The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

by Davis, Mark E
Published in Molecular pharmaceutics

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

by Mima, Yu, Hashimoto, Yosuke, Shimizu, Taro, Kiwada, Hiroshi, Ishida, Tatsuhiro
Published in Molecular pharmaceutics

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties

by Hoque, Jiaul, Prakash, Relekar G, Paramanandham, Krishnamoorthy, Shome, Bibek R, Haldar, Jayanta
Published in Molecular pharmaceutics

Brain Targeting of Temozolomide via the Intranasal Route Using Lipid-Based Nanoparticles: Brain Pharmacokinetic and Scintigraphic Analyses

by Khan, Anam, Imam, Syed Sarim, Aqil, Mohammed, Ahad, Abdul, Sultana, Yasmin, Ali, Asgar, Khan, Khalid
Published in Molecular pharmaceutics

Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo

by Feng, Lan, Wu, Huali, Ma, Ping, Mumper, Russell J, Benhabbour, S Rahima
Published in International journal of nanomedicine

Delivering siRNA and Chemotherapeutic Molecules Across BBB and BTB for Intracranial Glioblastoma Therapy

by Yang, Zhen-zhen, Gao, Wei, Liu, Yu-jie, Pang, Ning, Qi, Xian-rong
Published in Molecular pharmaceutics

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

by Hu, Quanyin, Sun, Wujin, Lu, Yue, Bomba, Hunter N, Ye, Yanqi, Jiang, Tianyue, Isaacson, Ari J, Gu, Zhen
Published in Nano letters

MiR-155 Inhibitor-Laden Exosomes Reverse Resistance to Cisplatin in a 3D Tumor Spheroid and Xenograft Model of Oral Cancer

by Sayyed, Adil Ali, Gondaliya, Piyush, Mali, Mukund, Pawar, Abhijeet, Bhat, Palak, Khairnar, Amit, Arya, Neha, Kalia, Kiran
Published in Molecular pharmaceutics

New Folate-Grafted Chitosan Derivative To Improve Delivery of Paclitaxel-Loaded Solid Lipid Nanoparticles for Lung Tumor Therapy by Inhalation

by Rosière, Rémi, Van Woensel, Matthias, Gelbcke, Michel, Mathieu, Véronique, Hecq, Julien, Mathivet, Thomas, Vermeersch, Marjorie, Van Antwerpen, Pierre, Amighi, Karim, Wauthoz, Nathalie
Published in Molecular pharmaceutics

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

by He, Zhijian, Wan, Xiaomeng, Schulz, Anita, Bludau, Herdis, Dobrovolskaia, Marina A, Stern, Stephan T, Montgomery, Stephanie A, Yuan, Hong, Li, Zibo, Alakhova, Daria, Sokolsky, Marina, Darr, David B, Perou, Charles M, Jordan, Rainer, Luxenhofer, Robert, Kabanov, Alexander V
Published in Biomaterials

Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy

by Zang, Xinlong, Zhang, Xiaoxu, Hu, Haiyang, Qiao, Mingxi, Zhao, Xiuli, Deng, Yihui, Chen, Dawei
Published in Molecular pharmaceutics

Polyphenolic Nanoparticle Platforms (PARCELs) for In Vitro and In Vivo mRNA Delivery

by Ma, Yutian, Tiwade, Palas B., VanKeulen-Miller, Rachel, Narasipura, Eshan A., Fenton, Owen S.
Published in Nano letters

Synergistic Antitumor Potency of a Self-Assembling Peptide Hydrogel for the Local Co-delivery of Doxorubicin and Curcumin in the Treatment of Head and Neck Cancer

by Karavasili, Christina, Andreadis, Dimitrios A, Katsamenis, Orestis L, Panteris, Emmanuel, Anastasiadou, Pinelopi, Kakazanis, Zacharias, Zoumpourlis, Vasilis, Markopoulou, Catherine K, Koutsopoulos, Sotirios, Vizirianakis, Ioannis S, Fatouros, Dimitrios G
Published in Molecular pharmaceutics

Melanin-like Nanoparticles as an Alternative to Natural Melanin in Retinal Pigment Epithelium Cells and Their Therapeutic Effects against Age-Related Macular Degeneration

by Kwon, Yong-Su, Zheng, Min, Zhang, Alice Yang, Han, Zongchao
Published in ACS nano

Iron Oxide Nanoparticles Induce Autophagosome Accumulation through Multiple Mechanisms: Lysosome Impairment, Mitochondrial Damage, and ER Stress

by Zhang, Xudong, Zhang, Hongqiu, Liang, Xin, Zhang, Jinxie, Tao, Wei, Zhu, Xianbing, Chang, Danfeng, Zeng, Xiaowei, Liu, Gan, Mei, Lin
Published in Molecular pharmaceutics

Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody–Drug Conjugates

by Matsuda, Yutaka, Seki, Takuya, Yamada, Kei, Ooba, Yuri, Takahashi, Kazutoshi, Fujii, Tomohiro, Kawaguchi, Sayaka, Narita, Takahiro, Nakayama, Akira, Kitahara, Yoshiro, Mendelsohn, Brian A, Okuzumi, Tatsuya
Published in Molecular pharmaceutics

Self-Regulated Carboxyphenylboronic Acid-Modified Mesoporous Silica Nanoparticles with “Touch Switch” Releasing Property for Insulin Delivery

by Hou, Lin, Zheng, Yazhen, Wang, Yongchao, Hu, Yurong, Shi, Jinjin, Liu, Qi, Zhang, Huijuan, Zhang, Zhenzhong
Published in ACS applied materials & interfaces

Targeted Mitochondrial COQ 10 Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells

by Velichkovska, Martina, Surnar, Bapurao, Nair, Madhavan, Dhar, Shanta, Toborek, Michal
Published in Molecular pharmaceutics

Nanoparticle-Mediated Trapping of Wnt Family Member 5A in Tumor Microenvironments Enhances Immunotherapy for B‑Raf Proto-Oncogene Mutant Melanoma

by Liu, Qi, Zhu, Hongda, Tiruthani, Karthik, Shen, Limei, Chen, Fengqian, Gao, Keliang, Zhang, Xueqiong, Hou, Lin, Wang, Degeng, Liu, Rihe, Huang, Leaf
Published in ACS nano

Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates

by Fang, Siteng, Brems, Brittany M., Olawode, Emmanuel O., Miller, Jared T., Brooks, Tracy A., Tumey, L. Nathan
Published in Molecular pharmaceutics