The GTEx Consortium atlas of genetic regulatory effects across human tissues

by Anand, Shankara, Ardlie, Kristin G., Graubert, Aaron, Hadley, Kane, Handsaker, Robert E., Huang, Katherine H., Kashin, Seva, Li, Xiao, MacArthur, Daniel G., Meier, Samuel R., Segrè, Ayellet V., Barbeira, Alvaro N., Battle, Alexis, Cotter, Daniel J., Das, Sayantan, de Goede, Olivia M., Einson, Jonah, Ferraro, Nicole M., Fresard, Laure, Gamazon, Eric R., Gay, Nicole R., Gloudemans, Michael J., Guigó, Roderic, Hame, Andrew R., He, Yuan, Hoffman, Paul J., Im, Hae Kyung, Jo, Brian, Kasela, Silva, Li, Xin, Mangul, Serghei, Mohammadi, Pejman, Montgomery, Stephen B., Muñoz-Aguirre, Manuel, Nobel, Andrew B., Oliva, Meritxell, Parsana, Princy, Rao, Abhiram S., Reverter, Ferran, Sabatti, Chiara, Saha, Ashis, Strober, Benjamin J., Teran, Nicole A., Viñuela, Ana, Wen, Xiaoquan, Ferreira, Pedro G., Yeger-Lotem, Esti, Barcus, Mary E., Bradbury, Debra, Krubit, Tanya, McLean, Jeffrey A., Qi, Liqun, Robinson, Karna, Smith, Anna M., Sobin, Leslie, Tabor, David E., Bridge, Jason, Foster, Barbara A., Hunter, Marcus, Johns, Christopher, Johnson, Mark, Karasik, Ellen, Kopen, Gene, Moser, Michael T., Roe, Brian, Shad, Saboor, Thomas, Jeffrey A., Washington, Michael, Rohrer, Daniel C., Valley, Dana R., Davis, David A., Mash, Deborah C., Mosavel, Maghboeba, Siminoff, Laura A., Flicek, Paul, Juettemann, Thomas, Kent, W. James, Powell, Conner C., Rosenbloom, Kate R., Ruffier, Magali, Sheppard, Dan, Taylor, Kieron, Abell, Nathan S., Akey, Joshua, Demanelis, Kathryn, Feinberg, Andrew P., Hansen, Kasper D., Jiang, Lihua, Kibriya, Muhammad G., Li, Jin Billy, Li, Qin, Lin, Shin, Pierce, Brandon L., Skol, Andrew D., Snyder, Michael, Stamatoyannopoulos, John, Tang, Hua, Guan, Ping, Nierras, Concepcion R., Rao, Abhi K.
Published in Science (American Association for the Advancement of Science)

Systematic analysis of complex genetic interactions

by Kuzmin, Elena, VanderSluis, Benjamin, Wang, Wen, Tan, Guihong, Deshpande, Raamesh, Chen, Yiqun, Usaj, Matej, Balint, Attila, Mattiazzi Usaj, Mojca, van Leeuwen, Jolanda, Koch, Elizabeth N, Pons, Carles, Dagilis, Andrius J, Pryszlak, Michael, Wang, Jason Zi Yang, Hanchard, Julia, Riggi, Margot, Xu, Kaicong, Heydari, Hamed, San Luis, Bryan-Joseph, Shuteriqi, Ermira, Zhu, Hongwei, Van Dyk, Nydia, Sharifpoor, Sara, Costanzo, Michael, Loewith, Robbie, Caudy, Amy, Bolnick, Daniel, Brown, Grant W, Andrews, Brenda J, Boone, Charles, Myers, Chad L
Published in Science (American Association for the Advancement of Science)

A triple-star system with a misaligned and warped circumstellar disk shaped by disk tearing

by Kraus, Stefan, Kreplin, Alexander, Young, Alison K, Bate, Matthew R, Monnier, John D, Harries, Tim J, Avenhaus, Henning, Kluska, Jacques, Laws, Anna S E, Rich, Evan A, Willson, Matthew, Aarnio, Alicia N, Adams, Fred C, Andrews, Sean M, Anugu, Narsireddy, Bae, Jaehan, Ten Brummelaar, Theo, Calvet, Nuria, Curé, Michel, Davies, Claire L, Ennis, Jacob, Espaillat, Catherine, Gardner, Tyler, Hartmann, Lee, Hinkley, Sasha, Labdon, Aaron, Lanthermann, Cyprien, LeBouquin, Jean-Baptiste, Schaefer, Gail H, Setterholm, Benjamin R, Wilner, David, Zhu, Zhaohuan
Published in Science (American Association for the Advancement of Science)

The impact of sex on gene expression across human tissues

by Oliva, Meritxell, Muñoz-Aguirre, Manuel, Kim-Hellmuth, Sarah, Wucher, Valentin, Gewirtz, Ariel D H, Cotter, Daniel J, Parsana, Princy, Kasela, Silva, Balliu, Brunilda, Viñuela, Ana, Castel, Stephane E, Mohammadi, Pejman, Aguet, François, Zou, Yuxin, Khramtsova, Ekaterina A, Skol, Andrew D, Garrido-Martín, Diego, Reverter, Ferran, Brown, Andrew, Evans, Patrick, Gamazon, Eric R, Payne, Anthony, Bonazzola, Rodrigo, Barbeira, Alvaro N, Hamel, Andrew R, Martinez-Perez, Angel, Soria, José Manuel, Pierce, Brandon L, Stephens, Matthew, Eskin, Eleazar, Dermitzakis, Emmanouil T, Segrè, Ayellet V, Im, Hae Kyung, Engelhardt, Barbara E, Ardlie, Kristin G, Montgomery, Stephen B, Battle, Alexis J, Lappalainen, Tuuli, Guigó, Roderic, Stranger, Barbara E
Published in Science (American Association for the Advancement of Science)

Determinants of telomere length across human tissues

by Demanelis, Kathryn, Jasmine, Farzana, Chen, Lin S, Chernoff, Meytal, Tong, Lin, Delgado, Dayana, Zhang, Chenan, Shinkle, Justin, Sabarinathan, Mekala, Lin, Hannah, Ramirez, Eduardo, Oliva, Meritxell, Kim-Hellmuth, Sarah, Stranger, Barbara E, Lai, Tsung-Po, Aviv, Abraham, Ardlie, Kristin G, Aguet, François, Ahsan, Habibul, Doherty, Jennifer A, Kibriya, Muhammad G, Pierce, Brandon L
Published in Science (American Association for the Advancement of Science)

Cell type-specific genetic regulation of gene expression across human tissues

by Kim-Hellmuth, Sarah, Aguet, François, Oliva, Meritxell, Muñoz-Aguirre, Manuel, Kasela, Silva, Wucher, Valentin, Castel, Stephane E, Hamel, Andrew R, Viñuela, Ana, Roberts, Amy L, Mangul, Serghei, Wen, Xiaoquan, Wang, Gao, Barbeira, Alvaro N, Garrido-Martín, Diego, Nadel, Brian B, Zou, Yuxin, Bonazzola, Rodrigo, Quan, Jie, Brown, Andrew, Martinez-Perez, Angel, Soria, José Manuel, Getz, Gad, Dermitzakis, Emmanouil T, Small, Kerrin S, Stephens, Matthew, Xi, Hualin S, Im, Hae Kyung, Guigó, Roderic, Segrè, Ayellet V, Stranger, Barbara E, Ardlie, Kristin G, Lappalainen, Tuuli
Published in Science (American Association for the Advancement of Science)

The chromatin accessibility landscape of primary human cancers

by Corces, M Ryan, Granja, Jeffrey M, Shams, Shadi, Louie, Bryan H, Seoane, Jose A, Zhou, Wanding, Silva, Tiago C, Groeneveld, Clarice, Wong, Christopher K, Cho, Seung Woo, Satpathy, Ansuman T, Mumbach, Maxwell R, Hoadley, Katherine A, Robertson, A Gordon, Sheffield, Nathan C, Felau, Ina, Castro, Mauro A A, Berman, Benjamin P, Staudt, Louis M, Zenklusen, Jean C, Laird, Peter W, Curtis, Christina, Greenleaf, William J, Chang, Howard Y
Published in Science (American Association for the Advancement of Science)

Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

by Kuzmin, Elena, VanderSluis, Benjamin, Nguyen Ba, Alex N, Wang, Wen, Koch, Elizabeth N, Usaj, Matej, Khmelinskii, Anton, Usaj, Mojca Mattiazzi, van Leeuwen, Jolanda, Kraus, Oren, Tresenrider, Amy, Pryszlak, Michael, Hu, Ming-Che, Varriano, Brenda, Costanzo, Michael, Knop, Michael, Moses, Alan, Myers, Chad L, Andrews, Brenda J, Boone, Charles
Published in Science (American Association for the Advancement of Science)

Transcriptomic signatures across human tissues identify functional rare genetic variation

by Ferraro, Nicole M, Strober, Benjamin J, Einson, Jonah, Abell, Nathan S, Aguet, Francois, Barbeira, Alvaro N, Brandt, Margot, Bucan, Maja, Castel, Stephane E, Davis, Joe R, Greenwald, Emily, Hess, Gaelen T, Hilliard, Austin T, Kember, Rachel L, Kotis, Bence, Park, YoSon, Peloso, Gina, Ramdas, Shweta, Scott, Alexandra J, Smail, Craig, Tsang, Emily K, Zekavat, Seyedeh M, Ziosi, Marcello, Aradhana, Ardlie, Kristin G, Assimes, Themistocles L, Bassik, Michael C, Brown, Christopher D, Correa, Adolfo, Hall, Ira, Im, Hae Kyung, Li, Xin, Natarajan, Pradeep, Lappalainen, Tuuli, Mohammadi, Pejman, Montgomery, Stephen B, Battle, Alexis
Published in Science (American Association for the Advancement of Science)

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

by Gandal, Michael J, Haney, Jillian R, Parikshak, Neelroop N, Leppa, Virpi, Ramaswami, Gokul, Hartl, Chris, Schork, Andrew J, Appadurai, Vivek, Buil, Alfonso, Werge, Thomas M, Liu, Chunyu, White, Kevin P, Horvath, Steve, Geschwind, Daniel H
Published in Science (American Association for the Advancement of Science)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

by Zanoni, Paolo, Khetarpal, Sumeet A., Larach, Daniel B., Hancock-Cerutti, William F., Millar, John S., Cuchel, Marina, DerOhannessian, Stephanie, Kontush, Anatol, Surendran, Praveen, Saleheen, Danish, Trompet, Stella, Jukema, J. Wouter, De Craen, Anton, Deloukas, Panos, Sattar, Naveed, Ford, Ian, Packard, Chris, Majumder, Abdullah al Shafi, Alam, Dewan S., Di Angelantonio, Emanuele, Abecasis, Goncalo, Chowdhury, Rajiv, Erdmann, Jeanette, Nordestgaard, Børge G., Nielsen, Sune F., Tybjærg-Hansen, Anne, Schmidt, Ruth Frikke, Kuulasmaa, Kari, Liu, Dajiang J., Perola, Markus, Blankenberg, Stefan, Salomaa, Veikko, Männistö, Satu, Amouyel, Philippe, Arveiler, Dominique, Ferrieres, Jean, Müller-Nurasyid, Martina, Ferrario, Marco, Kee, Frank, Willer, Cristen J., Samani, Nilesh, Schunkert, Heribert, Butterworth, Adam S., Howson, Joanna M. M., Peloso, Gina M., Stitziel, Nathan O., Danesh, John, Kathiresan, Sekar, Rader, Daniel J.
Published in Science (American Association for the Advancement of Science)

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

by Roy, Sushmita, Ernst, Jason, Kharchenko, Peter V, Kheradpour, Pouya, Negre, Nicolas, Eaton, Matthew L, Landolin, Jane M, Bristow, Christopher A, Ma, Lijia, Lin, Michael F, Washietl, Stefan, Arshinoff, Bradley I, Ay, Ferhat, Meyer, Patrick E, Robine, Nicolas, Washington, Nicole L, Di Stefano, Luisa, Berezikov, Eugene, Brown, Christopher D, Candeias, Rogerio, Carlson, Joseph W, Carr, Adrian, Jungreis, Irwin, Marbach, Daniel, Sealfon, Rachel, Tolstorukov, Michael Y, Will, Sebastian, Alekseyenko, Artyom A, Artieri, Carlo, Booth, Benjamin W, Brooks, Angela N, Dai, Qi, Davis, Carrie A, Duff, Michael O, Feng, Xin, Gorchakov, Andrey A, Gu, Tingting, Henikoff, Jorja G, Kapranov, Philipp, Li, Renhua, MacAlpine, Heather K, Malone, John, Minoda, Aki, Nordman, Jared, Okamura, Katsutomo, Perry, Marc, Powell, Sara K, Riddle, Nicole C, Sakai, Akiko, Samsonova, Anastasia, Sandler, Jeremy E, Schwartz, Yuri B, Sher, Noa, Spokony, Rebecca, Sturgill, David, van Baren, Marijke, Wan, Kenneth H, Yang, Li, Yu, Charles, Feingold, Elise, Good, Peter, Guyer, Mark, Lowdon, Rebecca, Ahmad, Kami, Andrews, Justen, Berger, Bonnie, Brenner, Steven E, Brent, Michael R, Cherbas, Lucy, Elgin, Sarah C.R, Gingeras, Thomas R, Grossman, Robert, Hoskins, Roger A, Kaufman, Thomas C, Kent, William, Kuroda, Mitzi I, Orr-Weaver, Terry, Perrimon, Norbert, Pirrotta, Vincenzo, Posakony, James W, Ren, Bing, Russell, Steven, Cherbas, Peter, Graveley, Brenton R, Lewis, Suzanna, Micklem, Gos, Oliver, Brian, Park, Peter J, Celniker, Susan E, Henikoff, Steven, Karpen, Gary H, Lai, Eric C, MacAlpine, David M, Stein, Lincoln D, White, Kevin P, Kellis, Manolis
Published in Science (American Association for the Advancement of Science)

Exploring genetic suppression interactions on a global scale

by van Leeuwen, Jolanda, Pons, Carles, Mellor, Joseph C., Yamaguchi, Takafumi N., Friesen, Helena, Koschwanez, John, Ušaj, Mojca Mattiazzi, Pechlaner, Maria, Takar, Mehmet, Ušaj, Matej, VanderSluis, Benjamin, Andrusiak, Kerry, Bansal, Pritpal, Baryshnikova, Anastasia, Boone, Claire E., Cao, Jessica, Cote, Atina, Gebbia, Marinella, Horecka, Gene, Horecka, Ira, Kuzmin, Elena, Legro, Nicole, Liang, Wendy, van Lieshout, Natascha, McNee, Margaret, San Luis, Bryan-Joseph, Shaeri, Fatemeh, Shuteriqi, Ermira, Sun, Song, Yang, Lu, Youn, Ji-Young, Yuen, Michael, Costanzo, Michael, Gingras, Anne-Claude, Aloy, Patrick, Oostenbrink, Chris, Murray, Andrew, Graham, Todd R., Myers, Chad L., Andrews, Brenda J., Roth, Frederick P., Boone, Charles
Published in Science (American Association for the Advancement of Science)