Common germline-somatic variant interactions in advanced urothelial cancer

by Vosoughi, Aram, Zhang, Tuo, Shohdy, Kyrillus S, Vlachostergios, Panagiotis J, Wilkes, David C, Bhinder, Bhavneet, Tagawa, Scott T, Nanus, David M, Molina, Ana M, Beltran, Himisha, Sternberg, Cora N, Motanagh, Samaneh, Robinson, Brian D, Xiang, Jenny, Fan, Xiao, Chung, Wendy K, Rubin, Mark A, Elemento, Olivier, Sboner, Andrea, Mosquera, Juan Miguel, Faltas, Bishoy M
Published in Nature communications

Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

by Tang, Fanying, Xu, Duo, Wang, Shangqian, Wong, Chen Khuan, Martinez-Fundichely, Alexander, Lee, Cindy J, Cohen, Sandra, Park, Jane, Hill, Corinne E, Eng, Kenneth, Bareja, Rohan, Han, Teng, Liu, Eric Minwei, Palladino, Ann, Di, Wei, Gao, Dong, Abida, Wassim, Beg, Shaham, Puca, Loredana, Meneses, Maximiliano, de Stanchina, Elisa, Berger, Michael F, Gopalan, Anuradha, Dow, Lukas E, Mosquera, Juan Miguel, Beltran, Himisha, Sternberg, Cora N, Chi, Ping, Scher, Howard I, Sboner, Andrea, Chen, Yu, Khurana, Ekta
Published in Science (American Association for the Advancement of Science)

High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

by DONG LIN, WYATT, Alexander W, BELL, Robert H, ANDERSON, Shawn, HURTADO-COLL, Antonio, FAZLI, Ladan, SHARMA, Manju, BELTRAN, Himisha, RUBIN, Mark, COX, Michael, GOUT, Peter W, MORRIS, James, HUI XUE, GOLDENBERG, Larry, VOLIK, Stanislav V, GLEAVE, Martin E, COLLINS, Colin C, YUZHUO WANG, YUWEI WANG, XIN DONG, HAEGERT, Anne, WU, Rebecca, BRAHMBHATT, Sonal, FAN MO, JONG, Lina
Published in Cancer research (Chicago, Ill.)

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

by Li, Qiuhui, Deng, Qu, Chao, Hsueh-Ping, Liu, Xin, Lu, Yue, Lin, Kevin, Liu, Bigang, Tang, Gregory W, Zhang, Dingxiao, Tracz, Amanda, Jeter, Collene, Rycaj, Kiera, Calhoun-Davis, Tammy, Huang, Jiaoti, Rubin, Mark A, Beltran, Himisha, Shen, Jianjun, Chatta, Gurkamal, Puzanov, Igor, Mohler, James L, Wang, Jianmin, Zhao, Ruizhe, Kirk, Jason, Chen, Xin, Tang, Dean G
Published in Nature communications

Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

by Cyrta, Joanna, Augspach, Anke, De Filippo, Maria Rosaria, Prandi, Davide, Thienger, Phillip, Benelli, Matteo, Cooley, Victoria, Bareja, Rohan, Wilkes, David, Chae, Sung-Suk, Cavaliere, Paola, Dephoure, Noah, Uldry, Anne-Christine, Lagache, Sophie Braga, Roma, Luca, Cohen, Sandra, Jaquet, Muriel, Brandt, Laura P., Alshalalfa, Mohammed, Puca, Loredana, Sboner, Andrea, Feng, Felix, Wang, Shangqian, Beltran, Himisha, Lotan, Tamara, Spahn, Martin, Kruithof-de Julio, Marianna, Chen, Yu, Ballman, Karla V., Demichelis, Francesca, Piscuoglio, Salvatore, Rubin, Mark A.
Published in Nature communications

The treatment landscape of metastatic prostate cancer

by Yamada, Yasutaka, Beltran, Himisha
Published in Cancer letters

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

by Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.
Published in Cancer cell

The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer

by Beltran, Himisha, Jendrisak, Adam, Landers, Mark, Mosquera, Juan Miguel, Kossai, Myriam, Louw, Jessica, Krupa, Rachel, Graf, Ryon P, Schreiber, Nicole A, Nanus, David M, Tagawa, Scott T, Marrinucci, Dena, Dittamore, Ryan, Scher, Howard I
Published in Clinical cancer research

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets

by Beltran, Himisha, Rickman, David S, Park, Kyung, Chae, Sung Suk, Sboner, Andrea, MacDonald, Theresa Y, Wang, Yuwei, Sheikh, Karen L, Terry, Stéphane, Tagawa, Scott T, Dhir, Rajiv, Nelson, Joel B, de la Taille, Alexandre, Allory, Yves, Gerstein, Mark B, Perner, Sven, Pienta, Kenneth J, Chinnaiyan, Arul M, Wang, Yuzhuo, Collins, Colin C, Gleave, Martin E, Demichelis, Francesca, Nanus, David M, Rubin, Mark A
Published in Cancer discovery

Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy

by Beltran, Himisha, Wyatt, Alexander W, Chedgy, Edmund C, Donoghue, Adam, Annala, Matti, Warner, Evan W, Beja, Kevin, Sigouros, Michael, Mo, Fan, Fazli, Ladan, Collins, Colin C, Eastham, James, Morris, Michael, Taplin, Mary-Ellen, Sboner, Andrea, Halabi, Susan, Gleave, Martin E
Published in Clinical cancer research

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

by Akamatsu, Shusuke, Wyatt, Alexander W., Lin, Dong, Lysakowski, Summer, Zhang, Fan, Kim, Soojin, Tse, Charan, Wang, Kendric, Mo, Fan, Haegert, Anne, Brahmbhatt, Sonal, Bell, Robert, Adomat, Hans, Kawai, Yoshihisa, Xue, Hui, Dong, Xin, Fazli, Ladan, Tsai, Harrison, Lotan, Tamara L., Kossai, Myriam, Mosquera, Juan Miguel, Rubin, Mark A., Beltran, Himisha, Zoubeidi, Amina, Wang, Yuzhuo, Gleave, Martin E., Collins, Colin C.
Published in Cell reports (Cambridge)

SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy

by Conteduca, Vincenza, Ku, Sheng-Yu, Puca, Loredana, Slade, Megan, Fernandez, Luisa, Hess, Judy, Bareja, Rohan, Vlachostergios, Panagiotis J, Sigouros, Michael, Mosquera, Juan Miguel, Sboner, Andrea, Nanus, David M, Elemento, Olivier, Dittamore, Ryan, Tagawa, Scott T, Beltran, Himisha
Published in Molecular cancer therapeutics

PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

by Liu, Bo, Li, Likun, Yang, Guang, Geng, Chuandong, Luo, Yong, Wu, Wenhui, Manyam, Ganiraju C, Korentzelos, Dimitrios, Park, Sanghee, Tang, Zhe, Wu, Cheng, Dong, Zhenyang, Sigouros, Michael, Sboner, Andrea, Beltran, Himisha, Chen, Yu, Corn, Paul G, Tetzlaff, Michael T, Troncoso, Patricia, Broom, Bradley, Thompson, Timothy C
Published in Clinical cancer research

Epigenetic Repression of miR-31 Disrupts Androgen Receptor Homeostasis and Contributes to Prostate Cancer Progression

by LIN, Pei-Chun, CHIU, Ya-Lin, MELNICK, Ari M, ELEMENTO, Olivier, DEMICHELIS, Francesca, RUBIN, Mark A, BANERJEE, Samprit, PARK, Kyung, MOSQUERA, Juan Miguel, GIANNOPOULOU, Eugenia, ALVES, Pedro, TEWARI, Ashutosh K, GERSTEIN, Mark B, BELTRAN, Himisha
Published in Cancer research (Chicago, Ill.)

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

by Mosquera, Juan Miguel, Beltran, Himisha, Park, Kyung, MacDonald, Theresa Y, Robinson, Brian D, Tagawa, Scott T, Perner, Sven, Bismar, Tarek A, Erbersdobler, Andreas, Dhir, Rajiv, Nelson, Joel B, Nanus, David M, Rubin, Mark A
Published in Neoplasia (New York, N.Y.)

Chemokine receptor CXCR7 activates Aurora Kinase A and promotes neuroendocrine prostate cancer growth

by Gritsina, Galina, Fong, Ka-Wing, Lu, Xiaodong, Lin, Zhuoyuan, Xie, Wanqing, Agarwal, Shivani, Lin, Dong, Schiltz, Gary E, Beltran, Himisha, Corey, Eva, Morrissey, Colm, Wang, Yuzhuo, Zhao, Jonathan C, Hussain, Maha, Yu, Jindan
Published in The Journal of clinical investigation

New Therapies for Castration-Resistant Prostate Cancer: Efficacy and Safety

by Beltran, Himisha, Beer, Tomasz M, Carducci, Michael A, de Bono, Johann, Gleave, Martin, Hussain, Maha, Kelly, William K, Saad, Fred, Sternberg, Cora, Tagawa, Scott T, Tannock, Ian F
Published in European urology

A phase I/II study of rovalpituzumab tesirine in delta-like 3—expressing advanced solid tumors

by Mansfield, Aaron S., Hong, David S., Hann, Christine L., Farago, Anna F., Beltran, Himisha, Waqar, Saiama N., Hendifar, Andrew E., Anthony, Lowell B., Taylor, Matthew H., Bryce, Alan H., Tagawa, Scott T., Lewis, Karl, Niu, Jiaxin, Chung, Christine H., Cleary, James M., Rossi, Michael, Ludwig, Carrianne, Valenzuela, Ricardo, Luo, Yan, Aggarwal, Rahul
Published in NPJ precision oncology

Circulating tumor cell heterogeneity in neuroendocrine prostate cancer by single cell copy number analysis

by Conteduca, Vincenza, Ku, Sheng-Yu, Fernandez, Luisa, Dago-Rodriquez, Angel, Lee, Jerry, Jendrisak, Adam, Slade, Megan, Gilbertson, Cole, Manohar, Jyothi, Sigouros, Michael, Wang, Yipeng, Dittamore, Ryan, Wenstrup, Rick, Mosquera, Juan Miguel, Schonhoft, Joseph D., Beltran, Himisha
Published in NPJ precision oncology

Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy

by Hongo, Hiroshi, Kosaka, Takeo, Hayashi, Hideyuki, Nakamura, Kohei, Nishihara, Hiroshi, Mikami, Shuji, Beltran, Himisha, Oya, Mototsugu
Published in Asian journal of andrology