Patterns of cis regulatory variation in diverse human populations

by Stranger, Barbara E, Montgomery, Stephen B, Dimas, Antigone S, Parts, Leopold, Stegle, Oliver, Ingle, Catherine E, Sekowska, Magda, Smith, George Davey, Evans, David, Gutierrez-Arcelus, Maria, Price, Alkes, Raj, Towfique, Nisbett, James, Nica, Alexandra C, Beazley, Claude, Durbin, Richard, Deloukas, Panos, Dermitzakis, Emmanouil T
Published in PLoS genetics

Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes

by Stranger, Barbara E, Forrest, Matthew S, Dunning, Mark, Ingle, Catherine E, Beazley, Claude, Thorne, Natalie, Redon, Richard, Bird, Christine P, de Grassi, Anna, Lee, Charles, Tyler-Smith, Chris, Carter, Nigel, Scherer, Stephen W, Tavaré, Simon, Deloukas, Panagiotis, Hurles, Matthew E, Dermitzakis, Emmanouil T
Published in Science (American Association for the Advancement of Science)

Modifier effects between regulatory and protein-coding variation

by Dimas, Antigone S, Stranger, Barbara E, Beazley, Claude, Finn, Robert D, Ingle, Catherine E, Forrest, Matthew S, Ritchie, Matthew E, Deloukas, Panos, Tavaré, Simon, Dermitzakis, Emmanouil T
Published in PLoS genetics

Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling

by Chen, Edwin, Beer, Philip A., Godfrey, Anna L., Ortmann, Christina A., Li, Juan, Costa-Pereira, Ana P., Ingle, Catherine E., Dermitzakis, Emmanouil T., Campbell, Peter J., Green, Anthony R.
Published in Cancer cell

Fast-evolving noncoding sequences in the human genome

by Bird, Christine P, Stranger, Barbara E, Liu, Maureen, Thomas, Daryl J, Ingle, Catherine E, Beazley, Claude, Miller, Webb, Hurles, Matthew E, Dermitzakis, Emmanouil T
Published in Genome biology

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

by White, Jacqueline K., Gerdin, Anna-Karin, Karp, Natasha A., Ryder, Ed, Bussell, James N., Salisbury, Jennifer, Clare, Simon, Ingham, Neil J., Podrini, Christine, Houghton, Richard, Estabel, Jeanne, Bottomley, Joanna R., Melvin, David G., Sunter, David, Barnes, Caroline, Cambridge, Emma, Carragher, Damian, Chana, Prabhjoat, Clarke, Kay, Igosheva, Natalia, Ismail, Ozama, Jackson, Hannah, Kane, Leanne, Lacey, Rosalind, Lucas, Mark, McGill, Katherine, McIntyre, Rebecca E., Messager, Sophie, Mottram, Lynda, Mulderrig, Lee, Pearson, Selina, Roberson, Laura-Anne, Salsbury, Grace, Sanger, Daniel, Shannon, Carl, Thompson, Paul C., Tuck, Elizabeth, Bushell, Wendy, Cook, Ross, Dalvi, Priya, Gleeson, Diane, Habib, Bishoy, Hardy, Matt, Miklejewska, Evelina, Price, Stacey, Sethi, Debarati, von Schiller, Dominique, Vyas, Sapna, West, Anthony P., Evans, Arthur, Holroyd, Simon, Iyer, Vivek, Lewis, Morag, Oakley, Darren, Richardson, David, Smedley, Damian, Agu, Chukwuma, Bryant, Jackie, Delaney, Liz, Gueorguieva, Nadia I., Tharagonnet, Helen, Townsend, Anne J., Biggs, Daniel, Collinson, Adam, Dumeau, Charles-Etienne, Grau, Evelyn, Harrison, Sarah, Ingle, Catherine E., Kundi, Helen, Madich, Alla, Mayhew, Danielle, Metcalf, Tom, Pass, Johanna, Reynolds, Helen, Sinclair, Caroline, Wardle-Jones, Hannah, Woods, Michael, Alexander, Liam, Brown, Terry, Flack, Francesca, Griggs, Nicola, McDermott, Jordan, Rogerson, Claire, White, Gemma, Zielezinski, Pawel, DiTommaso, Tia, Edwards, Andrew, Mahajan, Mary Ann, Yalcin, Binnaz, Tannahill, David, Logan, Darren W., MacArthur, Daniel G., Flint, Jonathan, Mahajan, Vinit B., Smyth, Ian, Watt, Fiona M., Skarnes, William C., Dougan, Gordon, Adams, David J., Bradley, Allan
Published in Cell

Modifier Effects between Regulatory and Protein-Coding Variation: e1000244

by Dimas, Antigone S, Stranger, Barbara E, Beazley, Claude, Finn, Robert D, Ingle, Catherine E, Forrest, Matthew S, Ritchie, Matthew E, Deloukas, Panos, Tavaré, Simon, Dermitzakis, Emmanouil T
Published in PLoS genetics

Prediction of Late Disease Recurrence and Extended Adjuvant Letrozole Benefit by the HOXB13/IL17BR Biomarker

by SGROI, Dennis C, CARNEY, Erin, SCHNABEL, Catherine A, ERLANDER, Mark G, INGLE, James N, PORTER, Peggy, MUSS, Hyman B, PRITCHARD, Katherine I, DONGSHENG TU, RIMM, David L, GOSS, Paul E, ZARRELLA, Elizabeth, STEFFEL, Lauren, BINNS, Shemeica N, FINKELSTEIN, Dianne M, SZYMONIFKA, Jackie, BHAN, Atul K, SHEPHERD, Lois E, YI ZHANG
Published in JNCI : Journal of the National Cancer Institute

Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner

by Dimas, Antigone S, Deutsch, Samuel, Stranger, Barbara E, Montgomery, Stephen B, Borel, Christelle, Attar-Cohen, Homa, Ingle, Catherine, Beazley, Claude, Arcelus, Maria Gutierrez, Sekowska, Magdalena, Gagnebin, Marilyne, Nisbett, James, Deloukas, Panos, Dermitzakis, Emmanouil T, Antonarakis, Stylianos E
Published in Science (American Association for the Advancement of Science)

Phase III Randomized Trial of Bisphosphonates as Adjuvant Therapy in Breast Cancer: S0307

by Gralow, Julie R, Barlow, William E, Paterson, Alexander H G, M'iao, Jieling L, Lew, Danika L, Stopeck, Alison T, Hayes, Daniel F, Hershman, Dawn L, Schubert, Mark M, Clemons, Mark, Van Poznak, Catherine H, Dees, Elizabeth C, Ingle, James N, Falkson, Carla I, Elias, Anthony D, Messino, Michael J, Margolis, Jeffrey H, Dakhil, Shaker R, Chew, Helen K, Dammann, Kim Z, Abrams, Jeffrey S, Livingston, Robert B, Hortobagyi, Gabriel N
Published in JNCI : Journal of the National Cancer Institute

Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial

by Goss, Paul E, Prof, Hershman, Dawn L, Prof, Cheung, Angela M, Prof, Ingle, James N, Prof, Khosla, Sundeep, MD, Stearns, Vered, Prof, Chalchal, Haji, MD, Rowland, Kendrith, Prof, Muss, Hyman B, Prof, Linden, Hannah M, Prof, Scher, Judite, MSc, Pritchard, Kathleen I, Prof, Elliott, Catherine R, MSc, Badovinac-Crnjevic, Tanja, MD, St Louis, Jessica, BA, Chapman, Judith-Anne W, Prof, Shepherd, Lois E, Prof
Published in The lancet oncology

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

by Balmus, Gabriel, Larrieu, Delphine, Barros, Ana C, Collins, Casey, Abrudan, Monica, Demir, Mukerrem, Geisler, Nicola J, Lelliott, Christopher J, White, Jacqueline K, Karp, Natasha A, Atkinson, James, Kirton, Andrea, Jacobsen, Matt, Clift, Dean, Rodriguez, Raphael, Adams, David J, Jackson, Stephen P
Published in Nature communications

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

by Grundberg, Elin, Meduri, Eshwar, Sandling, Johanna K., Hedman, Åsa K., Keildson, Sarah, Buil, Alfonso, Busche, Stephan, Yuan, Wei, Nisbet, James, Sekowska, Magdalena, Wilk, Alicja, Barrett, Amy, Small, Kerrin S., Ge, Bing, Caron, Maxime, Shin, So-Youn, Ahmadi, Kourosh R., Ainali, Chrysanthi, Barrett, Amy, Bataille, Veronique, Bell, Jordana T., Buil, Alfonso, Deloukas, Panos, Dermitzakis, Emmanouil T., Dimas, Antigone S., Durbin, Richard, Glass, Daniel, Grundberg, Elin, Hassanali, Neelam, Hedman, Åsa K., Ingle, Catherine, Knowles, David, Krestyaninova, Maria, Lindgren, Cecilia M., Lowe, Christopher E., McCarthy, Mark I., Meduri, Eshwar, di Meglio, Paola, Min, Josine L., Montgomery, Stephen B., Nestle, Frank O., Nica, Alexandra C., Nisbet, James, O’Rahilly, Stephen, Parts, Leopold, Potter, Simon, Sandling, Johanna, Sekowska, Magdalena, Shin, So-Youn, Small, Kerrin S., Soranzo, Nicole, Spector, Tim D., Surdulescu, Gabriela, Travers, Mary E., Tsaprouni, Loukia, Tsoka, Sophia, Wilk, Alicja, Yang, Tsun-Po, Zondervan, Krina T., Lathrop, Mark, Dermitzakis, Emmanouil T., McCarthy, Mark I., Spector, Timothy D., Bell, Jordana T., Deloukas, Panos
Published in American journal of human genetics

Systematic evidence map (SEM) template: Report format and methods used for the US EPA Integrated Risk Information System (IRIS) program, Provisional Peer Reviewed Toxicity Value (P...

by Thayer, Kristina A., Angrish, Michelle, Arzuaga, Xabier, Carlson, Laura M., Davis, Allen, Dishaw, Laura, Druwe, Ingrid, Gibbons, Catherine, Glenn, Barbara, Jones, Ryan, Phillip Kaiser, J., Keshava, Channa, Keshava, Nagalakshmi, Kraft, Andrew, Lizarraga, Lucina, Persad, Amanda, Radke, Elizabeth G., Rice, Glenn, Schulz, Brittany, Shaffer, Rachel M., Shannon, Teresa, Shapiro, Andrew, Thacker, Shane, Vulimiri, Suryanarayana V., Williams, Antony J., Woodall, George, Yost, Erin, Blain, Robyn, Duke, Katherine, Goldstone, Alexandra E., Hartman, Pam, Hobbie, Kevin, Ingle, Brandall, Lemeris, Courtney, Lin, Cynthia, Lindahl, Alex, McKinley, Kristen, Soleymani, Parnian, Vetter, Nicole
Published in Environment international

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

by Bell, Jordana T, Tsai, Pei-Chien, Yang, Tsun-Po, Pidsley, Ruth, Nisbet, James, Glass, Daniel, Mangino, Massimo, Zhai, Guangju, Zhang, Feng, Valdes, Ana, Shin, So-Youn, Dempster, Emma L, Murray, Robin M, Grundberg, Elin, Hedman, Asa K, Nica, Alexandra, Small, Kerrin S, Dermitzakis, Emmanouil T, McCarthy, Mark I, Mill, Jonathan, Spector, Tim D, Deloukas, Panos
Published in PLoS genetics

Corrigendum to “Systematic evidence map (SEM) template: Report format and methods used for the US EPA Integrated Risk Information System (IRIS) program, Provisional Peer Reviewed T...

by Thayer, Kristina A., Angrish, Michelle, Arzuaga, Xabier, Carlson, Laura M., Davis, Allen, Dishaw, Laura, Druwe, Ingrid, Gibbons, Catherine, Glenn, Barbara, Jones, Ryan, Phillip Kaiser, J., Keshava, Channa, Keshava, Nagalakshmi, Kraft, Andrew, Lizarraga, Lucina, Persad, Amanda, Radke, Elizabeth G., Rice, Glenn, Schulz, Brittany, Shaffer, Rachel M., Shannon, Teresa, Shapiro, Andrew, Thacker, Shane, Vulimiri, Suryanarayana V., Williams, Antony J., Woodall, George, Yost, Erin, Blain, Robyn, Duke, Katherine, Goldstone, Alexandra E., Hartman, Pam, Hobbie, Kevin, Ingle, Brandall, Lemeris, Courtney, Lin, Cynthia, Lindahl, Alex, McKinley, Kristen, Soleymani, Parnian, Vetter, Nicole
Published in Environment international

Human and mouse essentiality screens as a resource for disease gene discovery

by Cacheiro, Pilar, Muñoz-Fuentes, Violeta, Murray, Stephen A, Dickinson, Mary E, Bucan, Maja, Nutter, Lauryl M J, Peterson, Kevin A, Haselimashhadi, Hamed, Flenniken, Ann M, Morgan, Hugh, Westerberg, Henrik, Konopka, Tomasz, Hsu, Chih-Wei, Christiansen, Audrey, Lanza, Denise G, Beaudet, Arthur L, Heaney, Jason D, Fuchs, Helmut, Gailus-Durner, Valerie, Sorg, Tania, Prochazka, Jan, Novosadova, Vendula, Lelliott, Christopher J, Wardle-Jones, Hannah, Wells, Sara, Teboul, Lydia, Cater, Heather, Stewart, Michelle, Hough, Tertius, Wurst, Wolfgang, Sedlacek, Radislav, Adams, David J, Seavitt, John R, Tocchini-Valentini, Glauco, Mammano, Fabio, Braun, Robert E, McKerlie, Colin, Herault, Yann, de Angelis, Martin Hrabě, Mallon, Ann-Marie, Lloyd, K C Kent, Brown, Steve D M, Parkinson, Helen, Meehan, Terrence F, Smedley, Damian
Published in Nature communications

Effects of Celecoxib and Low-dose Aspirin on Outcomes in Adjuvant Aromatase Inhibitor-Treated Patients: CCTG MA.27

by Strasser-Weippl, Kathrin, Higgins, Michaela J, Chapman, Judith-Anne W, Ingle, James N, Sledge, George W, Budd, George T, Ellis, Matthew J, Pritchard, Kathleen I, Clemons, Mark J, Badovinac-Crnjevic, Tanja, Han, Lei, Gelmon, Karen A, Rabaglio, Manuela, Elliott, Catherine, Shepherd, Lois E, Goss, Paul E
Published in JNCI : Journal of the National Cancer Institute

Gene expression changes with age in skin, adipose tissue, blood and brain

by Glass, Daniel, Viñuela, Ana, Davies, Matthew N, Ramasamy, Adaikalavan, Parts, Leopold, Knowles, David, Brown, Andrew A, Hedman, Asa K, Small, Kerrin S, Buil, Alfonso, Grundberg, Elin, Nica, Alexandra C, Di Meglio, Paola, Nestle, Frank O, Ryten, Mina, Durbin, Richard, McCarthy, Mark I, Deloukas, Panagiotis, Dermitzakis, Emmanouil T, Weale, Michael E, Bataille, Veronique, Spector, Tim D
Published in Genome Biology

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

by Law, Philip J, Timofeeva, Maria, Fernandez-Rozadilla, Ceres, Broderick, Peter, Studd, James, Fernandez-Tajes, Juan, Farrington, Susan, Svinti, Victoria, Palles, Claire, Orlando, Giulia, Sud, Amit, Holroyd, Amy, Penegar, Steven, Theodoratou, Evropi, Vaughan-Shaw, Peter, Campbell, Harry, Zgaga, Lina, Hayward, Caroline, Campbell, Archie, Harris, Sarah, Deary, Ian J, Starr, John, Gatcombe, Laura, Pinna, Maria, Briggs, Sarah, Martin, Lynn, Jaeger, Emma, Sharma-Oates, Archana, East, James, Leedham, Simon, Arnold, Roland, Johnstone, Elaine, Wang, Haitao, Kerr, David, Kerr, Rachel, Maughan, Tim, Kaplan, Richard, Al-Tassan, Nada, Palin, Kimmo, Hänninen, Ulrika A, Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G, Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Buchanan, Daniel D, Win, Aung-Ko, Hopper, John, Jenkins, Mark E, Lindor, Noralane M, Newcomb, Polly A, Gallinger, Steven, Duggan, David, Casey, Graham, Hoffmann, Per, Nöthen, Markus M, Jöckel, Karl-Heinz, Easton, Douglas F, Pharoah, Paul D P, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Harkin, Andrea, Allan, Karen, McQueen, John, Paul, James, Iveson, Timothy, Saunders, Mark, Butterbach, Katja, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Kirac, Iva, Matošević, Petar, Hofer, Philipp, Brezina, Stefanie, Gsur, Andrea, Cheadle, Jeremy P, Aaltonen, Lauri A, Tomlinson, Ian, Houlston, Richard S, Dunlop, Malcolm G
Published in Nature communications