Dramatic Response to Combination Erlotinib and Crizotinib in a Patient with Advanced, EGFR-Mutant Lung Cancer Harboring De Novo MET Amplification

by Gainor, Justin F., Niederst, Matthew J., Lennerz, Jochen K., Dagogo-Jack, Ibiayi, Stevens, Sara, Shaw, Alice T., Sequist, Lecia V., Engelman, Jeffrey A.
Published in Journal of thoracic oncology

J-ALEX: alectinib versus crizotinib in ALK -positive lung cancer

by Gainor, Justin F, Shaw, Alice T
Published in The Lancet (British edition)

ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non–Small Cell Lung Cancer

by Lin, Jessica J., Ritterhouse, Lauren L., Ali, Siraj M., Bailey, Mark, Schrock, Alexa B., Gainor, Justin F., Ferris, Lorin A., Mino-Kenudson, Mari, Miller, Vincent A., Iafrate, Anthony J., Lennerz, Jochen K., Shaw, Alice T.
Published in Journal of thoracic oncology

Efficacy of Platinum/Pemetrexed Combination Chemotherapy in ALK-Positive NSCLC Refractory to Second-Generation ALK Inhibitors

by Lin, Jessica J., Schoenfeld, Adam J., Zhu, Viola W., Yeap, Beow Y., Chin, Emily, Rooney, Marguerite, Plodkowski, Andrew J., Digumarthy, Subba R., Dagogo-Jack, Ibiayi, Gainor, Justin F., Ou, Sai-Hong Ignatius, Riely, Gregory J., Shaw, Alice T.
Published in Journal of thoracic oncology

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

by Voutouri, Chrysovalantis, Hardin, C Corey, Naranbhai, Vivek, Nikmaneshi, Mohammad R, Khandekar, Melin J, Gainor, Justin F, Stylianopoulos, Triantafyllos, Munn, Lance L, Jain, Rakesh K
Published in Proceedings of the National Academy of Sciences - PNAS

Emergence of a RET V804M Gatekeeper Mutation During Treatment With Vandetanib in RET-Rearranged NSCLC

by Dagogo-Jack, Ibiayi, Stevens, Sara E., Lin, Jessica J., Nagy, Rebecca, Ferris, Lorin, Shaw, Alice T., Gainor, Justin F.
Published in Journal of thoracic oncology

Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer

by Bauer, Todd M., Shaw, Alice T., Johnson, Melissa L., Navarro, Alejandro, Gainor, Justin F., Thurm, Holger, Pithavala, Yazdi K., Abbattista, Antonello, Peltz, Gerson, Felip, Enriqueta
Published in Targeted oncology

Low peripheral blood derived neutrophil-to-lymphocyte ratio (dNLR) is associated with increased tumor T-cell infiltration and favorable outcomes to first-line pembrolizumab in non-...

by Alessi, Joao V, Ricciuti, Biagio, Alden, Stephanie L, Bertram, Arrien A, Lin, Jessica J, Sakhi, Mustafa, Nishino, Mizuki, Vaz, Victor R, Lindsay, James, Turner, Madison M, Pfaff, Kathleen, Sharma, Bijaya, Felt, Kristen D, Rodig, Scott J., Gainor, Justin F., Awad, Mark M.
Published in Journal for immunotherapy of cancer

Endocrine immune-related adverse events: a double-edged sword?

by Rengarajan, Michelle, Gainor, Justin F.
Published in Translational lung cancer research

Programmed Cell Death Ligand 1 Expression in Resected Lung Adenocarcinomas: Association with Immune Microenvironment

by Huynh, Tiffany G., Morales-Oyarvide, Vicente, Campo, Meghan J., Gainor, Justin F., Bozkurtlar, Emine, Uruga, Hironori, Zhao, Ling, Gomez-Caraballo, Maria, Hata, Aaron N., Mark, Eugene J., Lanuti, Michael, Engelman, Jeffrey A., Mino-Kenudson, Mari
Published in Journal of thoracic oncology

A Phase 2 Study of Capmatinib in Patients With MET-Altered Lung Cancer Previously Treated With a MET Inhibitor

by Dagogo-Jack, Ibiayi, Moonsamy, Philicia, Gainor, Justin F., Lennerz, Jochen K., Piotrowska, Zofia, Lin, Jessica J., Lennes, Inga T., Sequist, Lecia V., Shaw, Alice T., Goodwin, Kelly, Stevens, Sara E., Do, Andrew, Digumarthy, Subba R., Price, Kristin, Muzikansky, Alona, Hata, Aaron N., Heist, Rebecca S.
Published in Journal of thoracic oncology

Efficacy of Alectinib in Patients with ALK-Positive NSCLC and Symptomatic or Large CNS Metastases

by Lin, Jessica J., Jiang, Ginger Y., Joshipura, Nencyben, Ackil, Jennifer, Digumarthy, Subba R., Rincon, Sandra P., Yeap, Beow Y., Gainor, Justin F., Shaw, Alice T.
Published in Journal of thoracic oncology

A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti–PD-1 antibody, in patients with advanced solid tumors

by Naing, Aung, Gainor, Justin F, Gelderblom, Hans, Forde, Patrick M, Butler, Marcus O, Lin, Chia-Chi, Sharma, Sunil, Ochoa de Olza, Maria, Varga, Andrea, Taylor, Matthew, Schellens, Jan H M, Wu, Hongqian, Sun, Haiying, Silva, Antonio P, Faris, Jason, Mataraza, Jennifer, Cameron, Scott, Bauer, Todd M
Published in Journal for immunotherapy of cancer

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

by Isozaki, Hideko, Sakhtemani, Ramin, Abbasi, Ammal, Nikpour, Naveed, Stanzione, Marcello, Oh, Sunwoo, Langenbucher, Adam, Monroe, Susanna, Su, Wenjia, Cabanos, Heidie Frisco, Siddiqui, Faria M, Phan, Nicole, Jalili, Pégah, Timonina, Daria, Bilton, Samantha, Gomez-Caraballo, Maria, Archibald, Hannah L, Nangia, Varuna, Dionne, Kristin, Riley, Amanda, Lawlor, Matthew, Banwait, Mandeep Kaur, Cobb, Rosemary G, Zou, Lee, Dyson, Nicholas J, Ott, Christopher J, Benes, Cyril, Getz, Gad, Chan, Chang S, Shaw, Alice T, Gainor, Justin F, Lin, Jessica J, Sequist, Lecia V, Piotrowska, Zofia, Yeap, Beow Y, Engelman, Jeffrey A, Lee, Jake June-Koo, Maruvka, Yosef E, Buisson, Rémi, Lawrence, Michael S, Hata, Aaron N
Published in Nature (London)

Factors Associated With Developing Neurocognitive Adverse Events in Patients Receiving Lorlatinib After Progression on Other Targeted Therapies

by Dagogo-Jack, Ibiayi, Abbattista, Antonello, Murphy, John F., Krulewicz, Stan, Do, Andrew, Peterson, Jennifer, Lin, Jessica J., Gainor, Justin F., Messina, Rossella, Krueger, Elizabeth A., Thurm, Holger, Yeap, Beow Y.
Published in Journal of thoracic oncology

Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model

by Dubois, Christophe, Panicot-Dubois, Laurence, Gainor, Justin F, Furie, Barbara C, Furie, Bruce
Published in The Journal of clinical investigation

Pharmacodynamic Biomarkers: Falling Short of the Mark?

by GAINOR, Justin F, LONGO, Dan L, CHABNER, Bruce A
Published in Clinical cancer research

P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer

by Katayama, Ryohei, Sakashita, Takuya, Yanagitani, Noriko, Ninomiya, Hironori, Horiike, Atsushi, Friboulet, Luc, Gainor, Justin F., Motoi, Noriko, Dobashi, Akito, Sakata, Seiji, Tambo, Yuichi, Kitazono, Satoru, Sato, Shigeo, Koike, Sumie, John Iafrate, A., Mino-Kenudson, Mari, Ishikawa, Yuichi, Shaw, Alice T., Engelman, Jeffrey A., Takeuchi, Kengo, Nishio, Makoto, Fujita, Naoya
Published in EBioMedicine

Alectinib Dose Escalation Reinduces Central Nervous System Responses in Patients with Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer Relapsing on Standard Dose Alec...

by Gainor, Justin F., Chi, Andrew S., Logan, Jennifer, Hu, Ranliang, Oh, Kevin S., Brastianos, Priscilla K., Shih, Helen A., Shaw, Alice T.
Published in Journal of thoracic oncology

Deep Learning to Estimate RECIST in Patients with NSCLC Treated with PD-1 Blockade

by Arbour, Kathryn C, Luu, Anh Tuan, Luo, Jia, Rizvi, Hira, Plodkowski, Andrew J, Sakhi, Mustafa, Huang, Kevin B, Digumarthy, Subba R, Ginsberg, Michelle S, Girshman, Jeffrey, Kris, Mark G, Riely, Gregory J, Yala, Adam, Gainor, Justin F, Barzilay, Regina, Hellmann, Matthew D
Published in Cancer discovery