Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-i...

by Liu, Xinxue, Shaw, Robert H, Stuart, Arabella S V, Greenland, Melanie, Aley, Parvinder K, Andrews, Nick J, Cameron, J Claire, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Dinesh, Tanya, England, Anna, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Green, Christopher A, Hallis, Bassam, Heath, Paul T, Hill, Helen, Lambe, Teresa, Lazarus, Rajeka, Libri, Vincenzo, Long, Fei, Mujadidi, Yama F, Plested, Emma L, Provstgaard-Morys, Samuel, Ramasamy, Maheshi N, Ramsay, Mary, Read, Robert C, Robinson, Hannah, Singh, Nisha, Turner, David P J, Turner, Paul J, Walker, Laura L, White, Rachel, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Munro, Alasdair P S, Bartholomew, Jazz, Presland, Laura, Horswill, Sarah, Warren, Sarah, Varkonyi-Clifford, Sophie, Saich, Stephen, Adams, Kirsty, Ricamara, Marivic, Turner, Nicola, Yee Ting, Nicole Y, Whittley, Sarah, Rampling, Tommy, Desai, Amisha, Brown, Claire H, Qureshi, Ehsaan, Gokani, Karishma, Naker, Kush, Kellett Wright, Johanna K, Williams, Rachel L, Riaz, Tawassal, Penciu, Florentina D, Di Maso, Claudio, Howe, Elizabeth G, Vichos, Iason, Ghulam Farooq, Mujtaba, Noristani, Rabiullah, Yao, Xin L, Oldfield, Neil J, Hammersley, Daniel, Belton, Sue, Royal, Simon, San Francisco Ramos, Alberto, Hultin, Cecilia, Galiza, Eva P, Shiham, Farah, Solórzano, Carla, Sainsbury, Hannah, Davies, Kelly, Ambrose, Pauline, Hitchins, Lisa, Baker, Natalie, Leung, Stephanie, Fothergill, Ross, Godwin, Kerry, Buttigieg, Karen, Shaik, Imam, Brown, Phill, Knight, Chanice, Lall, Paminder, Allen, Lauren
Published in The Lancet (British edition)

Optimizing the Mizoroki–Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups

by Sweeney, Joseph B., Adams, Kirsty, Doulcet, Julien, Thapa, Bimod, Tran, Fanny, Crook, Robert
Published in Journal of catalysis

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

by Pollock, Katrina M., Cheeseman, Hannah M., Szubert, Alexander J., Libri, Vincenzo, Boffito, Marta, Owen, David, Bern, Henry, McFarlane, Leon R., O'Hara, Jessica, Lemm, Nana-Marie, McKay, Paul, Rampling, Tommy, Yim, Yee Ting N., Milinkovic, Ana, Kingsley, Cherry, Cole, Tom, Fagerbrink, Susanne, Aban, Marites, Tanaka, Maniola, Mehdipour, Savviz, Robbins, Alexander, Budd, William, Faust, Saul, Hassanin, Hana, Cosgrove, Catherine A., Winston, Alan, Fidler, Sarah, Dunn, David, McCormack, Sheena, Shattock, Robin J., Adams, Kirsty, Amini, Fahimah, Atako, Nafisah B, Bakri, Amalina, Barclay, Wendy, Brodnicki, Elizabeth, Brown, Jonathan C, Byrne, Ruth, Chilvers, Rowena, Coelho, Sofia, Day, Suzanne, Desai, Monica, Dorman, Eleanor, Elliott, Tamara, Flight, Katie E, Fletcher, James, Galang, John, Gohil, Jagruti, Gupta, Aneta, Harlow, Chris, Hu, Kai, Kalyan, Mohini, Lagrue, Dominic, Liscano, Ely, Njenga, Cecilia, Polra, Krunal, Powlette, Derecia A, Randell, Paul, Rauchenberger, Mary, Redknap, Ianto, Ricamara, Maravic, Rogers, Paul, Sallah, Hadijatou, Samnuan, Karnyart, Schumacher, Michael, Shah, Zareena, Shaw, Rachel, Shaw, Thomas, Sivapatham, Stefan, Slater, Susie, Sorley, Kim, Storch, Regina, Tan, Elizabeth, Tan, Tricia, Thielemans, Lieze, Whitely, Sarah, Valentine, Charlotte, Varghese, Jeeva, Vikraman, Asha, Wilkins, Martin
Published in EClinicalMedicine

An iron-catalysed C-C bond-forming spirocyclization cascade providing sustainable access to new 3D heterocyclic frameworks

by Adams, Kirsty, Ball, Anthony K, Birkett, James, Brown, Lee, Chappell, Ben, Gill, Duncan M, Lo, P K Tony, Patmore, Nathan J, Rice, Craig R, Ryan, James, Raubo, Piotr, Sweeney, Joseph B
Published in Nature chemistry

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

by Houslay, Kirsty F, Christian, Frank, MacLeod, Ruth, Adams, David R, Houslay, Miles D, Baillie, George S
Published in Biochemical journal

Maternal Disease With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses

by Hall, Jennifer, Adams, Nadine Hack, Bartlett, Linda, Seale, Anna C, Lamagni, Theresa, Bianchi-Jassir, Fiorella, Lawn, Joy E, Baker, Carol J, Cutland, Clare, Heath, Paul T, Ip, Margaret, Le Doare, Kirsty, Madhi, Shabir A, Rubens, Craig E, Saha, Samir K, Schrag, Stephanie, Sobanjo-Ter Meulen, Ajoke, Vekemans, Johan, Gravett, Michael G
Published in Clinical infectious diseases

Health behaviours and potentially preventable hospitalisation: a prospective study of older Australian adults

by Tran, Bich, Falster, Michael O, Douglas, Kirsty, Blyth, Fiona, Jorm, Louisa R
Published in PloS one

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

by Heath, Paul T, Galiza, Eva P, Baxter, David N, Boffito, Marta, Browne, Duncan, Burns, Fiona, Chadwick, David R, Clark, Rebecca, Cosgrove, Catherine, Galloway, James, Goodman, Anna L, Heer, Amardeep, Higham, Andrew, Iyengar, Shalini, Arham Jamal, Jeanes, Christopher, Kalra, Philip A, Kyriakidou, Christina, McAuley, Daniel F, Meyrick, Agnieszka, Minassian, Angela M, Minton, Jane, Moore, Patrick, Munsoor, Imrozia, Nicholls, Helen, Osanlou, Orod, Packham, Jonathan, Pretswell, Carol H, Alberto San Francisco Ramos, Saralaya, Dinesh, Sheridan, Ray P, Smith, Richard, Soiza, Roy L, Swift, Pauline A, Thomson, Emma C, Turner, Jeremy, Viljoen, Marianne E, Albert, Gary, Cho, Iksung, Dubovsky, Filip, Glenn, Greg, Rivers, Joy, Robertson, Andreana, Smith, Kathy, Toback, Seth
Published in New England Journal of Medicine

Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis

by Smith, Emily R., Oakley, Erin, Grandner, Gargi Wable, Rukundo, Gordon, Farooq, Fouzia, Ferguson, Kacey, Baumann, Sasha, Adams Waldorf, Kristina Maria, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Bevilacqua, Elisa, Bracero, Nabal, Brandt, Justin S., Broutet, Natalie, Carrillo, Jorge, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, del Mar Gil, Maria, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J., Favre, Guillaume, Fernandez Buhigas, Irene, Flaherman, Valerie, Gale, Christopher, Godwin, Christine L., Gottlieb, Sami, Gratacós, Eduard, He, Siran, Hernandez, Olivia, Jones, Stephanie, Joshi, Sheetal, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen L., Lanzone, Antonio, Laurita Longo, Valentina, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M., Madhi, Shabir A., Magee, Laura A., Martinez-Portilla, Raigam Jafet, Metz, Torri D., Miller, Emily S., Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B., Nunes, Marta C., Onyango, Dickens, Panchaud, Alice, Poon, Liona C., Raiten, Daniel, Regan, Lesley, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Thwin, Soe Soe, Tippett Barr, Beth A., Tolosa, Jorge E., Tug, Niyazi, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Whitehead, Clare, Wood, Mollie, Yang, Huixia, Zavala, Rebecca, Tielsch, James M.
Published in American journal of obstetrics and gynecology

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial

by Gray, Alasdair J, O’Brien, Rachel, Storey, Robert F, Archibald, Kenneth, McCann, Gerry, Carley, Simon, Chapman, Andrew, Raju, Vikram, Luke, Kym, Huggett, Robert, Beattie, Anna, Smith, Simon, Saif-El-Dean, Abdel-Rahman, Holloway, Ben, Davies, Ceri, Donnelly, Patrick, Carter, Justin, Dungu, Jason, Hothi, Sandeep, Rosewarne, David, Grahamslaw, Julia, McLaughlin, Siobhan, Phillips, Alyson, Pirie, Janet, Brown, Hridesh, Fletcher, Catherine, Hill, Shery, Mofidi, Hasan, Jeffrey, Memory, Harrison, Debbie, Sutton, Abdullah, Grey, Tom, Hartley, David, Sandeman, Julie, Bhuie, James, Briggs, Claire, Burnett, Abby, McLeod, Sara, Thomas, Daniel, Speakman, Ranjit, Thomas, Gillian, Donaldson, Fiona, Rofe, Jennifer, Bailey, Leslie, Bremner, Ifti, Phillipson, Saroj, David, Osman, Lowe, Ross, Roditi, Susan, Fell, Laszlo, Sunderland, Joanne, Turner, Lois, Bell, Giulia, Benedetti, Kirsty, Mak, Rebecca, Sanchez-Vidal, Susan, Murray, Tom, Darby, Eunice, Lin, Melanie, Dawson, Claire, Dowling, Karen, Lewis, Nicky, San, Kelly, Tabor, Kealy, Davies, Nokukhanya, Flett, Huon, Gray, Stephen, Mahmoudi, John, Paisey, Charles, Peebles, Drew, Rakhit, John, Shah, James, Sirohi, Wagas, Wilkinson, Arthur, McGlynn, Chris, Bloom, Olivia, Page, Helen, Power, Imogen, Routledge, Leah, Hammond, Jayne, Almaden-Boyle, Kim, Duff, Scot, Mackintosh, Laura, Queripcz, Alan, Stockport, Clare, Sevillano, Vincent, Milgate, Elizabeth, Smallwood, Charlotte, Broadie, David, O’Keeffe, Donna, Patience, Lesley, Patience, Faheem, Ahmad, Nicola, Brown, John, Byrne, Damien, Hopkins, Hayley, Buchanan, Christine, Harkess, Lynsey, Rodriguez, Pamela, White
Published in BMJ (Online)

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

by Stephens, Tim, Kahan, Brennan, Brett, Stephen, Ackland, Gareth, Everingham, Kirsty, Abraham, Ajit, Gillies, Michael, Anderson, Iain, Drake, Sharon, Girling, Alan, Faiz, Omar, Blunt, Mark, Cabreros, Leilani, Obideyi, Ayodele, Brodbeck, Andreas, Gay, Mike, Pushpa, Nathan, Noble, Paul, Van De Velde, Niko, Singh, Satish, Gerstina, Nabua, Kuldip, Rai, Murray, Therese, Aryal, Kamal, Moncaster, Gareth, Abercrombie, John, Wells, John, Natarajan, Nat, Doughan, Samer, Mackinnon, John, Lawton, Greg, Watson, Mark, Stacey, Brenda, Fletcher, Steve, Prestwich, Stewart, Sharma, Abhiram, Hill, Oliver, Rose, Alastair, Narula, Harjeet, Buckley, Sarah, Dowling, Susan, Robin, Nicole, Januszewska, Marta, Bodger, Phoebe, Abbott, Tom, Full, Jens, Rehman, Almas, Mohr, Otto, Mateo, Dolores, Machesney, Michael, Borgeaud, Nathan, Harwood, Elizabeth, Moonesinghe, Ramani, Rafi, Amir, McNelis, Una, Roy, Alistair, Rimmer, Catherine, Monkhouse, Diane, Bhowmick, Arnab, Mcmullan, Sean, Doyle, Donna, Patel, Panna, Stergios, Tezas, Coldwell, Chris, Bronder, Christine, Stotz, Martin, Sugavanam, Anita, Tan, Melanie, Vashisht, Shubha, Vaganov, Sergei, Liasis, Lampros, Husain, Tariq, Baxter, Linden, Wilson, Chris, Williams, Dewi, Taylor, Lynn, Dickinson, Natalie, Gibson, Simon, Tan, Kerwei, Stevenson, Richard, Carey, Kate, Razouk, Khaled, Girgis, Amira, Somasekar, Krishnamurthy, Morgan-Jones, Tom, Martin, Michael, Watters, Malcolm, Sunthareswaran, Rame, Bell, Louise, Nash, Guy, Christie, Iain, Patrick, Abigail, Hanousek, Jan, Paddle, Jonathan, Pickford, Alison, Tucker, Olga, Leno, Emma, Colley, Julie, Wollaston, Julie, Singh, Jagdeep
Published in The Lancet (British edition)

Expert opinion on the management of pain in hospitalised older patients with cognitive impairment: a mixed methods analysis of a national survey

by Rodger, Kirsty T M, Greasley-Adams, Corinne, Hodge, Zoe, Reynish, Emma
Published in BMC geriatrics

Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial

by Mackenzie, Isla S, Hawkey, Christopher J, Ford, Ian, Greenlaw, Nicola, Pigazzani, Filippo, Rogers, Amy, Struthers, Allan D, Begg, Alan G, Wei, Li, Avery, Anthony J, Taggar, Jaspal S, Walker, Andrew, Duce, Suzanne L, Barr, Rebecca J, Dumbleton, Jennifer S, Rooke, Evelien D, Townend, Jonathan N, Ritchie, Lewis D, MacDonald, Thomas M, Ahmed, Husnat, Arthur, Peter, Aziz, Jane, Barnes, Lawrence, Boyle, Sarah, Brighton, Tom, Brown, Morris, Caulfield, Mark, Dawson, Jesse, Denvir, Martin, Doney, Alexander SF, Doshi, Sagar, Dryburgh, Moira, Eddleston, Michael, Finlayson, Jim, Fuat, Ahmet, Furnace, Jacqueline, Grieve, JW Kerr, Guthrie, Greg, Ham, Sharon, Isaard, Emma, Jennings, Claudine, Johnson, Richard, Kerr, Claire, Khan, Sohail, Krishnan, Kailash, Long, Susan, Mackintosh, Anne, Macleod, Mary Joan, McCormack, Terry, McEleny, Paul, Morar, Monique, Nadir, Adnan, Newby, David, Petrie, Colin, Preiss, David, Ralston, Stuart, Randall, Marc, Routledge, Helen, Shakir, Saad, Sharma, Raj, Shepherd, Bridget, Sims, Don, Snedden, Gordon, Trevelyan, Jasper, Weir, Christopher, Weir, Robin, Wetherall, Kirsty, Wilson, Robbie, Wilson, Adam, Zutis, Kris
Published in The Lancet (British edition)

Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy

by Lee, Yu-Ri, Khan, Kamal, Armfield-Uhas, Kim, Srikanth, Sujata, Thompson, Nicola A, Pardo, Mercedes, Yu, Lu, Norris, Joy W, Peng, Yunhui, Gripp, Karen W, Aleck, Kirk A, Li, Chumei, Spence, Ed, Choi, Tae-Ik, Kwon, Soo Jeong, Park, Hee-Moon, Yu, Daseuli, Heo, Won Do, Mooney, Marie R, Baig, Shahid M, Wentzensen, Ingrid M, Telegrafi, Aida, McWalter, Kirsty, Moreland, Trevor, Roadhouse, Chelsea, Ramsey, Keri, Lyons, Michael J, Skinner, Cindy, Alexov, Emil, Katsanis, Nicholas, Stevenson, Roger E, Choudhary, Jyoti S, Adams, David J, Kim, Cheol-Hee, Davis, Erica E, Schwartz, Charles E
Published in Nature communications

Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

by McManus, Richard J, Little, Paul, Stuart, Beth, Raftery, James, Zhang, Jin, Zhu, Shihua, May, Carl R, Mair, Frances S, Smith, Peter, Band, Rebecca, Ogburn, Emma, Allen, Julie, Nuttall, Jacqui, Williams, Bryan, Yardley, Lucy, Jones, Adam, Hussain, Ajmal, LaLonde, Anna, Malik, Asim, Hernandez-Diaz, Basilio, Cranfield, Ben, Bobrow, Cathy, Keast, Christopher, Henderson, Clare, Henderson, Dan, Noble, Debbie, Williams, Edward, Mohri, Fatima, Dougall, Greig, Luckhurst, Heidi, Brown, Jan, Flett, Jennifer, Rutter, Heather, Thompson, Julian, Ramanan, Kanjhana, Madronal, Karen, Etherington, Katie, Tsoi, Kenney, Knox, Kyle, Amin, Laila, Hirst, Lisa, Allen, Lucy, Skellern, Luke, Gaw, Matthew, Prendergast, Matthew, Faisal, Muhammad, Moore, Patrick, Conley, Paul, Wilson, Penny, Zamir, Rebecca, Danson, Ruth, Lawes, Ruth, Cartwright, Simon, Doggett, Stephen, Sevenoaks, Tamsin, Watson, Tara, Talbot, Tess, Herbert, Thomas, Wright, Tony, Sharma, Vanshika, Telford, Vicki, Almashta, Zaid, Ali, Zishan, Claxton, Andy, Asante, Barbara, Weare, Becki, Mulvihill, Carole, Sherwood, Caroline, Roberts, Debbie, Qasim, Irene, King, Jill, Johal, Kam, Barnes, Katie, Bowden, Kelly-Marie, Peniket, Lara, Carnegie, Leann, Neale, Linda, Davey, Lisa, Bartlett, Liz, Smith, Louise, Clack, Lucy, Kay, Pam, Cutts, Rebecca, Pearse, Robert, Atkinson, Ruth, Barter, Sally, Mackie, Sally, Cook, Sandra, Elderfield, Sarah, Marchant, Stephanie, Wright, Stephanie, Keene, Sue, Smith, Sue, Stone, Tracy, Joyce, Tricia, Le Marechal, Trudie, Kettle, Vicky, Osborne, Victoria, Cubiss, Wendy, Bailey, Zoe
Published in BMJ (Online)

User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers and household contacts

by McLennan, Kirsty, Barton, Ellen, Lang, Christie, Adams, Ian R., McAllister, Gina, Reijns, Martin A.M., Templeton, Kate, Johannessen, Ingólfur, Leckie, Alastair, Gilbert, Nick
Published in Diagnostic microbiology and infectious disease

Exercises to improve function of the rheumatoid hand (SARAH): a randomised controlled trial

by Lamb, Sarah E, Dr, Williamson, Esther M, PhD, Heine, Peter J, BSc, Adams, Jo, PhD, Dosanjh, Sukhdeep, PhD, Dritsaki, Melina, PhD, Glover, Matthew J, MSc, Lord, Joanne, PhD, McConkey, Christopher, MSc, Nichols, Vivien, MSc, Rahman, Anisur, PhD, Underwood, Martin, MD, Williams, Mark A, PhD
Published in The Lancet (British edition)

Using DNA sequencing data to quantify T cell fraction and therapy response

by Bentham, Robert, Litchfield, Kevin, Watkins, Thomas B K, Lim, Emilia L, Rosenthal, Rachel, Martínez-Ruiz, Carlos, Hiley, Crispin T, Bakir, Maise Al, Salgado, Roberto, Moore, David A, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Published in Nature (London)

Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19

by Izadi, Zara, Brenner, Erica J, Mahil, Satveer K, Dand, Nick, Yiu, Zenas Z N, Yates, Mark, Ungaro, Ryan C, Zhang, Xian, Agrawal, Manasi, Colombel, Jean-Frederic, Gianfrancesco, Milena A, Hyrich, Kimme L, Strangfeld, Anja, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Klingberg, Eva, Cuomo, Giovanna, Caprioli, Marta, Cruz-Machado, Ana Rita, Mazeda Pereira, Ana Carolina, Hasseli, Rebecca, Pfeil, Alexander, Lorenz, Hanns-Martin, Hoyer, Bimba Franziska, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Seet, Andrea M, Al Emadi, Samar, Wise, Leanna, Gilbert, Emily L, Duarte-García, Alí, Valenzuela-Almada, Maria O, Isnardi, Carolina A, Quintana, Rosana, Soriano, Enrique R, Hsu, Tiffany Y-T, D'Silva, Kristin M, Sparks, Jeffrey A, Patel, Naomi J, Xavier, Ricardo Machado, Marques, Claudia Diniz Lopes, Kakehasi, Adriana Maria, Flipo, René-Marc, Claudepierre, Pascal, Cantagrel, Alain, Goupille, Philippe, Wallace, Zachary S, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Robinson, Philip C, Machado, Pedro M, Griffiths, Christopher E M, Barker, Jonathan N, Smith, Catherine H, Yazdany, Jinoos, Kappelman, Michael D
Published in JAMA network open

Multi-disciplinary community respiratory team management of patients with chronic respiratory illness during the COVID-19 pandemic

by Turner, Emily, Johnson, Emma, Levin, Kate, Gingles, Stewart, Mackay, Elaine, Roux, Claire, Milligan, Marianne, Mackie, Marion, Farrell, Kirsten, Murray, Kirsty, Adams, Suzanne, Brand, Joan, Anderson, David, Bayes, Hannah
Published in NPJ primary care respiratory medicine