Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay

by Aviner, Ranen, Frydman, Judith
Published in Cold Spring Harbor perspectives in biology

4.0-Å resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

by Cong, Yao, Baker, Matthew L, Jakana, Joanita, Woolford, David, Miller, Erik J, Reissmann, Stefanie, Kumar, Ramya N, Redding-Johanson, Alyssa M, Batth, Tanveer S, Mukhopadhyay, Aindrila, Ludtke, Steven J, Frydman, Judith, Chiu, Wah
Published in Proceedings of the National Academy of Sciences - PNAS

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

by Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Published in eLife

Proteostasis Function and Disfunction: The Folding Machines that Maintain Proteome Health

by Frydman, Judith
Published in Biophysical journal

Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle

by Cong, Yao, Schröder, Gunnar F, Meyer, Anne S, Jakana, Joanita, Ma, Boxue, Dougherty, Matthew T, Schmid, Michael F, Reissmann, Stefanie, Levitt, Michael, Ludtke, Steven L, Frydman, Judith, Chiu, Wah
Published in The EMBO journal

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

by Galaz-Montoya, Jesús G., Shahmoradian, Sarah H., Shen, Koning, Frydman, Judith, Chiu, Wah
Published in Communications biology

Identification of the TRiC/CCT Substrate Binding Sites Uncovers the Function of Subunit Diversity in Eukaryotic Chaperonins

by Spiess, Christoph, Miller, Erik J., McClellan, Amie J., Frydman, Judith
Published in Molecular cell

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

by Sontag, Emily M., Joachimiak, Lukasz A., Tan, Zhiqun, Tomlinson, Anthony, Housman, David E., Glabe, Charles G., Potkin, Steven G., Frydman, Judith, Thompson, Leslie M.
Published in Proceedings of the National Academy of Sciences - PNAS

The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation

by Dalton, Kevin M, Frydman, Judith, Pande, Vijay S
Published in PloS one

TRiC's tricks inhibit huntingtin aggregation

by Shahmoradian, Sarah H, Galaz-Montoya, Jesus G, Schmid, Michael F, Cong, Yao, Ma, Boxue, Spiess, Christoph, Frydman, Judith, Ludtke, Steven J, Chiu, Wah
Published in eLife

Misfolded proteins partition between two distinct quality control compartments

by Frydman, Judith, Kaganovich, Daniel, Kopito, Ron
Published in Nature

Principles of Cotranslational Ubiquitination and Quality Control at the Ribosome

by Duttler, Stefanie, Pechmann, Sebastian, Frydman, Judith
Published in Molecular cell

Human transdifferentiated neurons reveal lysosomal repair deficits in Alzheimer's disease

by Chou, Ching-Chieh, Frydman, Judith
Published in Molecular genetics and metabolism

Cryo-EM Structure of a Group II Chaperonin in the Prehydrolysis ATP-Bound State Leading to Lid Closure

by Zhang, Junjie, Ma, Boxue, DiMaio, Frank, Douglas, Nicholai R., Joachimiak, Lukasz A., Baker, David, Frydman, Judith, Levitt, Michael, Chiu, Wah
Published in Structure (London)

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90

by Franzosa, Eric A, Albanèse, Véronique, Frydman, Judith, Xia, Yu, McClellan, Amie J
Published in PloS one

Closing the Folding Chamber of the Eukaryotic Chaperonin Requires the Transition State of ATP Hydrolysis

by Meyer, Anne S., Gillespie, Joel R., Walther, Dirk, Millet, Ian S., Doniach, Sebastian, Frydman, Judith
Published in Cell

Mechanism of nucleotide sensing in group II chaperonins

by Pereira, Jose H, Ralston, Corie Y, Douglas, Nicholai R, Kumar, Ramya, Lopez, Tom, McAndrew, Ryan P, Knee, Kelly M, King, Jonathan A, Frydman, Judith, Adams, Paul D
Published in The EMBO journal

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

by Gestaut, Daniel, Limatola, Antonio, Joachimiak, Lukasz, Frydman, Judith
Published in Current opinion in structural biology

Hsp110 Cooperates with Different Cytosolic HSP70 Systems in a Pathway for de Novo Folding

by Yam, Alice Yen-Wen, Albanèse, Véronique, Lin, Hen-Tzu Jill, Frydman, Judith
Published in The Journal of biological chemistry

The Machines that Fold Proteins in the Eukaryotic Cytosol

by Frydman, Judith
Published in Biophysical journal