Spatially confined sub-tumor microenvironments in pancreatic cancer

by Grünwald, Barbara T., Devisme, Antoine, Andrieux, Geoffroy, Vyas, Foram, Aliar, Kazeera, McCloskey, Curtis W., Macklin, Andrew, Jang, Gun Ho, Denroche, Robert, Romero, Joan Miguel, Bavi, Prashant, Bronsert, Peter, Notta, Faiyaz, O’Kane, Grainne, Wilson, Julie, Knox, Jennifer, Tamblyn, Laura, Udaskin, Molly, Radulovich, Nikolina, Fischer, Sandra E., Boerries, Melanie, Gallinger, Steven, Kislinger, Thomas, Khokha, Rama
Published in Cell

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

by Chen, Yi-an, Lemire, Mathieu, Choufani, Sanaa, Butcher, Darci T., Grafodatskaya, Daria, Zanke, Brent W., Gallinger, Steven, Hudson, Thomas J., Weksberg, Rosanna
Published in Epigenetics

GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

by O'Kane, Grainne M, Grünwald, Barbara T, Jang, Gun-Ho, Masoomian, Mehdi, Picardo, Sarah, Grant, Robert C, Denroche, Robert E, Zhang, Amy, Wang, Yifan, Lam, Bernard, Krzyzanowski, Paul M, Lungu, Illinca M, Bartlett, John M S, Peralta, Melanie, Vyas, Foram, Khokha, Rama, Biagi, James, Chadwick, Dianne, Ramotar, Stephanie, Hutchinson, Shawn, Dodd, Anna, Wilson, Julie M, Notta, Faiyaz, Zogopoulos, George, Gallinger, Steven, Knox, Jennifer J, Fischer, Sandra E
Published in Clinical cancer research

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

by Dominguez-Valentin, Mev, Sampson, Julian R, Seppälä, Toni T, Ten Broeke, Sanne W, Plazzer, John-Paul, Nakken, Sigve, Engel, Christoph, Aretz, Stefan, Jenkins, Mark A, Sunde, Lone, Bernstein, Inge, Capella, Gabriel, Balaguer, Francesc, Thomas, Huw, Evans, D Gareth, Burn, John, Greenblatt, Marc, Hovig, Eivind, de Vos Tot Nederveen Cappel, Wouter H, Sijmons, Rolf H, Bertario, Lucio, Tibiletti, Maria Grazia, Cavestro, Giulia Martina, Lindblom, Annika, Della Valle, Adriana, Lopez-Köstner, Francisco, Gluck, Nathan, Katz, Lior H, Heinimann, Karl, Vaccaro, Carlos A, Büttner, Reinhard, Görgens, Heike, Holinski-Feder, Elke, Morak, Monika, Holzapfel, Stefanie, Hüneburg, Robert, Knebel Doeberitz, Magnus von, Loeffler, Markus, Rahner, Nils, Schackert, Hans K, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Hopper, John L, Win, Aung Ko, Haile, Robert W, Lindor, Noralane M, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A, Figueiredo, Jane C, Thibodeau, Stephen N, Wadt, Karin, Therkildsen, Christina, Okkels, Henrik, Ketabi, Zohreh, Moreira, Leticia, Sánchez, Ariadna, Serra-Burriel, Miquel, Pineda, Marta, Navarro, Matilde, Blanco, Ignacio, Green, Kate, Lalloo, Fiona, Crosbie, Emma J, Hill, James, Denton, Oliver G, Frayling, Ian M, Rødland, Einar Andreas, Vasen, Hans, Mints, Miriam, Neffa, Florencia, Esperon, Patricia, Alvarez, Karin, Kariv, Revital, Rosner, Guy, Pinero, Tamara Alejandra, Gonzalez, María Laura, Kalfayan, Pablo, Tjandra, Douglas, Winship, Ingrid M, Macrae, Finlay, Möslein, Gabriela, Mecklin, Jukka-Pekka, Nielsen, Maartje, Møller, Pål
Published in Genetics in medicine

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

by Kreso, Antonija, O'Brien, Catherine A., van Galen, Peter, Gan, Olga I., Notta, Faiyaz, Brown, Andrew M. K., Ng, Karen, Ma, Jing, Wienholds, Erno, Dunant, Cyrille, Pollett, Aaron, Gallinger, Steven, McPherson, John, Mullighan, Charles G., Shibata, Darryl, Dick, John E.
Published in Science (American Association for the Advancement of Science)

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

by Notta, Faiyaz, Chan-Seng-Yue, Michelle, Lemire, Mathieu, Li, Yilong, Wilson, Gavin W, Connor, Ashton A, Denroche, Robert E, Liang, Sheng-Ben, Brown, Andrew M K, Kim, Jaeseung C, Wang, Tao, Simpson, Jared T, Beck, Timothy, Borgida, Ayelet, Buchner, Nicholas, Chadwick, Dianne, Hafezi-Bakhtiari, Sara, Dick, John E, Heisler, Lawrence, Hollingsworth, Michael A, Ibrahimov, Emin, Jang, Gun Ho, Johns, Jeremy, Jorgensen, Lars G T, Law, Calvin, Ludkovski, Olga, Lungu, Ilinca, Ng, Karen, Pasternack, Danielle, Petersen, Gloria M, Shlush, Liran I, Timms, Lee, Tsao, Ming-Sound, Wilson, Julie M, Yung, Christina K, Zogopoulos, George, Bartlett, John M S, Alexandrov, Ludmil B, Real, Francisco X, Cleary, Sean P, Roehrl, Michael H, McPherson, John D, Stein, Lincoln D, Hudson, Thomas J, Campbell, Peter J, Gallinger, Steven
Published in Nature (London)

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

by Connor, Ashton A., Denroche, Robert E., Jang, Gun Ho, Lemire, Mathieu, Zhang, Amy, Chan-Seng-Yue, Michelle, Wilson, Gavin, Grant, Robert C., Merico, Daniele, Lungu, Ilinca, Bartlett, John M.S., Chadwick, Dianne, Liang, Sheng-Ben, Eagles, Jenna, Mbabaali, Faridah, Miller, Jessica K., Krzyzanowski, Paul, Armstrong, Heather, Luo, Xuemei, Jorgensen, Lars G.T., Romero, Joan M., Bavi, Prashant, Fischer, Sandra E., Serra, Stefano, Hafezi-Bakhtiari, Sara, Caglar, Derin, Roehrl, Michael H.A., Cleary, Sean, Hollingsworth, Michael A., Petersen, Gloria M., Thayer, Sarah, Law, Calvin H.L., Nanji, Sulaiman, Golan, Talia, Smith, Alyssa L., Borgida, Ayelet, Dodd, Anna, Hedley, David, Wouters, Bradly G., O'Kane, Grainne M., Wilson, Julie M., Zogopoulos, George, Notta, Faiyaz, Knox, Jennifer J., Gallinger, Steven
Published in Cancer cell

NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma

by Jones, Martin R, Williamson, Laura M, Topham, James T, Lee, Michael K C, Goytain, Angela, Ho, Julie, Denroche, Robert E, Jang, GunHo, Pleasance, Erin, Shen, Yaoquing, Karasinska, Joanna M, McGhie, John P, Gill, Sharlene, Lim, Howard J, Moore, Malcolm J, Wong, Hui-Li, Ng, Tony, Yip, Stephen, Zhang, Wei, Sadeghi, Sara, Reisle, Carolyn, Mungall, Andrew J, Mungall, Karen L, Moore, Richard A, Ma, Yussanne, Knox, Jennifer J, Gallinger, Steven, Laskin, Janessa, Marra, Marco A, Schaeffer, David F, Jones, Steven J M, Renouf, Daniel J
Published in Clinical cancer research

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

by Klein, Alison P, Wolpin, Brian M, Risch, Harvey A, Stolzenberg-Solomon, Rachael Z, Mocci, Evelina, Zhang, Mingfeng, Canzian, Federico, Childs, Erica J, Hoskins, Jason W, Zhong, Jun, Chen, Fei, Albanes, Demetrius, Andreotti, Gabriella, Arslan, Alan A, Berndt, Sonja I, Blackford, Amanda, Borges, Michael, Borgida, Ayelet, Bracci, Paige M, Brais, Lauren, Brennan, Paul, Brenner, Hermann, Buring, Julie, Campa, Daniele, Capurso, Gabriele, Cavestro, Giulia Martina, Chaffee, Kari G, Chung, Charles C, Cleary, Sean, Cotterchio, Michelle, Dijk, Frederike, Foretova, Lenka, Fuchs, Charles, Funel, Niccola, Gallinger, Steven, M Gaziano, J Michael, Gazouli, Maria, Giles, Graham G, Giovannucci, Edward, Goodman, Gary E, Goodman, Phyllis J, Hackert, Thilo, Haiman, Christopher, Hartge, Patricia, Hasan, Manal, Hegyi, Peter, Helzlsouer, Kathy J, Holcatova, Ivana, Holly, Elizabeth A, Hoover, Robert, Hung, Rayjean J, Jamroziak, Krzysztof, Janout, Vladimir, Kaaks, Rudolf, Klein, Eric A, Kogevinas, Manolis, Kulke, Matthew H, Kupcinskas, Juozas, Kurtz, Robert J, Laheru, Daniel, Landi, Stefano, Lee, I-Min, LeMarchand, Loic, Lu, Lingeng, Malats, Núria, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Mohelníková-Duchoňová, Beatrice, Neale, Rachel E, Neoptolemos, John P, Oberg, Ann L, Olson, Sara H, Orlow, Irene, Pasquali, Claudio, Patel, Alpa V, Pezzilli, Raffaele, Porta, Miquel, Real, Francisco X, Rothman, Nathaniel, Scelo, Ghislaine, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Silverman, Debra, Soucek, Pavel, Sund, Malin, Tavano, Francesca, Thornquist, Mark D, Tobias, Geoffrey S, Van Den Eeden, Stephen K, Vodicka, Pavel, Wactawski-Wende, Jean, Wang, Zhaoming, Wentzensen, Nicolas, White, Emily, Yu, Herbert, Chanock, Stephen, Obazee, Ofure, Amundadottir, Laufey T
Published in Nature communications

Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer

by Win, Aung Ko, Jenkins, Mark A, Dowty, James G, Antoniou, Antonis C, Lee, Andrew, Giles, Graham G, Buchanan, Daniel D, Clendenning, Mark, Rosty, Christophe, Ahnen, Dennis J, Thibodeau, Stephen N, Casey, Graham, Gallinger, Steven, Le Marchand, Loïc, Haile, Robert W, Potter, John D, Zheng, Yingye, Lindor, Noralane M, Newcomb, Polly A, Hopper, John L, MacInnis, Robert J
Published in Cancer epidemiology, biomarkers & prevention

Improving prognostic performance in resectable pancreatic ductal adenocarcinoma using radiomics and deep learning features fusion in CT images

by Zhang, Yucheng, Lobo-Mueller, Edrise M, Karanicolas, Paul, Gallinger, Steven, Haider, Masoom A, Khalvati, Farzad
Published in Scientific reports

CT texture features are associated with overall survival in pancreatic ductal adenocarcinoma - a quantitative analysis

by Eilaghi, Armin, Baig, Sameer, Zhang, Yucheng, Zhang, Junjie, Karanicolas, Paul, Gallinger, Steven, Khalvati, Farzad, Haider, Masoom A
Published in BMC medical imaging

Prognostic Value of CT Radiomic Features in Resectable Pancreatic Ductal Adenocarcinoma

by Khalvati, Farzad, Zhang, Yucheng, Baig, Sameer, Lobo-Mueller, Edrise M, Karanicolas, Paul, Gallinger, Steven, Haider, Masoom A
Published in Scientific reports

Senescent Carcinoma-Associated Fibroblasts Upregulate IL8 to Enhance Prometastatic Phenotypes

by Wang, Tao, Notta, Faiyaz, Navab, Roya, Joseph, Joella, Ibrahimov, Emin, Xu, Jing, Zhu, Chang-Qi, Borgida, Ayelet, Gallinger, Steven, Tsao, Ming-Sound
Published in Molecular cancer research

ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21

by O'Brien, Catherine A., Kreso, Antonija, Ryan, Paul, Hermans, Karin G., Gibson, Lianne, Wang, Yadong, Tsatsanis, Andrew, Gallinger, Steven, Dick, John E.
Published in Cancer cell

Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes

by Miyabayashi, Koji, Baker, Lindsey A, Deschênes, Astrid, Traub, Benno, Caligiuri, Giuseppina, Plenker, Dennis, Alagesan, Brinda, Belleau, Pascal, Li, Siran, Kendall, Jude, Jang, Gun Ho, Kawaguchi, Risa Karakida, Somerville, Tim D D, Tiriac, Hervé, Hwang, Chang-Il, Burkhart, Richard A, Roberts, Nicholas J, Wood, Laura D, Hruban, Ralph H, Gillis, Jesse, Krasnitz, Alexander, Vakoc, Christopher R, Wigler, Michael, Notta, Faiyaz, Gallinger, Steven, Park, Youngkyu, Tuveson, David A
Published in Cancer discovery

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

by Roberts, Nicholas J, Norris, Alexis L, Petersen, Gloria M, Bondy, Melissa L, Brand, Randall, Gallinger, Steven, Kurtz, Robert C, Olson, Sara H, Rustgi, Anil K, Schwartz, Ann G, Stoffel, Elena, Syngal, Sapna, Zogopoulos, George, Ali, Syed Z, Axilbund, Jennifer, Chaffee, Kari G, Chen, Yun-Ching, Cote, Michele L, Childs, Erica J, Douville, Christopher, Goes, Fernando S, Herman, Joseph M, Iacobuzio-Donahue, Christine, Kramer, Melissa, Makohon-Moore, Alvin, McCombie, Richard W, McMahon, K Wyatt, Niknafs, Noushin, Parla, Jennifer, Pirooznia, Mehdi, Potash, James B, Rhim, Andrew D, Smith, Alyssa L, Wang, Yuxuan, Wolfgang, Christopher L, Wood, Laura D, Zandi, Peter P, Goggins, Michael, Karchin, Rachel, Eshleman, James R, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert, Hruban, Ralph H, Klein, Alison P
Published in Cancer discovery

The New Era of Transplant Oncology: Liver Transplantation for Nonresectable Colorectal Cancer Liver Metastases

by Gorgen, Andre, Muaddi, Hala, Zhang, Wei, McGilvray, Ian, Gallinger, Steven, Sapisochin, Gonzalo
Published in Canadian journal of gastroenterology & hepatology

Overall Survival and Clinical Characteristics of BRCA‐Associated Cholangiocarcinoma: A Multicenter Retrospective Study

by Golan, Talia, Raitses‐Gurevich, Maria, Kelley, Robin K., Bocobo, Andrea G., Borgida, Ayelet, Shroff, Rachna T., Holter, Spring, Gallinger, Steven, Ahn, Daniel H., Aderka, Dan, Apurva, Jain, Bekaii‐Saab, Tanois, Friedman, Eitan, Javle, Milind
Published in The oncologist (Dayton, Ohio)

Recurrence after liver resection for hepatocellular carcinoma: Risk factors, treatment, and outcomes

by Shah, Shimul A., MD, Cleary, Sean P., MD, MSc, Wei, Alice C., MD, MSc, Yang, Ilun, MD, Taylor, Bryce R., MD, Hemming, Alan W., MD, Langer, Bernard, MD, Grant, David R., MD, Greig, Paul D., MD, Gallinger, Steven, MD, MSc
Published in Surgery