Targeting Neuroinflammation to Treat Alzheimer’s Disease

by Ardura-Fabregat, A., Boddeke, E. W. G. M., Boza-Serrano, A., Brioschi, S., Castro-Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, Michael T., Hoeijmakers, L., Hoffmann, A., Iaccarino, L., Jahnert, S., Kuhbandner, K., Landreth, G., Lonnemann, N., Löschmann, P. A., McManus, R. M., Paulus, A., Reemst, K., Sanchez-Caro, J. M., Tiberi, A., Van der Perren, A., Vautheny, A., Venegas, C., Webers, A., Weydt, P., Wijasa, T. S., Xiang, X., Yang, Y.
Published in CNS drugs

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

by Mattei, D, Ivanov, A, Ferrai, C, Jordan, P, Guneykaya, D, Buonfiglioli, A, Schaafsma, W, Przanowski, P, Deuther-Conrad, W, Brust, P, Hesse, S, Patt, M, Sabri, O, Ross, T L, Eggen, B J L, Boddeke, E W G M, Kaminska, B, Beule, D, Pombo, A, Kettenmann, H, Wolf, S A
Published in Translational psychiatry

Functional expression of the fractalkine (CX 3C) receptor and its regulation by lipopolysaccharide in rat microglia

by Boddeke, Erik W.G.M, Meigel, Inge, Frentzel, Stefan, Biber, Knut, Renn, Li Q, Gebicke-Härter, Peter
Published in European journal of pharmacology

SDZ-ENS-163, A SELECTIVE MUSCARINIC M1 RECEPTOR AGONIST, FACILITATES THE INDUCTION OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

by BODDEKE, EWGM, ENZ, A, SHAPIRO, G
Published in European journal of pharmacology

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

by Gerrits, Emma, Brouwer, Nieske, Kooistra, Susanne M., Woodbury, Maya E., Vermeiren, Yannick, Lambourne, Mirjam, Mulder, Jan, Kummer, Markus, Möller, Thomas, Biber, Knut, Dunnen, Wilfred F. A. den, De Deyn, Peter P., Eggen, Bart J. L., Boddeke, Erik W. G. M.
Published in Acta neuropathologica

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

by Galatro, Thais F, Holtman, Inge R, Lerario, Antonio M, Vainchtein, Ilia D, Brouwer, Nieske, Sola, Paula R, Veras, Mariana M, Pereira, Tulio F, Leite, Renata E P, Möller, Thomas, Wes, Paul D, Sogayar, Mari C, Laman, Jon D, den Dunnen, Wilfred, Pasqualucci, Carlos A, Oba-Shinjo, Sueli M, Boddeke, Erik W G M, Marie, Suely K N, Eggen, Bart J L
Published in Nature neuroscience

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

by Bhat, Krishna P.L., Balasubramaniyan, Veerakumar, Vaillant, Brian, Ezhilarasan, Ravesanker, Hummelink, Karlijn, Hollingsworth, Faith, Wani, Khalida, Heathcock, Lindsey, James, Johanna D., Goodman, Lindsey D., Conroy, Siobhan, Long, Lihong, Lelic, Nina, Wang, Suzhen, Gumin, Joy, Raj, Divya, Kodama, Yoshinori, Raghunathan, Aditya, Olar, Adriana, Joshi, Kaushal, Pelloski, Christopher E., Heimberger, Amy, Kim, Se Hoon, Cahill, Daniel P., Rao, Ganesh, Den Dunnen, Wilfred F.A., Boddeke, Hendrikus W.G.M., Phillips, Heidi S., Nakano, Ichiro, Lang, Frederick F., Colman, Howard, Sulman, Erik P., Aldape, Kenneth
Published in Cancer cell

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

by Vinet, Jonathan, Weering, Hilmar R J van, Heinrich, Annette, Kälin, Roland E, Wegner, Anja, Brouwer, Nieske, Heppner, Frank L, Rooijen, Nico van, Boddeke, Hendrikus W G M, Biber, Knut
Published in Journal of neuroinflammation

Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex

by Gerrits, Emma, Giannini, Lucia A A, Brouwer, Nieske, Melhem, Shamiram, Seilhean, Danielle, Le Ber, Isabelle, Kamermans, Alwin, Kooij, Gijs, de Vries, Helga E, Boddeke, Erik W G M, Seelaar, Harro, van Swieten, John C, Eggen, Bart J L
Published in Nature neuroscience

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

by van Zwam, Marloes, Huizinga, Ruth, Melief, Marie-José, Wierenga-Wolf, Annet F., van Meurs, Marjan, Voerman, Jane S., Biber, Knut P. H., Boddeke, Hendrikus W. G. M., Höpken, Uta E., Meisel, Christian, Meisel, Andreas, Bechmann, Ingo, Hintzen, Rogier Q., ‘t Hart, Bert A., Amor, Sandra, Laman, Jon D., Boven, Leonie A.
Published in Journal of molecular medicine (Berlin, Germany)

Vesicle-Mediated Transport and Release of CCL21 in Endangered Neurons: A Possible Explanation for Microglia Activation Remote from a Primary Lesion

by de Jong, Eiko K, Dijkstra, Ineke M, Hensens, Marjolein, Brouwer, Nieske, van Amerongen, Machteld, Liem, Robert S. B, Boddeke, Hendrikus W. G. M, Biber, Knut
Published in The Journal of neuroscience

Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening...

by Raj, Divya D. A., Moser, Jill, Pol, Susanne M. A., Os, Ronald P., Holtman, Inge R., Brouwer, Nieske, Oeseburg, Hisko, Schaafsma, Wandert, Wesseling, Evelyn M., Dunnen, Wilfred, Biber, Knut P. H., Vries, Helga E., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Published in Aging cell

The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts

by Boddeke, Erik W.G.M., Wilffert, Bob, Heynis, Jaap B., Hugtenburg, Jacqueline G., Jap, Walther T.J., Veldsema-Currie, Robin D., Van Zwieten, Pieter A.
Published in European journal of pharmacology

Neuronal chemokines: versatile messengers in central nervous system cell interaction

by de Haas, A H, van Weering, H R J, de Jong, E K, Boddeke, H W G M, Biber, K P H
Published in Molecular neurobiology

Inflammatory biomarkers in Alzheimer's disease plasma

by Morgan, Angharad R., Touchard, Samuel, Barkhof, Frederik, Bertram, Lars, Bos, Isabelle, Dobricic, Valerija, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Kettunen, Petronella, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Scheltens, Philip, Soininen, Hikka, Tsolaki, Magda, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, Lovestone, Simon, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Crofts, Anna L., Foster, Andrew C., Kitzbichler, Manfred G., Lynall, Mary-Ellen, Maurice, Christina, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Cavanagh, Jonathan, Deith, Catherine, McColl, Alison, Scouller, Paul, Sutherland, Murray, Khan, Shahid, Murphy, Phil, Patel, Jai, de Boer, Peter, Drevets, Wayne C., Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Cash, Diana, Mondelli, Valeria, Nikkheslat, Naghmeh, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Worrell, Courtney, Plath, Niels, Egebjerg, Jan, Gastambide, Francois, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Jones, Helen, Lovestone, Simon, Mada, Francisca, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Sporn, Jonathan, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Murray, Rosemary, Wlazly, Dominika, Mount, Howard
Published in Alzheimer's & dementia

Transcriptional profiling of macaque microglia reveals an evolutionary preserved gene expression program

by Dubbelaar, M.L., Misrielal, C., Bajramovic, J.J., Burm, S.M., Zuiderwijk-Sick, E.A., Brouwer, N., Grit, C., Kooistra, S.M., Shinjo, S.M.O., Marie, S.K.N., Boddeke, H.W.G.M., Eggen, B.J.L.
Published in Brain, behavior, & immunity. Health

Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia

by Biber, K, Dijkstra, I, Trebst, C, De Groot, C.J.A, Ransohoff, R.M, Boddeke, H.W.G.M
Published in Neuroscience

Cultured rat microglia express functional β-chemokine receptors

by Boddeke, Erik W.G.M, Meigel, Ingeborg, Frentzel, Stefan, Gourmala, Nouciba G, Harrison, Jeffrey K, Buttini, Manuel, Spleiss, O, Gebicke-Härter, Peter
Published in Journal of neuroimmunology

Functionally deficient neuronal differentiation of mouse embryonic neural stem cells in vitro

by Balasubramaniyan, V, de Haas, A.H, Bakels, R, Koper, A, Boddeke, H.W.G.M, Copray, J.C.V.M
Published in Neuroscience research

Role of Calcineurin in Ca2+‐Induced Release of Catecholamines and Neuropeptides

by Hens, Jacques J. H., De Wit, Marina, Ghijsen, Wim E. J. M., Leenders, A. G. Miriam, Boddeke, Hendrik W. G. M., Kissmehl, Roland, Wiegant, Victor M., Weller, Ulrich, Gispen, Willem‐Hendrik, De Graan, Pierre N. E.
Published in Journal of neurochemistry