Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

by Do, Ron, Stitziel, Nathan O, Won, Hong-Hee, Jørgensen, Anders Berg, Duga, Stefano, Angelica Merlini, Pier, Kiezun, Adam, Farrall, Martin, Goel, Anuj, Zuk, Or, Guella, Illaria, Asselta, Rosanna, Lange, Leslie A, Peloso, Gina M, Auer, Paul L, Girelli, Domenico, Martinelli, Nicola, Farlow, Deborah N, DePristo, Mark A, Roberts, Robert, Stewart, Alexander F R, Saleheen, Danish, Danesh, John, Epstein, Stephen E, Sivapalaratnam, Suthesh, Hovingh, G Kees, Kastelein, John J, Samani, Nilesh J, Schunkert, Heribert, Erdmann, Jeanette, Shah, Svati H, Kraus, William E, Davies, Robert, Nikpay, Majid, Johansen, Christopher T, Wang, Jian, Hegele, Robert A, Hechter, Eliana, Marz, Winfried, Kleber, Marcus E, Huang, Jie, Johnson, Andrew D, Li, Mingyao, Burke, Greg L, Gross, Myron, Liu, Yongmei, Assimes, Themistocles L, Heiss, Gerardo, Lange, Ethan M, Folsom, Aaron R, Taylor, Herman A, Olivieri, Oliviero, Hamsten, Anders, Clarke, Robert, Reilly, Dermot F, Yin, Wu, Rivas, Manuel A, Donnelly, Peter, Rossouw, Jacques E, Psaty, Bruce M, Herrington, David M, Wilson, James G, Rich, Stephen S, Bamshad, Michael J, Tracy, Russell P, Cupples, L Adrienne, Rader, Daniel J, Reilly, Muredach P, Spertus, John A, Cresci, Sharon, Hartiala, Jaana, Tang, W H Wilson, Hazen, Stanley L, Allayee, Hooman, Reiner, Alex P, Carlson, Christopher S, Kooperberg, Charles, Jackson, Rebecca D, Boerwinkle, Eric, Lander, Eric S, Schwartz, Stephen M, Siscovick, David S, McPherson, Ruth, Tybjaerg-Hansen, Anne, Abecasis, Goncalo R, Watkins, Hugh, Nickerson, Deborah A, Ardissino, Diego, Sunyaev, Shamil R, O'Donnell, Christopher J, Altshuler, David, Gabriel, Stacey, Kathiresan, Sekar
Published in Nature (London)

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

by Fu, Wenqing, O'Connor, Timothy D, Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M, Gabriel, Stacey, Rieder, Mark J, Altshuler, David, Shendure, Jay, Nickerson, Deborah A, Bamshad, Michael J, Akey, Joshua M
Published in Nature (London)

Health Outcomes After Stopping Conjugated Equine Estrogens Among Postmenopausal Women With Prior Hysterectomy: A Randomized Controlled Trial

by LaCroix, Andrea Z, Chlebowski, Rowan T, Manson, JoAnn E, Aragaki, Aaron K, Johnson, Karen C, Martin, Lisa, Margolis, Karen L, Stefanick, Marcia L, Brzyski, Robert, Curb, J. David, Howard, Barbara V, Lewis, Cora E, Wactawski-Wende, Jean, WHI Investigators, for the
Published in JAMA : the journal of the American Medical Association

Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in Postmenopausal Women

by Chlebowski, Rowan T, Anderson, Garnet L, Gass, Margery, Lane, Dorothy S, Aragaki, Aaron K, Kuller, Lewis H, Manson, JoAnn E, Stefanick, Marcia L, Ockene, Judith, Sarto, Gloria E, Johnson, Karen C, Wactawski-Wende, Jean, Ravdin, Peter M, Schenken, Robert, Hendrix, Susan L, Rajkovic, Aleksandar, Rohan, Thomas E, Yasmeen, Shagufta, Prentice, Ross L, WHI Investigators, for the
Published in JAMA : the journal of the American Medical Association

Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

by Lange, Leslie A., Schmidt, Ellen M., Bizon, Chris, Jun, Goo, Auer, Paul, Li, Kuo-ping, Locke, Adam, Rivas, Manuel A., Feitosa, Mary F., Zhang, Qunyuan, Huffman, Jennifer E., Crosby, Jacy, Robinson, Jennifer G., Crosslin, David R., Rosenthal, Elisabeth A., Tsai, Michael, Rieder, Mark J., Fox, Ervin R., van Duijn, Cornelia M., Taylor, Herman A., Loos, Ruth J.F., Ballantyne, Christie M., Reiner, Alexander P., Cupples, L. Adrienne, Kang, Hyun Min, Lettre, Guillaume, Rader, Daniel J., Reilly, Muredach P., Stoletzki, Nina, Barr, R. Graham, Benjamin, Emelia J., Carr, Jeff, Dupuis, Josée, Ellis, Jaclyn, Fornage, Myriam, Goff, David, Grody, Wayne, Heard-Costa, Nancy L., Levy, Daniel, Li, Dalin, Loria, Cay, Mackey, Rachel, Quinlan, Aaron R., Rice, Kenneth, Sanders, Jill P., Tracy, Russell P., Tsai, Michael Y., Wassel, Chrstina L., Watson, Karol, Wilson, Gregory, Wilson, James G., Zakai, Neil A., Nalls, Michael, Bamshad, Michael J., Accurso, Frank, Beaty, Terri, Caplan, Daniel, Chidekel, Aaron, Christiani, David C., De Paula, Alicia, Gutierrez, Hector, Hassoun, Paul M., Hiatt, Peter, Hummer, Laura K., Kim, Yoonhee, Lin, Xihong, Louie, Tin L., Mathias, Rasika A., McNamara, John, McNamara, Sharon, Nielson, Dennis, Orenstein, David, O’Sullivan, Brian, Passero, Mary Ann, Perkett, Elizabeth, Spencer, Terry, Tabor, Holly K., Weiss, Robert, Wigley, Fred, Wise, Robert A., Wurfel, Mark M., Eichler, Evan E., Fu, Wenqing, Smith, Joshua D., Tennessen, Jacob A., Peters, Ulrike, Brzyski, Robert, Curb, J. David, Eaton, Charles B., Heiss, Gerardo, Johnson, Karen C., Lasser, Norman, Lin, Dan-Yu, Logsdon, Benjamin A., Manson, JoAnn E., Martin, Lisa, Stein, Evan, Applebaum-Bowden, Deborah, Paltoo, Dina N., Sturcke, Anne
Published in American journal of human genetics

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

by Guo, Dong-chuan, Regalado, Ellen, Casteel, Darren E., Santos-Cortez, Regie L., Gong, Limin, Kim, Jeong Joo, Dyack, Sarah, Horne, S. Gabrielle, Chang, Guijuan, Jondeau, Guillaume, Boileau, Catherine, Coselli, Joseph S., Li, Zhenyu, Leal, Suzanne M., Shendure, Jay, Rieder, Mark J., Bamshad, Michael J., Nickerson, Deborah A., Kim, Choel, Milewicz, Dianna M.
Published in American journal of human genetics

Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure

by Pandey, Ambarish, MD, LaMonte, Michael, PhD, MPH, Klein, Liviu, MD, MS, Ayers, Colby, MS, Psaty, Bruce M., MD, PhD, Eaton, Charles B., MD, MS, Allen, Norrina B., PhD, de Lemos, James A., MD, Carnethon, Mercedes, PhD, Greenland, Philip, MD, Berry, Jarett D., MD, MS
Published in Journal of the American College of Cardiology

Model-based assessment of replicability for genome-wide association meta-analysis

by McGuire, Daniel, Jiang, Yu, Liu, Mengzhen, Weissenkampen, J Dylan, Eckert, Scott, Yang, Lina, Chen, Fang, Berg, Arthur, Vrieze, Scott, Jiang, Bibo, Li, Qunhua, Liu, Dajiang J
Published in Nature communications

Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer

by Chlebowski, Rowan T., Johnson, Karen C., Kooperberg, Charles, Pettinger, Mary, Wactawski-Wende, Jean, Rohan, Tom, Rossouw, Jacques, Lane, Dorothy, O’Sullivan, Mary Jo, Yasmeen, Shagufta, Hiatt, Robert A., Shikany, James M., Vitolins, Mara, Khandekar, Janu, Hubbell, F. Allan
Published in JNCI : Journal of the National Cancer Institute

Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial

by Chlebowski, Rowan T, Prof, Schwartz, Ann G, Prof, Wakelee, Heather, MD, Anderson, Garnet L, PhD, Stefanick, Marcia L, Prof, Manson, JoAnn E, Prof, Rodabough, Rebecca J, MS, Chien, Jason W, MD, Wactawski-Wende, Jean, Prof, Gass, Margery, MD, Kotchen, Jane Morley, Prof, Johnson, Karen C, Prof, O'Sullivan, Mary Jo, Prof, Ockene, Judith K, Prof, Chen, Chu, Prof, Hubbell, F Allan, Prof
Published in The Lancet (British edition)

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials

by Manson, JoAnn E, Chlebowski, Rowan T, Stefanick, Marcia L, Aragaki, Aaron K, Rossouw, Jacques E, Prentice, Ross L, Anderson, Garnet, Howard, Barbara V, Thomson, Cynthia A, LaCroix, Andrea Z, Wactawski-Wende, Jean, Jackson, Rebecca D, Limacher, Marian, Margolis, Karen L, Wassertheil-Smoller, Sylvia, Beresford, Shirley A, Cauley, Jane A, Eaton, Charles B, Gass, Margery, Hsia, Judith, Johnson, Karen C, Kooperberg, Charles, Kuller, Lewis H, Lewis, Cora E, Liu, Simin, Martin, Lisa W, Ockene, Judith K, O’Sullivan, Mary Jo, Powell, Lynda H, Simon, Michael S, Van Horn, Linda, Vitolins, Mara Z, Wallace, Robert B
Published in JAMA : the journal of the American Medical Association

Pathogenic Variants for Mendelian and Complex Traits in Exomes of 6,517 European and African Americans: Implications for the Return of Incidental Results

by Tabor, Holly K., Auer, Paul L., Jamal, Seema M., Chong, Jessica X., Yu, Joon-Ho, Gordon, Adam S., Graubert, Timothy A., O’Donnell, Christopher J., Rich, Stephen S., Nickerson, Deborah A., Bamshad, Michael J.
Published in American journal of human genetics

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

by Gordon, Adam S, Tabor, Holly K, Johnson, Andrew D, Snively, Beverly M, Assimes, Themistocles L, Auer, Paul L, Ioannidis, John P A, Peters, Ulrike, Robinson, Jennifer G, Sucheston, Lara E, Wang, Danxin, Sotoodehnia, Nona, Rotter, Jerome I, Psaty, Bruce M, Jackson, Rebecca D, Herrington, David M, O'Donnell, Christopher J, Reiner, Alexander P, Rich, Stephen S, Rieder, Mark J, Bamshad, Michael J, Nickerson, Deborah A
Published in Human molecular genetics

Trans-ethnic meta-analysis of white blood cell phenotypes

by Keller, Margaux F, Reiner, Alexander P, Okada, Yukinori, van Rooij, Frank J A, Johnson, Andrew D, Chen, Ming-Huei, Smith, Albert V, Morris, Andrew P, Tanaka, Toshiko, Ferrucci, Luigi, Zonderman, Alan B, Lettre, Guillaume, Harris, Tamara, Garcia, Melissa, Bandinelli, Stefania, Qayyum, Rehan, Yanek, Lisa R, Becker, Diane M, Becker, Lewis C, Kooperberg, Charles, Keating, Brendan, Reis, Jared, Tang, Hua, Boerwinkle, Eric, Kamatani, Yoichiro, Matsuda, Koichi, Kamatani, Naoyuki, Nakamura, Yusuke, Kubo, Michiaki, Liu, Simin, Dehghan, Abbas, Felix, Janine F, Hofman, Albert, Uitterlinden, André G, van Duijn, Cornelia M, Franco, Oscar H, Longo, Dan L, Singleton, Andrew B, Psaty, Bruce M, Evans, Michelle K, Cupples, L Adrienne, Rotter, Jerome I, O'Donnell, Christopher J, Takahashi, Atsushi, Wilson, James G, Ganesh, Santhi K, Nalls, Mike A
Published in Human molecular genetics

Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review

by Driban, Jeffrey B, Harkey, Matthew S, Barbe, Mary F, Ward, Robert J, MacKay, James W, Davis, Julie E, Lu, Bing, Price, Lori Lyn, Eaton, Charles B, Lo, Grace H, McAlindon, Timothy E
Published in BMC musculoskeletal disorders

Common and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project

by Johnsen, Jill M., Auer, Paul L., Morrison, Alanna C., Jiao, Shuo, Wei, Peng, Haessler, Jeffrey, Fox, Keolu, McGee, Sean R., Smith, Joshua D., Carlson, Christopher S., Smith, Nicholas, Boerwinkle, Eric, Kooperberg, Charles, Nickerson, Deborah A., Rich, Stephen S., Green, David, Peters, Ulrike, Cushman, Mary, Reiner, Alex P.
Published in Blood

Comparison of the Framingham and Reynolds Risk Scores for Global Cardiovascular Risk Prediction in the Multiethnic Women's Health Initiative

by COOK, Nancy R, PAYNTER, Nina P, EATON, Charles B, MANSON, Joann E, MARTIN, Lisa W, ROBINSON, Jennifer G, ROSSOUW, Jacques E, WASSERTHEIL-SMOLLER, Sylvia, RIDKER, Paul M
Published in Circulation (New York, N.Y.)

Relationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease

by Chomistek, Andrea K., ScD, Manson, JoAnn E., MD, DrPH, Stefanick, Marcia L., PhD, Lu, Bing, MD, DrPH, Sands-Lincoln, Megan, PhD, Going, Scott B., PhD, Garcia, Lorena, PhD, Allison, Matthew A., MD, Sims, Stacy T., PhD, LaMonte, Michael J., PhD, Johnson, Karen C., MD, Eaton, Charles B., MD
Published in Journal of the American College of Cardiology

Infertility and Risk of Heart Failure in the Women’s Health Initiative

by Lau, Emily S., Wang, Dongyu, Roberts, Mary, Taylor, Christy N., Murugappan, Gayathree, Shadyab, Aladdin H., Schnatz, Peter F., Farland, Leslie V., Wood, Malissa J., Scott, Nandita S., Eaton, Charles B., Ho, Jennifer E.
Published in Journal of the American College of Cardiology

Evaluation and Comparison of Food Records, Recalls, and Frequencies for Energy and Protein Assessment by Using Recovery Biomarkers

by PRENTICE, Ross L, MOSSAVAR-RAHMANI, Yasmin, THOMSON, Cynthia, JOHNSON, Karen C, OCKENE, Judy, SARTO, Gloria, HEISS, Gerardo, NEUHOUSER, Marian L, YING HUANG, VAN HORN, Linda, BERESFORD, Shirley A. A, CAAN, Bette, TINKER, Lesley, SCHOELLER, Dale, BINGHAM, Sheila, EATON, Charles B
Published in American journal of epidemiology