Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

by Li, Xiaodun, Francies, Hayley E, Secrier, Maria, Perner, Juliane, Miremadi, Ahmad, Galeano-Dalmau, Núria, Barendt, William J, Letchford, Laura, Leyden, Genevieve M, Goffin, Emma K, Barthorpe, Andrew, Lightfoot, Howard, Chen, Elisabeth, Gilbert, James, Noorani, Ayesha, Devonshire, Ginny, Bower, Lawrence, Grantham, Amber, MacRae, Shona, Grehan, Nicola, Wedge, David C, Fitzgerald, Rebecca C, Garnett, Mathew J
Published in Nature communications

The mutREAD method detects mutational signatures from low quantities of cancer DNA

by Perner, Juliane, Abbas, Sujath, Nowicki-Osuch, Karol, Devonshire, Ginny, Eldridge, Matthew D, Tavaré, Simon, Fitzgerald, Rebecca C
Published in Nature communications

Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

by Antonowicz, Stefan, Bodai, Zsolt, Wiggins, Tom, Markar, Sheraz R, Boshier, Piers R, Goh, Yan Mei, Adam, Mina E, Lu, Haonan, Kudo, Hiromi, Rosini, Francesca, Goldin, Robert, Moralli, Daniela, Green, Catherine M, Peters, Chris J, Habib, Nagy, Gabra, Hani, Fitzgerald, Rebecca C, Takats, Zoltan, Hanna, George B
Published in Nature communications

Chromosomal copy number heterogeneity predicts survival rates across cancers

by van Dijk, Erik, van den Bosch, Tom, Lenos, Kristiaan J., El Makrini, Khalid, Nijman, Lisanne E., van Essen, Hendrik F. B., Lansu, Nico, Boekhout, Michiel, Hageman, Joris H., Fitzgerald, Rebecca C., Punt, Cornelis J. A., Tuynman, Jurriaan B., Snippert, Hugo J. G., Kops, Geert J. P. L., Medema, Jan Paul, Ylstra, Bauke, Vermeulen, Louis, Miedema, Daniël M.
Published in Nature communications

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma

by Abbas, Sujath, Pich, Oriol, Devonshire, Ginny, Zamani, Shahriar A, Katz-Summercorn, Annalise, Killcoyne, Sarah, Cheah, Calvin, Nutzinger, Barbara, Grehan, Nicola, Lopez-Bigas, Nuria, Fitzgerald, Rebecca C, Secrier, Maria
Published in Nature communications

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

by An, Jiyuan, Gharahkhani, Puya, Law, Matthew H, Ong, Jue-Sheng, Han, Xikun, Olsen, Catherine M, Neale, Rachel E, Lai, John, Vaughan, Tom L, Gockel, Ines, Thieme, René, Böhmer, Anne C, Jankowski, Janusz, Fitzgerald, Rebecca C, Schumacher, Johannes, Palles, Claire, Whiteman, David C, MacGregor, Stuart
Published in Nature communications

Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

by Mourikis, Thanos P, Benedetti, Lorena, Foxall, Elizabeth, Temelkovski, Damjan, Nulsen, Joel, Perner, Juliane, Cereda, Matteo, Lagergren, Jesper, Howell, Michael, Yau, Christopher, Fitzgerald, Rebecca C, Scaffidi, Paola, Ciccarelli, Francesca D
Published in Nature communications

Author Correction: Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

by An, Jiyuan, Gharahkhani, Puya, Law, Matthew H, Ong, Jue-Sheng, Han, Xikun, Olsen, Catherine M, Neale, Rachel E, Lai, John, Vaughan, Tom L, Gockel, Ines, Thieme, René, Böhmer, Anne C, Jankowski, Janusz, Fitzgerald, Rebecca C, Schumacher, Johannes, Palles, Claire, Whiteman, David C, MacGregor, Stuart
Published in Nature communications

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

by Ong, Jue-Sheng, Dixon-Suen, Suzanne C, Han, Xikun, An, Jiyuan, Liyanage, Upekha, Dusingize, Jean-Cluade, Schumacher, Johannes, Gockel, Ines, Böhmer, Anne, Jankowski, Janusz, Palles, Claire, O'Mara, Tracy, Spurdle, Amanda, Law, Matthew H, Iles, Mark M, Pharoah, Paul, Berchuck, Andrew, Zheng, Wei, Thrift, Aaron P, Olsen, Catherine, Neale, Rachel E, Gharahkhani, Puya, Webb, Penelope M, MacGregor, Stuart
Published in Nature communications

Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

by Donovan-Banfield, I'ah, Penrice-Randal, Rebekah, Goldswain, Hannah, Rzeszutek, Aleksandra M, Pilgrim, Jack, Bullock, Katie, Saunders, Geoffrey, Northey, Josh, Dong, Xiaofeng, Ryan, Yan, Reynolds, Helen, Tetlow, Michelle, Walker, Lauren E, FitzGerald, Richard, Hale, Colin, Lyon, Rebecca, Woods, Christie, Ahmad, Shazaad, Hadjiyiannakis, Dennis, Periselneris, Jimstan, Knox, Emma, Middleton, Calley, Lavelle-Langham, Lara, Shaw, Victoria, Greenhalf, William, Edwards, Thomas, Lalloo, David G, Edwards, Christopher J, Darby, Alistair C, Carroll, Miles W, Griffiths, Gareth, Khoo, Saye H, Hiscox, Julian A, Fletcher, Thomas
Published in Nature communications

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

by de la Fuente, Alerie Guzman, Dittmer, Marie, Heesbeen, Elise J, de la Vega Gallardo, Nira, White, Jessica A, Young, Andrew, McColgan, Tiree, Dashwood, Amy, Mayne, Katie, Cabeza-Fernández, Sonia, Falconer, John, Rodriguez-Baena, Francisco Javier, McMurran, Christopher E, Inayatullah, Mohammed, Rawji, Khalil S, Franklin, Robin J M, Dooley, James, Liston, Adrian, Ingram, Rebecca J, Tiwari, Vijay K, Penalva, Rosana, Dombrowski, Yvonne, Fitzgerald, Denise C
Published in Nature communications

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

by Matejcic, Marco, Saunders, Edward J, Dadaev, Tokhir, Brook, Mark N, Wang, Kan, Sheng, Xin, Olama, Ali Amin Al, Schumacher, Fredrick R, Ingles, Sue A, Govindasami, Koveela, Benlloch, Sara, Berndt, Sonja I, Albanes, Demetrius, Koutros, Stella, Muir, Kenneth, Stevens, Victoria L, Gapstur, Susan M, Tangen, Catherine M, Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Kraft, Peter, Cancel-Tassin, Géraldine, Sorensen, Karina D, Maehle, Lovise, Grindedal, Eli M, Strom, Sara S, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Travis, Ruth C, Hamilton, Robert J, Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G, Kibel, Adam S, Vega, Ana, Bensen, Jeanette T, Kogevinas, Manolis, Penney, Kathryn L, Park, Jong Y, Stanford, Janet L, Cybulski, Cezary, Nordestgaard, Børge G, Brenner, Hermann, Maier, Christiane, Kim, Jeri, Teixeira, Manuel R, Neuhausen, Susan L, De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F, Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A, Gago-Dominguez, Manuela, Roobol, Monique J, Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa A, Pandha, Hardev, Thibodeau, Stephen N, Schaid, Daniel J, Wiklund, Fredrik, Chanock, Stephen J, Easton, Douglas F, Eeles, Rosalind A, Kote-Jarai, Zsofia, Conti, David V, Haiman, Christopher A
Published in Nature communications