Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

by Levina, Aleksandra, Fleming, Kaelin D, Burke, John E, Leonard, Thomas A
Published in Nature communications

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

by Choi, Yong Mi, Ajjaji, Dalila, Fleming, Kaelin D, Borbat, Peter P, Jenkins, Meredith L, Moeller, Brandon E, Fernando, Shaveen, Bhatia, Surita R, Freed, Jack H, Burke, John E, Thiam, Abdou Rachid, Airola, Michael V
Published in Nature communications

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

by Rathinaswamy, Manoj K., Fleming, Kaelin D., Dalwadi, Udit, Pardon, Els, Harris, Noah J., Yip, Calvin K., Steyaert, Jan, Burke, John E.
Published in Structure (London)

The middle lipin domain adopts a membrane-binding dimeric protein fold

by Gu, Weijing, Gao, Shujuan, Wang, Huan, Fleming, Kaelin D, Hoffmann, Reece M, Yang, Jong Won, Patel, Nimi M, Choi, Yong Mi, Burke, John E, Reue, Karen, Airola, Michael V
Published in Nature communications

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

by Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E
Published in eLife

Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation

by Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D, Stariha, Jordan T B, Pardon, Els, Steyaert, Jan, Burke, John E, Leonard, Thomas A
Published in Proceedings of the National Academy of Sciences - PNAS

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

by Pokorny, Daniel, Truebestein, Linda, Fleming, Kaelin D., Burke, John E., Leonard, Thomas A.
Published in The Journal of biological chemistry

Biochemical Characterization of the TINTIN Module of the NuA4 Complex Reveals Allosteric Regulation of Nucleosome Interaction

by Dalwadi, Udit, Corrado, Elaina, Fleming, Kaelin D., Moeller, Brandon E., Nam, Sung-Eun, Burke, John E., Yip, Calvin K.
Published in Molecular and cellular biology

Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex

by Harris, Noah J., Jenkins, Meredith L., Dalwadi, Udit, Fleming, Kaelin D., Nam, Sung-Eun, Parson, Matthew A.H., Yip, Calvin K., Burke, John E.
Published in Journal of molecular biology

Structure of autoinhibited Akt1 reveals mechanism of PIP 3 -mediated activation

by Truebestein, Linda, Hornegger, Harald, Anrather, Dorothea, Hartl, Markus, Fleming, Kaelin D, Stariha, Jordan T B, Pardon, Els, Steyaert, Jan, Burke, John E, Leonard, Thomas A
Published in Proceedings of the National Academy of Sciences - PNAS

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

by Rathinaswamy, Manoj K., Dalwadi, Udit, Fleming, Kaelin D., Adams, Carson, Stariha, Jordan T. B., Pardon, Els, Baek, Minkyung, Vadas, Oscar, DiMaio, Frank, Steyaert, Jan, Hansen, Scott D., Yip, Calvin K., Burke, John E.
Published in Science advances

The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity

by Jenkins, Meredith L, Harris, Noah J, Dalwadi, Udit, Fleming, Kaelin D, Ziemianowicz, Daniel S, Rafiei, Atefeh, Martin, Emily M, Schriemer, David C, Yip, Calvin K, Burke, John E
Published in Communications biology

Disease-related mutations in PI3K[gamma] disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

by Rathinaswamy, Manoj K, Gaieb, Zied, Fleming, Kaelin D, Borsari, Chiara, Harris, Noah J, Moeller, Brandon E, Wymann, Matthias P, Amaro, Rommie E, Burke, John E
Published in eLife

Further evidence supporting the use of sodium oxybate for the treatment of cataplexy: a double-blind, placebo-controlled study in 228 patients

by Xyrem ® International Study Group
Published in Sleep medicine

Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo: Clearwater Beach, FL, USA. 9-11 June 2016

by Velraja, Supriya, Alencar, Michelle, Durkalec-Michalski, Krzysztof, Jeszka, Jan, de Jesus Ferreira, Amanda Maria, Lieb, Allison E., Mullen, Katie A., Eckerson, Joan M., Forsse, Jeffrey, Tinsley, Grant, Spillane, Mike, Jagim, A., Wright, G., de Souza, Daniel Costa, Browne, Rodrigo Alberto Vieira, Mathews, Suresh T., Holland, A. Maleah, Mumford, Petey W., Wilson, Jacob M., Roberts, Michael D., Trexler, Eric T., Hirsch, Katie R., Mock, Meredith G., Johnston, Carol, Pascoe, David D., Warning, Brooke, Peacock, Corey A., Ojalvo, Sara Perez, Komorowski, James, Norton, Layne, Gai, Chris, Donelson, Seth, Couvillion, Kaylee, Dolan, Jeff, Xing, Dante, Chernesky, Kyshia, Pellegrino, J., McFadden, B., Ordway, C., Stone, Jason D., Oliver, Jonathan M., Pellegrino, Joseph K., Walker, Alan J., Sanders, David J., McFadden, Bridget A., Ordway, Chris E., Bello, Marissa, Poyssick, Anthony J., Fragala, Maren S., Patel, Romil K., Newton, Annie, Young, Kaelin C., Silver, Tobin, Vargas, Leo, Tamayo, Armando, Antonio, Jose, Zavala, P., Fairman, Ciaran M., Hudson, Geoffrey M., Bergstrom, Haley, Oyharçabal, Sebastian, Johnson, Kelly E., Endito, Marvin R., Mermier, Christine M., Kerksick, Chad M., Linden, Melissa, Gills, Joshua L, Parker, Kimberly, Dobbins, Chris, Romer, Braden, Szymanski, David, Deemer, Sarah E., Kerksick, C., Stecker, R., Witherbee, K., Byrd, M. Travis, Bell, Zachary, Colas, Megan, Vansickle, Andrea, Slack, Grant, Ruffner, Kayla, Mendel, Ronald, Blue, Malia M. N., Roelofs, Erica J., Martinez, Nic, Hoover, Thomas H., Collins, P. B., Colletta, A., Jung, Y. P., Greenwood, M., Kreider, R. B., Urbina, Stacie, Bennett, Haley, Wilborn, Colin, Taylor, Lem, Cholewa, Jason M, Campbell, Bill, Rossi, Fabricio, O’Connor, A., Jung, Y. Peter
Published in Journal of the International Society of Sports Nutrition