Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML by Lo Presti, Vania, Meringa, Angelo, Dunnebach, Ester, van Velzen, Alice, Moreira, Aida Valera, Stam, Ronald W, Kotecha, Rishi S, Krippner-Heidenreich, Anja, Heidenreich, Olaf T, Plantinga, Maud, Cornel, Annelisa, Sebestyen, Zsolt, Kuball, Jurgen, van Til, Niek P, Nierkens, S

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Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1 by Cornel, Annelisa M., van der Sman, Loutje, van Dinter, Jip T, Arrabito, Marta, Dunnebach, Ester, van Hoesel, Marliek, Kluiver, Thomas A, Lopes, Ana P, Dautzenberg, Noël M M, Dekker, Linde, van Rijn, Jorik M, van den Beemt, Denise A M H, Buhl, Juliane L, du Chatinier, Aimee, Barneh, Farnaz, Lu, Yuyan, Lo Nigro, Luca, Krippner-Heidenreich, Anja, Sebestyén, Zsolt, Kuball, Jurgen, Hulleman, Esther, Drost, Jarno, van Heesch, Sebastiaan, Heidenreich, Olaf T, Peng, Weng Chuan, Nierkens, Stefan

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Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia by Shi, Yuzhe, Beckett, Melanie C, Blair, Helen J, Tirtakusuma, Ricky, Nakjang, Sirintra, Enshaei, Amir, Halsey, Christina, Vormoor, Josef, Heidenreich, Olaf, Krippner-Heidenreich, Anja, van Delft, Frederik W

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Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth by Kellaway, Sophie G, Potluri, Sandeep, Keane, Peter, Blair, Helen J, Ames, Luke, Worker, Alice, Chin, Paulynn S, Ptasinska, Anetta, Derevyanko, Polina K, Adamo, Assunta, Coleman, Daniel J L, Khan, Naeem, Assi, Salam A, Krippner-Heidenreich, Anja, Raghavan, Manoj, Cockerill, Peter N, Heidenreich, Olaf, Bonifer, Constanze

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RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia by Grinev, Vasily V, Barneh, Farnaz, Ilyushonak, Ilya M, Nakjang, Sirintra, Smink, Job, van Oort, Anita, Clough, Richard, Seyani, Michael, McNeill, Hesta, Reza, Mojgan, Martinez-Soria, Natalia, Assi, Salam A, Ramanouskaya, Tatsiana V, Bonifer, Constanze, Heidenreich, Olaf

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3098 – RUNX1/RUNX1T1 ORCHESTRATES THE LEUKAEMIC MICROENVIRONMENT by Heidenreich, Olaf, Derevyanko, Polina, Krippner-Heidenreich, Anja, Swart, Laura

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Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia by Barneh, Farnaz, Koedijk, Joost B., Wijnen, Noa E., Meulendijks, Tom, Ashtiani, Minoo, Dunnebach, Ester, Dautzenberg, Noël, Cornel, Annelisa M., Krippner-Heidenreich, Anja, Klein, Kim, Zwaan, Michel C., Kuball, Jürgen, Nierkens, Stefan, Cloos, Jacqueline, Kaspers, Gertjan J.L., Heidenreich, Olaf

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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia by Lin, Wei-Yu, Fordham, Sarah E, Hungate, Eric, Sunter, Nicola J, Elstob, Claire, Xu, Yaobo, Park, Catherine, Quante, Anne, Strauch, Konstantin, Gieger, Christian, Skol, Andrew, Rahman, Thahira, Sucheston-Campbell, Lara, Wang, Junke, Hahn, Theresa, Clay-Gilmour, Alyssa I, Jones, Gail L, Marr, Helen J, Jackson, Graham H, Menne, Tobias, Collin, Mathew, Ivey, Adam, Hills, Robert K, Burnett, Alan K, Russell, Nigel H, Fitzgibbon, Jude, Larson, Richard A, Le Beau, Michelle M, Stock, Wendy, Heidenreich, Olaf, Alharbi, Abrar, Allsup, David J, Houlston, Richard S, Norden, Jean, Dickinson, Anne M, Douglas, Elisabeth, Lendrem, Clare, Daly, Ann K, Palm, Louise, Piechocki, Kim, Jeffries, Sally, Bornhäuser, Martin, Röllig, Christoph, Altmann, Heidi, Ruhnke, Leo, Kunadt, Desiree, Wagenführ, Lisa, Cordell, Heather J, Darlay, Rebecca, Andersen, Mette K, Fontana, Maria C, Martinelli, Giovanni, Marconi, Giovanni, Sanz, Miguel A, Cervera, José, Gómez-Seguí, Inés, Cluzeau, Thomas, Moreilhon, Chimène, Raynaud, Sophie, Sill, Heinz, Voso, Maria Teresa, Lo-Coco, Francesco, Dombret, Hervé, Cheok, Meyling, Preudhomme, Claude, Gale, Rosemary E, Linch, David, Gaal-Wesinger, Julia, Masszi, Andras, Nowak, Daniel, Hofmann, Wolf-Karsten, Gilkes, Amanda, Porkka, Kimmo, Milosevic Feenstra, Jelena D, Kralovics, Robert, Grimwade, David, Meggendorfer, Manja, Haferlach, Torsten, Krizsán, Szilvia, Bödör, Csaba, Stölzel, Friedrich, Onel, Kenan, Allan, James M

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RUNX1::RUNX1T1 Impairs the Differentiation Potential of Primary AML Cells by Derevianko, Polina K, Swart, Laura E., Ashtiani, Minoo, Kellaway, Sophie, Krippner-Heidenreich, Anja, Schiffelers, Raymond M., Vormoor, Josef, Heidenreich, Olaf

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Epidemiology and biology of relapse after stem cell transplantation by Horowitz, Mary, Schreiber, Hans, Elder, Alex, Heidenreich, Olaf, Vormoor, Josef, Toffalori, Christina, Vago, Luca, Kröger, Nicolaus

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The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98‐rearranged AML by Rasouli, Milad, Blair, Helen, Troester, Selina, Szoltysek, Katarzyna, Cameron, Rachel, Ashtiani, Minoo, Krippner‐Heidenreich, Anja, Grebien, Florian, McGeehan, Gerard, Zwaan, C. Michel, Heidenreich, Olaf

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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation by Martinez-Soria, Natalia, McKenzie, Lynsey, Draper, Julia, Ptasinska, Anetta, Issa, Hasan, Potluri, Sandeep, Blair, Helen J., Pickin, Anna, Isa, Asmida, Chin, Paulynn Suyin, Tirtakusuma, Ricky, Coleman, Daniel, Nakjang, Sirintra, Assi, Salam, Forster, Victoria, Reza, Mojgan, Law, Ed, Berry, Philip, Mueller, Dorothee, Osborne, Cameron, Elder, Alex, Bomken, Simon N., Pal, Deepali, Allan, James M., Veal, Gareth J., Cockerill, Peter N., Wichmann, Christian, Vormoor, Josef, Lacaud, Georges, Bonifer, Constanze, Heidenreich, Olaf

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Targeting the innate immune system in pediatric and adult AML by Perzolli, Alicia, Koedijk, Joost B, Zwaan, C Michel, Heidenreich, Olaf

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H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells by Godfrey, Laura, Crump, Nicholas T, O'Byrne, Sorcha, Lau, I-Jun, Rice, Siobhan, Harman, Joe R, Jackson, Thomas, Elliott, Natalina, Buck, Gemma, Connor, Christopher, Thorne, Ross, Knapp, David J H F, Heidenreich, Olaf, Vyas, Paresh, Menendez, Pablo, Inglott, Sarah, Ancliff, Philip, Geng, Huimin, Roberts, Irene, Roy, Anindita, Milne, Thomas A

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Author Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia by Lin, Wei-Yu, Fordham, Sarah E, Hungate, Eric, Sunter, Nicola J, Elstob, Claire, Xu, Yaobo, Park, Catherine, Quante, Anne, Strauch, Konstantin, Gieger, Christian, Skol, Andrew, Rahman, Thahira, Sucheston-Campbell, Lara, Wang, Junke, Hahn, Theresa, Clay-Gilmour, Alyssa I, Jones, Gail L, Marr, Helen J, Jackson, Graham H, Menne, Tobias, Collin, Mathew, Ivey, Adam, Hills, Robert K, Burnett, Alan K, Russell, Nigel H, Fitzgibbon, Jude, Larson, Richard A, Le Beau, Michelle M, Stock, Wendy, Heidenreich, Olaf, Alharbi, Abrar, Allsup, David J, Houlston, Richard S, Norden, Jean, Dickinson, Anne M, Douglas, Elisabeth, Lendrem, Clare, Daly, Ann K, Palm, Louise, Piechocki, Kim, Jeffries, Sally, Bornhäuser, Martin, Röllig, Christoph, Altmann, Heidi, Ruhnke, Leo, Kunadt, Desiree, Wagenführ, Lisa, Cordell, Heather J, Darlay, Rebecca, Andersen, Mette K, Fontana, Maria C, Martinelli, Giovanni, Marconi, Giovanni, Sanz, Miguel A, Cervera, José, Gómez-Seguí, Inés, Cluzeau, Thomas, Moreilhon, Chimène, Raynaud, Sophie, Sill, Heinz, Voso, Maria Teresa, Lo-Coco, Francesco, Dombret, Hervé, Cheok, Meyling, Preudhomme, Claude, Gale, Rosemary E, Linch, David, Gaal-Wesinger, Julia, Masszi, Andras, Nowak, Daniel, Hofmann, Wolf-Karsten, Gilkes, Amanda, Porkka, Kimmo, Milosevic Feenstra, Jelena D, Kralovics, Robert, Grimwade, David, Meggendorfer, Manja, Haferlach, Torsten, Krizsán, Szilvia, Bödör, Csaba, Stölzel, Friedrich, Onel, Kenan, Allan, James M

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P444: SINGLE CELL RNASEQ UNCOVERING THE ROLE OF A LEUKEMIC DRIVER GENE FUSION CBFΒ::MYH11 IN THE LEUKEMIC–NICHE SIGNALING by Derevyanko, Polina, V Dolgikh, Alexandra, Ashtiani, Minoo, Krippner‐Heidenreich, Anja, Nelson, Ryan, Bushweller, John, Barbitoff, Yury, V Predeus, Alexander, Heidenreich, Olaf

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P437: EFFECTIVE IMMUNOTHERAPY OF PEDIATRIC T(8;21) ACUTE MYELOID LEUKEMIA BY REPURPOSING CD3XCD19 TARGETING BISPECIFIC ANTIBODIES by Wijnen, Noa, Barneh, Farnaz, Meulendijks, Thomas, Klein, Kim, Duddebach, Ester, Cornel, Annelisa, Dautzenberg, Noël, Ashtiani, Minoo, Krippner‐Heidenreich, Anja, Nierkens, Stefan, Heidenreich, Olaf, Kaspers, Gertjan

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Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL by Tirtakusuma, Ricky, Milne, Paul, Blair, Helen J, Shi, Yuzhe, Bomken, Simon, Heidenreich, Olaf

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Inhibition of the Menin-MLL1 Interaction in MLL-Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation by Szoltysek, Katarzyna, Cameron, Rachel L., Krippner-Heidenreich, Anja, Rasouli, Milad, Hehir-Kwa, Jayne Y., Schweighart, Elizabeth K., Ashtiani, Minoo, Stutterheim, Janine, Vormoor, Josef, Heidenreich, Olaf

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Susceptibility of pediatric acute lymphoblastic leukemia to STAT3 inhibition depends on p53 induction by Gasparoli, Luca, Virely, Clemence, Tsakaneli, Alexia, Che, Noelia, Edwards, Darren, Bartram, Jack, Hubank, Michael, Pal, Deepali, Heidenreich, Olaf, Martens, Joost H A, De Boer, Jasper, Williams, Owen

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