Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

by Pickard, Adam, Calverley, Ben C, Chang, Joan, Garva, Richa, Gago, Sara, Lu, Yinhui, Kadler, Karl E
Published in PLoS pathogens

Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workers

by Harris, Ross J., Whitaker, Heather J., Andrews, Nick J., Aiano, Felicity, Amin-Chowdhury, Zahin, Flood, Jessica, Borrow, Ray, Linley, Ezra, Ahmad, Shazaad, Stapley, Lorraine, Hallis, Bassam, Amirthalingam, Gayatri, Höschler, Katja, Parker, Ben, Horsley, Alex, Brooks, Timothy J.G., Brown, Kevin E., Ramsay, Mary E., Ladhani, Shamez N.
Published in The Journal of infection

St Andrew's COVID-19 surgery safety (StACS) study: Elective plastic surgery, trauma & burns

by Miranda, B.H., Hughes, W.R.M., Pinto-Lopes, R., Mathur, B.S., Ramakrishnan, V.V., Sood, M.K., Ahmad, Fateh, Banwell, Miles E, Barnes, David E, El-Muttardi, Naguib, Griffiths, Matthew, Hussain, Amer, Iwuagwu, Fortune C, Kangesu, Loshan, Khan, Waseem, Martin, Niall, Mopuri, Nabil, Morgan, Mary, Morris, Paul, Rorison, Patricia, Shelley, Odhran, Sierakowski, Adam, Tare, Makarand, Tzafetta, Kallirroi, Zweifel, Claire J, Appukuttan, Aswin, Balgaumwala, Tasneem, Counter, Oliver, Deelip Dhake, Swapnil, Fernandez-Diaz, Oscar F, Gathura, Esther, Harris, Nicola, Constantin Ion Jica, Romulus, Katechia, Devvrat, Lavender, Scott, Martin, David G, Mertic, Alex, Miranda, Adela, Myers, Jo, Nasrallah, Fady, Pantelides, Nicholas, Prior, Sheila, Raveendran, Sreekanth, Sell, Tracey, Sinha, Reetu, Smeeton, Ben T, Smith, Alex C D, Sofos, Stratos, Strong, Ben, Tang, Jasmine Y M, Thacoor, Amitabh, Tucker, Anne, Turkentine, Michele, Cornforth, Mark, Cowdery, Sally, Marasca, Alessandro, Palmer, Helen, Watts, Carole, Watts, Jan, Wiltshire, Rachel, Sing, Quillan Young, Zberea, Diana E, Mabvuure, Nigel T
Published in Journal of plastic, reconstructive & aesthetic surgery

Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

by Volz, Erik, Mishra, Swapnil, Chand, Meera, Barrett, Jeffrey C, Johnson, Robert, Geidelberg, Lily, Hinsley, Wes R, Laydon, Daniel J, Dabrera, Gavin, O'Toole, Áine, Amato, Robert, Ragonnet-Cronin, Manon, Harrison, Ian, Jackson, Ben, Ariani, Cristina V, Boyd, Olivia, Loman, Nicholas J, McCrone, John T, Gonçalves, Sónia, Jorgensen, David, Myers, Richard, Hill, Verity, Jackson, David K, Gaythorpe, Katy, Groves, Natalie, Sillitoe, John, Kwiatkowski, Dominic P, Flaxman, Seth, Ratmann, Oliver, Bhatt, Samir, Hopkins, Susan, Gandy, Axel, Rambaut, Andrew, Ferguson, Neil M
Published in Nature (London)

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

by Shepherd, James, Koshy, Cherian, Wise, Emma, Curran, Tanya, Adams, Helen, Moore, Catrin, Khokhar, Fahad A., Reynolds, Nicola, Afifi, Safiah, Price, Anna, Kitchen, Christine, Merrick, Ian, Connor, Thomas R., Bresner, Catherine, Robson, Samuel C., Menegazzo, Mirko, Clark, Gemma, Fleming, Vicki M., Howson-Wells, Hannah C., Bird, Paul, Helmer, Thomas, Fallon, Karlie, du Plessis, Louis, Attwood, Stephen, Vasylyeva, Tetyana, Chaudhry, Yasmin, Moses, Samuel, Ryan, Felicity, Brown, Julianne Rose, Lee, Jack C.D., Alcolea-Medina, Adela, Moore, Nathan, Cortes, Nicholas, Williams, Rebecca, Smith, Darren L., Holmes, Alison, Price, James, Rowan, Aileen, Taylor, Graham P., Watts, Joanne, Ludden, Catherine, George, Ryan P., Li, Kathy K., Carmichael, Stephen N., Johnson, Natasha, Orton, Richard J., Hale, Antony D., Harper, Katherine L., Eltringham, Gary, Coupland, Lindsay J., Barton, Edward, Scott, Garren, Yew, Wen C., Resende Silva, Paola C., Justice, Anita, Chand, Meera, Williams, David, Harrison, Ian, Chalker, Vicki, Heyburn, David, Downing, Fatima, Watkins, Joanne, Howe, Robin, Taylor, Sarah, Wain, John, Rudder, Steven, Gilroy, Rachel A.J., Alikhan, Nabil-Fareed, Casey, Anna, Liggett, Steven, Caller, Laura G., Panchbhaya, Yasmin N., Forrest, Leysa M., Findlay, Jacqueline, Beggs, Andrew, Hesketh, Andrew R., Higginson, Ellen E., Aggarwal, Dinesh, Colquhoun, Rachel, Ashworth, Jordan, McCrone, J.T., Michell, Stephen L., Hughes, Margaret, Rainbow, Lucille, Haldenby, Sam T., Green, Luke R., Parker, Matthew D., Bridgewater, Hannah E., Alam, Mohammad T., Quail, Mike, Thurston, Scott, Beaver, Charlotte, McMinn, Liz, Puethe, Christoph, Tonkin-Hill, Gerry, Smith, Christen, Jamrozy, Dorota, Patel, Minal, Drury, Eleanor, Loman, Nicholas J.
Published in Cell

Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experience

by Proudfoot, Alastair G., O’Brien, Ben, Schilling, Richard, Gould, Doug W., McGlennan, Alan
Published in Intensive care medicine

Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform

by Nab, Linda, Parker, Edward P K, Andrews, Colm D, Hulme, William J, Fisher, Louis, Morley, Jessica, Mehrkar, Amir, MacKenna, Brian, Inglesby, Peter, Morton, Caroline E, Bacon, Sebastian C J, Hickman, George, Evans, David, Ward, Tom, Smith, Rebecca M, Davy, Simon, Dillingham, Iain, Maude, Steven, Butler-Cole, Ben F C, O’Dwyer, Thomas, Stables, Catherine L, Bridges, Lucy, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Zheng, Bang, Williamson, Elizabeth J, Eggo, Rosalind M, Evans, Stephen J W, Goldacre, Ben, Tomlinson, Laurie A, Walker, Alex J
Published in The Lancet. Public health

‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

by Mandal, Swapna, Barnett, Joseph, Brill, Simon E, Brown, Jeremy S, Denneny, Emma K, Hare, Samanjit S, Heightman, Melissa, Hillman, Toby E, Jacob, Joseph, Jarvis, Hannah C, Lipman, Marc C I, Naidu, Sindhu B, Nair, Arjun, Porter, Joanna C, Tomlinson, Gillian S, Hurst, John R
Published in Thorax

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

by Reimer, Katharina C., Nagai, James S., Varghese, Finny S., Overheul, Gijs J., Roverts, Rona, Willemsen, Brigith, Beukenboom, Marcel, Dunnen, Wilfred den, Triana, Sergio H., Timm, Marie-Cherelle, van den Berge, Bartholomeus T., Nlandu, Quincy, Heijnert, Joelle, Bindels, Eric M.J., Hoogenboezem, Remco M., Mooren, Fieke, Kuppe, Christoph, Grünberg, Katrien, Steenbergen, Eric J., Czogalla, Jan, Sommerdijk, Nico, Akiva, Anat, Boor, Peter, Huber, Tobias B., Bar-David, Elad, Barr, Haim, Boby, Melissa L., Borden, Bruce, Bowman, Gregory R., Brun, Juliane, BVNBS, Sarma, Carbery, Anna, Chernychenko, Eugene, Clyde, Austin, Coffland, Joseph E., Cole, Jason, Cox, Lisa, Dudgeon, Tim, Dunnett, Louise, Erez, Noam, Fate, Gwen, Ferrins, Lori, Foster, Richard, Foster, Holly, Gabizon, Ronen, Gawriljuk, Victor O., Gehrtz, Paul, Gileadi, Carina, Giroud, Charline, Glen, Robert, Gorichko, Marian, Griffen, Ed J., Heer, Jag, Hill, Michelle, Horrell, Sam, Jajack, Andrew, De Jonghe, Steven, Kantsadi, Anastassia L., Koekemoer, Lizbe, Lee, Alpha A., Lefker, Bruce A., Macdonald, Hannah Bruce, Maclean, Beth, McCorkindale, Willam, McGovern, Briana L., Michurin, Oleg, Morris, Aaron, Morris, Garret M., Neyts, Johan, Oliva, Glaucius, Overheul, Gijs J., Owen, David, Psenak, Vladimir, Pai, Ruby, Paran, Nir, Perry, Benjamin, Pingle, Maneesh, Politi, Boaz, Powell, Ailsa, Puni, Reut, Resnick, Efrat, Rosales, Romel, Schofield, Chris, Shafeev, Mikhail, Sittner, Assa, Skyner, Rachael, Spencer, John, Tamir, Hadas, Tennant, Rachael, Tumber, Anthony, van Rij, Ronald P., Voelz, Vincent, Volkamer, Andra, von Delft, Annette, White, Kris M., Wright, Nathan, Zidane, Hadeer, Costa, Ivan G., Schneider, Rebekka K., Smeets, Bart
Published in Cell stem cell

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY

by Green, Amelia, Curtis, Helen, Hulme, William, Williamson, Elizabeth, McDonald, Helen, Bhaskaran, Krishnan, Rentsch, Christopher, Schultze, Anna, MacKenna, Brian, Mahalingasivam, Viyaasan, Tomlinson, Laurie, Walker, Alex, Fisher, Louis, Massey, Jon, Andrews, Colm, Hopcroft, Lisa, Morton, Caroline, Croker, Richard, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Evans, David, Inglesby, Peter, Hickman, George, Ward, Tom, Davy, Simon, Mathur, Rohini, Tazare, John, Eggo, Rosalind, Wing, Kevin, Wong, Angel, Forbes, Harriet, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Evans, Stephen, Smeeth, Liam, Goldacre, Ben
Published in BMC medicine

Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

by Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Bacon, Seb, Frampton, Adam E, Mehrkar, Amir, Inglesby, Peter, Davy, Simon, Roberts, Keith, Patalay, Praveetha, Goldacre, Ben, MacKenna, Brian, Walker, Alex J
Published in eLife

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

by Collier, Dami A, Ferreira, Isabella A T M, Kotagiri, Prasanti, Datir, Rawlings P, Lim, Eleanor Y, Touizer, Emma, Meng, Bo, Abdullahi, Adam, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, Le Gresley, Emma, Caputo, Daniela, Bergamaschi, Laura, Smith, Kenneth G C, Bradley, John R, Ceron-Gutierrez, Lourdes, Cortes-Acevedo, Paulina, Barcenas-Morales, Gabriela, Linterman, Michelle A, McCoy, Laura E, Davis, Chris, Thomson, Emma, Lyons, Paul A, McKinney, Eoin, Doffinger, Rainer, Wills, Mark, Gupta, Ravindra K
Published in Nature (London)

Implementing Germ Defence digital behaviour change intervention via all primary care practices in England to reduce respiratory infections during the COVID-19 pandemic: an efficien...

by Ainsworth, Ben, Horwood, Jeremy, Walter, Scott R, Miller, Sascha, Chalder, Melanie, De Vocht, Frank, Denison-Day, James, Elwenspoek, Martha M C, Curtis, Helen J, Bates, Chris, Mehrkar, Amir, Bacon, Seb, Goldacre, Ben, Craggs, Pippa, Amlôt, Richard, Francis, Nick, Little, Paul, Macleod, John, Moore, Michael, Morton, Kate, Rice, Cathy, Sterne, Jonathan, Stuart, Beth, Towler, Lauren, Willcox, Merlin L, Yardley, Lucy
Published in Implementation science : IS

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Tr...

by Perkins, Gavin D, Ji, Chen, Connolly, Bronwen A, Couper, Keith, Lall, Ranjit, Baillie, J. Kenneth, Bradley, Judy M, Dark, Paul, Dave, Chirag, De Soyza, Anthony, Dennis, Anna V, Devrell, Anne, Fairbairn, Sara, Ghani, Hakim, Gorman, Ellen A, Green, Christopher A, Hart, Nicholas, Hee, Siew Wan, Kimbley, Zoe, Madathil, Shyam, McGowan, Nicola, Messer, Benjamin, Naisbitt, Jay, Norman, Chloe, Parekh, Dhruv, Parkin, Emma M, Patel, Jaimin, Regan, Scott E, Ross, Clare, Rostron, Anthony J, Saim, Mohammad, Simonds, Anita K, Skilton, Emma, Stallard, Nigel, Steiner, Michael, Vancheeswaran, Rama, Yeung, Joyce, McAuley, Daniel F
Published in JAMA : the journal of the American Medical Association

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

by Kläser, Kerstin, Molteni, Erika, Graham, Mark, Canas, Liane S, Österdahl, Marc F, Antonelli, Michela, Chen, Liyuan, Deng, Jie, Murray, Benjamin, Kerfoot, Eric, Wolf, Jonathan, May, Anna, Fox, Ben, Capdevila, Joan, Modat, Marc, Hammers, Alexander, Spector, Tim D, Steves, Claire J, Sudre, Carole H, Ourselin, Sebastien, Duncan, Emma L
Published in Scientific reports

Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, ph...

by Kehoe, Patrick Gavin, Turner, Nicholas, Howden, Beth, Jarutyte, Lina, Clegg, Shona Louise, Malone, Ian Brian, Barnes, Josephine, Nielsen, Casper, Sudre, Carole Hélène, Wilson, Aileen, Thai, Ngoc Jade, Blair, Peter Sinclair, Coulthard, Elizabeth, Lane, Janet Athene, Passmore, Peter, Taylor, Jodi, Mutsaerts, Henk-Jan, Thomas, David Lee, Fox, Nick Charles, Wilkinson, Ian, Ben-Shlomo, Yoav, Harkness, Kirsty, Kuruvilla, Tarun, McShane, Rupert, Connelly, Peter, Duncan, Gordon, Calvert, Lucy, Lawrie, Alasdair, Sheridan, Matthew, Jackson, Eric, Udeze, Bernard, Pearson, Stephen, Langheinrich, Tobias, Wagle, Suvarna, Butchart, Joseph, Macharouthu, Ajay, Donaldson, Andrew, Neil, Wendy, Pattan, Vivek, Findlay, David, Thomas, Alan, Barber, Robert, Byrne, Andrew, Dalvi, Madhusudan, Negi, Rashi, McGuinness, Bernadette
Published in Lancet neurology

Impact of the COVID-19 pandemic on antipsychotic prescribing in individuals with autism, dementia, learning disability, serious mental illness or living in a care home: a federated...

by Macdonald, Orla, Green, Amelia, Walker, Alex, Curtis, Helen, Croker, Richard, Brown, Andrew, Butler-Cole, Ben, Andrews, Colm, Massey, Jon, Inglesby, Peter, Morton, Caroline, Fisher, Louis, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian, Davy, Simon, Evans, David, Dillingham, Iain, Ward, Tom, Hulme, William, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Parkes, Nasreen, Wood, Ian, Goldacre, Ben, Mackenna, Brian
Published in BMJ mental health

A National Audit of Pancreatic Enzyme Prescribing in Pancreatic Cancer from 2015 to 2023 in England Using OpenSAFELY-TPP

by Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Butler-Cole, Ben, Mehrkar, Amir, Roberts, Keith J., Goldacre, Ben, Walker, Alex J., MacKenna, Brian
Published in Seminars in oncology nursing

Research priorities for COVID-19 sensor technology

by Tong, Allison, Sorrell, Tania C, Black, Andrew J, Caillaud, Corinne, Chrzanowski, Wojciech, Li, Eugena, Martinez-Martin, David, McEwan, Alistair, Wang, Rex, Motion, Alice, Bedoya, Alvaro Casas, Huang, Jun, Azizi, Lamiae, Eggleton, Benjamin J
Published in Nature biotechnology

Modeling COVID-19 disease processes by remote elicitation of causal Bayesian networks from medical experts

by Mascaro, Steven, Wu, Yue, Woodberry, Owen, Nyberg, Erik P, Pearson, Ross, Ramsay, Jessica A, Mace, Ariel O, Foley, David A, Snelling, Thomas L, Nicholson, Ann E
Published in BMC medical research methodology