Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

by Tan, Winnie, van Twest, Sylvie, Leis, Andrew, Bythell-Douglas, Rohan, Murphy, Vincent J, Sharp, Michael, Parker, Michael W, Crismani, Wayne, Deans, Andrew J
Published in eLife

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

by Yang, Sile F, Nelson, Christopher B, Wells, Jadon K, Fernando, Madushan, Lu, Robert, Allen, Joshua A M, Malloy, Lisa, Lamm, Noa, Murphy, Vincent J, Mackay, Joel P, Deans, Andrew J, Cesare, Anthony J, Sobinoff, Alexander P, Pickett, Hilda A
Published in Nature communications

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin

by Tan, Winnie, Murphy, Vincent J, Charron, Aude, van Twest, Sylvie, Sharp, Michael, Constantinou, Angelos, Parker, Michael W, Crismani, Wayne, Bythell-Douglas, Rohan, Deans, Andrew J
Published in PloS one

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

by Swuec, Paolo, Renault, Ludovic, Borg, Aaron, Shah, Fenil, Murphy, Vincent J., van Twest, Sylvie, Snijders, Ambrosius P., Deans, Andrew J., Costa, Alessandro
Published in Cell reports (Cambridge)

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

by Tan, Winnie, van Twest, Sylvie, Murphy, Vincent J, Deans, Andrew J
Published in Frontiers in cell and developmental biology

Branchpoint translocation by fork remodelers as a general mechanism of R-loop removal

by Hodson, Charlotte, van Twest, Sylvie, Dylewska, Malgorzata, O’Rourke, Julienne J., Tan, Winnie, Murphy, Vincent J., Walia, Mannu, Abbouche, Lara, Nieminuszczy, Jadwiga, Dunn, Elyse, Bythell-Douglas, Rohan, Heierhorst, Jörg, Niedzwiedz, Wojciech, Deans, Andrew J.
Published in Cell reports (Cambridge)

MACSE: Multiple Alignment of Coding SEquences accounting for frameshifts and stop codons

by Ranwez, Vincent, Harispe, Sébastien, Delsuc, Frédéric, Douzery, Emmanuel J P
Published in PloS one

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

by Aykul, Senem, Corpina, Richard A, Goebel, Erich J, Cunanan, Camille J, Dimitriou, Alexandra, Kim, Hyon Jong, Zhang, Qian, Rafique, Ashique, Leidich, Raymond, Wang, Xin, McClain, Joyce, Jimenez, Johanna, Nannuru, Kalyan C, Rothman, Nyanza J, Lees-Shepard, John B, Martinez-Hackert, Erik, Murphy, Andrew J, Thompson, Thomas B, Economides, Aris N, Idone, Vincent
Published in eLife

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

by Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J, Madem, Sirisha Kudumala, Adcott, Jennifer, Kerr, Fiona, Wong, Chi Tung, Vincent, Alec, Godenschwege, Tanja, Boucrot, Emmanuel, Partridge, Linda
Published in PLoS biology

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

by Küpers, Leanne K, Monnereau, Claire, Salas, Lucas A, Ghantous, Akram, Page, Christian M, Wilcox, Allen J, Czamara, Darina, Novoloaca, Alexei, Hoyo, Cathrine, Breton, Carrie V, Allard, Catherine, Just, Allan C, Bakulski, Kelly M, Holloway, John W, Everson, Todd M, Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A, Merid, Simon Kebede, Rezwan, Faisal I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine A S, Richardson, Tom G, Magnus, Maria C, Nohr, Ellen A, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L, Jima, Dereje D, Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O, Hertz-Picciotto, Irva, Gehring, Ulrike, Marsit, Carmen J, Beilin, Lawrence J, Vonk, Judith M, Jarvelin, Marjo-Riitta, Bergström, Anna, Örtqvist, Anne K, Ewart, Susan, Villa, Pia M, Moore, Sophie E, Willemsen, Gonneke, Standaert, Arnout R L, Sørensen, Thorkild I A, Yang, Ivana V, Kechris, Katerina, Nawrot, Tim S, Silver, Matt J, Gong, Yun Yun, Richiardi, Lorenzo, Litonjua, Augusto A, Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L, Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A, Croen, Lisa A, Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Arshad, Syed Hasan, Routledge, Michael N, Boomsma, Dorret I, Feinberg, Andrew P, Newschaffer, Craig J, Moisse, Matthieu, Fallin, M Daniele, Melén, Erik, Prentice, Andrew M, Kajantie, Eero, Almqvist, Catarina, Dabelea, Dana, Boezen, H Marike, Wright, Rosalind J, Hivert, Marie-France, Sunyer, Jordi, Munthe-Kaas, Monica C, Corpeleijn, Eva, Holland, Nina, Herceg, Zdenko, Binder, Elisabeth B, Davey Smith, George, Jaddoe, Vincent W V, Lie, Rolv T, Nystad, Wenche, London, Stephanie J, Relton, Caroline L, Snieder, Harold, Felix, Janine F
Published in Nature communications

Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity

by Overstreet, Anne-Marie C, Grayson, Bernadette E, Boger, Antonia, Bakke, Danika, Carmody, Erin M, Bales, Cayla E, Paski, Shirley C, Murphy, Stephen F, Dethlefs, Christopher R, Shannon, Kara J, Adlaka, Katie R, Wolford, Claire E, Campiti, Vincent J, Raghunandan, Christina V, Seeley, Randy J, Boone, David L
Published in Scientific reports

WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

by Anginot, Adrienne, Nguyen, Julie, Abou Nader, Zeina, Rondeau, Vincent, Bonaud, Amélie, Kalogeraki, Maria, Boutin, Antoine, Lemos, Julia P, Bisio, Valeria, Koenen, Joyce, Hanna Doumit Sakr, Lea, Picart, Amandine, Coudert, Amélie, Provot, Sylvain, Dulphy, Nicolas, Aurrand-Lions, Michel, Mancini, Stéphane J C, Lazennec, Gwendal, McDermott, David H, Guidez, Fabien, Blin-Wakkach, Claudine, Murphy, Philip M, Cohen-Solal, Martine, Espéli, Marion, Rouleau, Matthieu, Balabanian, Karl
Published in Nature communications

Social brain activation during mentalizing in a large autism cohort: the Longitudinal European Autism Project

by Moessnang, Carolin, Baumeister, Sarah, Tillmann, Julian, Goyard, David, Charman, Tony, Ambrosino, Sara, Baron-Cohen, Simon, Beckmann, Christian, Bölte, Sven, Bours, Carsten, Crawley, Daisy, Dell'Acqua, Flavio, Durston, Sarah, Ecker, Christine, Frouin, Vincent, Hayward, Hannah, Holt, Rosemary, Johnson, Mark, Jones, Emily, Lai, Meng-Chuan, Lombardo, Michael V, Mason, Luke, Oldenhinkel, Marianne, Persico, Antonio, Cáceres, Antonia San José, Spooren, Will, Loth, Eva, Murphy, Declan G M, Buitelaar, Jan K, Banaschewski, Tobias, Brandeis, Daniel, Tost, Heike, Meyer-Lindenberg, Andreas
Published in Molecular autism

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

by Akbari, Parsa, Sosina, Olukayode A, Bovijn, Jonas, Landheer, Karl, Nielsen, Jonas B, Kim, Minhee, Aykul, Senem, De, Tanima, Haas, Mary E, Hindy, George, Lin, Nan, Dinsmore, Ian R, Luo, Jonathan Z, Hectors, Stefanie, Geraghty, Benjamin, Germino, Mary, Panagis, Lampros, Parasoglou, Prodromos, Walls, Johnathon R, Halasz, Gabor, Atwal, Gurinder S, Jones, Marcus, LeBlanc, Michelle G, Still, Christopher D, Carey, David J, Giontella, Alice, Orho-Melander, Marju, Berumen, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M, Emberson, Jonathan R, Collins, Rory, Rader, Daniel J, Zambrowicz, Brian, Murphy, Andrew J, Balasubramanian, Suganthi, Overton, John D, Reid, Jeffrey G, Shuldiner, Alan R, Cantor, Michael, Abecasis, Goncalo R, Ferreira, Manuel A R, Sleeman, Mark W, Gusarova, Viktoria, Altarejos, Judith, Harris, Charles, Economides, Aris N, Idone, Vincent, Karalis, Katia, Della Gatta, Giusy, Mirshahi, Tooraj, Yancopoulos, George D, Melander, Olle, Marchini, Jonathan, Tapia-Conyer, Roberto, Locke, Adam E, Baras, Aris, Verweij, Niek, Lotta, Luca A
Published in Nature communications

Release Kinetics and In Vitro Characterization of Sodium Percarbonate and Calcium Peroxide to Oxygenate Bioprinted Tissue Models

by Ke, Dongxu, Kengla, Carlos, Lee, Sang Jin, Yoo, James J., Zhu, Xuesong, Murphy, Sean Vincent
Published in International journal of molecular sciences

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

by Castillo-Tandazo, Wilson, Smeets, Monique F, Murphy, Vincent, Liu, Rui, Hodson, Charlotte, Heierhorst, Jörg, Deans, Andrew J, Walkley, Carl R
Published in PLoS genetics

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

by Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S, Murphy, Kendelle J, Herrmann, David, Reed, Daniel A, Lucas, Morghan C, Warren, Sean C, Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T, Da Silva, Andrew, Leung, Wilfred, Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W, Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A, Whitelock, John M, Gill, Anthony J, Sansom, Owen J, Croucher, David R, Parker, Benjamin L, Pajic, Marina, Morton, Jennifer P, Cox, Thomas R, Timpson, Paul
Published in Nature communications

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

by Papadimitriou, Nikos, Bull, Caroline J, Jenab, Mazda, Hughes, David J, Bell, Joshua A, Sanderson, Eleanor, Timpson, Nicholas J, Smith, George Davey, Albanes, Demetrius, Campbell, Peter T, Küry, Sébastien, Le Marchand, Loic, Ulrich, Cornelia M, Visvanathan, Kala, Figueiredo, Jane C, Newcomb, Polly A, Pai, Rish K, Peters, Ulrike, Tsilidis, Kostas K, Boer, Jolanda M A, Vincent, Emma E, Mariosa, Daniela, Gunter, Marc J, Richardson, Tom G, Murphy, Neil
Published in BMC medicine

A remarkable case of micro-endemism in Laonastes aenigmamus (Diatomyidae, Rodentia) revealed by nuclear and mitochondrial DNA sequence data

by Nicolas, Violaine, Herbreteau, Vincent, Couloux, Arnaud, Keovichit, Kham, Douangboupha, Bounneuang, Hugot, Jean-Pierre
Published in PloS one

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

by Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J H, Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, de Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M, Hipp, Joerg, Holt, Rosemary J, Johnson, Mark H, Isaksson, Johan, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K
Published in Molecular autism