Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

by Lorendeau, Doriane, Rinaldi, Gianmarco, Boon, Ruben, Spincemaille, Pieter, Metzger, Kristine, Jäger, Christian, Christen, Stefan, Dong, Xiangyi, Kuenen, Sabine, Voordeckers, Karin, Verstreken, Patrik, Cassiman, David, Vermeersch, Pieter, Verfaillie, Catherine, Hiller, Karsten, Fendt, Sarah-Maria
Published in Metabolic engineering

Liver disease in cystic fibrosis presents as non-cirrhotic portal hypertension

by Witters, Peter, Libbrecht, Louis, Roskams, Tania, De Boeck, Kris, Dupont, Lieven, Proesmans, Marijke, Vermeulen, François, Maleux, Geert, Monbaliu, Diethard, Pirenne, Jacques, Cassiman, David
Published in Journal of cystic fibrosis

Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers

by Cassiman, David, Libbrecht, Louis, Desmet, Valeer, Denef, Carl, Roskams, Tania
Published in Journal of hepatology

Long-term follow-up in PMM2-CDG: are we ready to start treatment trials?

by Witters, Peter, Honzik, Tomas, Bauchart, Eric, Altassan, Ruqaiah, Pascreau, Tiffany, Bruneel, Arnaud, Vuillaumier, Sandrine, Seta, Nathalie, Borgel, Delphine, Matthijs, Gert, Jaeken, Jaak, Meersseman, Wouter, Cassiman, David, Pascale de, Lonlay, Morava, Eva
Published in Genetics in medicine

Long-term outcome of transjugular intrahepatic portosystemic shunt for portal hypertension in autosomal recessive polycystic kidney disease

by Verbeeck, Sarah, Mekahli, Djalila, Cassiman, David, Maleux, Geert, Witters, Peter
Published in Digestive and liver disease

Unusual yellow scaly colonic mucosal appearance: Tangier disease

by Struyve, Mathieu, Ferrante, Marc, van Overbeke, Lode, Meersseman, Wouter, Cassiman, David, Mortier, Leen
Published in Gastrointestinal endoscopy

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL

by Kampen, Kim R, Sulima, Sergey O, Verbelen, Benno, Girardi, Tiziana, Vereecke, Stijn, Rinaldi, Gianmarco, Verbeeck, Jelle, Op de Beeck, Joyce, Uyttebroeck, Anne, Meijerink, Jules P P, Moorman, Anthony V, Harrison, Christine J, Spincemaille, Pieter, Cools, Jan, Cassiman, David, Fendt, Sarah-Maria, Vermeersch, Pieter, De Keersmaecker, Kim
Published in Leukemia

Cost-Effectiveness Assessment of Orphan Drugs: A Scientific and Political Conundrum

by Simoens, Steven, Picavet, Eline, Dooms, Marc, Cassiman, David, Morel, Thomas
Published in Applied health economics and health policy

Uncovering monocyte transcription, functional and metabolic signatures in recovery and non-recovery ACLF patients

by de Azevedo, Rita Furtado Feio, Korf, Hannelie, Boesch, Markus, Radenkovic, Silvia, Wallays, Marie, Smets, Lena, Van Melkebeke, Lukas, Ghesquière, Bart, Cassiman, David, Meersseman, Philippe, Van Malenstein, Hannah, Nevens, Frederik, Laleman, Wim, Verbeek, Jef, van der Merwe, Schalk
Published in Journal of hepatology

CLINICAL AND BIOCHEMICAL FOOTPRINTS OF INHERITED METABOLIC DISORDERS: A LESSON FROM THE KNOWLEDGEBASE

by Ferreira, Carlos R., Cassiman, David, Garanto, Alejandro, Hoffmann, Georg F., Horvath, Gabriella A., Martinelli, Diego, Stowe, Robert M., van Karnebeek, Clara D.M., Blau, Nenad
Published in Molecular genetics and metabolism

Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin

by Spincemaille, Pieter, Chandhok, Gursimran, Zibert, Andree, Schmidt, Hartmut, Verbeek, Jef, Chaltin, Patrick, Cammue, Bruno P, Cassiman, David, Thevissen, Karin
Published in Microbial cell

Distinct immunometabolic signatures in circulating immune cells define disease outcomes in acute-on-chronic liver failure

by de Azevedo, Rita Furtado Feio, Boesch, Markus, Radenkovic, Silvia, Wallays, Marie, Van Melkebeke, Lukas, Boeckx, Bram, Philips, Gino, Smets, Lena, Laleman, Wim, Meersseman, Philippe, Wilmer, Alexander, Cassiman, David, Van Malenstein, Hannah, Clària, Joan, Nevens, Frederik, Verbeek, Jef, Moreau, Richard, Arroyo, Vicente, Lambrechts, Dieter, Ghesquière, Bart, Korf, Hannelie, van der Merwe, Schalk
Published in Journal of hepatology

SAT-390 - Distinct immunometabolic signatures in circulating immune cells define disease outcomes in acute-on-chronic liver failure

by de Azevedo, Rita Furtado Feio, Boesch, Markus, Radenkovic, Silvia, Wallays, Marie, Van Melkebeke, Lukas, Boeckx, Bram, Philips, Gino, Smets, Lena, Laleman, Wim, Meersseman, Philippe, Wilmer, Alexander, Cassiman, David, Van Malenstein, Hannah, Clària, Joan, Nevens, Frederik, Verbeek, Jef, Moreau, Richard, Arroyo, Vicente, Lambrechts, Dieter, Ghesquière, Bart, Korf, Hannelie, van der Merwe, Schalk
Published in Journal of hepatology

Cause of death in patients with chronic visceral and chronic neurovisceral acid sphingomyelinase deficiency (Niemann-Pick disease type B and B variant): Literature review and repor...

by Cassiman, David, Packman, Seymour, Bembi, Bruno, Turkia, Hadhami Ben, Al-Sayed, Moeenaldeen, Schiff, Manuel, Imrie, Jackie, Mabe, Paulina, Takahashi, Tsutomu, Mengel, Karl Eugen, Giugliani, Roberto, Cox, Gerald F.
Published in Molecular genetics and metabolism

Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease

by Magro Dos Reis, Inês, Houben, Tom, Oligschläger, Yvonne, Bücken, Leoni, Steinbusch, Hellen, Cassiman, David, Lütjohann, Dieter, Westerterp, Marit, Prickaerts, Jos, Plat, Jogchum, Shiri-Sverdlov, Ronit
Published in Journal of lipid research

Endoscopic resection of ampullary lesions: a single-center 8-year retrospective cohort study of 91 patients with long-term follow-up

by Laleman, Wim, Verreth, Annelies, Topal, Baki, Aerts, Raymond, Komuta, Mina, Roskams, Tania, Van der Merwe, Schalk, Cassiman, David, Nevens, Frederik, Verslype, Chris, Van Steenbergen, Werner
Published in Surgical endoscopy

SGLT2 Inhibitors for Treatment of Refractory Hypomagnesemia: A Case Report of 3 Patients

by Ray, Evan C., Boyd-Shiwarski, Cary R., Liu, Pengfei, Novacic, Danica, Cassiman, David
Published in Kidney medicine

A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge

by Ailliet, Scott, Vandenberghe, Rik, Schiemsky, Toon, Van Overbeke, Lode, Demaerel, Philippe, Meersseman, Wouter, Cassiman, David, Vermeersch, Pieter
Published in Biochemia medica

Overlapping and divergent hepatic and lipoprotein phenotypes in untreated adults with acid sphingomyelinase deficiency versus untreated adults with Gaucher disease from two pivotal...

by Cassiman, David, Mistry, Pramod K., Jones, Simon A., Lachmann, Robin, Lukina, Elena, Prada, Carlos E., Thurberg, Beth L., Wasserstein, Melissa P., Foster, Meredith C., Patel, Reema M., Ribes, Manuel, Underhill, Lisa H., Peterschmitt, M. Judith
Published in Molecular genetics and metabolism

Abstract 1789: Repurposing the anti-depressant sertraline to target serine/glycine synthesis addicted cancer

by Geeraerts, Shauni L., Kampen, Kim R., Rinaldi, Gianmarco, Gupta, Purvi, Planque, Mélanie, De Cremer, Kaat, De Brucker, Katrijn, Vereecke, Stijn, Verbelen, Benno, Vermeersch, Pieter, Cassiman, David, Fendt, Sarah-Maria, Voet, Arnout, Cammue, Bruno P.A., Thevissen, Karin, De Keersmaecker, Kim
Published in Cancer research (Chicago, Ill.)