Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

by Catton, Erin A, Bonsor, Daniel A, Herrera, Carolina, Stålhammar-Carlemalm, Margaretha, Lyndin, Mykola, Turner, Claire E, Soden, Jo, van Strijp, Jos A G, Singer, Bernhard B, van Sorge, Nina M, Lindahl, Gunnar, McCarthy, Alex J
Published in Nature communications

Using visual lateralization to model learning and memory in zebrafish larvae

by Andersson, Madelene Åberg, Ek, Fredrik, Olsson, Roger
Published in Scientific reports

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

by Hendricks, Audrey E, Bochukova, Elena G, Marenne, Gaëlle, Keogh, Julia M, Atanassova, Neli, Bounds, Rebecca, Wheeler, Eleanor, Mistry, Vanisha, Henning, Elana, Körner, Antje, Muddyman, Dawn, McCarthy, Shane, Hinney, Anke, Hebebrand, Johannes, Scott, Robert A, Langenberg, Claudia, Wareham, Nick J, Surendran, Praveen, Howson, Joanna M, Butterworth, Adam S, Danesh, John, Nordestgaard, Børge G, Nielsen, Sune F, Afzal, Shoaib, Papadia, Sofia, Ashford, Sofie, Garg, Sumedha, Millhauser, Glenn L, Palomino, Rafael I, Kwasniewska, Alexandra, Tachmazidou, Ioanna, O'Rahilly, Stephen, Zeggini, Eleftheria, Barroso, Inês, Farooqi, I Sadaf
Published in Scientific reports

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

by Bonham, Luke W, Steele, Natasha Z R, Karch, Celeste M, Broce, Iris, Geier, Ethan G, Wen, Natalie L, Momeni, Parastoo, Hardy, John, Miller, Zachary A, Gorno-Tempini, Maria Luisa, Hess, Christopher P, Lewis, Patrick, Miller, Bruce L, Seeley, William W, Manzoni, Claudia, Desikan, Rahul S, Baranzini, Sergio E, Ferrari, Raffaele, Yokoyama, Jennifer S
Published in Scientific reports

Accessible and reliable neurometric testing in humans using a smartphone platform

by Boele, H J, Jung, C, Sherry, S, Roggeveen, L E M, Dijkhuizen, S, Öhman, J, Abraham, E, Uvarov, A, Boele, C P, Gultig, K, Rasmussen, A, Vinueza-Veloz, M F, Medina, J F, Koekkoek, S K E, De Zeeuw, C I, Wang, S S-H
Published in Scientific reports

The spatial RNA integrity number assay for in situ evaluation of transcriptome quality

by Kvastad, Linda, Carlberg, Konstantin, Larsson, Ludvig, Villacampa, Eva Gracia, Stuckey, Alexander, Stenbeck, Linnea, Mollbrink, Annelie, Zamboni, Margherita, Magnusson, Jens Peter, Basmaci, Elisa, Shamikh, Alia, Prochazka, Gabriela, Schaupp, Anna-Lena, Borg, Åke, Fugger, Lars, Nistér, Monica, Lundeberg, Joakim
Published in Communications biology

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

by Went, Molly, Sud, Amit, Försti, Asta, Halvarsson, Britt-Marie, Weinhold, Niels, Kimber, Scott, van Duin, Mark, Thorleifsson, Gudmar, Holroyd, Amy, Johnson, David C, Li, Ni, Orlando, Giulia, Law, Philip J, Ali, Mina, Chen, Bowang, Mitchell, Jonathan S, Gudbjartsson, Daniel F, Kuiper, Rowan, Stephens, Owen W, Bertsch, Uta, Broderick, Peter, Campo, Chiara, Bandapalli, Obul R, Einsele, Hermann, Gregory, Walter A, Gullberg, Urban, Hillengass, Jens, Hoffmann, Per, Jackson, Graham H, Jöckel, Karl-Heinz, Johnsson, Ellinor, Kristinsson, Sigurður Y, Mellqvist, Ulf-Henrik, Nahi, Hareth, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Swerdlow, Anthony, Eeles, Rosalind A, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Nickel, Jolanta, Nöthen, Markus M, Rafnar, Thorunn, Ross, Fiona M, da Silva Filho, Miguel Inacio, Thomsen, Hauke, Turesson, Ingemar, Vangsted, Annette, Andersen, Niels Frost, Waage, Anders, Walker, Brian A, Wihlborg, Anna-Karin, Broyl, Annemiek, Davies, Faith E, Thorsteinsdottir, Unnur, Langer, Christian, Hansson, Markus, Goldschmidt, Hartmut, Kaiser, Martin, Sonneveld, Pieter, Stefansson, Kari, Morgan, Gareth J, Hemminki, Kari, Nilsson, Björn, Houlston, Richard S
Published in Nature communications

Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington's disease

by Stan, Tiberiu Loredan, Soylu-Kucharz, Rana, Burleigh, Stephen, Prykhodko, Olena, Cao, Ling, Franke, Naomi, Sjögren, Marie, Haikal, Caroline, Hållenius, Frida, Björkqvist, Maria
Published in Scientific reports

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

by Nik-Zainal, Serena, Davies, Helen, Staaf, Johan, Ramakrishna, Manasa, Glodzik, Dominik, Zou, Xueqing, Martincorena, Inigo, Alexandrov, Ludmil B, Martin, Sancha, Wedge, David C, Van Loo, Peter, Ju, Young Seok, Smid, Marcel, Brinkman, Arie B, Morganella, Sandro, Aure, Miriam R, Lingjærde, Ole Christian, Langerød, Anita, Ringnér, Markus, Ahn, Sung-Min, Boyault, Sandrine, Brock, Jane E, Broeks, Annegien, Butler, Adam, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Fatima, Aquila, Foekens, John A, Gerstung, Moritz, Hooijer, Gerrit K J, Jang, Se Jin, Jones, David R, Kim, Hyung-Yong, King, Tari A, Krishnamurthy, Savitri, Lee, Hee Jin, Lee, Jeong-Yeon, Li, Yilong, McLaren, Stuart, Menzies, Andrew, Mustonen, Ville, O'Meara, Sarah, Pauporté, Iris, Pivot, Xavier, Purdie, Colin A, Raine, Keiran, Ramakrishnan, Kamna, Rodríguez-González, F Germán, Romieu, Gilles, Sieuwerts, Anieta M, Simpson, Peter T, Shepherd, Rebecca, Stebbings, Lucy, Stefansson, Olafur A, Teague, Jon, Tommasi, Stefania, Treilleux, Isabelle, Van den Eynden, Gert G, Vermeulen, Peter, Vincent-Salomon, Anne, Yates, Lucy, Caldas, Carlos, van't Veer, Laura, Tutt, Andrew, Knappskog, Stian, Tan, Benita Kiat Tee, Jonkers, Jos, Borg, Åke, Ueno, Naoto T, Sotiriou, Christos, Viari, Alain, Futreal, P Andrew, Campbell, Peter J, Span, Paul N, Van Laere, Steven, Lakhani, Sunil R, Eyfjord, Jorunn E, Thompson, Alastair M, Birney, Ewan, Stunnenberg, Hendrik G, van de Vijver, Marc J, Martens, John W M, Børresen-Dale, Anne-Lise, Richardson, Andrea L, Kong, Gu, Thomas, Gilles, Stratton, Michael R
Published in Nature (London)

Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo

by Frost, Hanna K, Andersson, Tomas, Johansson, Sebastian, Englund-Johansson, U, Ekström, Per, Dahlin, Lars B, Johansson, Fredrik
Published in Scientific reports

Identification of bacterial biofilm and the Staphylococcus aureus derived protease, staphopain, on the skin surface of patients with atopic dermatitis

by Sonesson, Andreas, Przybyszewska, Kornelia, Eriksson, Sigrid, Mörgelin, Matthias, Kjellström, Sven, Davies, Julia, Potempa, Jan, Schmidtchen, Artur
Published in Scientific reports

Genetic insights into biological mechanisms governing human ovarian ageing

by Hussain, Jazib, Claringbould, Annique, Bakker, Olivier B, Walters, Robin G, Terao, Chikashi, Onland-Moret, N Charlotte, Olsen, Kristina W, Arnold, Alice M, Bandinelli, Stefania, Bergmann, Sven, Bochud, Murielle, Boerwinkle, Eric, Bowker, Nicholas, Broer, Linda, Buring, Julie E, Campbell, Archie, Corre, Tanguy, Couch, Fergus J, Cross, Simon S, Cucca, Francesco, Smith, George Davey, de Mutsert, Renée, Dwek, Miriam, Eriksson, Mikael, Esko, Tõnu, Fasching, Peter A, Faul, Jessica D, García-Closas, Montserrat, Grallert, Harald, Gudbjartsson, Daniel F, Guénel, Pascal, Håkansson, Niclas, Hayward, Caroline, Heiss, Gerardo, Høffding, Miya K, Hottenga, Jouke J, Hu, Frank, Hunter, David, Kardia, Sharon L R, Kartsonaki, Christiana, Karlsson, Robert, Kraft, Peter, Kurian, Allison W, Langenberg, Claudia, Laven, Joop S E, Lawlor, Deborah A, Li, Jingmei, Lindstrom, Sara, Lindstrom, Tricia, Linet, Martha, Luan, Jian'an, Mägi, Reedik, Mangino, Massimo, Mbarek, Hamdi, Medland, Sarah E, Meitinger, Thomas, Metspalu, Andres, Newman, Anne, Nyholt, Dale R, Olshan, Andrew F, Olsson, Håkan, Perjakova, Natalia, Porcu, Eleonora, Rahman, Iffat, Rennert, Hedy S, Rosendaal, Frits R, Rossouw, Jacques, Rudan, Igor, Rueedi, Rico, Saloustros, Emmanouil, Sandler, Dale P, Schmidt, Marjanka K, Schraut, Katharina E, Shekari, Saleh, Smith, Jennifer A, Southey, Melissa C, Spector, Tim D, Styrkarsdottir, Unnur, Teumer, Alexander, Toniolo, Daniela, Traglia, Michela, Uitterlinden, André G, Ulivi, Sheila, Vachon, Celine M, Völker, Uwe, Völzke, Henry, Wareham, Nicholas J, Wilcox, Amber N, van Dijk, Ko Willems, Wilson, James F, Wolffenbuttel, Bruce H R, Wolk, Alicja, Wood, Andrew R, Burgess, Stephen, Daniel, Jeremy A, Easton, Douglas F, Namekawa, Satoshi H, Solc, Petr, Murabito, Joanne M, Perry, John R B
Published in Nature (London)

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

by Escala-Garcia, Maria, Canisius, Sander, Keeman, Renske, Anton-Culver, Hoda, Arndt, Volker, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Bojesen, Stig E, Bolla, Manjeet K, Brenner, Hermann, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dörk, Thilo, Easton, Douglas F, Ekici, Arif B, Eliassen, A Heather, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Giles, Graham G, Grip, Mervi, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hartikainen, Jaana M, Heemskerk-Gerritsen, Bernadette A M, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Hunter, David J, Jacot, William, Jakubowska, Anna, John, Esther M, Jung, Audrey Y, Kaaks, Rudolf, Khusnutdinova, Elza, Koppert, Linetta B, Kraft, Peter, Kristensen, Vessela N, Kurian, Allison W, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Luben, Robert N, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Mavroudis, Dimitrios, Muranen, Taru A, Nevanlinna, Heli, Olshan, Andrew F, Olsson, Håkan, Park-Simon, Tjoung-Won, Patel, Alpa V, Peterlongo, Paolo, Punie, Kevin, Radice, Paolo, Rennert, Gad, Rennert, Hedy S, Romero, Atocha, Roylance, Rebecca, Rüdiger, Thomas, Ruebner, Matthias, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Scott, Christopher, Southey, Melissa C, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Teras, Lauren R, Thomas, Emilie, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, Wang, Qin, Winqvist, Robert, Wolk, Alicja, Ziogas, Argyrios, Michailidou, Kyriaki, Chenevix-Trench, Georgia, Bachelot, Thomas, Schmidt, Marjanka K
Published in Scientific reports

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

by Wang, Xiaoliang, Kapoor, Pooja Middha, Auer, Paul L, Dennis, Joe, Dunning, Alison M, Wang, Qin, Lush, Michael, Michailidou, Kyriaki, Bolla, Manjeet K, Aronson, Kristan J, Murphy, Rachel A, Brooks-Wilson, Angela, Lee, Derrick G, Cordina-Duverger, Emilie, Guénel, Pascal, Truong, Thérèse, Mulot, Claire, Teras, Lauren R, Patel, Alpa V, Dossus, Laure, Kaaks, Rudolf, Hoppe, Reiner, Lo, Wing-Yee, Brüning, Thomas, Hamann, Ute, Czene, Kamila, Gabrielson, Marike, Hall, Per, Eriksson, Mikael, Jung, Audrey, Becher, Heiko, Couch, Fergus J, Larson, Nicole L, Olson, Janet E, Ruddy, Kathryn J, Giles, Graham G, MacInnis, Robert J, Southey, Melissa C, Le Marchand, Loic, Wilkens, Lynne R, Haiman, Christopher A, Olsson, Håkan, Augustinsson, Annelie, Krüger, Ute, Wagner, Philippe, Scott, Christopher, Winham, Stacey J, Vachon, Celine M, Perou, Charles M, Olshan, Andrew F, Troester, Melissa A, Hunter, David J, Eliassen, Heather A, Tamimi, Rulla M, Brantley, Kristen, Andrulis, Irene L, Figueroa, Jonine, Chanock, Stephen J, Ahearn, Thomas U, García-Closas, Montserrat, Evans, Gareth D, Newman, William G, van Veen, Elke M, Howell, Anthony, Wolk, Alicja, Håkansson, Niclas, Anton-Culver, Hoda, Ziogas, Argyrios, Jones, Michael E, Orr, Nick, Schoemaker, Minouk J, Swerdlow, Anthony J, Kitahara, Cari M, Linet, Martha, Prentice, Ross L, Easton, Douglas F, Milne, Roger L, Kraft, Peter, Chang-Claude, Jenny, Lindström, Sara
Published in Scientific reports

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

by Vijayakrishnan, Jayaram, Studd, James, Broderick, Peter, Kinnersley, Ben, Holroyd, Amy, Law, Philip J, Kumar, Rajiv, Allan, James M, Harrison, Christine J, Moorman, Anthony V, Vora, Ajay, Roman, Eve, Rachakonda, Sivaramakrishna, Kinsey, Sally E, Sheridan, Eamonn, Thompson, Pamela D, Irving, Julie A, Koehler, Rolf, Hoffmann, Per, Nöthen, Markus M, Heilmann-Heimbach, Stefanie, Jöckel, Karl-Heinz, Easton, Douglas F, Pharaoh, Paul D P, Dunning, Alison M, Peto, Julian, Canzian, Frederico, Swerdlow, Anthony, Eeles, Rosalind A, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Greaves, Mel, Zimmerman, Martin, Bartram, Claus R, Schrappe, Martin, Stanulla, Martin, Hemminki, Kari, Houlston, Richard S
Published in Nature communications

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

by Liu, Jingjing, Prager-van der Smissen, Wendy J C, Collée, J Margriet, Bolla, Manjeet K, Ahearn, Thomas U, Aittomäki, Kristiina, Ambrosone, Christine B, Andrulis, Irene L, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Auvinen, Päivi, Becher, Heiko, Bermisheva, Marina, Bernstein, Leslie, Bogdanova, Natalia V, Bogdanova-Markov, Nadja, Brenner, Hermann, Brucker, Sara Y, Burwinkel, Barbara, Cai, Qiuyin, Cai, Hui, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Christiaens, Melissa, Clarke, Christine L, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dos-Santos-Silva, Isabel, Eliassen, A Heather, Gago-Dominguez, Manuela, Gapstur, Susan M, Gaudet, Mia M, Guénel, Pascal, Harrington, Patricia A, Hart, Steven N, Hartman, Mikael, Hillemanns, Peter, Hou, Ming-Feng, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, John, Esther M, Kaaks, Rudolf, Kang, Daehee, Kim, Sung-Won, Kurian, Allison W, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Luben, Robert N, Lubiński, Jan, Manoukian, Siranoush, Margolin, Sara, Mariapun, Shivaani, Matsuo, Keitaro, Maurer, Tabea, Mavroudis, Dimitrios, Menon, Usha, Neuhausen, Susan L, Olopade, Olufunmilayo I, Olson, Janet E, Olsson, Håkan, Park, Sue K, Peterlongo, Paolo, Plaseska-Karanfilska, Dijana, Rack, Brigitte, Rau-Murthy, Rohini, Rennert, Hedy S, Rhenius, Valerie, Ruebner, Matthias, Schmutzler, Rita K, Scott, Christopher, Shah, Mitul, Shen, Chen-Yang, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C, Tamimi, Rulla M, Tapper, William J, Torres, Diana, Vachon, Celine M, Yamaji, Taiki, Ziogas, Argyrios, Torres-Mejía, Gabriela, Dörk, Thilo, Swerdlow, Anthony J, Hamann, Ute, Schmidt, Marjanka K, Dunning, Alison M, Pharoah, Paul D P, Easton, Douglas F, Hooning, Maartje J, Martens, John W M
Published in Scientific reports

Two truncating variants in FANCC and breast cancer risk

by Mannermaa, Arto, Bolla, Manjeet K, Dennis, Joe, Ahearn, Thomas, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Freeman, Laura E Beane, Behrens, Sabine, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Brauch, Hiltrud, Burwinkel, Barbara, Choi, Ji-Yeob, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Eccles, Diana M, Ekici, Arif B, Eriksson, Mikael, Figueroa, Jonine, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gapstur, Susan M, García-Closas, Montserrat, Giles, Graham G, Goldberg, Mark S, Goldgar, David E, Haeberle, Lothar, Håkansson, Niclas, Hartman, Mikael, Hauke, Jan, Hein, Alexander, Hillemanns, Peter, Hogervorst, Frans B L, Hooning, Maartje J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, John, Esther M, Jung, Audrey, Kang, Daehee, Kapoor, Pooja Middha, Khusnutdinova, Elza, Kim, Sung-Won, Kitahara, Cari M, Kwong, Ava, Marchand, Loic Le, Li, Jingmei, Lindström, Sara, Lo, Wing-Yee, Long, Jirong, Lubiński, Jan, Manoukian, Siranoush, Meindl, Alfons, Menon, Usha, Milne, Roger L, Mohd Taib, Nur Aishah, Mulligan, Anna Marie, Nevanlinna, Heli, Neven, Patrick, Olshan, Andrew F, Olson, Janet E, Park, Sue K, Plaseska-Karanfilska, Dijana, Presneau, Nadege, Rack, Brigitte, Radice, Paolo, Rashid, Muhammad U, Rennert, Hedy S, Romero, Atocha, Ruebner, Matthias, Schmidt, Marjanka K, Schmutzler, Rita K, Scott, Christopher, Simard, Jacques, Slager, Susan, Smichkoska, Snezhana, Southey, Melissa C, Stone, Jennifer, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Terry, Mary Beth, Torres, Diana, Torres-Mejía, Gabriela, Truong, Thérèse, Vachon, Celine M, Wendt, Camilla, Yu, Jyh-Cherng, Ziogas, Argyrios, Ziv, Elad, Dunning, Alison M, Pharoah, Paul D P
Published in Scientific reports

Adipose cell size changes are associated with a drastic actin remodeling

by Hansson, Björn, Morén, Björn, Fryklund, Claes, Vliex, Lars, Wasserstrom, Sebastian, Albinsson, Sebastian, Berger, Karin, Stenkula, Karin G
Published in Scientific reports

Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability

by Movert, Elin, Bolarin, Jaume Salgado, Valfridsson, Christine, Velarde, Jorge, Skrede, Steinar, Nekludov, Michael, Hyldegaard, Ole, Arnell, Per, Svensson, Mattias, Norrby-Teglund, Anna, Cho, Kyu Hong, Elhaik, Eran, Wessels, Michael R, Råberg, Lars, Carlsson, Fredric
Published in Nature communications

A comparison of AAV-vector production methods for gene therapy and preclinical assessment

by Davidsson, Marcus, Negrini, Matilde, Hauser, Swantje, Svanbergsson, Alexander, Lockowandt, Marcus, Tomasello, Giuseppe, Manfredsson, Fredric P, Heuer, Andreas
Published in Scientific reports