Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors

by Shang, Xun, Marchioni, Fillipo, Evelyn, Chris R., Sipes, Nisha, Zhou, Xuan, Seibel, William, Wortman, Matthew, Zheng, Yi
Published in Proceedings of the National Academy of Sciences - PNAS

Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance

by Kesarwani, Meenu, Huber, Erika, Kincaid, Zachary, Evelyn, Chris R, Biesiada, Jacek, Rance, Mark, Thapa, Mahendra B, Shah, Neil P, Meller, Jarek, Zheng, Yi, Azam, Mohammad
Published in Scientific reports

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling

by Evelyn, Chris R, Wade, Susan M, Wang, Qin, Wu, Mei, Iñiguez-Lluhí, Jorge A, Merajver, Sofia D, Neubig, Richard R
Published in Molecular cancer therapeutics

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

by Evelyn, Chris R., Bell, Jessica L., Ryu, Jenny G., Wade, Susan M., Kocab, Andrew, Harzdorf, Nicole L., Hollis Showalter, H.D., Neubig, Richard R., Larsen, Scott D.
Published in Bioorganic & medicinal chemistry letters

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

by Aittaleb, Mohamed, Gao, Guang, Evelyn, Chris R., Neubig, Richard R., Tesmer, John J.G.
Published in Cellular signalling

Combined Rational Design and a High Throughput Screening Platform for Identifying Chemical Inhibitors of a Ras-activating Enzyme

by Evelyn, Chris R., Biesiada, Jacek, Duan, Xin, Tang, Hong, Shang, Xun, Papoian, Ruben, Seibel, William L., Nelson, Sandra, Meller, Jaroslaw, Zheng, Yi
Published in The Journal of biological chemistry

Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

by Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J.G
Published in Science (American Association for the Advancement of Science)

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

by Shang, Xun, Marchioni, Fillipo, Sipes, Nisha, Evelyn, Chris R., Jerabek-Willemsen, Moran, Duhr, Stefan, Seibel, William, Wortman, Matthew, Zheng, Yi
Published in Chemistry & biology

Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1

by Evelyn, Chris R., Duan, Xin, Biesiada, Jacek, Seibel, William L., Meller, Jaroslaw, Zheng, Yi
Published in Chemistry & biology

High-Throughput Screening for Small-Molecule Inhibitors of LARG-Stimulated RhoA Nucleotide Binding via a Novel Fluorescence Polarization Assay

by Evelyn, Chris R., Ferng, Timothy, Rojas, Rafael J., Larsen, Martha J., Sondek, John, Neubig, Richard R.
Published in SLAS discovery

Structure of G[alpha]q-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

by Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J G
Published in Science (American Association for the Advancement of Science)

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks

by Evelyn, Chris R, Lisabeth, Erika M, Wade, Susan M, Haak, Andrew J, Johnson, Craig N, Lawlor, Elizabeth R, Neubig, Richard R
Published in Microarrays (Basel, Switzerland)

Structure of$\text{G}\alpha _{\text{q}}-\text{p}63\text{RhoGEF}-\text{RhoA}$Complex Reveals a Pathway for the Activation of RhoA by GPCRs

by Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R., Vettel, Christiane, Baltus, Doris, Evelyn, Chris R., Neubig, Richard R., Wieland, Thomas, Tesmer, John J. G.
Published in Science (American Association for the Advancement of Science)

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

by Lutz, Susanne, Shankaranarayanan, Aruna, Coco, Cassandra, Ridilla, Marc, Nance, Mark R, Vettel, Christiane, Baltus, Doris, Evelyn, Chris R, Neubig, Richard R, Wieland, Thomas, Tesmer, John J G
Published in Science (American Association for the Advancement of Science)

The antimicrobial potential of Streptomyces from insect microbiomes

by Chevrette, Marc G, Carlson, Caitlin M, Ortega, Humberto E, Thomas, Chris, Ananiev, Gene E, Barns, Kenneth J, Book, Adam J, Cagnazzo, Julian, Carlos, Camila, Flanigan, Will, Grubbs, Kirk J, Horn, Heidi A, Hoffmann, F Michael, Klassen, Jonathan L, Knack, Jennifer J, Lewin, Gina R, McDonald, Bradon R, Muller, Laura, Melo, Weilan G P, Pinto-Tomás, Adrián A, Schmitz, Amber, Wendt-Pienkowski, Evelyn, Wildman, Scott, Zhao, Miao, Zhang, Fan, Bugni, Tim S, Andes, David R, Pupo, Monica T, Currie, Cameron R
Published in Nature communications

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

by de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul
Published in Cell stem cell

IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase–associated lipocalin during acute kidney injury

by Skrypnyk, Nataliya I., Gist, Katja M., Okamura, Kayo, Montford, John R., You, Zhiying, Yang, Haichun, Moldovan, Radu, Bodoni, Evelyn, Blaine, Judith T., Edelstein, Charles L., Soranno, Danielle E., Kirkbride-Romeo, Lara A., Griffin, Benjamin R., Altmann, Chris, Faubel, Sarah
Published in Kidney international

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

by Tacconelli, Evelina, Carrara, Elena, Savoldi, Alessia, Harbarth, Stephan, Mendelson, Marc, Monnet, Dominique L, Pulcini, Céline, Kahlmeter, Gunnar, Kluytmans, Jan, Carmeli, Yehuda, Ouellette, Marc, Outterson, Kevin, Patel, Jean, Cavaleri, Marco, Cox, Edward M, Houchens, Chris R, Grayson, M Lindsay, Hansen, Paul, Singh, Nalini, Theuretzbacher, Ursula, Magrini, Nicola, Aboderin, Aaron Oladipo, Al-Abri, Seif Salem, Awang Jalil, Nordiah, Benzonana, Nur, Bhattacharya, Sanjay, Brink, Adrian John, Burkert, Francesco Robert, Cars, Otto, Cornaglia, Giuseppe, Dyar, Oliver James, Friedrich, Alex W, Gales, Ana C, Gandra, Sumanth, Giske, Christian Georg, Goff, Debra A, Goossens, Herman, Gottlieb, Thomas, Guzman Blanco, Manuel, Hryniewicz, Waleria, Kattula, Deepthi, Jinks, Timothy, Kanj, Souha S, Kerr, Lawrence, Kieny, Marie-Paule, Kim, Yang Soo, Kozlov, Roman S, Labarca, Jaime, Laxminarayan, Ramanan, Leder, Karin, Leibovici, Leonard, Levy-Hara, Gabriel, Littman, Jasper, Malhotra-Kumar, Surbhi, Manchanda, Vikas, Moja, Lorenzo, Ndoye, Babacar, Pan, Angelo, Paterson, David L, Paul, Mical, Qiu, Haibo, Ramon-Pardo, Pilar, Rodríguez-Baño, Jesús, Sanguinetti, Maurizio, Sengupta, Sharmila, Sharland, Mike, Si-Mehand, Massinissa, Silver, Lynn L, Song, Wonkeung, Steinbakk, Martin, Thomsen, Jens, Thwaites, Guy E, van der Meer, Jos WM, Van Kinh, Nguyen, Vega, Silvio, Villegas, Maria Virginia, Wechsler-Fördös, Agnes, Wertheim, Heiman Frank Louis, Wesangula, Evelyn, Woodford, Neil, Yilmaz, Fidan O, Zorzet, Anna
Published in The Lancet infectious diseases

Where and with whom does a brief social-belonging intervention promote progress in college?

by Walton, Gregory M, Murphy, Mary C, Logel, Christine, Yeager, David S, Goyer, J Parker, Brady, Shannon T, Emerson, Katherine T U, Paunesku, David, Fotuhi, Omid, Blodorn, Alison, Boucher, Kathryn L, Carter, Evelyn R, Gopalan, Maithreyi, Henderson, Amy, Kroeper, Kathryn M, Murdock-Perriera, Lisel Alice, Reeves, Stephanie L, Ablorh, Tsotso T, Ansari, Shahana, Chen, Susie, Fisher, Peter, Galvan, Manuel, Gilbertson, Madison Kawakami, Hulleman, Chris S, Le Forestier, Joel M, Lok, Christopher, Mathias, Katie, Muragishi, Gregg A, Netter, Melanie, Ozier, Elise, Smith, Eric N, Thoman, Dustin B, Williams, Heidi E, Wilmot, Matthew O, Hartzog, Cassie, Li, X Alice, Krol, Natasha
Published in Science (American Association for the Advancement of Science)

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

by Howrigan, Daniel P., Abbott, Liam E., Tashman, Katherine, Singh, Tarjinder, Watts, Nick, Lal, Dennis, Hakonarson, Hakon, Weckhuysen, Sarah, Petrovski, Slavé, Cossette, Patrick, Cotsapas, Chris, De Jonghe, Peter, Guerrini, Renzo, Marson, Anthony G., Depondt, Chantal, Striano, Pasquale, Freyer, Catharine, Regan, Brigid M., Leu, Costin, Johns, Esther M.C., Macdonald, Alexandra, Bahlo, Melanie, Todaro, Marian, Stamberger, Hannah, Sadoway, Tara R., Kousiappa, Ioanna, Tanteles, George A., Štěrbová, Katalin, Kunz, Wolfram S., Zsurka, Gábor, Elger, Christian E., Rademacher, Michael, van Baalen, Andreas, von Spiczak, Sarah, Afawi, Zaid, Canavati, Christina, Kluger, Gerhard, Blatt, Ilan, Weber, Yvonne G., Wolking, Stefan, Rau, Sarah, Steinhoff, Bernhard J., Schulze-Bonhage, Andreas, Borggräfe, Ingo, Madeleyn, Rene, Kälviäinen, Reetta, Linnankivi, Tarja, Chung, Seo-Kyung, Balestrini, Simona, Braatz, Vera, Johnson, Michael R., Auce, Pauls, Sham, Pak C., Lui, Colin H.T., Doherty, Colin P., Shukralla, Arif, El-Naggar, Hany, Vari, Maria Stella, Salpietro, Vincenzo, Tinuper, Paolo, Gagliardi, Monica, Montomoli, Martino, Doccini, Viola, Inoue, Yushi, Yamakawa, Kazuhiro, Tumiene, Birute, Sadleir, Lynette G., Caglayan, S. Hande, Arslan, Mutluay, Yis, Uluc, Topaloglu, Pınar, Baykan, Betül, Salman, Barış, Haryanyan, Garen, Özkara, Çiğdem, Poduri, Annapurna, Shiedley, Beth R., Shain, Catherine, French, Jacqueline A., Kuzniecky, Ruben I., Hegde, Manu, Helbig, Katherine L., Piras, Federica, Reif, Andreas, McQuillin, Andrew, Johnstone, Mandy, Palotie, Aarno, Carvalho, Celia Barreto, Achtyes, Eric D., Azevedo, Maria Helena, Kotov, Roman, Lehrer, Douglas S., Marder, Stephen R., Medeiros, Helena, Morley, Christopher P., Rapaport, Mark H., Knowles, James A., McCarroll, Steven A., Lowenstein, Daniel H., Goldstein, David B.
Published in American journal of human genetics