From target discovery to clinical drug development with human genetics

by Trajanoska, Katerina, Bhérer, Claude, Taliun, Daniel, Zhou, Sirui, Richards, J. Brent, Mooser, Vincent
Published in Nature (London)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

by Munroe, Patricia B, Smith, Albert V, Verwoert, Germaine C, Amin, Najaf, Teumer, Alexander, Zhao, Jing Hua, Parsa, Afshin, Dehghan, Abbas, Peden, John F, Rudan, Igor, Chambers, John C, Fox, Ervin R, Alexander, Myriam, Tabara, Yasuharu, Seielstad, Mark, Kuznetsova, Tatiana, Ludwig, Barbara, Tomaszewski, Maciej, O'Connell, Jeffrey R, Kardia, Sharon L, Hingorani, Aroon D, Lawlor, Debbie A, Lawrence, Robert W, Clarke, Robert, Ongen, Halit, Li, Yali, Adair, Linda S, Lee, Nanette R, Bolton, Judith A Hoffman, Chaturvedi, Nish, Islam, Muhammad, Kulkarni, Smita R, Groop, Leif, Voight, Benjamin F, Guarrera, Simonetta, Plump, Andrew, Barroso, Inês, Vartiainen, Erkki, Burton, Paul R, Dong, Yanbin, Wang, Xiaoling, Lohman, Kurt K, Smith, Nicholas L, Kinra, Sanjay, Prabhakaran, Dorairaj, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A, Kita, Yoshikuni, Wichmann, H-Erich, Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Wong, Andrew, Raffel, Leslie J, Yao, Jie, Schwartz, Stephen M, Ikram, M Arfan, Rasheed, Asif, Watkins, Hugh, Bakker, Stephan J L, van Gilst, Wiek H, Janipalli, Charles S, Rivadeneira, Fernando, Ala-Korpela, Mika, Soininen, Pasi, Völzke, Henry, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Zhai, Guangju, Nalls, Michael A, Terzic, Janos, Kumar, M V Kranthi, Charchar, Fadi J, Schwarz, Peter E H, Guo, Xiuqing, Bots, Michiel L, Samani, Nilesh J, Palmer, Lyle J, Casas, Juan P, Vineis, Paolo, Raitakari, Olli, Wong, Tien Y, Tai, E Shyong, Cooper, Richard S, Rao, Dabeeru C, Harris, Tamara B, Morris, Richard W, Kivimaki, Mika, Coresh, Josef, Navis, Gerjan, Han, Bok-Ghee, Melander, Olle, Gyllensten, Ulf B, Rettig, Rainer, Uda, Manuela, Psaty, Bruce M, Abecasis, Gonçalo R
Published in Nature (London)

Biological, clinical and population relevance of 95 loci for blood lipids

by Caulfield, Mark J, Ordovas, Jose M, Kuzawa, Christopher W, Samani, Nilesh J, Crawford, Gabriel, Lokki, Marja-Liisa, Magnusson, Patrik K. E, Wilson, James G, Ricketts, Sally L, Pedersen, Nancy L, Döring, Angela, Hicks, Andrew A, Twee-Hee Ong, Rick, McPherson, Ruth, Martin, Nicholas G, Chambers, John, Burtt, Noel P, Bonnycastle, Lori L, Seielstad, Mark, Koseki, Masahiro, Kaprio, Jaakko, Rieder, Mark, Khaw, Kay-Tee, Zee, Robert Y. L, Campbell, Harry, Havulinna, Aki S, Sandhu, Manjinder S, Orho-Melander, Marju, Reilly, Muredach P, Taylor Jr, Herman A, Uitterlinden, Andre G, Musunuru, Kiran, Willer, Cristen J, Stefansson, Kari, Smit, Johannes H, Kathiresan, Sekar, Borecki, Ingrid B, Gyllensten, Ulf, Munroe, Patricia B, Pramstaller, Peter P, McArdle, Wendy, Tall, Alan R, Oostra, Ben A, Waterworth, Dawn M, Luan, Jian'an, Zhang, Weihua, Boomsma, Dorret I, Wright, Alan F, Vitart, Veronique, Cecile J. W. Janssens, A, Jin Go, Min, Erdmann, Jeanette, Abecasis, Gonçalo R, Launer, Lenore J, Hua Zhao, Jing, Ejebe, Kenechi G, Assimes, Themistocles L, Sabatti, Chiara, Waeber, Gérard, Aulchenko, Yurii S, Lange, Leslie A, Pirruccello, James P, Boerwinkle, Eric, Rudan, Igor, Ballantyne, Christie M, Groop, Leif C, Lakatta, Edward G, Schadt, Eric E, Scuteri, Angelo, Pattaro, Cristian, Schunkert, Heribert, Ferrucci, Luigi, Li, Xiaohui, Marroni, Fabio, Johansen, Christopher T, Bandinelli, Stefania, Feitosa, Mary F, Sanna, Serena, Rader, Daniel J, Loos, Ruth J. F, Igl, Wilmar, Vollenweider, Peter, Whitfield, John B, Salomaa, Veikko, Gieger, Christian, Hegele, Robert A, Wong, Tien Y, Demissie, Serkalem, Hayward, Caroline, Kastelein, John J.P, Nieminen, Markku S, Lucas, Gavin, Guiducci, Candace, Wilson, James F, Ingelsson, Erik, Wareham, Nicholas J, Boekholdt, S. Matthijs, Rose, Lynda M, Chen, Yii-der I, König, Inke R
Published in Nature (London)

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

by JACQUEMONT, Sébastien, REYMOND, Alexandre, THORLEIFSSON, Gudmar, BELFIORE, Marco, BOUQUILLON, Sonia, CAMPION, Dominique, DE LEEUW, Nicole, DE VRIES, Bert B. A, ESKO, Tõnu, FERNANDEZ, Bridget A, FERNANDEZ-ARANDA, Fernando, FERNANDEZ-REAL, José Manuel, ZUFFEREY, Flore, GRATACOS, Mònica, GUILMATRE, Audrey, HOYER, Juliane, JARVELIN, Marjo-Riitta, FRANK KOOY, R, KURG, Ants, LE CAIGNEC, Cédric, MÄNNIK, Katrin, PLATT, Orah S, SANLAVILLE, Damien, HAREWOOD, Louise, VAN HAELST, Mieke M, VILLATORO GOMEZ, Sergi, WALHA, Faida, WU, Bai-Lin, YU, Yongguo, ABOURA, Azzedine, ADDOR, Marie-Claude, ALEMBIK, Yves, ANTONARAKIS, Stylianos E, ARVEILER, Benoît, WALTERS, Robin G, BARTH, Magalie, BEDNAREK, Nathalie, BENA, Frédérique, BERGMANN, Sven, BERI, Mylène, BERNARDINI, Laura, BLAUMEISER, Bettina, BONNEAU, Dominique, BOTTANI, Armand, BOUTE, Odile, KUTALIK, Zoltán, BRUNNER, Han G, CAILLEY, Dorothee, CALLIER, Patrick, CHIESA, Jean, CHRAST, Jacqueline, COIN, Lachlan, COUTTON, Charles, CUISSET, Jean-Marie, CUVELLIER, Jean-Christophe, DAVID, Albert, MARTINET, Danielle, YIPING SHEN, VALSESIA, Armand, BECKMANN, Noam D
Published in Nature (London)

Prepublication data sharing

by Birney, Ewan, Hudson, Thomas J, Green, Eric D, Gunter, Chris, Eddy, Sean, Rogers, Jane, Harris, Jennifer R, Ehrlich, S Dusko, Apweiler, Rolf, Austin, Christopher P, Berglund, Lisa, Bobrow, Martin, Bountra, Chas, Brookes, Anthony J, Cambon-Thomsen, Anne, Carter, Nigel P, Chisholm, Rex L, Contreras, Jorge L, Cooke, Robert M, Crosby, William L, Dewar, Ken, Durbin, Richard, Dyke, Stephanie O M, Ecker, Joseph R, El Emam, Khaled, Feuk, Lars, Gabriel, Stacey B, Gallacher, John, Gelbart, William M, Granell, Antoni, Guarner, Francisco, Hubbard, Tim, Jackson, Scott A, Jennings, Jennifer L, Joly, Yann, Jones, Steven M, Kaye, Jane, Kennedy, Karen L, Knoppers, Bartha Maria, Kyrpides, Nikos C, Lowrance, William W, Luo, Jingchu, MacKay, John J, Martín-Rivera, Luis, McCombie, W Richard, McPherson, John D, Miller, Linda, Miller, Webb, Moerman, Don, Mooser, Vincent, Morton, Cynthia C, Ostell, James M, Ouellette, B F Francis, Parkhill, Julian, Raina, Parminder S, Rawlings, Christopher, Scherer, Steven E, Scherer, Stephen W, Schofield, Paul N, Sensen, Christoph W, Stodden, Victoria C, Sussman, Michael R, Tanaka, Toshihiro, Thornton, Janet, Tsunoda, Tatsuhiko, Valle, David, Vuorio, Eero I, Walker, Neil M, Wallace, Susan, Weinstock, George, Whitman, William B, Worley, Kim C, Wu, Cathy, Wu, Jiayan, Yu, Jun
Published in Nature (London)

A novel highly-penetrant form of obesity due to microdeletions on chromosome 16p11.2

by Walters, R. G., Jacquemont, S., Valsesia, A., de Smith, A. J., Martinet, D., Andersson, J., Falchi, M., Chen, F., Andrieux, J., Lobbens, S., Delobel, B., Stutzmann, F., Moustafa, J. S. El-Sayed, Chèvre, J.-C., Lecoeur, C., Vatin, V., Bouquillon, S., Buxton, J. L., Boute, O., Holder-Espinasse, M., Cuisset, J.-M., Lemaitre, M.-P., Ambresin, A.-E., Brioshi, A., Gaillard, M., Giusti, V., Fellmann, F., Ferrarini, A., Hadjikhani, N., Campion, D., Guilmatre, A., Goldenberg, A., Calmels, N., Mandel, J.-L., Le Caignec, C., David, A., Isidor, B., Cordier, M.-P., Dupuis-Girod, S., Labalme, A., Sanlaville, D., Béri-Deixheimer, M., Jonveaux, P., Leheup, B., Õunap, K., Bochukova, E. G., Henning, E., Keogh, J., Ellis, R. J., MacDermot, K. D., Vincent-Delorme, C., Plessis, G., Touraine, R., Philippe, A., Malan, V., Mathieu-Dramard, M., Chiesa, J., Blaumeiser, B., Kooy, R. F., Caiazzo, R., Pigeyre, M., Balkau, B., Sladek, R., Bergmann, S., Mooser, V., Waterworth, D., Reymond, A., Vollenweider, P., Waeber, G., Kurg, A., Palta, P., Esko, T., Metspalu, A., Nelis, M., Elliott, P., Hartikainen, A.-L., McCarthy, M. I., Peltonen, L., Carlsson, L., Jacobson, P., Sjöström, L., Huang, N., Hurles, M. E., O’Rahilly, S., Farooqi, I. S., Männik, K., Jarvelin, M.-R., Pattou, F., Meyre, D., Walley, A. J., Coin, L. J. M., Blakemore, A. I. F., Froguel, P., Beckmann, J. S.
Published in Nature (London)