emilia Ottosson, Mollet, Inês Guerra, Esguerra, Jonathan Lou, Taneera, Jalal, Storm, Petter, Osmark, Peter, Ladenvall, Claes, Prasad, Rashmi B., Hansson, Karin B., Finotello, Francesca, Uvebrant, Kristina, Ofori, Jones K., Di Camillo, Barbara, Krus, Ulrika, Cilio, Corrado M., Hansson, Ola, Eliasson, Lena, Rosengren, Anders H., Renström, Erik, Wollheim, Claes B., Groop, Leif

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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes by Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B, Alföldi, Jessica, Francioli, Laurent C, Gauthier, Laura D, Hill, Andrew J, O'Donnell-Luria, Anne H, Karczewski, Konrad J, MacArthur, Daniel G

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Influence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time by Ottosson-Laakso, Emilia, Tuomi, Tiinamaija, Forsén, Björn, Gullström, Monika, Groop, Per-Henrik, Groop, Leif, Vikman, Petter

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Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy by Karpanen, Terhi, Bry, Maija, Ollila, Hanna M, Seppänen-Laakso, Tuulikki, Liimatta, Erkki, Leskinen, Hanna, Kivelä, Riikka, Helkamaa, Teemu, Merentie, Mari, Jeltsch, Michael, Paavonen, Karri, Andersson, Leif C, Mervaala, Eero, Hassinen, Ilmo E, Ylä-Herttuala, Seppo, Orešič, Matej, Alitalo, Kari

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Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals by Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O'Donnell-Luria, Anne H, Francioli, Laurent C, Cook, Stuart A, Barton, Paul J R, MacArthur, Daniel G, Ware, James S

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Elevated circulating follistatin associates with an increased risk of type 2 diabetes by Wu, Chuanyan, Borné, Yan, Gao, Rui, López Rodriguez, Maykel, Roell, William C, Wilson, Jonathan M, Regmi, Ajit, Luan, Cheng, Aly, Dina Mansour, Peter, Andreas, Machann, Jürgen, Staiger, Harald, Fritsche, Andreas, Birkenfeld, Andreas L, Tao, Rongya, Wagner, Robert, Canouil, Mickaël, Hong, Mun-Gwan, Schwenk, Jochen M, Ahlqvist, Emma, Kaikkonen, Minna U, Nilsson, Peter, Shore, Angela C, Khan, Faisel, Natali, Andrea, Melander, Olle, Orho-Melander, Marju, Nilsson, Jan, Häring, Hans-Ulrich, Renström, Erik, Wollheim, Claes B, Engström, Gunnar, Weng, Jianping, Pearson, Ewan R, Franks, Paul W, White, Morris F, Duffin, Kevin L, Vaag, Allan Arthur, Laakso, Markku, Stefan, Norbert, Groop, Leif, De Marinis, Yang

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes by Goodrich, Julia K, Singer-Berk, Moriel, Son, Rachel, Sveden, Abigail, Wood, Jordan, England, Eleina, Weisburd, Ben, Watts, Nick, Caulkins, Lizz, Dornbos, Peter, Koesterer, Ryan, Zappala, Zachary, Zhang, Haichen, Atzmon, Gil, Barzilai, Nir, Blangero, John, Bonnycastle, Lori L, Bowden, Donald W, Centeno-Cruz, Federico, Chambers, John C, Chami, Nathalie, Chan, Edmund, Chan, Juliana, Contreras-Cubas, Cecilia, Córdova, Emilio, Correa, Adolfo, Duggirala, Ravindranath, Dupuis, Josée, Garay-Sevilla, Ma Eugenia, Gieger, Christian, González-Villalpando, Clicerio, Groop, Leif, Gross, Myron, Haiman, Christopher, Hanis, Craig L, Hansen, Torben, Heard-Costa, Nancy L, Henderson, Brian E, Hernandez, Juan Manuel Malacara, Hwang, Mi Yeong, Islas-Andrade, Sergio, Jørgensen, Marit E, Kang, Hyun Min, Kim, Bong-Jo, Kim, Young Jin, Koistinen, Heikki A, Kooner, Jaspal Singh, Kuusisto, Johanna, Kwak, Soo-Heon, Laakso, Markku, Lange, Leslie, Lee, Jong-Young, Lee, Juyoung, Lehman, Donna M, Linneberg, Allan, Loos, Ruth J F, Meigs, James B, Meitinger, Thomas, Mendoza-Caamal, Elvia, Morris, Andrew D, Ng, Maggie C Y, Nilsson, Peter M, O'Donnell, Christopher J, Orozco, Lorena, Palmer, Colin N A, Park, Kyong Soo, Preuss, Michael, Reiner, Alexander P, Revilla-Monsalve, Cristina, Rich, Stephen S, Rotter, Jerome I, Saleheen, Danish, Schurmann, Claudia, Sim, Xueling, Small, Kerrin S, So, Wing Yee, Spector, Timothy D, Strauch, Konstantin, Strom, Tim M, Tai, E Shyong, Tam, Claudia H T, Teo, Yik Ying, Thameem, Farook, Tracy, Russell P, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Teresa, van Dam, Rob M, Vasan, Ramachandran S, Wilson, James G, Witte, Daniel R, Burtt, Noël P, Zaitlen, Noah, McCarthy, Mark I, Boehnke, Michael, Flannick, Jason, Mercader, Josep M, O'Donnell-Luria, Anne, Baxter, Samantha, Udler, Miriam S

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Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene by Knowles, Joshua W, Xie, Weijia, Zhang, Zhongyang, Chennamsetty, Indumathi, Chennemsetty, Indumathi, Assimes, Themistocles L, Paananen, Jussi, Hansson, Ola, Pankow, James, Goodarzi, Mark O, Carcamo-Orive, Ivan, Morris, Andrew P, Chen, Yii-Der I, Mäkinen, Ville-Petteri, Ganna, Andrea, Mahajan, Anubha, Guo, Xiuqing, Abbasi, Fahim, Greenawalt, Danielle M, Lum, Pek, Molony, Cliona, Lind, Lars, Lindgren, Cecilia, Raffel, Leslie J, Tsao, Philip S, Schadt, Eric E, Rotter, Jerome I, Sinaiko, Alan, Reaven, Gerald, Yang, Xia, Hsiung, Chao A, Groop, Leif, Cordell, Heather J, Laakso, Markku, Hao, Ke, Ingelsson, Erik, Frayling, Timothy M, Weedon, Michael N, Walker, Mark, Quertermous, Thomas

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Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention by Shaw, Jonathan E, Punjabi, Naresh M, Wilding, John P, Alberti, K George M M, Zimmet, Paul Z

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Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene by Knowles, Joshua W., Xie, Weijia, Zhang, Zhongyang, Chennemsetty, Indumathi, Assimes, Themistocles L., Paananen, Jussi, Hansson, Ola, Pankow, James, Goodarzi, Mark O., Carcamo-Orive, Ivan, Morris, Andrew P., Chen, Yii-Der I., Maekinen, Ville-Petteri, Ganna, Andrea, Mahajan, Anubha, Guo, Xiuqing, Abbasi, Fahim, Greenawalt, Danielle M., Lum, Pek, Molony, Cliona, Lind, Lars, Lindgren, Cecilia, Raffel, Leslie J., Tsao, Philip S., Schadt, Eric E., Rotter, Jerome I., Sinaiko, Alan, Reaven, Gerald, Yang, Xia, Hsiung, Chao A., Groop, Leif, Cordell, Heather J., Laakso, Markku, Hao, Ke, Ingelsson, Erik, Frayling, Timothy M., Weedon, Michael N., Walker, Mark, Quertermous, Thomas

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Islet Gene View-a tool to facilitate islet research by Asplund, Olof, Storm, Petter, Chandra, Vikash, Hatem, Gad, Ottosson-Laakso, Emilia, Mansour-Aly, Dina, Krus, Ulrika, Ibrahim, Hazem, Ahlqvist, Emma, Tuomi, Tiinamaija, Renström, Erik, Korsgren, Olle, Wierup, Nils, Ibberson, Mark, Solimena, Michele, Marchetti, Piero, Wollheim, Claes, Artner, Isabella, Mulder, Hindrik, Hansson, Ola, Otonkoski, Timo, Groop, Leif, Prasad, Rashmi B

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A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes by Koeck, Thomas, Olsson, Anders H., Nitert, Marloes Dekker, Sharoyko, Vladimir V., Ladenvall, Claes, Kotova, Olga, Reiling, Erwin, Rönn, Tina, Parikh, Hemang, Taneera, Jalal, Eriksson, Johan G., Metodiev, Metodi D., Larsson, Nils-Göran, Balhuizen, Alexander, Luthman, Holger, Stančáková, Alena, Kuusisto, Johanna, Laakso, Markku, Poulsen, Pernille, Vaag, Allan, Groop, Leif, Lyssenko, Valeriya, Mulder, Hindrik, Ling, Charlotte

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Genetic determinants of circulating GIP and GLP-1 concentrations by Almgren, Peter, Lindqvist, Andreas, Krus, Ulrika, Hakaste, Liisa, Ottosson-Laakso, Emilia, Asplund, Olof, Sonestedt, Emily, Prasad, Rashmi B, Laurila, Esa, Orho-Melander, Marju, Melander, Olle, Tuomi, Tiinamaija, Holst, Jens Juul, Nilsson, Peter M, Wierup, Nils, Groop, Leif, Ahlqvist, Emma

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Author Correction: Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals by Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O'Donnell-Luria, Anne H, Francioli, Laurent C, Cook, Stuart A, Barton, Paul J R, MacArthur, Daniel G, Ware, James S

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Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes by Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B, Alföldi, Jessica, Francioli, Laurent C, Gauthier, Laura D, Hill, Andrew J, O'Donnell-Luria, Anne H, Karczewski, Konrad J, MacArthur, Daniel G

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Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes by Pulizzi, N., Lyssenko, V., Jonsson, A., Osmond, C., Laakso, M., Kajantie, E., Barker, D. J., Groop, L. C., Eriksson, J. G.

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Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population: e1004494 by Lim, Elaine T, Würtz, Peter, Havulinna, Aki S, Palta, Priit, Tukiainen, Taru, Rehnström, Karola, Esko, Tõnu, Mägi, Reedik, Inouye, Michael, Lappalainen, Tuuli, Chan, Yingleong, Salem, Rany M, Lek, Monkol, Flannick, Jason, Sim, Xueling, Manning, Alisa, Ladenvall, Claes, Bumpstead, Suzannah, Hämäläinen, Eija, Aalto, Kristiina, Maksimow, Mikael, Salmi, Marko, Blankenberg, Stefan, Ardissino, Diego, Shah, Svati, Horne, Benjamin, McPherson, Ruth, Hovingh, Gerald K, Reilly, Muredach P, Watkins, Hugh, Goel, Anuj, Farrall, Martin, Girelli, Domenico, Reiner, Alex P, Stitziel, Nathan O, Kathiresan, Sekar, Gabriel, Stacey, Barrett, Jeffrey C, Lehtimäki, Terho, Laakso, Markku, Groop, Leif, Kaprio, Jaakko, Perola, Markus, McCarthy, Mark I, Boehnke, Michael, Altshuler, David M, Lindgren, Cecilia M, Hirschhorn, Joel N, Metspalu, Andres, Freimer, Nelson B, Zeller, Tanja, Jalkanen, Sirpa, Koskinen, Seppo, Raitakari, Olli, Durbin, Richard, MacArthur, Daniel G, Salomaa, Veikko, Ripatti, Samuli, Daly, Mark J, Palotie, Aarno

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