Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

by Benyamin, Beben, Esko, Tonu, Ried, Janina S, Radhakrishnan, Aparna, Vermeulen, Sita H, Traglia, Michela, Gögele, Martin, Anderson, Denise, Broer, Linda, Podmore, Clara, Luan, Jian'an, Kutalik, Zoltan, Sanna, Serena, van der Meer, Peter, Tanaka, Toshiko, Wang, Fudi, Westra, Harm-Jan, Franke, Lude, Mihailov, Evelin, Milani, Lili, Hälldin, Jonas, Häldin, Jonas, Winkelmann, Juliane, Meitinger, Thomas, Thiery, Joachim, Peters, Annette, Waldenberger, Melanie, Rendon, Augusto, Jolley, Jennifer, Sambrook, Jennifer, Kiemeney, Lambertus A, Sweep, Fred C, Sala, Cinzia F, Schwienbacher, Christine, Pichler, Irene, Hui, Jennie, Demirkan, Ayse, Isaacs, Aaron, Amin, Najaf, Steri, Maristella, Waeber, Gérard, Verweij, Niek, Powell, Joseph E, Nyholt, Dale R, Heath, Andrew C, Madden, Pamela A F, Visscher, Peter M, Wright, Margaret J, Montgomery, Grant W, Martin, Nicholas G, Hernandez, Dena, Bandinelli, Stefania, van der Harst, Pim, Uda, Manuela, Vollenweider, Peter, Scott, Robert A, Langenberg, Claudia, Wareham, Nicholas J, van Duijn, Cornelia, Beilby, John, Pramstaller, Peter P, Hicks, Andrew A, Ouwehand, Willem H, Oexle, Konrad, Gieger, Christian, Metspalu, Andres, Camaschella, Clara, Toniolo, Daniela, Swinkels, Dorine W, Whitfield, John B
Published in Nature communications

Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

by Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B, Alföldi, Jessica, Francioli, Laurent C, Gauthier, Laura D, Hill, Andrew J, O'Donnell-Luria, Anne H, Karczewski, Konrad J, MacArthur, Daniel G
Published in Nature communications

Biological interpretation of genome-wide association studies using predicted gene functions

by Pers, Tune H, Karjalainen, Juha M, Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R, Yang, Jian, Lui, Julian C, Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K, Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S N, Hirschhorn, Joel N, Franke, Lude
Published in Nature communications

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

by Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O'Donnell-Luria, Anne H, Francioli, Laurent C, Cook, Stuart A, Barton, Paul J R, MacArthur, Daniel G, Ware, James S
Published in Nature communications

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

by Takeuchi, Fumihiko, Akiyama, Masato, Matoba, Nana, Katsuya, Tomohiro, Nakatochi, Masahiro, Tabara, Yasuharu, Narita, Akira, Saw, Woei-Yuh, Moon, Sanghoon, Spracklen, Cassandra N, Chai, Jin-Fang, Kim, Young-Jin, Zhang, Liang, Wang, Chaolong, Li, Huaixing, Li, Honglan, Wu, Jer-Yuarn, Dorajoo, Rajkumar, Nierenberg, Jovia L, Wang, Ya Xing, He, Jing, Bennett, Derrick A, Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Rakugi, Hiromi, Nakashima, Eitaro, Isono, Masato, Shirota, Matsuyuki, Hozawa, Atsushi, Ichihara, Sahoko, Matsubara, Tatsuaki, Yamamoto, Ken, Kohara, Katsuhiko, Igase, Michiya, Han, Sohee, Gordon-Larsen, Penny, Huang, Wei, Lee, Nanette R, Adair, Linda S, Hwang, Mi Yeong, Lee, Juyoung, Chee, Miao Li, Sabanayagam, Charumathi, Zhao, Wanting, Liu, Jianjun, Reilly, Dermot F, Sun, Liang, Huo, Shaofeng, Edwards, Todd L, Long, Jirong, Chang, Li-Ching, Chen, Chien-Hsiun, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Kelly, Tanika N, Bin Wei, Wen, Xu, Liang, Cai, Hui, Xiang, Yong-Bing, Lin, Kuang, Clarke, Robert, Walters, Robin G, Millwood, Iona Y, Li, Liming, Chambers, John C, Kooner, Jaspal S, Elliott, Paul, van der Harst, Pim, Chen, Zhengming, Sasaki, Makoto, Shu, Xiao-Ou, Jonas, Jost B, He, Jiang, Heng, Chew-Kiat, Chen, Yuan-Tsong, Zheng, Wei, Lin, Xu, Teo, Yik-Ying, Tai, E-Shyong, Cheng, Ching-Yu, Wong, Tien Yin, Sim, Xueling, Mohlke, Karen L, Yamamoto, Masayuki, Kim, Bong-Jo, Miki, Tetsuro, Nabika, Toru, Yokota, Mitsuhiro, Kamatani, Yoichiro, Kubo, Michiaki, Kato, Norihiro
Published in Nature communications

High-efficiency RNA-based reprogramming of human primary fibroblasts

by Kogut, Igor, McCarthy, Sandra M, Pavlova, Maryna, Astling, David P, Chen, Xiaomi, Jakimenko, Ana, Jones, Kenneth L, Getahun, Andrew, Cambier, John C, Pasmooij, Anna M G, Jonkman, Marcel F, Roop, Dennis R, Bilousova, Ganna
Published in Nature communications

Differential methylation of the TRPA1 promoter in pain sensitivity

by Bell, J T, Loomis, A K, Butcher, L M, Gao, F, Zhang, B, Hyde, C L, Sun, J, Wu, H, Ward, K, Harris, J, Scollen, S, Davies, M N, Schalkwyk, L C, Mill, J, Williams, F M K, Li, N, Deloukas, P, Beck, S, McMahon, S B, Wang, J, John, S L, Spector, T D
Published in Nature communications

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

by Cazier, J-B, Rao, S R, McLean, C M, Walker, A K, Walker, A L, Wright, B J, Jaeger, E E M, Kartsonaki, C, Marsden, L, Yau, C, Camps, C, Kaisaki, P, Taylor, J, Catto, J W, Tomlinson, I P M, Kiltie, A E, Hamdy, F C
Published in Nature communications

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

by Loh, Nellie Y, Minchin, James E N, Pinnick, Katherine E, Verma, Manu, Todorčević, Marijana, Denton, Nathan, Moustafa, Julia El-Sayed, Kemp, John P, Gregson, Celia L, Evans, David M, Neville, Matt J, Small, Kerrin S, McCarthy, Mark I, Mahajan, Anubha, Rawls, John F, Karpe, Fredrik, Christodoulides, Constantinos
Published in Nature communications

Author Correction: Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

by Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O'Donnell-Luria, Anne H, Francioli, Laurent C, Cook, Stuart A, Barton, Paul J R, MacArthur, Daniel G, Ware, James S
Published in Nature communications

Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

by Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B, Alföldi, Jessica, Francioli, Laurent C, Gauthier, Laura D, Hill, Andrew J, O'Donnell-Luria, Anne H, Karczewski, Konrad J, MacArthur, Daniel G
Published in Nature communications

Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease

by Cadby, Gemma, Giles, Corey, Melton, Phillip E, Huynh, Kevin, Mellett, Natalie A, Duong, Thy, Nguyen, Anh, Cinel, Michelle, Smith, Alex, Olshansky, Gavriel, Wang, Tingting, Brozynska, Marta, Inouye, Mike, McCarthy, Nina S, Ariff, Amir, Hung, Joseph, Hui, Jennie, Beilby, John, Dubé, Marie-Pierre, Watts, Gerald F, Shah, Sonia, Wray, Naomi R, Lim, Wei Ling Florence, Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M, Porter, Tenielle, Vacher, Michael, Bush, Ashley I, Rowe, Christopher C, Villemagne, Victor L, Ames, David, Masters, Colin L, Taddei, Kevin, Arnold, Matthias, Kastenmüller, Gabi, Nho, Kwangsik, Saykin, Andrew J, Han, Xianlin, Kaddurah-Daouk, Rima, Martins, Ralph N, Blangero, John, Meikle, Peter J, Moses, Eric K
Published in Nature communications

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

by Lu, Yingchang, Gustafsson, Stefan, Cousminer, Diana L, Drong, Alexander W, Evans, David M, Falchi, Mario, Li, Rui, Lu, Chen, Mägi, Reedik, Perry, John R B, Pers, Tune H, Sanna, Marianna, Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A E, Zhu, Zhihong, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S, Cederholm, Tommy, Choi, Hyung Jin, De Jager, Philip L, Dhonukshe-Rutten, Rosalie A M, Eury, Elodie, Fumeron, Frédéric, Gärtner, Simone, Han, Bok-Ghee, Hayward, Caroline, Hillege, Hans, Kent, Jack W, Liu, Tian, Lobbens, Stéphane, Michaëlsson, Karl, Nalls, Mike A, Nielson, Carrie M, Oozageer, Laticia, Pascoe, Laura, Polašek, Ozren, Ripatti, Samuli, Swart, Karin M A, Tikkanen, Emmi, van Schoor, Natasja M, Verweij, Niek, Wright, Alan F, Forrester, Terrence, Grarup, Niels, Kristiansson, Kati, Kuulasmaa, Teemu, Scott, Robert A, Wagner, Peter J, O'Connell, Jeffrey R, Oostra, Ben A, Shuldiner, Alan R, Song, Kijoung, Vandenput, Liesbeth, Vollenweider, Peter, Boettcher, Yvonne, Kivimaki, Mika, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A, Palotie, Aarno, Wareham, Nicholas J, Bennett, David A, Bertram, Lars, Blüher, Matthias, Cummings, Steven R, Czerwinski, Stefan A, Eckardt, Rahel, Hansen, Torben, Harris, Tamara B, Hastie, Nicholas, Jordan, Joanne M, Kajantie, Eero, Lehtimäki, Terho, Liu, Yongmei, Osmond, Clive, Perola, Markus, Rice, Treva K, Rivadeneira, Fernando, Sørensen, Thorkild I A, Tönjes, Anke, Tremblay, Angelo, Vitart, Veronique, Völzke, Henry, Walker, Mark, Bishop, D Timothy, Chambers, John C, Fox, Caroline, Franke, Lude, Hunter, David J, Kaplan, Robert C, Kooner, Jaspal S, Morris, Andrew P, North, Kari E, Ohlsson, Claes, Spector, Tim D, Mohlke, Karen L, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari
Published in Nature communications

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

by Willems, Sara M, Wright, Daniel J, Day, Felix R, Trajanoska, Katerina, Joshi, Peter K, Morris, John A, Matteini, Amy M, Garton, Fleur C, Grarup, Niels, Oskolkov, Nikolay, Thalamuthu, Anbupalam, Mangino, Massimo, Liu, Jun, Demirkan, Ayse, Lek, Monkol, Xu, Liwen, Wang, Guan, Oldmeadow, Christopher, Gaulton, Kyle J, Lotta, Luca A, Miyamoto-Mikami, Eri, Rivas, Manuel A, White, Tom, Loh, Po-Ru, Aadahl, Mette, Amin, Najaf, Attia, John R, Austin, Krista, Benyamin, Beben, Brage, Søren, Cheng, Yu-Ching, Cięszczyk, Paweł, Derave, Wim, Eriksson, Karl-Fredrik, Eynon, Nir, Linneberg, Allan, Lucia, Alejandro, Massidda, Myosotis, Mitchell, Braxton D, Miyachi, Motohiko, Murakami, Haruka, Padmanabhan, Sandosh, Pandey, Ashutosh, Papadimitriou, Ioannis, Rajpal, Deepak K, Sale, Craig, Schnurr, Theresia M, Sessa, Francesco, Shrine, Nick, Tobin, Martin D, Varley, Ian, Wain, Louise V, Wray, Naomi R, Lindgren, Cecilia M, MacArthur, Daniel G, Waterworth, Dawn M, McCarthy, Mark I, Pedersen, Oluf, Khaw, Kay-Tee, Kiel, Douglas P, Pitsiladis, Yannis, Fuku, Noriyuki, Franks, Paul W, North, Kathryn N, van Duijn, Cornelia M, Mather, Karen A, Hansen, Torben, Hansson, Ola, Spector, Tim, Murabito, Joanne M, Richards, J Brent, Rivadeneira, Fernando, Langenberg, Claudia, Perry, John R B, Wareham, Nick J, Scott, Robert A
Published in Nature communications

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

by Justice, Anne E, Winkler, Thomas W, Deng, Xuan, Czajkowski, Jacek, Lim, Elise, Kutalik, Zoltán, Xue, Luting, Wu, Joseph, Amin, Najaf, Bragg, Jennifer, Cadby, Gemma, Coggeshall, Scott, Huang, Tao, Jackson, Anne U, Justesen, Johanne Marie, Kinnunen, Leena, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Manichaikul, Ani, Pervjakova, Natalia, Strawbridge, Rona J, Vink, Jacqueline M, Vitart, Veronique, Wu, Ying, Hua Zhao, Jing, Adair, Linda S, Afaq, Saima, Biffar, Reiner, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L, Bottinger, Erwin, Braga, Daniele, Chambers, John C, de Craen, Anton J M, de Geus, Eco J C, Grallert, Harald, Harris, Tamara B, Heath, Andrew C, Hernandez, Dena, Huang, Jie, Hung, Joseph, Ingelsson, Erik, Jansson, John-Olov, Karlsson, Magnus, Koistinen, Heikki A, Kolovou, Genovefa, Krämer, Bernhard K, Leander, Karin, Ludolph-Donislawski, Anja, Lupoli, Sara, Marques-Vidal, Pedro, McKenzie, Colin A, Mellström, Dan, Menni, Cristina, Montgomery, Grant W, Narisu, Narisu, Oldehinkel, Albertine J, Rao, D C, Rawal, Rajesh, Rice, Treva, Sanna, Serena, Sarzynski, Mark A, Schlessinger, David, Silbernagel, Günther, Snieder, Harold, Staessen, Jan A, Stott, David J, Waeber, Gérard, Wild, Sarah, Willemsen, Gonneke, Wolffenbuttel, Bruce H R, Wright, Alan F, Bandinelli, Stefania, Böger, Carsten A, Cooper, Richard S, Cusi, Daniele, Ferrucci, Luigi, Franks, Paul W, Froguel, Philippe, Grabe, Hans-Jörgen, Kivimaki, Mika, Kooner, Jaspal S, Kuh, Diana, Laakso, Markku, Pasterkamp, Gerard, Peters, Annette, Peters, Ulrike, Psaty, Bruce M, Strauch, Konstantin, Wilson, James F, Boehnke, Michael, Hirschhorn, Joel N, Spector, Tim D, Strachan, David P, van Duijn, Cornelia M, Mohlke, Karen L, Liu, Ching-Ti, Borecki, Ingrid B
Published in Nature communications

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

by Ried, Janina S, Chu, Audrey Y, Eklund, Niina, Eriksson, Joel, Feitosa, Mary F, Goel, Anuj, Hayward, Caroline, Heard-Costa, Nancy L, Kutalik, Zoltán, Luan, Jian'an, Monda, Keri L, Prokopenko, Inga, Qi, Lu, Rose, Lynda M, Tachmazidou, Ioanna, van der Harst, Pim, Wang, Sophie R, Willems, Sara M, Wong, Andrew, Couto Alves, Alexessander, Beilby, John, Blangero, John, Campbell, Harry, Cucca, Fracensco, D'Avila, Francesca, Dedoussis, George, Dimitriou, Maria, Döring, Angela, Farmaki, Aliki-Eleni, Ferreira, Teresa, Fischer, Krista, Glorioso, Nicola, Harder, Marie Neergaard, Hastie, Nicholas, Hattersley, Andrew Tym, Heliövaara, Markku, Homuth, Georg, Hottenga, Jouke-Jan, Husemoen, Lise Lotte, Isaacs, Aaron, Ittermann, Till, Jula, Antti, Marie Justesen, Johanne, Kinnunen, Leena, Koistinen, Heikki A, Lichtner, Peter, Lorbeer, Roberto, Luben, Robert, Männistö, Satu, Milani, Lili, Morris, Andrew P, Osmond, Clive, Pilia, Maria G, Polašek, Ozren, Pramstaller, Peter P, Ribel-Madsen, Rasmus, Rice, Treva K, Ridker, Paul M, Sanna, Serena, Scholtens, Salome, Sparsø, Thomas Hempel, Steinthorsdottir, Valgerdur, Strauch, Konstantin, Swertz, Morris A, Van Vliet-Ostaptchouk, Jana V, Venturini, Cristina, Viikari, Jorma S, Widén, Elisabeth, Willemsen, Gonneke, Wilsgaard, Tom, Winkler, Thomas W, Wright, Alan F, Yerges-Armstrong, Laura M, Zillikens, M Carola, Cusi, Daniele, Hansen, Torben, Hu, Frank, Hveem, Kristian, Jarvelin, Marjo-Riitta, Kooner, Jaspal S, Kuh, Diana, Kuusisto, Johanna, Lakka, Timo A, Lehtimäki, Terho, Njølstad, Inger, Ohlsson, Claes, Pedersen, Oluf, Puolijoki, Hannu, Shudiner, Alan R, Sørensen, Thorkild I A, Uusitupa, Matti, Wareham, Nicholas J, Wilson, James F, Boehnke, Michael, Fox, Caroline, Groop, Leif C, McCarthy, Mark I, North, Kari E, Strachan, David P, Hirschhorn, Joel N
Published in Nature communications