Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

by Reiss, Simon, Rebhan, Ilka, Backes, Perdita, Romero-Brey, Ines, Erfle, Holger, Matula, Petr, Kaderali, Lars, Poenisch, Marion, Blankenburg, Hagen, Hiet, Marie-Sophie, Longerich, Thomas, Diehl, Sarah, Ramirez, Fidel, Balla, Tamas, Rohr, Karl, Kaul, Artur, Bühler, Sandra, Pepperkok, Rainer, Lengauer, Thomas, Albrecht, Mario, Eils, Roland, Schirmacher, Peter, Lohmann, Volker, Bartenschlager, Ralf
Published in Cell host & microbe

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents

by Kalaghatgi, Prabhav, Sikorski, Anna Maria, Knops, Elena, Rupp, Daniel, Sierra, Saleta, Heger, Eva, Neumann-Fraune, Maria, Beggel, Bastian, Walker, Andreas, Timm, Jörg, Walter, Hauke, Obermeier, Martin, Kaiser, Rolf, Bartenschlager, Ralf, Lengauer, Thomas
Published in PloS one

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

by Mailly, Laurent, Xiao, Fei, Lupberger, Joachim, Wilson, Garrick K, Aubert, Philippe, Duong, François H T, Calabrese, Diego, Leboeuf, Céline, Fofana, Isabel, Thumann, Christine, Bandiera, Simonetta, Lütgehetmann, Marc, Volz, Tassilo, Davis, Christopher, Harris, Helen J, Mee, Christopher J, Girardi, Erika, Chane-Woon-Ming, Béatrice, Ericsson, Maria, Fletcher, Nicola, Bartenschlager, Ralf, Pessaux, Patrick, Vercauteren, Koen, Meuleman, Philip, Villa, Pascal, Kaderali, Lars, Pfeffer, Sébastien, Heim, Markus H, Neunlist, Michel, Zeisel, Mirjam B, Dandri, Maura, McKeating, Jane A, Robinet, Eric, Baumert, Thomas F
Published in Nature biotechnology

Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly

by Jirasko, Vlastimil, Montserret, Roland, Lee, Ji Young, Gouttenoire, Jérôme, Moradpour, Darius, Penin, Francois, Bartenschlager, Ralf
Published in PLoS pathogens

The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly

by Shavinskaya, Anna, Boulant, Steeve, Penin, Francois, McLauchlan, John, Bartenschlager, Ralf
Published in The Journal of biological chemistry

Novel dengue virus NS2B/NS3 protease inhibitors

by Wu, Hongmei, Bock, Stefanie, Snitko, Mariya, Berger, Thilo, Weidner, Thomas, Holloway, Steven, Kanitz, Manuel, Diederich, Wibke E, Steuber, Holger, Walter, Christof, Hofmann, Daniela, Weißbrich, Benedikt, Spannaus, Ralf, Acosta, Eliana G, Bartenschlager, Ralf, Engels, Bernd, Schirmeister, Tanja, Bodem, Jochen
Published in Antimicrobial agents and chemotherapy

Efficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like Particles

by Steinmann, Eike, Brohm, Christiane, Kallis, Stephanie, Bartenschlager, Ralf, Pietschmann, Thomas
Published in Journal of Virology

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

by Garcia, Gustavo, Sharma, Arun, Ramaiah, Arunachalam, Sen, Chandani, Purkayastha, Arunima, Kohn, Donald B., Parcells, Mark S., Beck, Sebastian, Kim, Heeyoung, Bakowski, Malina A., Kirkpatrick, Melanie G., Riva, Laura, Wolff, Karen C., Han, Brandon, Yuen, Constance, Ulmert, David, Purbey, Prabhat K., Scumpia, Philip, Beutler, Nathan, Rogers, Thomas F., Chatterjee, Arnab K., Gabriel, Gülsah, Bartenschlager, Ralf, Gomperts, Brigitte, Svendsen, Clive N., Betz, Ulrich A.K., Damoiseaux, Robert D., Arumugaswami, Vaithilingaraja
Published in Cell reports (Cambridge)

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection

by Lee, Jae Seung, Tabata, Keisuke, Twu, Woan-Ing, Rahman, Md Shafiqur, Kim, Hee Sun, Yu, Jin Bae, Jee, Min Hyeok, Bartenschlager, Ralf, Jang, Sung Key
Published in PLoS pathogens

Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Do...

by APPEL, Nicole, PIETSCHMANN, Thomas, BARTENSCHLAGER, Ralf
Published in Journal of Virology

Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication

by Metz, Philippe, Dazert, Eva, Ruggieri, Alessia, Mazur, Johanna, Kaderali, Lars, Kaul, Artur, Zeuge, Ulf, Windisch, Marc P., Trippler, Martin, Lohmann, Volker, Binder, Marco, Frese, Michael, Bartenschlager, Ralf
Published in Hepatology (Baltimore, Md.)

MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles

by Menzel, Nicolas, Fischl, Wolfgang, Hueging, Kathrin, Bankwitz, Dorothea, Frentzen, Anne, Haid, Sibylle, Gentzsch, Juliane, Kaderali, Lars, Bartenschlager, Ralf, Pietschmann, Thomas
Published in PLoS pathogens

Construction and Characterization of Infectious Intragenotypic and Intergenotypic Hepatitis C Virus Chimeras

by Pietschmann, Thomas, Kaul, Artur, Koutsoudakis, George, Shavinskaya, Anna, Kallis, Stephanie, Steinmann, Eike, Abid, Karim, Negro, Francesco, Dreux, Marlene, Cosset, Francois-Loic, Bartenschlager, Ralf
Published in Proceedings of the National Academy of Sciences - PNAS

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

by Denolly, Solène, Stukalov, Alexey, Barayeu, Uladzimir, Rosinski, Alina N, Kritsiligkou, Paraskevi, Joecks, Sebastian, Dick, Tobias P, Pichlmair, Andreas, Bartenschlager, Ralf
Published in Nature communications

The hepatitis C virus replicon system: From basic research to clinical application

by Bartenschlager, Ralf
Published in Journal of hepatology

Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions

by Steinmann, Eike, Penin, Francois, Kallis, Stephanie, Patel, Arvind H, Bartenschlager, Ralf, Pietschmann, Thomas
Published in PLoS pathogens

NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes

by PAUL, David, ROMERO-BREY, Ines, GOUTTENOIRE, Jérôme, STOITSOVA, Savina, KRIJNSE-LOCKER, Jacomine, MORADPOUR, Darius, BARTENSCHLAGER, Ralf
Published in Journal of Virology

Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication

by Friebe, Peter, Bartenschlager, Ralf
Published in Journal of Virology

Characterization of the mode of action of a potent dengue virus capsid inhibitor

by Scaturro, Pietro, Trist, Iuni Margaret Laura, Paul, David, Kumar, Anil, Acosta, Eliana G, Byrd, Chelsea M, Jordan, Robert, Brancale, Andrea, Bartenschlager, Ralf
Published in Journal of virology

Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

by Kumar, Anil, Bühler, Sandra, Selisko, Barbara, Davidson, Andrew, Mulder, Klaas, Canard, Bruno, Miller, Sven, Bartenschlager, Ralf
Published in Journal of Virology