Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

by Whitehouse, Andrew J, Thomas, Sherine E, Brown, Karen P, Fanourakis, Alexander, Chan, Daniel S.-H, Libardo, M. Daben J, Mendes, Vitor, Boshoff, Helena I. M, Floto, R. Andres, Abell, Chris, Blundell, Tom L, Coyne, Anthony G
Published in Journal of medicinal chemistry

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection

by Péan, Claire B, Schiebler, Mark, Tan, Sharon W S, Sharrock, Jessica A, Kierdorf, Katrin, Brown, Karen P, Maserumule, M Charlotte, Menezes, Shinelle, Pilátová, Martina, Bronda, Kévin, Guermonprez, Pierre, Stramer, Brian M, Andres Floto, R, Dionne, Marc S
Published in Nature communications

Increased Virulence of Outer Membrane Porin Mutants of Mycobacterium abscessus

by de Moura, Vinicius C. N., Verma, Deepshikha, Everall, Isobel, Brown, Karen P., Belardinelli, Juan M., Shanley, Crystal, Stapleton, Megan, Parkhill, Julian, Floto, R. Andres, Ordway, Diane J., Jackson, Mary
Published in Frontiers in microbiology

Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design

by Thomas, Sherine E, McCarthy, William J, El Bakali, Jamal, Brown, Karen P, Kim, So Yeon, Blaszczyk, Michal, Mendes, Vítor, Abell, Chris, Floto, R Andres, Coyne, Anthony G, Blundell, Tom L
Published in Frontiers in molecular biosciences

Stepwise pathogenic evolution of Mycobacterium abscessus

by Bryant, Josephine M, Brown, Karen P, Burbaud, Sophie, Everall, Isobel, Belardinelli, Juan M, Rodriguez-Rincon, Daniela, Grogono, Dorothy M, Peterson, Chelsea M, Verma, Deepshikha, Evans, Ieuan E, Ruis, Christopher, Weimann, Aaron, Arora, Divya, Malhotra, Sony, Bannerman, Bridget, Passemar, Charlotte, Templeton, Kerra, MacGregor, Gordon, Jiwa, Kasim, Fisher, Andrew J, Blundell, Tom L, Ordway, Diane J, Jackson, Mary, Parkhill, Julian, Floto, R Andres
Published in Science (American Association for the Advancement of Science)

Discovery of Novel Inhibitors of Uridine Diphosphate‑N‑Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in...

by Acebrón-García-de-Eulate, Marta, Mayol-Llinàs, Joan, Holland, Matthew T. O, Kim, So Yeon, Brown, Karen P, Marchetti, Chiara, Hess, Jeannine, Di Pietro, Ornella, Mendes, Vitor, Abell, Chris, Floto, R. Andres, Coyne, Anthony G, Blundell, Tom L
Published in Journal of medicinal chemistry

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

by Charoensutthivarakul, Sitthivut, Thomas, Sherine E, Curran, Amy, Brown, Karen P, Belardinelli, Juan M, Whitehouse, Andrew J, Acebrón-García-de-Eulate, Marta, Sangan, Jaspar, Gramani, Subramanian G, Jackson, Mary, Mendes, Vitor, Floto, R. Andres, Blundell, Tom L, Coyne, Anthony G, Abell, Chris
Published in ACS infectious diseases

Cell Surface Remodeling of Mycobacterium abscessus under Cystic Fibrosis Airway Growth Conditions

by Wiersma, Crystal J, Belardinelli, Juan Manuel, Avanzi, Charlotte, Angala, Shiva Kumar, Everall, Isobel, Angala, Bhanupriya, Kendall, Edward, de Moura, Vinicius Calado Nogueira, Verma, Deepshikha, Benoit, Jeanne, Brown, Karen P, Jones, Victoria, Malcolm, Kenneth C, Strong, Michael, Nick, Jerry A, Floto, R. Andres, Parkhill, Julian, Ordway, Diane J, Davidson, Rebecca M, McNeil, Michael R, Jackson, Mary
Published in ACS infectious diseases

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

by Bryant, Josephine M., Grogono, Dorothy M., Rodriguez-Rincon, Daniela, Everall, Isobel, Brown, Karen P., Moreno, Pablo, Verma, Deepshikha, Hill, Emily, Drijkoningen, Judith, Gilligan, Peter, Esther, Charles R., Noone, Peadar G., Giddings, Olivia, Bell, Scott C., Thomson, Rachel, Wainwright, Claire E., Coulter, Chris, Pandey, Sushil, Wood, Michelle E., Stockwell, Rebecca E., Ramsay, Kay A., Sherrard, Laura J., Kidd, Timothy J., Jabbaur, Nassib, Johnson, Graham R., Knibbs, Luke D., Morawska, Lidia, Sly, Peter D., Jones, Andrew, Bilton, Diana, Laurenson, Ian, Ruddy, Michael, Bourke, Stephen, Bowler, Ian C. J. W., Chapman, Stephen J., Clayton, Andrew, Cullen, Mairi, Dempsey, Owen, Denton, Miles, Desai, Maya, Drew, Richard J., Edenborough, Frank, Evans, Jason, Folb, Jonathan, Daniels, Thomas, Humphrey, Helen, Isalska, Barbara, Jensen-Fangel, Søren, Jönsson, Bodil, Jones, Andrew M., Katzenstein, Terese L., Lillebaek, Troels, MacGregor, Gordon, Mayell, Sarah, Millar, Michael, Modha, Deborah, Nash, Edward F., O'Brien, Christopher, O'Brien, Deirdre, Ohri, Chandra, Pao, Caroline S., Peckham, Daniel, Perrin, Felicity, Perry, Audrey, Pressler, Tania, Prtak, Laura, Qvist, Tavs, Robb, Ali, Rodgers, Helen, Schaffer, Kirsten, Shafi, Nadia, van Ingen, Jakko, Walshaw, Martin, Watson, Danie, West, Noreen, Whitehouse, Joanna, Haworth, Charles S., Harris, Simon R., Ordway, Diane, Parkhill, Julian, Floto, R. Andres
Published in Science (American Association for the Advancement of Science)

Population-level genomics identifies the emergence and global spread of a human transmissible multidrug-resistant nontuberculous mycobacterium

by Bryant, Josephine M, Grogono, Dorothy M, Rodriguez-Rincon, Daniela, Everall, Isobel, Brown, Karen P, Moreno, Pablo, Verma, Deepshikha, Hill, Emily, Drijkoningen, Judith, Gilligan, Peter, Esther, Charles R, Noone, Peadar G, Giddings, Olivia, Bell, Scott C., Thomson, Rachel, Wainwright, Claire E., Coulter, Chris, Pandey, Sushil, Wood, Michelle E, Stockwell, Rebecca E, Ramsay, Kay A, Sherrard, Laura J, Kidd, Timothy J, Jabbour, Nassib, Johnson, Graham R, Knibbs, Luke D, Morawska, Lidia, Sly, Peter D, Jones, Andrew, Bilton, Diana, Laurenson, Ian, Ruddy, Michael, Bourke, Stephen, Bowler, Ian CJW, Chapman, Stephen J, Clayton, Andrew, Cullen, Mairi, Daniels, Thomas, Dempsey, Owen, Denton, Miles, Desai, Maya, Drew, Richard J, Edenborough, Frank, Evans, Jason, Folb, Jonathan, Humphrey, Helen, Isalska, Barbara, Jensen-Fangel, Søren, Jönsson, Bodil, Jones, Andrew M., Katzenstein, Terese L, Lillebaek, Troels, MacGregor, Gordon, Mayell, Sarah, Millar, Michael, Modha, Deborah, Nash, Edward F, O’Brien, Christopher, O’Brien, Deirdre, Ohri, Chandra, Pao, Caroline S, Peckham, Daniel, Perrin, Felicity, Perry, Audrey, Pressler, Tania, Prtak, Laura, Qvist, Tavs, Robb, Ali, Rodgers, Helen, Schaffer, Kirsten, Shafi, Nadia, van Ingen, Jakko, Walshaw, Martin, Watson, Danie, West, Noreen, Whitehouse, Joanna, Haworth, Charles S, Harris, Simon R, Ordway, Diane, Parkhill, Julian, Floto, R. Andres
Published in Science (American Association for the Advancement of Science)

ATP-Dependent Persister Formation in Escherichia coli

by Shan, Yue, Brown Gandt, Autumn, Rowe, Sarah E, Deisinger, Julia P, Conlon, Brian P, Lewis, Kim
Published in mBio

Identifying the components of the solid-electrolyte interphase in Li-ion batteries

by Wang, Luning, Menakath, Anjali, Han, Fudong, Wang, Yi, Zavalij, Peter Y, Gaskell, Karen J, Borodin, Oleg, Iuga, Dinu, Brown, Steven P, Wang, Chunsheng, Xu, Kang, Eichhorn, Bryan W
Published in Nature chemistry

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

by Ackerman, Margaret E, Mikhailova, Anastassia, Brown, Eric P, Dowell, Karen G, Walker, Bruce D, Bailey-Kellogg, Chris, Suscovich, Todd J, Alter, Galit
Published in PLoS pathogens

Cis and trans effects of human genomic variants on gene expression

by Bryois, Julien, Buil, Alfonso, Evans, David M, Kemp, John P, Montgomery, Stephen B, Conrad, Donald F, Ho, Karen M, Ring, Susan, Hurles, Matthew, Deloukas, Panos, Davey Smith, George, Dermitzakis, Emmanouil T
Published in PLoS genetics

Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

by Pitroda, Sean P, Khodarev, Nikolai N, Huang, Lei, Uppal, Abhineet, Wightman, Sean C, Ganai, Sabha, Joseph, Nora, Pitt, Jason, Brown, Miguel, Forde, Martin, Mangold, Kathy, Xue, Lai, Weber, Christopher, Segal, Jeremy P, Kadri, Sabah, Stack, Melinda E, Khan, Sajid, Paty, Philip, Kaul, Karen, Andrade, Jorge, White, Kevin P, Talamonti, Mark, Posner, Mitchell C, Hellman, Samuel, Weichselbaum, Ralph R
Published in Nature communications

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

by PATEL, Ketan R, BROWN, Victoria A, BRENNER, Dean E, STEWARD, William P, GESCHER, Andreas J, BROWN, Karen, JONES, Donald J. L, BRITTON, Robert G, HEMINGWAY, David, MILLER, Andrew S, WEST, Kevin P, BOOTH, Tristan D, PERLOFF, Marjorie, CROWELL, James A
Published in Cancer research (Chicago, Ill.)

Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

by Zhang, Qianfei, Ma, Chi, Duan, Yi, Heinrich, Bernd, Rosato, Umberto, Diggs, Laurence P, Ma, Lichun, Roy, Soumen, Fu, Qiong, Brown, Zachary J, Wabitsch, Simon, Thovarai, Vishal, Fu, Jianyang, Feng, Dechun, Ruf, Benjamin, Cui, Linda L, Subramanyam, Varun, Frank, Karen M, Wang, Sophie, Kleiner, David E, Ritz, Thomas, Rupp, Christian, Gao, Bin, Longerich, Thomas, Kroemer, Alexander, Wang, Xin Wei, Ruchirawat, Mathuros, Korangy, Firouzeh, Schnabl, Bernd, Trinchieri, Giorgio, Greten, Tim F
Published in Cancer discovery

Strain fields in twisted bilayer graphene

by Kazmierczak, Nathanael P, Van Winkle, Madeline, Ophus, Colin, Bustillo, Karen C, Carr, Stephen, Brown, Hamish G, Ciston, Jim, Taniguchi, Takashi, Watanabe, Kenji, Bediako, D Kwabena
Published in Nature materials

Cancer Prevention Europe

by Wild, Christopher P., Espina, Carolina, Bauld, Linda, Bonanni, Bernardo, Brenner, Hermann, Brown, Karen, Dillner, Joakim, Forman, David, Kampman, Ellen, Nilbert, Mef, Steindorf, Karen, Storm, Hans, Vineis, Paolo, Baumann, Michael, Schüz, Joachim
Published in Molecular oncology

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

by BROWN, Victoria A, PATEL, Ketan R, BROWN, Karen, STEWARD, William P, GESCHER, Andreas J, BRENNER, Dean E, VISKADURAKI, Maria, CROWELL, James A, PERLOFF, Marjorie, BOOTH, Tristan D, VASILININ, Grygoriy, SEN, Ananda, SCHINAS, Anna Maria, PICCIRILLI, Gianfranca
Published in Cancer research (Chicago, Ill.)