Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases by Smith, Adrian L, D’Angelo, Noel D, Bo, Yunxin Y, Booker, Shon K, Cee, Victor J, Herberich, Brad, Hong, Fang-Tsao, Jackson, Claire L. M, Lanman, Brian A, Liu, Longbin, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Tadesse, Seifu, Tamayo, Nuria A, Wurz, Ryan P, Yang, Kevin, Andrews, Kristin L, Whittington, Douglas A, McCarter, John D, Miguel, Tisha San, Zalameda, Leeanne, Jiang, Jian, Subramanian, Raju, Mullady, Erin L, Caenepeel, Sean, Freeman, Daniel J, Wang, Ling, Zhang, Nancy, Wu, Tian, Hughes, Paul E, Norman, Mark H

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Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511 by Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E

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Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors by Wurz, Ryan P., Sastri, Christine, D’Amico, Derin C., Herberich, Brad, Jackson, Claire L.M., Pettus, Liping H., Tasker, Andrew S., Wu, Bin, Guerrero, Nadia, Lipford, J. Russell, Winston, Jeffrey T., Yang, Yajing, Wang, Paul, Nguyen, Yen, Andrews, Kristin L., Huang, Xin, Lee, Matthew R., Mohr, Christopher, Zhang, J.D., Reid, Darren L., Xu, Yang, Zhou, Yihong, Wang, Hui-Ling

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Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511 by Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E

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Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid by Hirst, Robert A, Jackson, Claire L, Coles, Janice L, Williams, Gwyneth, Rutman, Andrew, Goggin, Patricia M, Adam, Elizabeth C, Page, Anthony, Evans, Hazel J, Lackie, Peter M, O'Callaghan, Christopher, Lucas, Jane S

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Construction and comparison of three reference‐quality genome assemblies for soybean by Valliyodan, Babu, Cannon, Steven B., Bayer, Philipp E., Shu, Shengqiang, Brown, Anne V., Ren, Longhui, Jenkins, Jerry, Chung, Claire Y.‐L., Chan, Ting‐Fung, Daum, Christopher G., Plott, Christopher, Hastie, Alex, Baruch, Kobi, Barry, Kerrie W., Huang, Wei, Patil, Gunvant, Varshney, Rajeev K., Hu, Haifei, Batley, Jacqueline, Yuan, Yuxuan, Song, Qijian, Stupar, Robert M., Goodstein, David M., Stacey, Gary, Lam, Hon‐Ming, Jackson, Scott A., Schmutz, Jeremy, Grimwood, Jane, Edwards, David, Nguyen, Henry T.

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Culture-independent evaluation of the appendix and rectum microbiomes in children with and without appendicitis by Jackson, Hope T, Mongodin, Emmanuel F, Davenport, Katherine P, Fraser, Claire M, Sandler, Anthony D, Zeichner, Steven L

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A Revised Protocol for Culture of Airway Epithelial Cells as a Diagnostic Tool for Primary Ciliary Dyskinesia by Coles, Janice L, Thompson, James, Horton, Katie L, Hirst, Robert A, Griffin, Paul, Williams, Gwyneth M, Goggin, Patricia, Doherty, Regan, Lackie, Peter M, Harris, Amanda, Walker, Woolf T, O'Callaghan, Christopher, Hogg, Claire, Lucas, Jane S, Blume, Cornelia, Jackson, Claire L

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XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease by Piróg, Katarzyna A, Dennis, Ella P, Hartley, Claire L, Jackson, Robert M, Soul, Jamie, Schwartz, Jean-Marc, Bateman, John F, Boot-Handford, Raymond P, Briggs, Michael D

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Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia by Best, Sunayna, Shoemark, Amelia, Rubbo, Bruna, Patel, Mitali P, Fassad, Mahmoud R, Dixon, Mellisa, Rogers, Andrew V, Hirst, Robert A, Rutman, Andrew, Ollosson, Sarah, Jackson, Claire L, Goggin, Patricia, Thomas, Simon, Pengelly, Reuben, Cullup, Thomas, Pissaridou, Eleni, Hayward, Jane, Onoufriadis, Alexandros, O’Callaghan, Christopher, Loebinger, Michael R, Wilson, Robert, Chung, Eddie MK, Kenia, Priti, Doughty, Victoria L, Carvalho, Julene S, Lucas, Jane S, Mitchison, Hannah M, Hogg, Claire

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High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations by Shoemark, Amelia, Moya, Eduardo, Hirst, Robert A, Patel, Mitali P, Robson, Evelyn A, Hayward, Jane, Scully, Juliet, Fassad, Mahmoud R, Lamb, William, Schmidts, Miriam, Dixon, Mellisa, Patel-King, Ramila S, Rogers, Andrew V, Rutman, Andrew, Jackson, Claire L, Goggin, Patricia, Rubbo, Bruna, Ollosson, Sarah, Carr, Siobhán, Walker, Woolf, Adler, Beryl, Loebinger, Michael R, Wilson, Robert, Bush, Andrew, Williams, Hywel, Boustred, Christopher, Jenkins, Lucy, Sheridan, Eamonn, Chung, Eddie M K, Watson, Christopher M, Cullup, Thomas, Lucas, Jane S, Kenia, Priti, O’Callaghan, Christopher, King, Stephen M, Hogg, Claire, Mitchison, Hannah M

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Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial by Lane, J Athene, PhD, Donovan, Jenny L, Prof, Davis, Michael, MSc, Walsh, Eleanor, MSc, Dedman, Daniel, MSc, Down, Liz, BSc, Turner, Emma L, PhD, Mason, Malcolm D, Prof, Metcalfe, Chris, PhD, Peters, Tim J, Prof, Martin, Richard M, PhD, Neal, David E, Prof, Hamdy, Freddie C, Prof

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Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatmen... by Neal, David E., Donovan, Jenny L., Martin, Richard M., Peters, Tim. J., Bollina, Prasad, Doherty, Alan, Gillatt, David, Hughes, Owen, Paez, Edgar, Rosario, Derek J., Rowe, Edward, Staffurth, John, Altman, Doug G., Hamdy, Freddie C., Lane, J. Athene, Hughes, Owen, Prescott, Stephen, Rowe, Edward, Aning, Jonathan, McNeill, Alan, Schwaibold, Hartwig, Herbert, Phillipa, Jones, Amanda, Lennon, Teresa, Lyons, Norma, Thompson, Pauline, Gray, Catherine, Askew, Sarah, Brain, Carole, Dark, Susan, Davis, Gill, Denizot, Jane, Dewhurst, Elspeth, Emmerson, Ingrid, Grant, Alison, Hawkins, Sarah, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Pisa, Anna, Robson, Lindsay, Samuel, Nikki, Sharkey, Irene, Smith, Donna, Taylor, Helen, Trewick, Nicola, Woodhouse, Colin, Ferguson, Catherine, Graham, John, Howard, Grahame, Law, Alastair, Russell, Simon, Thanvi, Narottam, Oxley, Jon, Robinson, Mary, Bhattarai, Selina, Deshmukh, Neeta, Griffiths, David, Grigor, Ken, Ash, Dominic, Bolton, Steven, Conway, John, Lamb, Susan, Lawrence, Gill, Lewis, Geraint, McQueen, Alison, Moore, Rollo, Potterton, Janet, Showler, Helen, Slade, Stephen, Townley, John, Wills, Lucy, Davies, Linda, Khazragui, Hanan, Noble, Sian, Bellis-Sheldon, Elizabeth, Bowtell, Joanne, Clark, Rebecca, Currer, Rosemary, Delaney, Gill, Farmer, Rebecca, Haddow, Jean, Halpin, Susan, Hattrick, Barbara, Liddiatt, Tanya, Moore, Susan, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Zietman, Anthony, Williams, Naomi, Toole, Jessica, Bell, Lindsey, Mauree, Jainnee, Ashby, Deborah, Cowan, Richard, Mellon, Killian, N’Dow, James, Schröder, Fritz, Roberts, Tracy

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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability by Burnett, Deborah L., Jackson, Katherine J.L., Langley, David B., Aggarwal, Anupriya, Stella, Alberto Ospina, Johansen, Matt D., Balachandran, Harikrishnan, Lenthall, Helen, Rouet, Romain, Walker, Gregory, Saunders, Bernadette M., Singh, Mandeep, Li, Hui, Henry, Jake Y., Jackson, Jennifer, Stewart, Alastair G., Witthauer, Franka, Spence, Matthew A., Hansbro, Nicole G., Jackson, Colin, Schofield, Peter, Milthorpe, Claire, Martinello, Marianne, Schulz, Sebastian R., Roth, Edith, Kelleher, Anthony, Emery, Sean, Britton, Warwick J., Rawlinson, William D., Karl, Rudolfo, Schäfer, Simon, Winkler, Thomas H., Brink, Robert, Bull, Rowena A., Hansbro, Philip M., Jäck, Hans-Martin, Turville, Stuart, Christ, Daniel, Goodnow, Christopher C.

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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology by Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El‐Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert

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A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis by Vannucchi, Alessandro M, Kantarjian, Hagop M, Kiladjian, Jean-Jacques, Gotlib, Jason, Cervantes, Francisco, Mesa, Ruben A, Sarlis, Nicholas J, Peng, Wei, Sandor, Victor, Gopalakrishna, Prashanth, Hmissi, Abdel, Stalbovskaya, Viktoriya, Gupta, Vikas, Harrison, Claire, Verstovsek, Srdan

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Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems by Barnosky, Anthony D., Hadly, Elizabeth A., Gonzalez, Patrick, Head, Jason, Polly, P. David, Lawing, A. Michelle, Eronen, Jussi T., Ackerly, David D., Alex, Ken, Biber, Eric, Blois, Jessica, Brashares, Justin, Ceballos, Gerardo, Davis, Edward, Dietl, Gregory P., Dirzo, Rodolfo, Doremus, Holly, Fortelius, Mikael, Greene, Harry W., Hellmann, Jessica, Hickler, Thomas, Jackson, Stephen T., Kemp, Melissa, Koch, Paul L., Kremen, Claire, Lindsey, Emily L., Looy, Cindy, Marshall, Charles R., Mendenhall, Chase, Mulch, Andreas, Mychajliw, Alexis M., Nowak, Carsten, Ramakrishnan, Uma, Schnitzler, Jan, Shrestha, Kashish Das, Solari, Katherine, Stegner, Lynn, Stegner, M. Allison, Stenseth, Nils Chr, Wake, Marvalee H., Zhang, Zhibin

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‘Malnutrition Universal Screening Tool’ predicts mortality and length of hospital stay in acutely ill elderly by Stratton, Rebecca J., King, Claire L., Stroud, Mike A., Jackson, Alan A., Elia, Marinos

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ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19 by El-Sayed Moustafa, Julia S, Jackson, Anne U, Brotman, Sarah M, Guan, Li, Villicaña, Sergio, Roberts, Amy L, Zito, Antonino, Bonnycastle, Lori, Erdos, Michael R, Narisu, Narisu, Stringham, Heather M, Welch, Ryan, Yan, Tingfen, Lakka, Timo, Parker, Stephen, Tuomilehto, Jaakko, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Acors, Sam, Kouphou, Neophytos, Wadge, Samuel, Duncan, Emma L, Steves, Claire J, Doores, Katie J, Malim, Michael H, Collins, Francis S, Pajukanta, Päivi, Boehnke, Michael, Koistinen, Heikki A, Laakso, Markku, Falchi, Mario, Bell, Jordana T, Scott, Laura J, Mohlke, Karen L, Small, Kerrin S

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A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration by Hallam, Thomas M, Cox, Thomas E, Smith-Jackson, Kate, Brocklebank, Vicky, Baral, April J, Tzoumas, Nikolaos, Steel, David H, Wong, Edwin K S, Shuttleworth, Victoria G, Lotery, Andrew J, Harris, Claire L, Marchbank, Kevin J, Kavanagh, David

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