PROTAC therapy as a new targeted therapy for lung cancer

by Li, Jennifer W., Zheng, Guangrong, Kaye, Frederic J., Wu, Lizi
Published in Molecular therapy

PTK2-associated gene signature could predict the prognosis of IPF

by Feng, Anlin, Caro, Yesenia Moreno, Gardner, Colin, Grischo, Garrett, Liang, Ying, Wickremasinghe, Praveen D, Polmann, Michaela, Kala, Mrinalini, Marlowe, Timothy, Black, Stephen M, Knox, Kenneth S, Wang, Ting
Published in Respiratory research

RE-MIND2: comparative effectiveness of tafasitamab plus lenalidomide versus polatuzumab vedotin/bendamustine/rituximab (pola-BR), CAR-T therapies, and lenalidomide/rituximab (R2) b...

by Nowakowski, Grzegorz S., Yoon, Dok Hyun, Mondello, Patrizia, Joffe, Erel, Peters, Anthea, Fleury, Isabelle, Greil, Richard, Ku, Matthew, Marks, Reinhard, Kim, Kibum, Zinzani, Pier Luigi, Trotman, Judith, Sabatelli, Lorenzo, Waltl, Eva E., Winderlich, Mark, Sporchia, Andrea, Kurukulasuriya, Nuwan C., Cordoba, Raul, Hess, Georg, Salles, Gilles
Published in Annals of hematology

Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma

by Panowski, Siler H, Srinivasan, Surabhi, Tan, Nguyen, Tacheva-Grigorova, Silvia K, Smith, Bryan, Mak, Yvonne S L, Ning, Hongxiu, Villanueva, Jonathan, Wijewarnasuriya, Dinali, Lang, Shanshan, Melton, Zea, Ghosh, Adit, Dusseaux, Mathilde, Galetto, Roman, Heyen, Jonathan R, Sai, Tao, Van Blarcom, Thomas, Chaparro-Riggers, Javier, Sasu, Barbra J
Published in Cancer research (Chicago, Ill.)

Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay

by Pitsillou, Eleni, Liang, Julia, Karagiannis, Chris, Ververis, Katherine, Darmawan, Kevion K., Ng, Ken, Hung, Andrew, Karagiannis, Tom C.
Published in Computational biology and chemistry

Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability

by Kilchrist, Kameron V, Dimobi, Somtochukwu C, Jackson, Meredith A, Evans, Brian C, Werfel, Thomas A, Dailing, Eric A, Bedingfield, Sean K, Kelly, Isom B, Duvall, Craig L
Published in ACS nano

Targeted protein degradation in antibacterial drug discovery?

by Gopal, Pooja, Dick, Thomas
Published in Progress in biophysics and molecular biology

Nanoparticle delivery of recombinant IL-2 (BALLkine-2) achieves durable tumor control with less systemic adverse effects in cancer immunotherapy

by Kim, Jun, Kang, Seounghun, Kim, Kyoung Won, Heo, Myeong-Gang, Park, Dae-In, Lee, Joon-Hyung, Lim, Nam Ju, Min, Dal-Hee, Won, Cheolhee
Published in Biomaterials

Proteolysis Targeting Chimeras (PROTACs) based on celastrol induce multiple protein degradation for triple-negative breast cancer treatment

by Gan, Xuelan, Wang, Fan, Luo, Jianguo, Zhao, Yunfei, Wang, Yan, Yu, Chao, Chen, Jun
Published in European journal of pharmaceutical sciences

Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

by Maneiro, Marı A, Forte, Nafsika, Shchepinova, Maria M, Kounde, Cyrille S, Chudasama, Vijay, Baker, James Richard, Tate, Edward W
Published in ACS chemical biology

FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates

by Lee, Byoung-Chul, Chalouni, Cecile, Doll, Sophia, Nalle, Sam C, Darwish, Martine, Tsai, Siao Ping, Kozak, Katherine R, Del-Rosario, Geoffrey, Yu, Shang-Fan, Erickson, Hans, Vandlen, Richard
Published in Bioconjugate chemistry

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils

by Abskharon, Romany, Pan, Hope, Sawaya, Michael R, Seidler, Paul M, Olivares, Eileen J, Chen, Yu, Murray, Kevin A, Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R, Cascio, Duilio, Nguyen, Binh A, Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K, Nana, Alissa L, Vinters, Harry V, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Steyaert, Jan, Glabe, Charles G, Ogorzalek Loo, Rachel R, Loo, Joseph A, Eisenberg, David S
Published in Proceedings of the National Academy of Sciences - PNAS

TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer

by Heiduk, Max, Klimova, Anna, Reiche, Charlotte, Digomann, David, Beer, Carolin, Aust, Daniela E, Distler, Marius, Weitz, Jürgen, Seifert, Adrian M, Seifert, Lena
Published in Clinical cancer research

Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion

by Reddy, K Sony, Amlabu, Emmanuel, Pandey, Alok K, Mitra, Pallabi, Chauhan, Virander S, Gaur, Deepak
Published in Proceedings of the National Academy of Sciences - PNAS

EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection

by Capper, David, Reifenberger, Guido, French, Pim J, Schweizer, Leonille, Weller, Michael, Touat, Mehdi, Niclou, Simone P, Euskirchen, Philipp, Haberler, Christine, Hegi, Monika E, Brandner, Sebastian, Le Rhun, Emilie, Rudà, Roberta, Sanson, Marc, Tabatabai, Ghazaleh, Sahm, Felix, Wen, Patrick Y, Wesseling, Pieter, Preusser, Matthias, van den Bent, Martin J
Published in Neuro-oncology (Charlottesville, Va.)

Drug repurposing in cancer

by Sleire, Linda, Førde, Hilde Elise, Netland, Inger Anne, Leiss, Lina, Skeie, Bente Sandvei, Enger, Per Øyvind
Published in Pharmacological research

Epidermal growth factor receptor PROTACs as an effective strategy for cancer therapy: A review

by Wang, Chao, Zhang, Yujing, Chen, Wujun, Wang, Yanhong, Xing, Dongming
Published in Biochimica et biophysica acta. Reviews on cancer

Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

by Korang, Steven Kwasi, Juul, Sophie, Nielsen, Emil Eik, Feinberg, Joshua, Siddiqui, Faiza, Ong, Giok, Klingenberg, Sarah, Veroniki, Areti Angeliki, Bu, Fanlong, Thabane, Lehana, Thomsen, Allan Randrup, Jakobsen, Janus C, Gluud, Christian
Published in Systematic reviews

Biophysical and mechanobiological considerations for T-cell-based immunotherapy

by Zhuang, Chuzhi, Gould, Jared E., Enninful, Archibald, Shao, Stephanie, Mak, Michael
Published in Trends in pharmacological sciences (Regular ed.)

Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application

by Banaszek, Natalia, Kurpiewska, Dominika, Kozak, Katarzyna, Rutkowski, Piotr, Sobczuk, Paweł
Published in Journal of cancer research and clinical oncology