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Search Results - De-Hoyos, Cheryl L
Search Results - De-Hoyos, Cheryl L
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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
by
Shen, Wen
,
De Hoyos, Cheryl L
,
Migawa, Michael T
,
Vickers, Timothy A
,
Sun, Hong
,
Low, Audrey
,
Bell, 3rd, Thomas A
,
Rahdar, Meghdad
,
Mukhopadhyay, Swagatam
,
Hart, Christopher E
,
Bell, Melanie
,
Riney, Stan
,
Murray, Susan F
,
Greenlee, Sarah
,
Crooke, Rosanne M
,
Liang, Xue-Hai
,
Seth, Punit P
,
Crooke, Stanley T
Published in
Nature biotechnology
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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes
by
Liang, Xue-hai
,
Sun, Hong
,
Hsu, Chih-Wei
,
Nichols, Joshua G
,
Vickers, Timothy A
,
De Hoyos, Cheryl L
,
Crooke, Stanley T
Published in
Nucleic acids research
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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides
by
Anderson, Brooke A
,
Freestone, Graeme C
,
Low, Audrey
,
De-Hoyos, Cheryl L
,
III, William J Drury
,
Østergaard, Michael E
,
Migawa, Michael T
,
Fazio, Michael
,
Wan, W Brad
,
Berdeja, Andres
,
Scandalis, Eli
,
Burel, Sebastien A
,
Vickers, Timothy A
,
Crooke, Stanley T
,
Swayze, Eric E
,
Liang, Xuehai
,
Seth, Punit P
Published in
Nucleic acids research
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Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops
by
Shen, Wen
,
Sun, Hong
,
De Hoyos, Cheryl L
,
Bailey, Jeffrey K
,
Liang, Xue-Hai
,
Crooke, Stanley T
Published in
Nucleic acids research
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RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery
by
Lima, Walt F
,
De Hoyos, Cheryl L
,
Liang, Xue-hai
,
Crooke, Stanley T
Published in
Nucleic acids research
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Acute hepatotoxicity of 2′ fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins
by
Shen, Wen
,
De Hoyos, Cheryl L
,
Sun, Hong
,
Vickers, Timothy A
,
Liang, Xue-hai
,
Crooke, Stanley T
Published in
Nucleic acids research
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
by
Migawa, Michael T
,
Shen, Wen
,
Wan, W Brad
,
Vasquez, Guillermo
,
Oestergaard, Michael E
,
Low, Audrey
,
De Hoyos, Cheryl L
,
Gupta, Ruchi
,
Murray, Susan
,
Tanowitz, Michael
,
Bell, Melanie
,
Nichols, Joshua G
,
Gaus, Hans
,
Liang, Xue-Hai
,
Swayze, Eric E
,
Crooke, Stanley T
,
Seth, Punit P
Published in
Nucleic acids research
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Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity
by
Liang, Xue-hai
,
Nichols, Joshua G
,
De Hoyos, Cheryl L
,
Crooke, Stanley T
Published in
Nucleic acids research
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Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation
by
Shen, Wen
,
Liang, Xue-Hai
,
Sun, Hong
,
De Hoyos, Cheryl L
,
Crooke, Stanley T
Published in
PloS one
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