Cancer gene mutation frequencies for the U.S. population

by Mendiratta, Gaurav, Ke, Eugene, Aziz, Meraj, Liarakos, David, Tong, Melinda, Stites, Edward C.
Published in Nature communications

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

by Yi, Jingjie, Tavana, Omid, Li, Huan, Wang, Donglai, Baer, Richard J, Gu, Wei
Published in Nature communications

A genome-wide positioning systems network algorithm for in silico drug repurposing

by Cheng, Feixiong, Lu, Weiqiang, Liu, Chuang, Fang, Jiansong, Hou, Yuan, Handy, Diane E, Wang, Ruisheng, Zhao, Yuzheng, Yang, Yi, Huang, Jin, Hill, David E, Vidal, Marc, Eng, Charis, Loscalzo, Joseph
Published in Nature communications

Mapping combinatorial drug effects to DNA damage response kinase inhibitors

by Zhang, Hanrui, Kreis, Julian, Schelhorn, Sven-Eric, Dahmen, Heike, Grombacher, Thomas, Zühlsdorf, Michael, Zenke, Frank T, Guan, Yuanfang
Published in Nature communications

Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility

by Ku, Angel A, Hu, Hsien-Ming, Zhao, Xin, Shah, Khyati N, Kongara, Sameera, Wu, Di, McCormick, Frank, Balmain, Allan, Bandyopadhyay, Sourav
Published in Nature communications

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

by Werba, Gregor, Weissinger, Daniel, Kawaler, Emily A, Zhao, Ende, Kalfakakou, Despoina, Dhara, Surajit, Wang, Lidong, Lim, Heather B, Oh, Grace, Jing, Xiaohong, Beri, Nina, Khanna, Lauren, Gonda, Tamas, Oberstein, Paul, Hajdu, Cristina, Loomis, Cynthia, Heguy, Adriana, Sherman, Mara H, Lund, Amanda W, Welling, Theodore H, Dolgalev, Igor, Tsirigos, Aristotelis, Simeone, Diane M
Published in Nature communications

A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

by Fletcher, Alice, Clift, Dean, de Vries, Emma, Martinez Cuesta, Sergio, Malcolm, Timothy, Meghini, Francesco, Chaerkady, Raghothama, Wang, Junmin, Chiang, Abby, Weng, Shao Huan Samuel, Tart, Jonathan, Wong, Edmond, Donohoe, Gerard, Rawlins, Philip, Gordon, Euan, Taylor, Jonathan D, James, Leo, Hunt, James
Published in Nature communications

Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery

by Wang, Zefeng, Shaabani, Shabnam, Gao, Xiang, Ng, Yuen Lam Dora, Sapozhnikova, Valeriia, Mertins, Philipp, Krönke, Jan, Dömling, Alexander
Published in Nature communications

Glycolytic flux control by drugging phosphoglycolate phosphatase

by Jeanclos, Elisabeth, Schlötzer, Jan, Hadamek, Kerstin, Yuan-Chen, Natalia, Alwahsh, Mohammad, Hollmann, Robert, Fratz, Stefanie, Yesilyurt-Gerhards, Dilan, Frankenbach, Tina, Engelmann, Daria, Keller, Angelika, Kaestner, Alexandra, Schmitz, Werner, Neuenschwander, Martin, Hergenröder, Roland, Sotriffer, Christoph, von Kries, Jens Peter, Schindelin, Hermann, Gohla, Antje
Published in Nature communications

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

by Pozner, Amir, Li, Li, Verma, Shiv Prakash, Wang, Shuxin, Barrott, Jared J, Nelson, Mary L, Yu, Jamie S E, Negri, Gian Luca, Colborne, Shane, Hughes, Christopher S, Zhu, Ju-Fen, Lambert, Sydney L, Carroll, Lara S, Smith-Fry, Kyllie, Stewart, Michael G, Kannan, Sarmishta, Jensen, Bodrie, John, Cini M, Sikdar, Saif, Liu, Hongrui, Dang, Ngoc Ha, Bourdage, Jennifer, Li, Jinxiu, Vahrenkamp, Jeffery M, Mortenson, Katelyn L, Groundland, John S, Wustrack, Rosanna, Senger, Donna L, Zemp, Franz J, Mahoney, Douglas J, Gertz, Jason, Zhang, Xiaoyang, Lazar, Alexander J, Hirst, Martin, Morin, Gregg B, Nielsen, Torsten O, Shen, Peter S, Jones, Kevin B
Published in Nature communications

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

by Sun, Hua, Cao, Song, Mo, Chia-Kuei, Wendl, Michael C., Davies, Sherri R., Hoog, Jeremy, Mudd, Jacqueline L., Dean, Dennis A., Chen, Li, Wyczalkowski, Matthew A., Jayasinghe, Reyka G., Rodrigues, Fernanda Martins, Van Tine, Brian A., Ma, Cynthia X., Aft, Rebecca, Schwarz, Julie K., Puram, Sidharth V., Dipersio, John F., Belmar, Julie, Wu, Yige, Zhou, Daniel Cui, Butterfield, Andrew, Fujita, Maihi, Yang, Chieh-Hsiang, Cortes-Sanchez, Emilio, Borovski, Tijana, Chin, Vicki, DiGiovanna, John, Frech, Christian, Koc, Soner, Randjelovic, Jelena, Seepo, Sara, Stankovic, Tamara, Dobrolecki, Lacey E., Ittmann, Michael, Hilsenbeck, Susan G., Kaochar, Salma, Chen, Huiqin, Gale, Kelly, Gibbons, Don, Ha, Min Jin, Kopetz, Scott, Lanier, Christopher D., Li, Dali, Majidi, Mourad, Menter, David, Scott, Stephen, Sorokin, Alexey, Wang, Jing, Xi, Yuanxin, Xu, Yi, Yang, Fei, Yennu-Nanda, Vashisht G., Zhang, Jianhua, Zhang, Ran, Zhang, Xiaoshan, Zheng, Xiaofeng, Fingerman, Dylan, Liu, Qin, Kossenkov, Andrew V., Rebecca, Vito W., Somasundaram, Rajasekharan, Tetzlaff, Michae T., Wickramasinghe, Jayamanna, Xu, Xiaowei, Lloyd, Michael W., Rubinstein, Jill, White, Brian, Wallace, Tiffany, Minna, John D., Boning, Gao, Girard, Luc, Park, Hyunsil, Nathanson, Katherine L., Chen Jr, Moon S., Cho, May, Polanco-Echeverry, Guadalupe, Gandara, David R., Lott, Paul, Arana, Alexa Morales, Reiss, Jonathan W., Rocha, Sienna, Toal, Ted, Zhang, Hongyong, Lewis, Michael T., Davies, Michael A., Herlyn, Meenhard, Fang, Bingliang, Roth, Jack A., Welm, Alana L., Welm, Bryan E., Chen, Feng, Fields, Ryan C., Li, Shunqiang, Govindan, Ramaswamy, Doroshow, James H., Evrard, Yvonne A., Chuang, Jeffrey H., Raphael, Benjamin J., Ding, Li
Published in Nature communications