B cells and tertiary lymphoid structures promote immunotherapy response

by Helmink, Beth A, Reddy, Sangeetha M, Gao, Jianjun, Zhang, Shaojun, Basar, Rafet, Thakur, Rohit, Yizhak, Keren, Sade-Feldman, Moshe, Blando, Jorge, Han, Guangchun, Gopalakrishnan, Vancheswaran, Xi, Yuanxin, Zhao, Hao, Amaria, Rodabe N, Tawbi, Hussein A, Cogdill, Alex P, Liu, Wenbin, LeBleu, Valerie S, Kugeratski, Fernanda G, Patel, Sapna, Davies, Michael A, Hwu, Patrick, Lee, Jeffrey E, Gershenwald, Jeffrey E, Lucci, Anthony, Arora, Reetakshi, Woodman, Scott, Keung, Emily Z, Gaudreau, Pierre-Olivier, Reuben, Alexandre, Spencer, Christine N, Burton, Elizabeth M, Haydu, Lauren E, Lazar, Alexander J, Zapassodi, Roberta, Hudgens, Courtney W, Ledesma, Deborah A, Ong, SuFey, Bailey, Michael, Warren, Sarah, Rao, Disha, Krijgsman, Oscar, Rozeman, Elisa A, Peeper, Daniel, Blank, Christian U, Schumacher, Ton N, Butterfield, Lisa H, Zelazowska, Monika A, McBride, Kevin M, Kalluri, Raghu, Allison, James, Petitprez, Florent, Fridman, Wolf Herman, Sautès-Fridman, Catherine, Hacohen, Nir, Rezvani, Katayoun, Sharma, Padmanee, Tetzlaff, Michael T, Wang, Linghua, Wargo, Jennifer A
Published in Nature (London)

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

by Spencer, Christine N, McQuade, Jennifer L, Gopalakrishnan, Vancheswaran, McCulloch, John A, Vetizou, Marie, Cogdill, Alexandria P, Khan, Md A Wadud, Zhang, Xiaotao, White, Michael G, Peterson, Christine B, Wong, Matthew C, Morad, Golnaz, Rodgers, Theresa, Badger, Jonathan H, Helmink, Beth A, Andrews, Miles C, Rodrigues, Richard R, Morgun, Andrey, Kim, Young S, Roszik, Jason, Hoffman, Kristi L, Zheng, Jiali, Zhou, Yifan, Medik, Yusra B, Kahn, Laura M, Johnson, Sarah, Hudgens, Courtney W, Wani, Khalida, Gaudreau, Pierre-Olivier, Harris, Angela L, Jamal, Mohamed A, Baruch, Erez N, Perez-Guijarro, Eva, Day, Chi-Ping, Merlino, Glenn, Pazdrak, Barbara, Lochmann, Brooke S, Szczepaniak-Sloane, Robert A, Arora, Reetakshi, Anderson, Jaime, Zobniw, Chrystia M, Posada, Eliza, Sirmans, Elizabeth, Simon, Julie, Haydu, Lauren E, Burton, Elizabeth M, Wang, Linghua, Dang, Minghao, Clise-Dwyer, Karen, Schneider, Sarah, Chapman, Thomas, Anang, Nana-Ama A S, Duncan, Sheila, Toker, Joseph, Malke, Jared C, Glitza, Isabella C, Amaria, Rodabe N, Tawbi, Hussein A, Diab, Adi, Wong, Michael K, Patel, Sapna P, Woodman, Scott E, Davies, Michael A, Ross, Merrick I, Gershenwald, Jeffrey E, Lee, Jeffrey E, Hwu, Patrick, Jensen, Vanessa, Samuels, Yardena, Straussman, Ravid, Ajami, Nadim J, Nelson, Kelly C, Nezi, Luigi, Petrosino, Joseph F, Futreal, P Andrew, Lazar, Alexander J, Hu, Jianhua, Jenq, Robert R, Tetzlaff, Michael T, Yan, Yan, Garrett, Wendy S, Huttenhower, Curtis, Sharma, Padmanee, Watowich, Stephanie S, Allison, James P, Cohen, Lorenzo, Trinchieri, Giorgio, Daniel, Carrie R, Wargo, Jennifer A
Published in Science (American Association for the Advancement of Science)

Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, pha...

by Amaria, Rodabe N, Prieto, Peter A, Tetzlaff, Michael T, Reuben, Alexandre, Andrews, Miles C, Ross, Merrick I, Glitza, Isabella C, Cormier, Janice, Hwu, Wen-Jen, Tawbi, Hussein A, Patel, Sapna P, Lee, Jeffrey E, Gershenwald, Jeffrey E, Spencer, Christine N, Gopalakrishnan, Vancheswaran, Bassett, Roland, Simpson, Lauren, Mouton, Rosalind, Hudgens, Courtney W, Zhao, Li, Zhu, Haifeng, Cooper, Zachary A, Wani, Khalida, Lazar, Alexander, Hwu, Patrick, Diab, Adi, Wong, Michael K, McQuade, Jennifer L, Royal, Richard, Lucci, Anthony, Burton, Elizabeth M, Reddy, Sangeetha, Sharma, Padmanee, Allison, James, Futreal, Phillip A, Woodman, Scott E, Davies, Michael A, Wargo, Jennifer A
Published in The lancet oncology

PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in Conjunctival Squamous Cell Carcinoma

by Nagarajan, Priyadharsini, El-Hadad, Christian, Gruschkus, Stephen K, Ning, Jing, Hudgens, Courtney W, Sagiv, Oded, Gross, Neil, Tetzlaff, Michael T, Esmaeli, Bita
Published in Investigative ophthalmology & visual science

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

by Fischer, Grant M, Jalali, Ali, Kircher, David A, Lee, Won-Chul, McQuade, Jennifer L, Haydu, Lauren E, Joon, Aron Y, Reuben, Alexandre, de Macedo, Mariana P, Carapeto, Fernando C L, Yang, Chendong, Srivastava, Anuj, Ambati, Chandrashekar R, Sreekumar, Arun, Hudgens, Courtney W, Knighton, Barbara, Deng, Wanleng, Ferguson, Sherise D, Tawbi, Hussein A, Glitza, Isabella C, Gershenwald, Jeffrey E, Vashisht Gopal, Y N, Hwu, Patrick, Huse, Jason T, Wargo, Jennifer A, Futreal, P Andrew, Putluri, Nagireddy, Lazar, Alexander J, DeBerardinis, Ralph J, Marszalek, Joseph R, Zhang, Jianjun, Holmen, Sheri L, Tetzlaff, Michael T, Davies, Michael A
Published in Cancer discovery

A First-in-Human Study and Biomarker Analysis of NKTR-214, a Novel IL2Rβγ-Biased Cytokine, in Patients with Advanced or Metastatic Solid Tumors

by Bentebibel, Salah-Eddine, Hurwitz, Michael E, Bernatchez, Chantale, Haymaker, Cara, Hudgens, Courtney W, Kluger, Harriet M, Tetzlaff, Michael T, Tagliaferri, Mary A, Zalevsky, Jonathan, Hoch, Ute, Fanton, Christie, Aung, Sandra, Hwu, Patrick, Curti, Brendan D, Tannir, Nizar M, Sznol, Mario, Diab, Adi
Published in Cancer discovery

The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell-Mediated Immunotherapies

by Varghese, Sruthy, Pramanik, Snigdha, Williams, Leila J, Hodges, Hannah R, Hudgens, Courtney W, Fischer, Grant M, Luo, Catherine K, Knighton, Barbara, Tan, Lin, Lorenzi, Philip L, Mackinnon, Andrew L, McQuade, Jennifer L, Hailemichael, Yared, Roszik, Jason, Peng, Weiyi, Vashisht Gopal, Y N
Published in Molecular cancer therapeutics

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

by Vellano, Christopher P, White, Michael G, Andrews, Miles C, Chelvanambi, Manoj, Witt, Russell G, Daniele, Joseph R, Titus, Mark, McQuade, Jennifer L, Conforti, Fabio, Burton, Elizabeth M, Lastrapes, Matthew J, Ologun, Gabriel, Cogdill, Alexandria P, Morad, Golnaz, Prieto, Peter, Lazar, Alexander J, Chu, Yanshuo, Han, Guangchun, Khan, M A Wadud, Helmink, Beth, Davies, Michael A, Amaria, Rodabe N, Kovacs, Jeffrey J, Woodman, Scott E, Patel, Sapna, Hwu, Patrick, Peoples, Michael, Lee, Jeffrey E, Cooper, Zachary A, Zhu, Haifeng, Gao, Guang, Banerjee, Hiya, Lau, Mike, Gershenwald, Jeffrey E, Lucci, Anthony, Keung, Emily Z, Ross, Merrick I, Pala, Laura, Pagan, Eleonora, Segura, Rossana Lazcano, Liu, Qian, Borthwick, Mikayla S, Lau, Eric, Yates, Melinda S, Westin, Shannon N, Wani, Khalida, Tetzlaff, Michael T, Haydu, Lauren E, Mahendra, Mikhila, Ma, XiaoYan, Logothetis, Christopher, Kulstad, Zachary, Johnson, Sarah, Hudgens, Courtney W, Feng, Ningping, Federico, Lorenzo, Long, Georgina V, Futreal, P Andrew, Arur, Swathi, Tawbi, Hussein A, Moran, Amy E, Wang, Linghua, Heffernan, Timothy P, Marszalek, Joseph R, Wargo, Jennifer A
Published in Nature (London)

Distinct Biological Types of Ocular Adnexal Sebaceous Carcinoma: HPV-Driven and Virus-Negative Tumors Arise through Nonoverlapping Molecular-Genetic Alterations

by Tetzlaff, Michael T, Curry, Jonathan L, Ning, Jing, Sagiv, Oded, Kandl, Thomas L, Peng, Bo, Bell, Diana, Routbort, Mark, Hudgens, Courtney W, Ivan, Doina, Kim, Tae-Boom, Chen, Ken, Eterovic, Agda Karina, Shaw, Kenna, Prieto, Victor G, Yemelyanova, Anna, Esmaeli, Bita
Published in Clinical cancer research

Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

by Feldmeyer, Laurence, Hudgens, Courtney W, Ray-Lyons, Genevieve, Nagarajan, Priyadharsini, Aung, Phyu P, Curry, Jonathan L, Torres-Cabala, Carlos A, Mino, Barbara, Rodriguez-Canales, Jaime, Reuben, Alexandre, Chen, Pei-Ling, Ko, Jennifer S, Billings, Steven D, Bassett, Roland L, Wistuba, Ignacio I, Cooper, Zachary A, Prieto, Victor G, Wargo, Jennifer A, Tetzlaff, Michael T
Published in Clinical cancer research

Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer

by Reddy, Sangeetha M, Reuben, Alexandre, Barua, Souptik, Jiang, Hong, Zhang, Shaojun, Wang, Linghua, Gopalakrishnan, Vancheswaran, Hudgens, Courtney W, Tetzlaff, Michael T, Reuben, James M, Tsujikawa, Takahiro, Coussens, Lisa M, Wani, Khalida, He, Yan, Villareal, Lily, Wood, Anita, Rao, Arvind, Woodward, Wendy A, Ueno, Naoto T, Krishnamurthy, Savitri, Wargo, Jennifer A, Mittendorf, Elizabeth A
Published in Cancer immunology research

PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer

by Wu, Cheng, Peng, Shan, Pilié, Patrick G, Geng, Chuandong, Park, Sanghee, Manyam, Ganiraju C, Lu, Yungang, Yang, Guang, Tang, Zhe, Kondraganti, Shakuntala, Wang, Daoqi, Hudgens, Courtney W, Ledesma, Debora A, Marques-Piubelli, Mario L, Torres-Cabala, Carlos A, Curry, Jonathan L, Troncoso, Patricia, Corn, Paul G, Broom, Bradley M, Thompson, Timothy C
Published in Molecular cancer therapeutics

Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma

by Haymaker, Cara, Johnson, Daniel H, Murthy, Ravi, Bentebibel, Salah-Eddine, Uemura, Marc I, Hudgens, Courtney W, Safa, Houssein, James, Marihella, Andtbacka, Robert H I, Johnson, Douglas B, Shaheen, Montaser, Davies, Michael A, Rahimian, Shah, Chunduru, Srinivas K, Milton, Denái R, Tetzlaff, Michael T, Overwijk, Willem W, Hwu, Patrick, Gabrail, Nashat, Agrawal, Sudhir, Doolittle, Gary, Puzanov, Igor, Markowitz, Joseph, Bernatchez, Chantale, Diab, Adi
Published in Cancer discovery

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

by Zhou, Yifan, Medik, Yusra B, Patel, Bhakti, Zamler, Daniel B, Chen, Sijie, Chapman, Thomas, Schneider, Sarah, Park, Elizabeth M, Babcock, Rachel L, Chrisikos, Taylor T, Kahn, Laura M, Dyevoich, Allison M, Pineda, Josue E, Wong, Matthew C, Mishra, Aditya K, Cass, Samuel H, Cogdill, Alexandria P, Johnson, Daniel H, Johnson, Sarah B, Wani, Khalida, Ledesma, Debora A, Hudgens, Courtney W, Wang, Jingjing, Wadud Khan, Md Abdul, Peterson, Christine B, Joon, Aron Y, Peng, Weiyi, Li, Haiyan S, Arora, Reetakshi, Tang, Ximing, Raso, Maria Gabriela, Zhang, Xuegong, Foo, Wai Chin, Tetzlaff, Michael T, Diehl, Gretchen E, Clise-Dwyer, Karen, Whitley, Elizabeth M, Gubin, Matthew M, Allison, James P, Hwu, Patrick, Ajami, Nadim J, Diab, Adi, Wargo, Jennifer A, Watowich, Stephanie S
Published in The Journal of experimental medicine

High expression of PD-1 and PD-L1 in ocular adnexal sebaceous carcinoma

by Kandl, Thomas J., Sagiv, Oded, Curry, Jonathan L., Ning, Jing, Ma, Junsheng, Hudgens, Courtney W., Van Arnam, John, Wargo, Jennifer A., Esmaeli, Bita, Tetzlaff, Michael T.
Published in Oncoimmunology

Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma

by Hahn, Andrew W, Menk, Ashley V, Rivadeneira, Dayana B, Augustin, Ryan C, Xu, Mingchu, Li, Jun, Wu, Xiaogang, Mishra, Aditya K, Gide, Tuba N, Quek, Camelia, Zang, Yan, Spencer, Christine N, Menzies, Alexander M, Daniel, Carrie R, Hudgens, Courtney W, Nowicki, Theodore, Haydu, Lauren E, Khan, M A Wadud, Gopalakrishnan, Vancheswaran, Burton, Elizabeth M, Malke, Jared, Simon, Julie M, Bernatchez, Chantale, Putluri, Nagireddy, Woodman, Scott E, Vashisht Gopal, Y N, Guerrieri, Renato, Fischer, Grant M, Wang, Jian, Wani, Khalida M, Thompson, John F, Lee, Jeffrey E, Hwu, Patrick, Ajami, Nadim, Gershenwald, Jeffrey E, Long, Georgina V, Scolyer, Richard A, Tetzlaff, Michael T, Lazar, Alexander J, Schadendorf, Dirk, Wargo, Jennifer A, Kirkwood, John M, DeBerardinis, Ralph J, Liang, Han, Futreal, Andrew, Zhang, Jianhua, Wilmott, James S, Peng, Weiyi, Davies, Michael A, Delgoffe, Greg M, Najjar, Yana G, McQuade, Jennifer L
Published in Clinical cancer research

Differential regulation of embryonic and adult β cell replication

by Gunasekaran, Uma, Hudgens, Courtney W., Wright, Brian T., Maulis, Matthew F., Gannon, Maureen
Published in Cell cycle (Georgetown, Tex.)

T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma

by Farah, Maya, Reuben, Alexandre, Spassova, Ivelina, Yang, Richard K., Kubat, Linda, Nagarajan, Priyadharsini, Ning, Jing, Li, Wen, Aung, Phyu P., Curry, Jonathan L., Torres-Cabala, Carlos A., Hudgens, Courtney W., Ugurel, Selma, Schadendorf, Dirk, Gumbs, Curtis, Little, Latasha D., Futreal, Andrew, Wistuba, Ignacio I., Prieto, Victor G., Wang, Linghua, Wong, Michael K., Wargo, Jennifer A., Becker, Jürgen C., Tetzlaff, Michael T.
Published in Journal of investigative dermatology

Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

by Vellano, Christopher P, White, Michael G, Andrews, Miles C, Chelvanambi, Manoj, Witt, Russell G, Daniele, Joseph R, Titus, Mark, McQuade, Jennifer L, Conforti, Fabio, Burton, Elizabeth M, Lastrapes, Matthew J, Ologun, Gabriel, Cogdill, Alexandria P, Morad, Golnaz, Prieto, Peter, Lazar, Alexander J, Chu, Yanshuo, Han, Guangchun, Khan, M A Wadud, Helmink, Beth, Davies, Michael A, Amaria, Rodabe N, Kovacs, Jeffrey J, Woodman, Scott E, Patel, Sapna, Hwu, Patrick, Peoples, Michael, Lee, Jeffrey E, Cooper, Zachary A, Zhu, Haifeng, Gao, Guang, Banerjee, Hiya, Lau, Mike, Gershenwald, Jeffrey E, Lucci, Anthony, Keung, Emily Z, Ross, Merrick I, Pala, Laura, Pagan, Eleonora, Segura, Rossana Lazcano, Liu, Qian, Borthwick, Mikayla S, Lau, Eric, Yates, Melinda S, Westin, Shannon N, Wani, Khalida, Tetzlaff, Michael T, Haydu, Lauren E, Mahendra, Mikhila, Ma, XiaoYan, Logothetis, Christopher, Kulstad, Zachary, Johnson, Sarah, Hudgens, Courtney W, Feng, Ningping, Federico, Lorenzo, Long, Georgina V, Futreal, P Andrew, Arur, Swathi, Tawbi, Hussein A, Moran, Amy E, Wang, Linghua, Heffernan, Timothy P, Marszalek, Joseph R, Wargo, Jennifer A
Published in Nature (London)

Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma

by Mitra, Akash, Andrews, Miles C, Roh, Whijae, De Macedo, Marianna Petaccia, Hudgens, Courtney W, Carapeto, Fernando, Singh, Shailbala, Reuben, Alexandre, Wang, Feng, Mao, Xizeng, Song, Xingzhi, Wani, Khalida, Tippen, Samantha, Ng, Kwok-Shing, Schalck, Aislyn, Sakellariou-Thompson, Donald A, Chen, Eveline, Reddy, Sangeetha M, Spencer, Christine N, Wiesnoski, Diana, Little, Latasha D, Gumbs, Curtis, Cooper, Zachary A, Burton, Elizabeth M, Hwu, Patrick, Davies, Michael A, Zhang, Jianhua, Bernatchez, Chantale, Navin, Nicholas, Sharma, Padmanee, Allison, James P, Wargo, Jennifer A, Yee, Cassian, Tetzlaff, Michael T, Hwu, Wen-Jen, Lazar, Alexander J, Futreal, P Andrew
Published in Nature communications