A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis by Rivas, Manuel A, Graham, Daniel, Sulem, Patrick, Stevens, Christine, Desch, A Nicole, Goyette, Philippe, Gudbjartsson, Daniel, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Degenhardt, Frauke, Mucha, Sören, Kurki, Mitja I, Li, Dalin, D'Amato, Mauro, Annese, Vito, Vermeire, Severine, Weersma, Rinse K, Halfvarson, Jonas, Paavola-Sakki, Paulina, Lappalainen, Maarit, Lek, Monkol, Cummings, Beryl, Tukiainen, Taru, Haritunians, Talin, Halme, Leena, Koskinen, Lotta L E, Ananthakrishnan, Ashwin N, Luo, Yang, Heap, Graham A, Visschedijk, Marijn C, MacArthur, Daniel G, Neale, Benjamin M, Ahmad, Tariq, Anderson, Carl A, Brant, Steven R, Duerr, Richard H, Silverberg, Mark S, Cho, Judy H, Palotie, Aarno, Saavalainen, Päivi, Kontula, Kimmo, Färkkilä, Martti, McGovern, Dermot P B, Franke, Andre, Stefansson, Kari, Rioux, John D, Xavier, Ramnik J, Daly, Mark J, Barrett, J, de Lane, K, Edwards, C, Hart, A, Hawkey, C, Jostins, L, Kennedy, N, Lamb, C, Lee, J, Lees, C, Mansfield, J, Mathew, C, Mowatt, C, Newman, B, Nimmo, E, Parkes, M, Pollard, M, Prescott, N, Randall, J, Rice, D, Satsangi, J, Simmons, A, Tremelling, M, Uhlig, H, Wilson, D, Abraham, C, Achkar, J P, Bitton, A, Boucher, G, Croitoru, K, Fleshner, P, Glas, J, Kugathasan, S, Limbergen, J V, Milgrom, R, Proctor, D, Regueiro, M, Schumm, P L, Sharma, Y, Stempak, J M, Targan, S R, Wang, M H

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Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank by Hollis, B., Chatzigeorgiou, C., Southam, L., Hatzikotoulas, K., Kluzek, S., Williams, A., Zeggini, E., Jostins-Dean, L., Watt, F.E.

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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study by Cleynen, Isabelle, PhD, Boucher, Gabrielle, MSc, Jostins, Luke, PhD, Schumm, L Philip, MA, Zeissig, Sebastian, PhD, Ahmad, Tariq, PhD, Andersen, Vibeke, Prof, Andrews, Jane M, Prof, Annese, Vito, MD, Brand, Stephan, Prof, Brant, Steven R, MD, Cho, Judy H, Prof, Daly, Mark J, Prof, Dubinsky, Marla, MD, Duerr, Richard H, Prof, Ferguson, Lynnette R, Prof, Franke, Andre, Prof, Gearry, Richard B, Prof, Goyette, Philippe, PhD, Hakonarson, Hakon, Prof, Halfvarson, Jonas, MD, Hov, Johannes R, PhD, Huang, Hailang, PhD, Kennedy, Nicholas A, PhD, Kupcinskas, Limas, Prof, Lawrance, Ian C, Prof, Lee, James C, PhD, Satsangi, Jack, Prof, Schreiber, Stephan, Prof, Théâtre, Emilie, PhD, van der Meulen-de Jong, Andrea E, MD, Weersma, Rinse K, Prof, Wilson, David C, Prof, Parkes, Miles, PhD, Vermeire, Severine, Prof, Rioux, John D, Prof, Mansfield, John, MD, Silverberg, Mark S, PhD, Radford-Smith, Graham, PhD, McGovern, Dermot P B, Prof, Barrett, Jeffrey C, Dr, Lees, Charlie W, Dr

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Host―microbe interactions have shaped the genetic architecture of inflammatory bowel disease by JOSTINS, Luke, RIPKE, Stephan, ESSERS, Jonah, MITROVIC, Mitja, NING, Kaida, CLEYNEN, Isabelle, THEATRE, Emilie, SPAIN, Sarah L, RAYCHAUDHURI, Soumya, GOYETTE, Philippe, ZHI WEI, ABRAHAM, Clara, WEERSMA, Rinse K, ACHKAR, Jean-Paul, AHMAD, Tariq, AMININEJAD, Leila, ANANTHAKRISHNAN, Ashwin N, ANDERSEN, Vibeke, ANDREWS, Jane M, BAIDOO, Leonard, BALSCHUN, Tobias, BAMPTON, Peter A, BITTON, Alain, DUERR, Richard H, BOUCHER, Gabrielle, BRAND, Stephan, BÜNING, Carsten, COHAIN, Ariella, CICHON, Sven, D'AMATO, Mauro, DE JONG, Dirk, DEVANEY, Kathy L, DUBINSKY, Marla, EDWARDS, Cathryn, MCGOVERN, Dermot P, ELLINGHAUS, David, FERGUSON, Lynnette R, FRANCHIMONT, Denis, FRANSEN, Karin, GEARRY, Richard, GEORGES, Michel, GIEGER, Christian, GLAS, Jürgen, HARITUNIANS, Talin, HART, Ailsa, HUI, Ken Y, HAWKEY, Chris, HEDL, Matija, XINLI HU, KARLSEN, Tom H, KUPCINSKAS, Limas, KUGATHASAN, Subra, LATIANO, Anna, LAUKENS, Debby, LAWRANCE, Ian C, LEES, Charlie W, LEE, James C, PHILIP SCHUMM, L, SHARMA, Yashoda, ANDERSON, Carl A

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Fine-mapping inflammatory bowel disease loci to single-variant resolution by Huang, Hailiang, Fang, Ming, Jostins, Luke, Umićević Mirkov, Maša, Boucher, Gabrielle, Anderson, Carl A, Andersen, Vibeke, Cleynen, Isabelle, Cortes, Adrian, Crins, François, D'Amato, Mauro, Deffontaine, Valérie, Dmitrieva, Julia, Docampo, Elisa, Elansary, Mahmoud, Farh, Kyle Kai-How, Franke, Andre, Gori, Ann-Stephan, Goyette, Philippe, Halfvarson, Jonas, Haritunians, Talin, Knight, Jo, Lawrance, Ian C, Lees, Charlie W, Louis, Edouard, Mariman, Rob, Meuwissen, Theo, Mni, Myriam, Momozawa, Yukihide, Parkes, Miles, Spain, Sarah L, Théâtre, Emilie, Trynka, Gosia, Satsangi, Jack, van Sommeren, Suzanne, Vermeire, Severine, Xavier, Ramnik J, Weersma, Rinse K, Duerr, Richard H, Mathew, Christopher G, Rioux, John D, McGovern, Dermot P B, Cho, Judy H, Georges, Michel, Daly, Mark J, Barrett, Jeffrey C

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Diversity of Human Copy Number Variation and Multicopy Genes by Sudmant, Peter H., Kitzman, Jacob O., Antonacci, Francesca, Alkan, Can, Malig, Maika, Tsalenko, Anya, Sampas, Nick, Bruhn, Laurakay, Shendure, Jay, Eichler, Evan E.

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Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease by Serra, Eva Gonçalves, Schwerd, Tobias, Moutsianas, Loukas, Cavounidis, Athena, Fachal, Laura, Pandey, Sumeet, Kammermeier, Jochen, Croft, Nicholas M, Posovszky, Carsten, Rodrigues, Astor, Russell, Richard K, Barakat, Farah, Auth, Marcus K H, Heuschkel, Robert, Zilbauer, Matthias, Fyderek, Krzysztof, Braegger, Christian, Travis, Simon P, Satsangi, Jack, Parkes, Miles, Thapar, Nikhil, Ferry, Helen, Matte, Julie C, Gilmour, Kimberly C, Wedrychowicz, Andrzej, Sullivan, Peter, Moore, Carmel, Sambrook, Jennifer, Ouwehand, Willem, Roberts, David, Danesh, John, Baeumler, Toni A, Fulga, Tudor A, Carrami, Eli M, Ahmed, Ahmed, Wilson, Rachel, Barrett, Jeffrey C, Elkadri, Abdul, Griffiths, Anne M, Snapper, Scott B, Shah, Neil, Muise, Aleixo M, Wilson, David C, Uhlig, Holm H, Anderson, Carl A

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Inferiority of laboras over incapacitance testing to measure spontaneous murine osteoarthritis pain by von Loga, I.S., Jostins, L., Miotla-Zarebska, J., Huang, Y.-S., Curtinha, M., Williams, R.O., Vincent, T.L.

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NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease by Schwerd, T, Bryant, R V, Pandey, S, Capitani, M, Meran, L, Cazier, J-B, Jung, J, Mondal, K, Parkes, M, Mathew, C G, Fiedler, K, McCarthy, D J, Sullivan, P B, Rodrigues, A, Travis, S P L, Moore, C, Sambrook, J, Ouwehand, W H, Roberts, D J, Danesh, J, Russell, R K, Wilson, D C, Kelsen, J R, Cornall, R, Denson, L A, Kugathasan, S, Knaus, U G, Serra, E G, Anderson, C A, Duerr, R H, McGovern, D Pb, Cho, J, Powrie, F, Li, V Sw, Muise, A M, Uhlig, H H

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GWAS of stool frequency provides insights into gastrointestinal motility and irritable bowel syndrome by Bonfiglio, Ferdinando, Liu, Xingrong, Smillie, Christopher, Pandit, Anita, Kurilshikov, Alexander, Bacigalupe, Rodrigo, Zheng, Tenghao, Nim, Hieu, Garcia-Etxebarria, Koldo, Bujanda, Luis, Andreasson, Anna, Agreus, Lars, Walter, Susanna, Abecasis, Gonçalo, Eijsbouts, Chris, Jostins, Luke, Parkes, Miles, Hughes, David A., Timpson, Nicholas, Raes, Jeroen, Franke, Andre, Kennedy, Nicholas A., Regev, Aviv, Zhernakova, Alexandra, Simren, Magnus, Camilleri, Michael, D’Amato, Mauro

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Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease by Serra, Eva Gonçalves, Schwerd, Tobias, Moutsianas, Loukas, Cavounidis, Athena, Fachal, Laura, Pandey, Sumeet, Kammermeier, Jochen, Croft, Nicholas M, Posovszky, Carsten, Rodrigues, Astor, Russell, Richard K, Barakat, Farah, Auth, Marcus K H, Heuschkel, Robert, Zilbauer, Matthias, Fyderek, Krzysztof, Braegger, Christian, Travis, Simon P, Satsangi, Jack, Parkes, Miles, Thapar, Nikhil, Ferry, Helen, Matte, Julie C, Gilmour, Kimberly C, Wedrychowicz, Andrzej, Sullivan, Peter, Moore, Carmel, Sambrook, Jennifer, Ouwehand, Willem, Roberts, David, Danesh, John, Baeumler, Toni A, Fulga, Tudor A, Carrami, Eli M, Ahmed, Ahmed, Wilson, Rachel, Barrett, Jeffrey C, Elkadri, Abdul, Griffiths, Anne M, Snapper, Scott B, Shah, Neil, Muise, Aleixo M, Wilson, David C, Uhlig, Holm H, Anderson, Carl A

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Lifetime Risk And Genetic Predisposition To Post-Traumatic Osteoarthritis Of The Knee: Time-To-Event And Related Analyses In The Uk Biobank by Hollis, B., Southam, L., Chatzigeorgiou, C., Hatzikotoulas, K., Kluzek, W.S., Williams, A., Zeggini, E., Jostins-Dean, L., Watt, F.E.

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OP001 Whole genome sequencing and imputation in inflammatory bowel disease identifies 26 novel loci and offers therapeutically-relevant mechanistic insights by Moutsianas, L., De Lange, K., Luo, Y., Lee, J., Jostins, L., Lamb, C., Kennedy, N., Mansfield, J., Parkes, M., Barrett, J., Anderson, C.

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Supportive Evidence For The Potential For Novel Biodiscovery In Osteoarthritis Through The Stepup Oa Consortium by Perry, T.A., Deng, Y., Hulley, P., Maciewicz, R.A., Mitchelmore, J., Perry, D., Larsson, S., Lemire, S., Struglics, A., Appleton, C.T., Kluzek, S., Arden, N.K., Felson, D.T., Marsden, B., Tom, B.D., Bondi, L., Kapoor, M., Kumar, V., Lohmander, L.S., Welting, T.J., Walsh, D.A., Valdes, A.M., Jostins-Dean, L., Watt, F.E., Vincent, T.L.

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Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis by Rivas, Manuel A, Graham, Daniel, Sulem, Patrick, Stevens, Christine, Desch, A Nicole, Goyette, Philippe, Gudbjartsson, Daniel, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Degenhardt, Frauke, Mucha, Sören, Kurki, Mitja I, Li, Dalin, D'Amato, Mauro, Annese, Vito, Vermeire, Severine, Weersma, Rinse K, Halfvarson, Jonas, Paavola-Sakki, Paulina, Lappalainen, Maarit, Lek, Monkol, Cummings, Beryl, Tukiainen, Taru, Haritunians, Talin, Halme, Leena, Koskinen, Lotta L E, Ananthakrishnan, Ashwin N, Luo, Yang, Heap, Graham A, Visschedijk, Marijn C, MacArthur, Daniel G, Neale, Benjamin M, Ahmad, Tariq, Anderson, Carl A, Brant, Steven R, Duerr, Richard H, Silverberg, Mark S, Cho, Judy H, Palotie, Aarno, Saavalainen, Päivi, Kontula, Kimmo, Färkkilä, Martti, McGovern, Dermot P B, Franke, Andre, Stefansson, Kari, Rioux, John D, Xavier, Ramnik J, Daly, Mark J

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P441 Whole-genome sequencing, haplotype characterisation and transcriptomic analysis in an extended multiplex kindred with 40 individuals affected with inflammatory bowel disease by Levine, A.P., Jostins, L., Sewell, G.W., Smith, P.J., Lovat, L.B., Walker, A.P., Barrett, J.C., Segal, A.W.

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OP017 Cross-disease study determines extent of sharing of associated loci between five seronegative auto-inflammatory diseases by Ellinghaus, D., Jostins, L., Cortes, A., Andreassen, O., Wang, Y., Spain, S., Elder, J., Trembath, R., Barker, J., Karlsen, T., Dale, A., McGovern, D., Schreiber, S., Brown, M., Barrett, J., Parkes, M., Franke, A.

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P055 Relationship of impaired macrophage cytokine release to genetic susceptibility polymorphisms in Crohn's disease by Sewell, G.W., Levine, A.P., Jostins, L., Harrison, P., Smith, P.J., Walker, A.P., Bloom, S.L., Segal, A.W., Smith, A.M.

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Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation by Ryzhakov, Grigory, Almuttaqi, Hannah, Corbin, Alastair L, Berthold, Dorothée L, Khoyratty, Tariq, Eames, Hayley L, Bullers, Samuel, Pearson, Claire, Ai, Zhichao, Zec, Kristina, Bonham, Sarah, Fischer, Roman, Jostins-Dean, Luke, Travis, Simon P L, Kessler, Benedikt M, Udalova, Irina A

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Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2 by Mukhopadhyay, Subhankar, Heinz, Eva, Porreca, Immacolata, Alasoo, Kaur, Yeung, Amy, Yang, Huei-Ting, Schwerd, Tobias, Forbester, Jessica L, Hale, Christine, Agu, Chukwuma A, Choi, Yoon Ha, Rodrigues, Julia, Capitani, Melania, Jostins-Dean, Luke, Thomas, David C, Travis, Simon, Gaffney, Daniel, Skarnes, William C, Thomson, Nicholas, Uhlig, Holm H, Dougan, Gordon, Powrie, Fiona

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