Scientific consensus on the COVID-19 pandemic: we need to act now

by Alwan, Nisreen A, Burgess, Rochelle Ann, Ashworth, Simon, Beale, Rupert, Bhadelia, Nahid, Bogaert, Debby, Dowd, Jennifer, Eckerle, Isabella, Goldman, Lynn R, Greenhalgh, Trisha, Gurdasani, Deepti, Hamdy, Adam, Hanage, William P, Hodcroft, Emma B, Hyde, Zoë, Kellam, Paul, Kelly-Irving, Michelle, Krammer, Florian, Lipsitch, Marc, McNally, Alan, McKee, Martin, Nouri, Ali, Pimenta, Dominic, Priesemann, Viola, Rutter, Harry, Silver, Joshua, Sridhar, Devi, Swanton, Charles, Walensky, Rochelle P, Yamey, Gavin, Ziauddeen, Hisham
Published in The Lancet

Superantigens and SARS-CoV-2

by Hamdy, Adam, Leonardi, Anthony
Published in Pathogens (Basel)

Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation

by Leonardi, Anthony J, Argyropoulos, Christos P, Hamdy, Adam, Proenca, Rui B
Published in Frontiers in immunology

Uncertainty around the Long-Term Implications of COVID-19

by Desforges, Marc, Gurdasani, Deepti, Hamdy, Adam, Leonardi, Anthony J
Published in Pathogens (Basel)

Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trialRe...

by Dhammika Leshan Wannigama, Cameron Hurst, Phatthranit Phattharapornjaroen, Parichart Hongsing, Natchalaikorn Sirichumroonwit, Kanokpoj Chanpiwat, Ali Hosseini Rad S.M., Robin James Storer, Puey Ounjai, Phitsanuruk Kanthawee, Natharin Ngamwongsatit, Rosalyn Kupwiwat, Chaisit Kupwiwat, James Michael Brimson, Naveen Kumar Devanga Ragupathi, Somrat Charuluxananan, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Vishnu Nayak Badavath, Mohan Amarasiri, Valerie Verhasselt, Anthony Kicic, Tanittha Chatsuwan, Kashif Pirzada, Farid Jalali, Angela M. Reiersen, Shuichi Abe, Hitoshi Ishikawa, Chanikan Tanasatitchai, Supamat Amphol, Ladda Nantawong, Prangrawee Sangchan, Varissara Sinkajarern, Thutpharritchn Phoonakh, Phornnapat Utenpattanun, Aye Mya Sithu Shein, Timporn Vitoonpong, Nichapha Chongthavonsatit, Yahya Mankong, Piyapong Chaichana, Jenjira Yaithet, Dumrongsak Pongprajak, Sukjai Traimuangpak, Gasit Saksirisampant, Phimonsiri Lamloeskittinon, Adam Adam Hamdy, Sinthu Sinthu Kosasih, Sirirat Sirirat Luk-in
Published in EClinicalMedicine

Covid-19: An urgent call for global “vaccines-plus” action

by scientists, clinicians, An open letter by a group of public health experts
Published in BMJ (Online)

The World Health Network: a global citizens' initiative

by Bar-Yam, Yaneer, Gurdasani, Deepti, Baker, Michael G, Scally, Gabriel, George, Simone, Kvalsvig, Amanda, Fhaoláin, Sinéad Ní, Chiou, Shu-Ti, Drury, John, Duckett, Stephen, Ding, Eric L, Gershenson, Carlos, Gibson, Christine, Greenhalgh, Trisha, Hamdy, Adam, Hyde, Zoë, James, Tiffany, Jimenez, Jose L, McKee, Martin, Michie, Susan, Pagel, Christina, Philippe, Cecile, Prather, Kim, Raina, Sunil K, Ricciardi, Walter, Rubin, Meir, Ryan, Tomás, Schneider, Matthias F, Staines, Anthony, West, Robert, Ziauddeen, Hisham
Published in The Lancet (British edition)

Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial

by Wannigama, Dhammika Leshan, Hurst, Cameron, Phattharapornjaroen, Phatthranit, Hongsing, Parichart, Sirichumroonwit, Natchalaikorn, Chanpiwat, Kanokpoj, Rad S.M., Ali Hosseini, Storer, Robin James, Ounjai, Puey, Kanthawee, Phitsanuruk, Ngamwongsatit, Natharin, Kupwiwat, Rosalyn, Kupwiwat, Chaisit, Brimson, James Michael, Devanga Ragupathi, Naveen Kumar, Charuluxananan, Somrat, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G., Badavath, Vishnu Nayak, Amarasiri, Mohan, Verhasselt, Valerie, Kicic, Anthony, Chatsuwan, Tanittha, Pirzada, Kashif, Jalali, Farid, Reiersen, Angela M., Abe, Shuichi, Ishikawa, Hitoshi, Tanasatitchai, Chanikan, Amphol, Supamat, Nantawong, Ladda, Sangchan, Prangrawee, Sinkajarern, Varissara, Phoonakh, Thutpharritchn, Utenpattanun, Phornnapat, Sithu Shein, Aye Mya, Vitoonpong, Timporn, Chongthavonsatit, Nichapha, Mankong, Yahya, Chaichana, Piyapong, Yaithet, Jenjira, Pongprajak, Dumrongsak, Traimuangpak, Sukjai, Saksirisampant, Gasit, Lamloeskittinon, Phimonsiri, Hamdy, Adam Adam, Kosasih, Sinthu Sinthu, Luk-in, Sirirat Sirirat
Published in EClinicalMedicine

iTRAQ identification of candidate serum biomarkers associated with metastatic progression of human prostate cancer

by Rehman, Ishtiaq, Evans, Caroline A, Glen, Adam, Cross, Simon S, Eaton, Colby L, Down, Jenny, Pesce, Giancarlo, Phillips, Joshua T, Yen, Ow Saw, Thalmann, George N, Wright, Phillip C, Hamdy, Freddie C
Published in PloS one

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

by Mancuso, Nicholas, Gayther, Simon, Gusev, Alexander, Zheng, Wei, Penney, Kathryn L, Kote-Jarai, Zsofia, Eeles, Rosalind, Freedman, Matthew, Haiman, Christopher, Pasaniuc, Bogdan
Published in Nature communications

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

by Abdelkader, Hamdy, Fathalla, Zeinab, Seyfoddin, Ali, Farahani, Mojtaba, Thrimawithana, Thilini, Allahham, Ayman, Alani, Adam W.G., Al-Kinani, Ali A., Alany, Raid G.
Published in Advanced drug delivery reviews

Epidemiology of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children

by Hamdy, Rana F, Hsu, Alice J, Stockmann, Chris, Olson, Jared A, Bryan, Matthew, Hersh, Adam L, Tamma, Pranita D, Gerber, Jeffrey S
Published in Pediatrics (Evanston)

A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data

by Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Walsh, Eleanor I, Turner, Emma L, Lane, J Athene, Martin, Richard M, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Parsons, J Kellogg, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, Zsofia, Amin Al Olama, Ali, Benlloch Garcia, Sara, Muir, Kenneth, Grönberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo Lj, Nordestgaard, Børge Grønne, Key, Timothy J, Travis, Ruth C, Pharoah, Paul D P, Pashayan, Nora, Khaw, Kay-Tee, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa A, Brenner, Hermann, Schöttker, Ben, Holleczek, Bernd, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Slavov, Chavdar Kroumov, Kaneva, Radka P, Mitev, Vanio I, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda B, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M
Published in Cancer epidemiology, biomarkers & prevention

Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage

by Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J, Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G, Kumar, Rajeev, Hamdy, Freddie C, Weyer-Czernilofsky, Ulrike, Sanderson, Michael P, Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M
Published in Cancer research (Chicago, Ill.)

Mutational signatures of ionizing radiation in second malignancies

by Behjati, Sam, Gundem, Gunes, Wedge, David C, Roberts, Nicola D, Tarpey, Patrick S, Cooke, Susanna L, Van Loo, Peter, Alexandrov, Ludmil B, Ramakrishna, Manasa, Davies, Helen, Nik-Zainal, Serena, Hardy, Claire, Latimer, Calli, Raine, Keiran M, Stebbings, Lucy, Menzies, Andy, Jones, David, Shepherd, Rebecca, Butler, Adam P, Teague, Jon W, Jorgensen, Mette, Khatri, Bhavisha, Pillay, Nischalan, Shlien, Adam, Futreal, P Andrew, Badie, Christophe, McDermott, Ultan, Bova, G Steven, Richardson, Andrea L, Flanagan, Adrienne M, Stratton, Michael R, Campbell, Peter J
Published in Nature communications

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts

by Seibert, Tyler M, Fan, Chun Chieh, Wang, Yunpeng, Zuber, Verena, Karunamuni, Roshan, Parsons, J Kellogg, Eeles, Rosalind A, Easton, Douglas F, Kote-Jarai, ZSofia, Al Olama, Ali Amin, Garcia, Sara Benlloch, Muir, Kenneth, Grönberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeky, Csilla, Tammela, Teuvo LJ, Nordestgaard, Børge G, Nielsen, Sune F, Weischer, Maren, Bisbjerg, Rasmus, Røder, M Andreas, Iversen, Peter, Key, Tim J, Travis, Ruth C, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S, Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Brenner, Hermann, Cuk, Katarina, Saum, Kai-Uwe, Park, Jong Y, Sellers, Thomas A, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Clements, Judith A, Spurdle, Amanda, Teixeira, Manuel R, Paulo, Paula, Maia, Sofia, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej, Karow, David S, Mills, Ian G, Andreassen, Ole A, Dale, Anders M
Published in BMJ (Online)

The evolutionary history of lethal metastatic prostate cancer

by Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B, Tubio, Jose M C, Papaemmanuil, Elli, Brewer, Daniel S, Kallio, Heini M L, Högnäs, Gunilla, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin J, Isaacs, William, Emmert-Buck, Michael R, Nykter, Matti, Foster, Christopher, Kote-Jarai, Zsofia, Easton, Douglas, Whitaker, Hayley C, Neal, David E, Cooper, Colin S, Eeles, Rosalind A, Visakorpi, Tapio, Campbell, Peter J, McDermott, Ultan, Wedge, David C, Bova, G Steven
Published in Nature (London)

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological fe...

by Rao, Srinivasa, Verrill, Clare, Cerundolo, Lucia, Alham, Nasullah Khalid, Kaya, Zeynep, O'Hanlon, Miriam, Hayes, Alicia, Lambert, Adam, James, Martha, Tullis, Iain D C, Niederer, Jane, Lovell, Shelagh, Omer, Altan, Lopez, Francisco, Leslie, Tom, Buffa, Francesca, Bryant, Richard J, Lamb, Alastair D, Vojnovic, Boris, Wedge, David C, Mills, Ian G, Woodcock, Dan J, Tomlinson, Ian, Hamdy, Freddie C
Published in Genome medicine

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

by Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Thompson, Wesley K, Martinez, Maria Elena, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Nielsen, Sune F, Nordestgaard, Børge G, Wiklund, Fredrik, Tangen, Catherine M, Giles, Graham G, Wolk, Alicja, Albanes, Demetrius, Travis, Ruth C, Blot, William J, Zheng, Wei, Sanderson, Maureen, Stanford, Janet L, Mucci, Lorelei A, West, Catharine M L, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Khaw, Kay-Tee, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Thibodeau, Stephen N, Rosenstein, Barry S, Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L, Huff, Chad, Teixeira, Manuel R, Multigner, Luc, Leach, Robin J, Cannon-Albright, Lisa, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, De Ruyck, Kim, Pandha, Hardev, Razack, Azad, Newcomb, Lisa F, Fowke, Jay H, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Bush, William S, Roobol, Monique J, Parent, Marie-Élise, Hu, Jennifer J, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M
Published in Nature communications

Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis

by Yarmolinsky, James, Bouras, Emmanouil, Constantinescu, Andrei, Burrows, Kimberley, Bull, Caroline J., Vincent, Emma E., Martin, Richard M., Dimopoulou, Olympia, Lewis, Sarah J., Moreno, Victor, Vujkovic, Marijana, Chang, Kyong-Mi, Voight, Benjamin F., Tsao, Philip S., Gunter, Marc J., Hampe, Jochen, Pellatt, Andrew J., Pharoah, Paul D. P., Schoen, Robert E., Gallinger, Steven, Jenkins, Mark A., Pai, Rish K., Gill, Dipender, Tsilidis, Kostas K.
Published in Diabetologia