Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer

by BROOKS, A. Nigel, KILGOUR, Elaine, SMITH, Paul D
Published in Clinical cancer research

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

by GAVINE, Paul R, MOONEY, Lorraine, NIGEL BROOKS, A, KLINOWSKA, Teresa, KILGOUR, Elaine, THOMAS, Andrew P, AL-KADHIMI, Katherine, BECK, Sarah, ROONEY, Claire, COLEMAN, Tanya, BAKER, Dawn, MELLOR, Martine J
Published in Cancer research (Chicago, Ill.)

FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547

by LIANG XIE, XINYING SU, BEIRONG GAO, DANPING SHEN, LIANHAI ZHANG, JIAFU JI, GAVINE, Paul R, JINGCHUAN ZHANG, KILGOUR, Elaine, XIAOLIN ZHANG, QUNSHENG JI, LIN ZHANG, XIAOLU YIN, LILI TANG, XIUHUA ZHANG, YANPING XU, ZEREN GAO, KUNJI LIU, MINHUA ZHOU
Published in Clinical cancer research

High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial

by Pearson, Alex, Smyth, Elizabeth, Babina, Irina S, Herrera-Abreu, Maria Teresa, Tarazona, Noelia, Peckitt, Clare, Kilgour, Elaine, Smith, Neil R, Geh, Catherine, Rooney, Claire, Cutts, Ros, Campbell, James, Ning, Jian, Fenwick, Kerry, Swain, Amanda, Brown, Gina, Chua, Sue, Thomas, Anne, Johnston, Stephen R D, Ajaz, Mazhar, Sumpter, Katherine, Gillbanks, Angela, Watkins, David, Chau, Ian, Popat, Sanjay, Cunningham, David, Turner, Nicholas C
Published in Cancer discovery

Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non―Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models

by JINGCHUAN ZHANG, LIN ZHANG, ZHENGWEI DONG, GUANSHAN ZHU, ZILIANG QIAN, LILI TANG, PING ZHAN, QUNSHENG JI, KILGOUR, Elaine, SMITH, Paul D, NIGEL BROOKS, A, THOMAS, Roman K, XINYING SU, GAVINE, Paul R, MING LI, LIANG XIE, MALCHERS, Florian, SHUQIONG FAN, XIAOLU YIN, YANPING XU, KUNJI LIU
Published in Clinical cancer research

Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection

by Cani, Andi K., Dolce, Emily M., Darga, Elizabeth P., Hu, Kevin, Liu, Chia‐Jen, Pierce, Jackie, Bradbury, Kieran, Kilgour, Elaine, Aung, Kimberly, Schiavon, Gaia, Carroll, Danielle, Carr, T. Hedley, Klinowska, Teresa, Lindemann, Justin, Marshall, Gayle, Rowlands, Vicky, Harrington, Elizabeth A., Barrett, J. Carl, Sathiyayogan, Nitharsan, Morrow, Christopher, Sero, Valeria, Armstrong, Anne C., Baird, Richard, Hamilton, Erika, Im, Seock‐Ah, Jhaveri, Komal, Patel, Manish R., Dive, Caroline, Tomlins, Scott A., Udager, Aaron M., Hayes, Daniel F., Paoletti, Costanza
Published in Molecular oncology

Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon

by Rooney, Claire, Geh, Catherine, Williams, Victoria, Heuckmann, Johannes M, Menon, Roopika, Schneider, Petra, Al-Kadhimi, Katherine, Dymond, Michael, Smith, Neil R, Baker, Dawn, French, Tim, Smith, Paul D, Harrington, Elizabeth A, Barrett, J Carl, Kilgour, Elaine
Published in PloS one

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor

by Vincent, Emma E, Elder, Douglas J E, Curwen, Jon, Kilgour, Elaine, Hers, Ingeborg, Tavaré, Jeremy M
Published in PloS one

Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance

by Kilgour, Elaine, Rothwell, Dominic G., Brady, Ged, Dive, Caroline
Published in Cancer cell

Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the 'U' out of 'CUP'

by Conway, Alicia-Marie, Mitchell, Claire, Kilgour, Elaine, Brady, Gerard, Dive, Caroline, Cook, Natalie
Published in British journal of cancer

Will liquid biopsies improve outcomes for patients with small-cell lung cancer?

by Blackhall, Fiona, Frese, Kristopher K, Simpson, Kathryn, Kilgour, Elaine, Brady, Ged, Dive, Caroline
Published in The lancet oncology

Lung adenocarcinoma promotion by air pollutants

by Hill, William, Lim, Emilia L, Weeden, Clare E, Lee, Claudia, Augustine, Marcellus, Chen, Kezhong, Kuan, Feng-Che, Marongiu, Fabio, Evans, Jr, Edward J, Moore, David A, Rodrigues, Felipe S, Pich, Oriol, Bakker, Bjorn, Cha, Hongui, Myers, Renelle, van Maldegem, Febe, Boumelha, Jesse, Veeriah, Selvaraju, Rowan, Andrew, Naceur-Lombardelli, Cristina, Karasaki, Takahiro, Sivakumar, Monica, De, Swapnanil, Caswell, Deborah R, Nagano, Ai, Black, James R M, Martínez-Ruiz, Carlos, Ryu, Min Hyung, Huff, Ryan D, Li, Shijia, Favé, Marie-Julie, Magness, Alastair, Suárez-Bonnet, Alejandro, Priestnall, Simon L, Lüchtenborg, Margreet, Lavelle, Katrina, Pethick, Joanna, Hardy, Steven, McRonald, Fiona E, Lin, Meng-Hung, Troccoli, Clara I, Ghosh, Moumita, Miller, York E, Merrick, Daniel T, Keith, Robert L, Al Bakir, Maise, Bailey, Chris, Hill, Mark S, Saal, Lao H, Chen, Yilun, George, Anthony M, Abbosh, Christopher, Kanu, Nnennaya, Lee, Se-Hoon, McGranahan, Nicholas, Berg, Christine D, Sasieni, Peter, Houlston, Richard, Turnbull, Clare, Lam, Stephen, Awadalla, Philip, Grönroos, Eva, Downward, Julian, Jacks, Tyler, Carlsten, Christopher, Malanchi, Ilaria, Hackshaw, Allan, Litchfield, Kevin, DeGregori, James, Jamal-Hanjani, Mariam, Swanton, Charles
Published in Nature (London)

Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non–Small Cell Lung Cancer: The SELECT-1 Randomized Cli...

by Jänne, Pasi A, van den Heuvel, Michel M, Barlesi, Fabrice, Cobo, Manuel, Mazieres, Julien, Crinò, Lucio, Orlov, Sergey, Blackhall, Fiona, Wolf, Juergen, Garrido, Pilar, Poltoratskiy, Artem, Mariani, Gabriella, Ghiorghiu, Dana, Kilgour, Elaine, Smith, Paul, Kohlmann, Alexander, Carlile, David J, Lawrence, David, Bowen, Karin, Vansteenkiste, Johan
Published in JAMA : the journal of the American Medical Association

Abstract 601: Liquid biopsy-based precision medicine for extra-pulmonary neuroendocrine carcinomas

by Frizziero, Melissa, Kilgour, Elaine, Simpson, Kathryn, Frese, Kristopher, Valle, Juan W., McNamara, Mairéad G., Dive, Caroline
Published in Cancer research (Chicago, Ill.)

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

by Ng, Kevin W, Boumelha, Jesse, Enfield, Katey S S, Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A, Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T C, Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R M, Watkins, Thomas B K, Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M, Al Bakir, Maise, Lim, Emilia L, Hill, Mark S, Wilson, Gareth A, Cook, Daniel E, Birkbak, Nicolai J, Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T, Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George
Published in Nature (London)

The evolution of lung cancer and impact of subclonal selection in TRACERx

by Frankell, Alexander M, Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L, Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S, Grigoriadis, Kristiana, Moore, David A, Black, James R M, Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas B K, Naceur-Lombardelli, Cristina, Cook, Daniel E, Salgado, Roberto, Wilson, Gareth A, Bailey, Chris, Angelova, Mihaela, Bentham, Robert, Martínez-Ruiz, Carlos, Abbosh, Christopher, Nicholson, Andrew G, Le Quesne, John, Biswas, Dhruva, Rosenthal, Rachel, Puttick, Clare, Hessey, Sonya, Lee, Claudia, Prymas, Paulina, Toncheva, Antonia, Smith, Jon, Xing, Wei, Nicod, Jerome, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Blyth, Kevin G, Fennell, Dean A, Forster, Martin D, Lee, Siow Ming, Falzon, Mary, Hewish, Madeleine, Shackcloth, Michael J, Lim, Eric, Benafif, Sarah, Russell, Peter, Boleti, Ekaterini, Krebs, Matthew G, Lester, Jason F, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Thakrar, Ricky M, Lawrence, David, Navani, Neal, Janes, Sam M, Dive, Caroline, Blackhall, Fiona H, Summers, Yvonne, Cave, Judith, Marafioti, Teresa, Herrero, Javier, Quezada, Sergio A, Peggs, Karl S, Schwarz, Roland F, Van Loo, Peter, Miedema, Daniël M, Birkbak, Nicolai J, Hiley, Crispin T, Hackshaw, Allan, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London)

A Phase Ib Open-Label Multicenter Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers

by Paik, Paul K, Shen, Ronglai, Berger, Michael F, Ferry, David, Soria, Jean-Charles, Mathewson, Alastair, Rooney, Claire, Smith, Neil R, Cullberg, Marie, Kilgour, Elaine, Landers, Donal, Frewer, Paul, Brooks, Nigel, André, Fabrice
Published in Clinical cancer research

Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

by Abbosh, Christopher, Frankell, Alexander M, Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L, Weiss, Jakob, Schroeder, Morgan R, Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R M, Martínez-Ruiz, Carlos, Bakir, Maise Al, Pich, Oriol, Watkins, Thomas B K, Lim, Emilia L, Huebner, Ariana, Moore, David A, Godin-Heymann, Nadia, L'Hernault, Anne, Bye, Hannah, Odell, Aaron, Roberts, Paula, Gomes, Fabio, Patel, Akshay J, Manzano, Elizabeth, Hiley, Crispin T, Carey, Nicolas, Riley, Joan, Cook, Daniel E, Hodgson, Darren, Stetson, Daniel, Barrett, J Carl, Kortlever, Roderik M, Evan, Gerard I, Hackshaw, Allan, Daber, Robert D, Shaw, Jacqui A, Aerts, Hugo J W L, Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, Birkbak, Nicolai J, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London)

Defining the Cytokine Storm – DECYST 01

by Faulkner, Rebecca, O'Dwyer, Sarah T., Winter-Roach, Brett, Kilgour, Elaine, Dive, Caroline, Jayson, Gordon C.
Published in European journal of surgical oncology

Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

by Wheatley, Roseanna C, Kilgour, Elaine, Jacobs, Timothy, Lamarca, Angela, Hubner, Richard A, Valle, Juan W, McNamara, Mairéad G
Published in British journal of cancer