High-throughput CRISPRi and CRISPRa technologies in 3D genome regulation for neuropsychiatric diseases

by Jones, Ian R, Ren, Xingjie, Shen, Yin
Published in Human molecular genetics

HPRep: Quantifying Reproducibility in HiChIP and PLAC-Seq Datasets

by Rosen, Jonathan D, Yang, Yuchen, Abnousi, Armen, Chen, Jiawen, Song, Michael, Jones, Ian R, Shen, Yin, Hu, Ming, Li, Yun
Published in Current issues in molecular biology

Seven newly identified loci for autoimmune thyroid disease

by Cooper, Jason D, Simmonds, Matthew J, Walker, Neil M, Burren, Oliver, Brand, Oliver J, Guo, Hui, Wallace, Chris, Stevens, Helen, Coleman, Gillian, Franklyn, Jayne A, Todd, John A, Gough, Stephen C L
Published in Human molecular genetics

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data

by Chen, Guo-Bo, Lee, Sang Hong, Brion, Marie-Jo A, Montgomery, Grant W, Wray, Naomi R, Radford-Smith, Graham L, Visscher, Peter M
Published in Human molecular genetics

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

by Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Gibbons, Laura, Plant, Darren, Wilson, Anthony G., Marinou, Ioanna, Morgan, Ann, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Worthington, Jane
Published in Human molecular genetics

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

by BAN, Maria, GORIS, An, DUBOIS, Bénédicte, HARBO, Hanne F, CELIUS, Elisabeth G, SPURKLAND, Anne, STRANGE, Richard, HAWKINS, Clive, ROBERTSON, Neil P, DUDBRIDGE, Frank, WASON, James, DE JAGER, Philip L, LORENTZEN, Aslaug R, HAFLER, David, RIOUX, John D, IVINSON, Adrian J, MCCAULEY, Jacob L, PERICAK-VANCE, Margaret, OKSENBERG, Jorge R, HAUSER, Stephen L, SEXTON, David, HAINES, Jonathan, SAWCER, Stephen, BAKER, Amie, MIHALOVA, Tania, INGRAM, Gillian, BOOTH, David R, HEARD, Robert N, STEWART, Graeme J, BOGAERT, Elke
Published in European journal of human genetics : EJHG

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23

by Orozco, Gisela, Hinks, Anne, Eyre, Steve, Ke, Xiayi, Gibbons, Laura J., Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Thomson, Wendy, Barton, Anne, Worthington, Jane
Published in Human molecular genetics

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

by Rai, Kunal, Huggins, Ian J., James, Smitha R., Karpf, Adam R., Jones, David A., Cairns, Bradley R.
Published in Cell

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization

by Walter, Thomas S., Mayo, Chris J., Brown, James, Carter, Lester, Diprose, Jonathan M., Siebold, Christian, Pickford, Mike G., Sutton, Geoff C., Berrow, Nick S., Berry, Ian M., Stewart-Jones, Guillaume B. E., Grimes, Jonathan M., Stammers, David K., Jones, E. Yvonne, Esnouf, Robert M., Owens, Ray J., Stuart, David I., Harlos, Karl
Published in Acta crystallographica. Section D, Biological crystallography.

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

by Hughes, Michelle A., Powley, Ian R., Jukes-Jones, Rebekah, Horn, Sebastian, Feoktistova, Maria, Fairall, Louise, Schwabe, John W.R., Leverkus, Martin, Cain, Kelvin, MacFarlane, Marion
Published in Molecular cell

ORegAnno: an open-access community-driven resource for regulatory annotation

by Griffith, Obi L, Montgomery, Stephen B, Bernier, Bridget, Chu, Bryan, Kasaian, Katayoon, Aerts, Stein, Mahony, Shaun, Sleumer, Monica C, Bilenky, Mikhail, Haeussler, Maximilian, Griffith, Malachi, Gallo, Steven M, Giardine, Belinda, Hooghe, Bart, Van Loo, Peter, Blanco, Enrique, Ticoll, Amy, Lithwick, Stuart, Portales-Casamar, Elodie, Donaldson, Ian J, Robertson, Gordon, Wadelius, Claes, De Bleser, Pieter, Vlieghe, Dominique, Halfon, Marc S, Wasserman, Wyeth, Hardison, Ross, Bergman, Casey M, Jones, Steven J.M
Published in Nucleic acids research

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

by Abeshouse, Adam, Armenia, Joshua, Auman, J. Todd, Bailey, Matthew H., Baker, Laurence, Balasundaram, Miruna, Balu, Saianand, Baylin, Stephen B., Behera, Madhusmita, Benz, Christopher, Bocklage, Thèrése, Boice, Lori, Bootwalla, Moiz S., Bowlby, Reanne, Boyd, Jeff, Castro, Patricia, Cherniack, Andrew D., Chudamani, Sudha, Cooper, Lee A.D., Davis, Ian J., Demetri, George D., Demicco, Elizabeth G., Ding, Li, DiSaia, Phil, Dottino, Peter, Eschbacher, Jennifer, Fedosenko, Konstantin, Ferguson, Martin L., Gao, Qingsong, Gastier-Foster, Julie M., Gerken, Mark, Godwin, Eryn M., Gordienko, Elena, Grilley-Olson, Juneko E., Gutman, David A., Hegde, Apurva M., Heiman, David I., Helsel, Carmen, Hoadley, Katherine A., Hobensack, Shital, Hornick, Jason L., Hoyle, Alan P., Iacocca, Mary, Ittmann, Michael, Jones, Steven J.M., Kim, Jaegil, Ladanyi, Marc, Lai, Phillip H., Larsson, Erik, Lee, Sanghoon, Lehmann, Kjong-Van, Levine, Douglas A., Liu, Jia, Liu, Wenbin, Liu, Eric Minwei, Lu, Yiling, Madan, Rashna, Magliocco, Anthony, Maki, Robert G., Martinez, Cathleen, Mayo, Michael, McLellan, Michael D., Mozgovoy, Evgeny, Mungall, Andrew J., Mungall, Karen, Noble, Michael S., Olvera, Narciso, Paklina, Oxana, Paulauskis, Joseph, Penny, Robert, Perou, Charles M., Perou, Amy H., Pollock, Raphael E., Ramalingam, Suresh S., Reilly, Colleen, Reynolds, Sheila M., Roach, Jeffrey, Roszik, Jason, Sadeghi, Sara, Saksena, Gordon, Sanchez-Vega, Francisco, Sander, Chris, Schein, Jacqueline E., Shelton, Candace, Shelton, Troy, Shi, Yan, Shmulevich, Ilya, Sipahimalani, Payal, Swanson, Patricia, Tarnuzzer, Roy, Thiessen, Nina, Thorne, Leigh B., Van Tine, Brian A., Verhaak, Roel, Voronina, Olga, Wang, Jing, Wise, Lisa, Wyczalkowski, Matthew, Yau, Christina, Yellapantula, Venkata
Published in Cell

Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder

by Song, Jie, Jonsson, Lina, Lu, Yi, Bergen, Sarah E, Karlsson, Robert, Smedler, Erik, Gordon-Smith, Katherine, Jones, Ian, Jones, Lisa, Craddock, Nick, Sullivan, Patrick F, Lichtenstein, Paul, Di Florio, Arianna, Landén, Mikael
Published in Molecular psychiatry

Protein-disulfide Isomerase-mediated Reduction of Two Disulfide Bonds of HIV Envelope Glycoprotein 120 Occurs Post-CXCR4 Binding and Is Required for Fusion

by Barbouche, Rym, Miquelis, Raymond, Jones, Ian M, Fenouillet, Emmanuel
Published in The Journal of biological chemistry

An epigenetic predictor of death captures multi-modal measures of brain health

by Hillary, Robert F, Stevenson, Anna J, Cox, Simon R, McCartney, Daniel L, Harris, Sarah E, Seeboth, Anne, Higham, Jon, Sproul, Duncan, Taylor, Adele M, Redmond, Paul, Corley, Janie, Pattie, Alison, Hernández, Maria Del C Valdés, Muñoz-Maniega, Susana, Bastin, Mark E, Wardlaw, Joanna M, Horvath, Steve, Ritchie, Craig W, Spires-Jones, Tara L, McIntosh, Andrew M, Evans, Kathryn L, Deary, Ian J, Marioni, Riccardo E
Published in Molecular psychiatry

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

by Briney, Bryan, Sok, Devin, Jardine, Joseph G., Kulp, Daniel W., Skog, Patrick, Menis, Sergey, Jacak, Ronald, Kalyuzhniy, Oleksandr, de Val, Natalia, Sesterhenn, Fabian, Le, Khoa M., Ramos, Alejandra, Jones, Meaghan, Saye-Francisco, Karen L., Blane, Tanya R., Spencer, Skye, Georgeson, Erik, Hu, Xiaozhen, Ozorowski, Gabriel, Adachi, Yumiko, Kubitz, Michael, Sarkar, Anita, Wilson, Ian A., Ward, Andrew B., Nemazee, David, Burton, Dennis R., Schief, William R.
Published in Cell

Omics Markers of Red Blood Cell Transfusion in Trauma

by LaCroix, Ian S, Cohen, Mitchell, Moore, Ernest E, Dzieciatkowska, Monika, Nemkov, Travis, Schaid, Jr, Terry R, Debot, Margaret, Jones, Kenneth, Silliman, Christopher C, Hansen, Kirk C, D'Alessandro, Angelo
Published in International journal of molecular sciences

Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity

by Levina, Natalia, Tötemeyer, Sabine, Stokes, Neil R., Louis, Petra, Jones, Michael A., Booth, Ian R.
Published in The EMBO journal

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

by Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I., Nicol, David, O’Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas B.K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles
Published in Cell

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

by Aggarwal, Geetika, Banerjee, Subhashis, Jones, Spencer A., Benchaar, Yousri, Bélanger, Jasmine, Sévigny, Myriam, Smith, Denise M., Niehoff, Michael L., Pavlack, Monica, de Vera, Ian Mitchelle S., Petkau, Terri L., Leavitt, Blair R., Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Morley, John E., Farr, Susan A., Dutchak, Paul A., Sephton, Chantelle F., Nguyen, Andrew D.
Published in The Journal of biological chemistry