Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

by Homburger, Julian R., Green, Eric M., Caleshu, Colleen, Sunitha, Margaret S., Taylor, Rebecca E., Ruppel, Kathleen M., Metpally, Raghu Prasad Rao, Colan, Steven D., Michels, Michelle, Day, Sharlene M., Olivotto, Iacopo, Bustamante, Carlos D., Dewey, Frederick E., Ho, Carolyn Y., Spudich, James A., Ashley, Euan A.
Published in Proceedings of the National Academy of Sciences - PNAS

Discordant clinical features of identical hypertrophic cardiomyopathy twins

by Repetti, Giuliana G, Kim, Yuri, Pereira, Alexandre C, Ingles, Jodie, Russell, Mark W, Lakdawala, Neal K, Ho, Carolyn Y, Day, Sharlene, Semsarian, Christopher, McDonough, Barbara, DePalma, Steven R, Quiat, Daniel, Green, Eric M, Seidman, Christine E, Seidman, J G
Published in Proceedings of the National Academy of Sciences - PNAS

Titin Truncating Variants in Adults Without Known Congestive Heart Failure

by Pirruccello, James P., Bick, Alexander, Chaffin, Mark, Aragam, Krishna G., Choi, Seung Hoan, Lubitz, Steven A., Ho, Carolyn Y., Ng, Kenney, Philippakis, Anthony, Ellinor, Patrick T., Kathiresan, Sekar, Khera, Amit V.
Published in Journal of the American College of Cardiology

External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy

by Norrish, Gabrielle, Qu, Chen, Field, Ella, Cervi, Elena, Khraiche, Diala, Klaassen, Sabine, Ojala, Tiina H, Sinagra, Gianfranco, Yamazawa, Hirokuni, Marrone, Chiara, Popoiu, Anca, Centeno, Fernando, Schouvey, Sylvie, Olivotto, Iacopo, Day, Sharlene M, Colan, Steve, Rossano, Joseph, Wittekind, Samuel G, Saberi, Sara, Russell, Mark, Helms, Adam, Ingles, Jodie, Semsarian, Christopher, Elliott, Perry M, Ho, Carolyn Y, Omar, Rumana Z, Kaski, Juan P
Published in European journal of preventive cardiology

Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy

by Kramer, Christopher M., MD, Appelbaum, Evan, MD, Desai, Milind Y., MD, Desvigne-Nickens, Patrice, MD, DiMarco, John P., MD, PhD, Friedrich, Matthias G., MD, Geller, Nancy, PhD, Heckler, Sarahfaye, BA, Ho, Carolyn Y., MD, Jerosch-Herold, Michael, PhD, Ivey, Elizabeth A., AS, Keleti, Julianna, PhD, Kim, Dong-Yun, PhD, Kolm, Paul, PhD, Kwong, Raymond Y., MD, Maron, Martin S., MD, Schulz-Menger, Jeanette, MD, Piechnik, Stefan, PhD, Watkins, Hugh, MD, Weintraub, William S., MD, Wu, Pan, PhD, Neubauer, Stefan, MD
Published in The American heart journal

Clinical Outcome and Phenotypic Expression in LAMP2 Cardiomyopathy

by Maron, Barry J, Roberts, William C, Arad, Michael, Haas, Tammy S, Spirito, Paolo, Wright, Gregory B, Almquist, Adrian K, Baffa, Jeanne M, Saul, J. Philip, Ho, Carolyn Y, Seidman, Jonathan, Seidman, Christine E
Published in JAMA : the journal of the American Medical Association

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

by Sequeira, Vasco, Wijnker, Paul J.M, Nijenkamp, Louise L.A.M, Kuster, Diederik W.D, Najafi, Aref, Witjas-Paalberends, E Rosalie, Regan, Jessica A, Boontje, Nicky, ten Cate, Folkert J, Germans, Tjeerd, Carrier, Lucie, Sadayappan, Sakthivel, van Slegtenhorst, Marjon A, Zaremba, Ruud, Foster, D Brian, Murphy, Anne M, Poggesi, Corrado, dos Remedios, Cris, Stienen, Ger J.M, Ho, Carolyn Y, Michels, Michelle, van der Velden, Jolanda
Published in Circulation research

Genetic Testing for Inherited Heart Disease

by Cirino, Allison L, Ho, Carolyn Y
Published in Circulation (New York, N.Y.)

Research priorities in sarcomeric cardiomyopathies

by van der Velden, Jolanda, Ho, Carolyn Y, Tardiff, Jil C, Olivotto, Iacopo, Knollmann, Bjorn C, Carrier, Lucie
Published in Cardiovascular research

3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry

by Heydari, Bobak, Satriano, Alessandro, Jerosch-Herold, Michael, Kolm, Paul, Kim, Dong-Yun, Cheng, Kathleen, Choi, Yuna L, Antiochos, Panagiotis, White, James A, Mahmod, Masliza, Chan, Kenneth, Raman, Betty, Desai, Milind Y, Ho, Carolyn Y, Dolman, Sarahfaye F, Desvigne-Nickens, Patrice, Maron, Martin S, Friedrich, Matthias G, Schulz-Menger, Jeanette, Piechnik, Stefan K, Appelbaum, Evan, Weintraub, William S, Neubauer, Stefan, Kramer, Christopher M, Kwong, Raymond Y
Published in JACC. Cardiovascular imaging

The Design of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) Trial

by Ho, Carolyn Y., McMurray, John J.V., Cirino, Allison L., Colan, Steven D., Day, Sharlene M., Desai, Akshay S., Lipshultz, Steven E., MacRae, Calum A., Shi, Ling, Solomon, Scott D., Orav, E. John, Braunwald, Eugene
Published in The American heart journal

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

by Witjas-Paalberends, E Rosalie, Güçlü, Ahmet, Germans, Tjeerd, Knaapen, Paul, Harms, Hendrik J, Vermeer, Alexa M C, Christiaans, Imke, Wilde, Arthur A M, Dos Remedios, Cris, Lammertsma, Adriaan A, van Rossum, Albert C, Stienen, Ger J M, van Slegtenhorst, Marjon, Schinkel, Arend F, Michels, Michelle, Ho, Carolyn Y, Poggesi, Corrado, van der Velden, Jolanda
Published in Cardiovascular research

Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression

by Ho, Carolyn Y, Lakdawala, Neal K, Cirino, Allison L, Lipshultz, Steven E, Sparks, Elizabeth, Abbasi, Siddique A, Kwong, Raymond Y, Antman, Elliott M, Semsarian, Christopher, González, Arantxa, López, Begoña, Diez, Javier, Orav, E John, Colan, Steven D, Seidman, Christine E
Published in JACC. Heart failure

Faster cross‐bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

by Witjas‐Paalberends, E. Rosalie, Ferrara, Claudia, Scellini, Beatrice, Piroddi, Nicoletta, Montag, Judith, Tesi, Chiara, Stienen, Ger J. M., Michels, Michelle, Ho, Carolyn Y., Kraft, Theresia, Poggesi, Corrado, Velden, Jolanda
Published in The Journal of physiology

Maximal Wall Thickness Measurement in Hypertrophic Cardiomyopathy: Biomarker Variability and its Impact on Clinical Care

by Captur, Gabriella, Manisty, Charlotte H, Raman, Betty, Marchi, Alberto, Wong, Timothy C, Ariga, Rina, Bhuva, Anish, Ormondroyd, Elizabeth, Lobascio, Ilaria, Camaioni, Claudia, Loizos, Savvas, Bonsu-Ofori, Jenade, Turer, Aslan, Zaha, Vlad G, Augutsto, João B, Davies, Rhodri H, Taylor, Andrew J, Nasis, Arthur, Al-Mallah, Mouaz H, Valentin, Sinitsyn, Perez de Arenaza, Diego, Patel, Vimal, Westwood, Mark, Petersen, Steffen E, Li, Chunming, Tang, Lijun, Nakamori, Shiro, Nezafat, Reza, Kwong, Raymond Y, Ho, Carolyn Y, Fraser, Alan G, Watkins, Hugh, Elliott, Perry M, Neubauer, Stefan, Lloyd, Guy, Olivotto, Iacopo, Nihoyannopoulos, Petros, Moon, James C
Published in JACC. Cardiovascular imaging

Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy

by Nauffal, Victor, Marstrand, Peter, Han, Larry, Parikh, Victoria N, Helms, Adam S, Ingles, Jodie, Jacoby, Daniel, Lakdawala, Neal K, Kapur, Sunil, Michels, Michelle, Owens, Anjali T, Ashley, Euan A, Pereira, Alexandre C, Rossano, Joseph W, Saberi, Sara, Semsarian, Christopher, Ware, James S, Wittekind, Samuel G, Day, Sharlene, Olivotto, Iacopo, Ho, Carolyn Y
Published in European heart journal

Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers

by Groarke, John D, Galazka, Patrycja Z, Cirino, Allison L, Lakdawala, Neal K, Thune, Jens J, Bundgaard, Henning, Orav, E John, Levine, Robert A, Ho, Carolyn Y
Published in European heart journal cardiovascular imaging

Integrating genetics and medicine: Disease-modifying treatment strategies for hypertrophic cardiomyopathy

by Ho, Carolyn Y
Published in Progress in pediatric cardiology

Is genotype clinically useful in predicting prognosis in hypertrophic cardiomyopathy?: Genetics and Clinical Destiny: Improving Care in Hypertrophic Cardiomyopathy

by HO, Carolyn Y, LANDSTROM, Andrew P, ACKERMAN, Michael J
Published in Circulation (New York, N.Y.)

Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation

by Thompson, Andrea D., Helms, Adam S., Kannan, Anamika, Yob, Jaime, Lakdawala, Neal K., Wittekind, Samuel G., Pereira, Alexandre C., Jacoby, Daniel L., Colan, Steven D., Ashley, Euan A., Saberi, Sara, Ware, James S., Ingles, Jodie, Semsarian, Christopher, Michels, Michelle, Mazzarotto, Francesco, Olivotto, Iacopo, Ho, Carolyn Y., Day, Sharlene M.
Published in Genetics in medicine