Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

by Achinger-Kawecka, Joanna, Valdes-Mora, Fatima, Luu, Phuc-Loi, Giles, Katherine A, Caldon, C Elizabeth, Qu, Wenjia, Nair, Shalima, Soto, Sebastian, Locke, Warwick J, Yeo-Teh, Nicole S, Gould, Cathryn M, Du, Qian, Smith, Grady C, Ramos, Irene R, Fernandez, Kristine F, Hoon, Dave S, Gee, Julia M W, Stirzaker, Clare, Clark, Susan J
Published in Nature communications

Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen

by Habashy, Hany Onsy, Powe, Desmond G, Staka, Cindy M, Rakha, Emad A, Ball, Graham, Green, Andrew R, Aleskandarany, Mohammed, Paish, E. Claire, Douglas Macmillan, R, Nicholson, Robert I, Ellis, Ian O, Gee, Julia M. W
Published in Breast cancer research and treatment

Dose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized Phase II study

by Kuter, Irene, Gee, Julia M. W., Hegg, Roberto, Singer, Christian F., Badwe, Rajendra A., Lowe, Elizabeth S., Emeribe, Ugochi A., Anderson, Elizabeth, Sapunar, Francisco, Finlay, Pauline, Nicholson, Robert I., Bines, José, Harbeck, Nadia
Published in Breast cancer research and treatment

Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer

by Ziliotto, Silvia, Gee, Julia M. W, Ellis, Ian O, Green, Andrew R, Finlay, Pauline, Gobbato, Anna, Taylor, Kathryn M
Published in Metallomics

Elevated Levels of Epidermal Growth Factor Receptor/c-erbB2 Heterodimers Mediate an Autocrine Growth Regulatory Pathway in Tamoxifen-Resistant MCF-7 Cells

by Knowlden, Janice M, Hutcheson, Iain R, Jones, Helen E, Madden, Tracieann, Gee, Julia M. W, Harper, Maureen E, Barrow, Denise, Wakeling, Alan E, Nicholson, Robert I
Published in Endocrinology (Philadelphia)

Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer

by Stone, Andrew, Valdés-Mora, Fatima, Gee, Julia M W, Farrow, Lynne, McClelland, Richard A, Fiegl, Heidi, Dutkowski, Carol, McCloy, Rachael A, Sutherland, Robert L, Musgrove, Elizabeth A, Nicholson, Robert I
Published in PloS one

Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro

by Jordan, Nicola J, Dutkowski, Carol M, Barrow, Denise, Mottram, Huw J, Hutcheson, Iain R, Nicholson, Robert I, Guichard, Sylvie M, Gee, Julia M W
Published in Breast cancer research : BCR

The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis

by Nimmanon, Thirayost, Ziliotto, Silvia, Ogle, Olivia, Burt, Anna, Gee, Julia M. W., Andrews, Glen K., Kille, Pete, Hogstrand, Christer, Maret, Wolfgang, Taylor, Kathryn M.
Published in Cellular and molecular life sciences : CMLS

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

by LAW, Jennifer H, HABIBI, Golareh, NICHOLSON, Robert I, CARBONI, Joan, GOTTARDIS, Marco, POLLAK, Michael, DUNN, Sandra E, KAIJI HU, MASOUDI, Hamid, WANG, Michelle Y. C, STRATFORD, Anna L, PARK, Eugene, GEE, Julia M. W, FINLAY, Pauline, JONES, Helen E
Published in Cancer research (Chicago, Ill.)

Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib (‘Iressa’) response and r...

by Knowlden, Janice M., Jones, Helen E., Barrow, Denise, Gee, Julia M. W., Nicholson, Robert I., Hutcheson, Iain R.
Published in Breast cancer research and treatment

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

by Saunus, Jodi M, De Luca, Xavier M, Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E, Lim, Malcolm, Lal, Samir, Vargas, A Cristina, Kutasovic, Jamie R, Dalley, Andrew J, Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M W, Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R, Rakha, Emad A, Ellis, Ian O, Nicolau, Jr, Dan V, Simpson, Peter T, Lakhani, Sunil R
Published in NPJ breast cancer

MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer

by Milevskiy, Michael J G, Gujral, Udai, Del Lama Marques, Carolina, Stone, Andrew, Northwood, Korinne, Burke, Lez J, Gee, Julia M W, Nephew, Kenneth, Clark, Susan, Brown, Melissa A
Published in British journal of cancer

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells

by Gallego-Ortega, David, Ledger, Anita, Roden, Daniel L, Law, Andrew M K, Magenau, Astrid, Kikhtyak, Zoya, Cho, Christina, Allerdice, Stephanie L, Lee, Heather J, Valdes-Mora, Fatima, Herrmann, David, Salomon, Robert, Young, Adelaide I J, Lee, Brian Y, Sergio, C Marcelo, Kaplan, Warren, Piggin, Catherine, Conway, James R W, Rabinovich, Brian, Millar, Ewan K A, Oakes, Samantha R, Chtanova, Tatyana, Swarbrick, Alexander, Naylor, Matthew J, O'Toole, Sandra, Green, Andrew R, Timpson, Paul, Gee, Julia M W, Ellis, Ian O, Clark, Susan J, Ormandy, Christopher J
Published in PLoS biology

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer

by Kalyuga, Maria, Gallego-Ortega, David, Lee, Heather J, Roden, Daniel L, Cowley, Mark J, Caldon, C Elizabeth, Stone, Andrew, Allerdice, Stephanie L, Valdes-Mora, Fatima, Launchbury, Rosalind, Statham, Aaron L, Armstrong, Nicola, Alles, M Chehani, Young, Adelaide, Egger, Andrea, Au, Wendy, Piggin, Catherine L, Evans, Cara J, Ledger, Anita, Brummer, Tilman, Oakes, Samantha R, Kaplan, Warren, Gee, Julia M W, Nicholson, Robert I, Sutherland, Robert L, Swarbrick, Alexander, Naylor, Matthew J, Clark, Susan J, Carroll, Jason S, Ormandy, Christopher J
Published in PLoS biology

Global characterization of signalling networks associated with tamoxifen resistance in breast cancer

by Browne, Brigid C, Hochgräfe, Falko, Wu, Jianmin, Millar, Ewan K. A, Barraclough, Jane, Stone, Andrew, McCloy, Rachael A, Lee, Christine S, Roberts, Caroline, Ali, Naveid A, Boulghourjian, Alice, Schmich, Fabian, Linding, Rune, Farrow, Lynn, Gee, Julia M. W, Nicholson, Robert I, O'Toole, Sandra A, Sutherland, Robert L, Musgrove, Elizabeth A, Butt, Alison J, Daly, Roger J
Published in The FEBS journal

In Vitro Effects on MCF-7 Breast Cancer Cells Of Signal Transduction Inhibitor/Tamoxifen/Eicosapentaenoic Acid Combinations and their Simultaneous Delivery Across Skin

by Davison, Zoë, Dutkowski, Carol, Gee, Julia M. W., Nicholson, Robert I., Heard, Charles M.
Published in Pharmaceutical research

Correction to: Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells

by Hutcheson, Iain R, Knowlden, Janice M, Hiscox, Steve E, Barrow, Denise, Gee, Julia M W, Robertson, John F, Ellis, Ian O, Nicholson, Robert I
Published in Breast cancer research : BCR

A randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primar...

by Robertson, John F R, Dixon, J Michael, Sibbering, D Mark, Jahan, Ali, Ellis, Ian O, Channon, Eddie, Hyman-Taylor, Pauline, Nicholson, Robert I, Gee, Julia M W
Published in Breast cancer research : BCR

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

by Eccles, Suzanne A, Aboagye, Eric O, Ali, Simak, Anderson, Annie S, Armes, Jo, Berditchevski, Fedor, Blaydes, Jeremy P, Brennan, Keith, Brown, Nicola J, Bryant, Helen E, Bundred, Nigel J, Burchell, Joy M, Campbell, Anna M, Carroll, Jason S, Clarke, Robert B, Coles, Charlotte E, Cook, Gary J R, Cox, Angela, Curtin, Nicola J, Dekker, Lodewijk V, Silva, Isabel dos Santos, Duffy, Stephen W, Easton, Douglas F, Eccles, Diana M, Edwards, Dylan R, Edwards, Joanne, Evans, D, Fenlon, Deborah F, Flanagan, James M, Foster, Claire, Gallagher, William M, Garcia-Closas, Montserrat, Gee, Julia M W, Gescher, Andy J, Goh, Vicky, Groves, Ashley M, Harvey, Amanda J, Harvie, Michelle, Hennessy, Bryan T, Hiscox, Stephen, Holen, Ingunn, Howell, Sacha J, Howell, Anthony, Hubbard, Gill, Hulbert-Williams, Nick, Hunter, Myra S, Jasani, Bharat, Jones, Louise J, Key, Timothy J, Kirwan, Cliona C, Kong, Anthony, Kunkler, Ian H, Langdon, Simon P, Leach, Martin O, Mann, David J, Marshall, John F, Martin, Lesley, Martin, Stewart G, Macdougall, Jennifer E, Miles, David W, Miller, William R, Morris, Joanna R, Moss, Sue M, Mullan, Paul, Natrajan, Rachel, O'Connor, James P B, O'Connor, Rosemary, Palmieri, Carlo, Pharoah, Paul D P, Rakha, Emad A, Reed, Elizabeth, Robinson, Simon P, Sahai, Erik, Saxton, John M, Schmid, Peter, Smalley, Matthew J, Speirs, Valerie, Stein, Robert, Stingl, John, Streuli, Charles H, Tutt, Andrew N J, Velikova, Galina, Walker, Rosemary A, Watson, Christine J, Williams, Kaye J, Young, Leonie S, Thompson, Alastair M
Published in Breast cancer research : BCR

DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer

by Stone, Andrew, Zotenko, Elena, Locke, Warwick J, Korbie, Darren, Millar, Ewan K A, Pidsley, Ruth, Stirzaker, Clare, Graham, Peter, Trau, Matt, Musgrove, Elizabeth A, Nicholson, Robert I, Gee, Julia M W, Clark, Susan J
Published in Nature communications