Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

by Scriba, Thomas J, Penn-Nicholson, Adam, Shankar, Smitha, Hraha, Tom, Thompson, Ethan G, Sterling, David, Nemes, Elisa, Darboe, Fatoumatta, Suliman, Sara, Amon, Lynn M, Mahomed, Hassan, Erasmus, Mzwandile, Whatney, Wendy, Johnson, John L, Boom, W Henry, Hatherill, Mark, Valvo, Joe, De Groote, Mary Ann, Ochsner, Urs A, Aderem, Alan, Hanekom, Willem A, Zak, Daniel E
Published in PLoS pathogens

IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort

by Spracklen, Timothy F, Mendelsohn, Simon C, Butters, Claire, Facey-Thomas, Heidi, Stander, Raphaella, Abrahams, Debbie, Erasmus, Mzwandile, Baguma, Richard, Day, Jonathan, Scott, Christiaan, Zühlke, Liesl J, Kassiotis, George, Scriba, Thomas J, Webb, Kate
Published in Frontiers in immunology

Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

by Kotze, Leigh Ann, van der Spuy, Gian, Leonard, Bryan, Penn-Nicholson, Adam, Musvosvi, Munyaradzi, McAnda, Shirley, Malherbe, Stephanus T, Erasmus, Mzwandile, Scriba, Thomas, Koegelenberg, Coenraad F N, Allwood, Brian W, Walzl, Gerhard, du Plessis, Nelita
Published in Frontiers in immunology

Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults

by Baguma, Richard, Mbandi, Stanley Kimbung, Rodo, Miguel J, Erasmus, Mzwandile, Day, Jonathan, Makhethe, Lebohang, de Kock, Marwou, van Rooyen, Michele, Stone, Lynnett, Bilek, Nicole, Steyn, Marcia, Africa, Hadn, Darboe, Fatoumatta, Chegou, Novel N, Tromp, Gerard, Walzl, Gerhard, Hatherill, Mark, Penn-Nicholson, Adam, Scriba, Thomas J
Published in Frontiers in immunology

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population

by Baguma, Richard, Penn-Nicholson, Adam, Smit, Erica, Erasmus, Mzwandile, Day, Jonathan, Makhethe, Lebohang, de Kock, Marwou, Hughes, E Jane, van Rooyen, Michele, Pienaar, Bernadette, Stone, Lynnett, Hanekom, Willem, Brennan, Michael J, Wallis, Robert S, Hatherill, Mark, Scriba, Thomas J
Published in PloS one

Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCR

by Mendelsohn, Simon C, Mbandi, Stanley Kimbung, Fiore-Gartland, Andrew, Penn-Nicholson, Adam, Musvosvi, Munyaradzi, Mulenga, Humphrey, Fisher, Michelle, Hadley, Katie, Erasmus, Mzwandile, Nombida, Onke, Tameris, Michèle, Walzl, Gerhard, Naidoo, Kogieleum, Churchyard, Gavin, Hatherill, Mark, Scriba, Thomas J
Published in Communications medicine

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

by Zak, Daniel E, PhD, Penn-Nicholson, Adam, PhD, Scriba, Thomas J, PhD, Thompson, Ethan, PhD, Suliman, Sara, PhD, Amon, Lynn M, PhD, Mahomed, Hassan, MD, Erasmus, Mzwandile, BSc, Whatney, Wendy, BScHons, Hussey, Gregory D, Prof, Abrahams, Deborah, DipMT, Kafaar, Fazlin, DipNur, Hawkridge, Tony, FCPHM, Verver, Suzanne, PhD, Hughes, E Jane, BScHons, Ota, Martin, MD, Sutherland, Jayne, PhD, Howe, Rawleigh, MD, Dockrell, Hazel M, Prof, Boom, W Henry, Prof, Thiel, Bonnie, MS, Ottenhoff, Tom H M, Prof, Mayanja-Kizza, Harriet, Prof, Crampin, Amelia C, FFPHM, Downing, Katrina, PhD, Hatherill, Mark, MD, Valvo, Joe, BS, Shankar, Smitha, MS, Parida, Shreemanta K, MD, Kaufmann, Stefan H E, Prof, Walzl, Gerhard, Prof, Aderem, Alan, PhD, Hanekom, Willem A, Prof
Published in The Lancet (British edition)

Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

by Suliman, Sara, Thompson, Ethan G, Sutherland, Jayne, Weiner, 3rd, January, Ota, Martin O C, Shankar, Smitha, Penn-Nicholson, Adam, Thiel, Bonnie, Erasmus, Mzwandile, Maertzdorf, Jeroen, Duffy, Fergal J, Hill, Philip C, Hughes, E Jane, Stanley, Kim, Downing, Katrina, Fisher, Michelle L, Valvo, Joe, Parida, Shreemanta K, van der Spuy, Gian, Tromp, Gerard, Adetifa, Ifedayo M O, Donkor, Simon, Howe, Rawleigh, Mayanja-Kizza, Harriet, Boom, W Henry, Dockrell, Hazel M, Ottenhoff, Tom H M, Hatherill, Mark, Aderem, Alan, Hanekom, Willem A, Scriba, Thomas J, Kaufmann, Stefan H E, Zak, Daniel E, Walzl, Gerhard
Published in American journal of respiratory and critical care medicine

Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection

by Nemes, Elisa, Rozot, Virginie, Geldenhuys, Hennie, Bilek, Nicole, Mabwe, Simbarashe, Abrahams, Deborah, Makhethe, Lebohang, Erasmus, Mzwandile, Keyser, Alana, Toefy, Asma, Cloete, Yolundi, Ratangee, Frances, Blauenfeldt, Thomas, Ruhwald, Morten, Walzl, Gerhard, Smith, Bronwyn, Loxton, Andre G, Hanekom, Willem A, Andrews, Jason R, Lempicki, Maria D, Ellis, Ruth, Ginsberg, Ann M, Hatherill, Mark, Scriba, Thomas J
Published in American journal of respiratory and critical care medicine

Biomarker-guided tuberculosis preventive therapy (CORTIS): a randomised controlled trial

by Scriba, Thomas J, Fiore-Gartland, Andrew, Borate, Bhavesh, Mendelsohn, Simon C, Hadley, Katie, Hikuam, Chris, Kaskar, Masooda, Bilek, Nicole, Self, Steven, Sumner, Tom, White, Richard G, Jaxa, Lungisa, Raphela, Rodney, Brumskine, William, Hiemstra, Andriëtte, Malherbe, Stephanus T, Naidoo, Kogieleum, Churchyard, Gavin, Hatherill, Mark, Baepanye, Kesenogile, Baepanye, Tshepiso, Clarke, Ken, Collignon, Marelize, Dlamini, Audrey, Eyre, Candice, Fikizolo, Moogo, Goliath, Thelma, Malefo-Grootboom, Shirley, Janse van Rensburg, Elba, Janse van Rensburg, Bonita, Kock, Adrianne, Lakhi, Aneessa, Langa, Nondumiso, Mabasa, Immaculate, Mabe, Dorah, Mabuza, Nkosinathi, Majola, Molly, Makhubalo, Blossom, Malay, Vernon, Market, Juanita, Mbipa, Nontsikelelo, Mmotsa, Tsiamo, Modipa, Sylvester, Moswegu, Palesa, Nel, Maryna, Ntamo, Bantubonke, Ntoahae, Lawerence, Ntshauba, Tedrius, Seabela, Letlhogonolo, Selepe, Pearl, Senne, Melissa, Serake, MG, Tshikovhi, Vincent, Tswaile, Lebogang, van Aswegen, Amanda, Mbata, Lungile, Takavamanya, Constance, Taljaard, Marthinette, Sayed, Sharfuddin, Nielson, Tanya, Ni Sein, Ni, Zulu, Mbali Ignatia, Maphanga, Nonhle Bridgette, Hlathi, Senzo Ralph, Gumede, Goodness Khanyisile, Jali, Zandile Patrica, Cwele, Thobelani, Dlamini, Celaphiwe, Nzimande, Sphelele Simo, Maharaj, Bhavna, Moosa, Atika, Corris, Cara-Mia, Luabeya, Angelique Kany Kany, Shenje, Justin, Rossouw, Susan, Braaf, Samentra, Carstens, Alida, Jansen, Ruwiyda, Mabwe, Simbarashe, Mulenga, Humphrey, Veldsman, Ashley, Makhete, Lebohgang, Steyn, Marcia, Buhlungu, Sivuyile, Erasmus, Margareth, Plaatjie, Patiswa, Veldtsman, Helen, Petersen, Christel, Moses, Miriam, Magawu, Nomsitho, Mactavie, Lauren, Filander, Elizabeth, Nqakala, Nambitha, Khoury, Justine, Kriel, Belinda, Tonsing, Susanne, Ahlers, Petri, Flinn, Marika, Chung, Eva, Sato, Alicia
Published in The Lancet infectious diseases

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

by Penn-Nicholson, Adam, Hraha, Thomas, Thompson, Ethan G, Sterling, David, Mbandi, Stanley Kimbung, Wall, Kirsten M, Fisher, Michelle, Suliman, Sara, Shankar, Smitha, Hanekom, Willem A, Janjic, Nebojsa, Hatherill, Mark, Kaufmann, Stefan H E, Sutherland, Jayne, Walzl, Gerhard, De Groote, Mary Ann, Ochsner, Urs, Zak, Daniel E, Scriba, Thomas J
Published in PLoS medicine

Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection

by Mpande, Cheleka A M, Musvosvi, Munyaradzi, Rozot, Virginie, Mosito, Boitumelo, Reid, Timothy D, Schreuder, Constance, Lloyd, Tessa, Bilek, Nicole, Huang, Huang, Obermoser, Gerlinde, Davis, Mark M, Ruhwald, Morten, Hatherill, Mark, Scriba, Thomas J, Nemes, Elisa
Published in American journal of respiratory and critical care medicine

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

by Mulenga, Humphrey, Musvosvi, Munyaradzi, Mendelsohn, Simon C, Penn-Nicholson, Adam, Kimbung Mbandi, Stanley, Fiore-Gartland, Andrew, Tameris, Michèle, Mabwe, Simbarashe, Africa, Hadn, Bilek, Nicole, Kafaar, Fazlin, Khader, Shabaana A, Carstens, Balie, Hadley, Katie, Hikuam, Chris, Erasmus, Mzwandile, Jaxa, Lungisa, Raphela, Rodney, Nombida, Onke, Kaskar, Masooda, Nicol, Mark P, Mbhele, Slindile, Van Heerden, Judi, Innes, Craig, Brumskine, William, Hiemstra, Andriëtte, Malherbe, Stephanus T, Hassan-Moosa, Razia, Walzl, Gerhard, Naidoo, Kogieleum, Churchyard, Gavin, Hatherill, Mark, Scriba, Thomas J
Published in American journal of respiratory and critical care medicine

Induction and Regulation of T-Cell Immunity by the Novel Tuberculosis Vaccine M72/AS01 in South African Adults

by DAY, Cheryl L, TAMERIS, Michele, BOLLAERTS, Anne, BOURGUIGNON, Patricia, COHEN, Joe, DEMOITIE, Marie-Ange, METTENS, Pascal, MORIS, Philippe, SADOFF, Jerald C, HAWKRIDGE, Anthony, HUSSEY, Gregory D, MAHOMED, Hassan, MANSOOR, Nazma, OFORI-ANYINAM, Opokua, HANEKOM, Willem A, VAN ROOYEN, Michele, DE KOCK, Marwou, GELDENHUYS, Hennie, ERASMUS, Mzwandile, MAKHETHE, Lebohang, JANE HUGHES, E, GELDERBLOEM, Sebastian
Published in American journal of respiratory and critical care medicine

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

by ABEL, Brian, TAMERIS, Michele, HAWKRIDGE, Anthony, VELDSMAN, Ashley, HATHERILL, Mark, SCHIRRU, Giulia, PAU, Maria Grazia, HENDRIKS, Jenny, WEVERLING, Gerrit Jan, GOUDSMIT, Jaap, SIZEMORE, Donata, BRUCE MCCLAIN, J, MANSOOR, Nazma, GOETZ, Margaret, GEARHART, Jacqueline, MAHOMED, Hassan, HUSSEY, Gregory D, SADOFF, Jerald C, HANEKOM, Willem A, GELDERBLOEM, Sebastian, HUGHES, Jane, ABRAHAMS, Deborah, MAKHETHE, Lebohang, ERASMUS, Mzwandile, DE KOCK, Marwou, VAN DER MERWE, Linda
Published in American journal of respiratory and critical care medicine

Diagnostic Accuracy of Early Secretory Antigenic Target-6-Free Interferon-gamma Release Assay Compared to QuantiFERON-TB Gold In-tube

by Nemes, Elisa, Abrahams, Deborah, Scriba, Thomas J, Ratangee, Frances, Keyser, Alana, Makhethe, Lebohang, Erasmus, Mzwandile, Mabwe, Simbarashe, Bilek, Nicole, Rozot, Virginie, Geldenhuys, Hennie, Hatherill, Mark, Lempicki, Maria D, Holm, Line Lindebo, Bogardus, Leah, Ginsberg, Ann M, Blauenfeldt, Thomas, Smith, Bronwyn, Ellis, Ruth D, Loxton, Andre G, Walzl, Gerhard, Andersen, Peter, Ruhwald, Morten
Published in Clinical infectious diseases

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

by Meier, Stuart, Seddon, James A, Maasdorp, Elizna, Kleynhans, Léanie, du Plessis, Nelita, Loxton, Andre G, Malherbe, Stephanus T, Zak, Daniel E, Thompson, Ethan, Duffy, Fergal J, Kaufmann, Stefan H E, Ottenhoff, Tom H M, Scriba, Thomas J, Suliman, Sara, Sutherland, Jayne S, Winter, Jill, Kuivaniemi, Helena, Walzl, Gerhard, Tromp, Gerard
Published in PloS one

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Rando...

by Nemes, Elisa, Hesseling, Anneke C, Tameris, Michele, Mauff, Katya, Downing, Katrina, Mulenga, Humphrey, Rose, Penelope, van der Zalm, Marieke, Mbaba, Sharon, Van As, Danelle, Hanekom, Willem A, Walzl, Gerhard, Scriba, Thomas J, McShane, Helen, Hatherill, Mark
Published in Clinical infectious diseases

Detection of Tuberculosis Recurrence, Diagnosis and Treatment Response by a Blood Transcriptomic Risk Signature in HIV-Infected Persons on Antiretroviral Therapy

by Darboe, Fatoumatta, Mbandi, Stanley Kimbung, Naidoo, Kogieleum, Yende-Zuma, Nonhlanhla, Lewis, Lara, Thompson, Ethan G, Duffy, Fergal J, Fisher, Michelle, Filander, Elizabeth, van Rooyen, Michele, Bilek, Nicole, Mabwe, Simbarashe, McKinnon, Lyle R, Chegou, Novel, Loxton, Andre, Walzl, Gerhard, Tromp, Gerard, Padayatchi, Nesri, Govender, Dhineshree, Hatherill, Mark, Karim, Salim Abdool, Zak, Daniel E, Penn-Nicholson, Adam, Scriba, Thomas J
Published in Frontiers in microbiology

The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014

by Brennan, Michael J, Tanner, Rachel, Morris, Sheldon, Scriba, Thomas J, Achkar, Jacqueline M, Zelmer, Andrea, Hokey, David A, Izzo, Angelo, Sharpe, Sally, Williams, Ann, Penn-Nicholson, Adam, Erasmus, Mzwandile, Stylianou, Elena, Hoft, Daniel F, McShane, Helen, Fletcher, Helen A
Published in Clinical and vaccine immunology