Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

by Shah, Sonia, Roselli, Carolina, Lin, Honghuang, Fatemifar, Ghazaleh, Hedman, Åsa K, Morley, Michael P, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Ärnlöv, Johan, Backman, Joshua D, Biggs, Mary L, Bloom, Heather L, Brown, Michael R, Buckbinder, Leonard, Chasman, Daniel I, Chen, Xing, Chen, Xu, Chung, Jonathan, Chutkow, William, Delgado, Graciela E, Denaxas, Spiros, Dörr, Marcus, Dudley, Samuel C, Dunn, Michael E, Felix, Stephan B, Finan, Chris, Ghanbari, Mohsen, Ghasemi, Sahar, Giedraitis, Vilmantas, Giulianini, Franco, Gottdiener, John S, Gross, Stefan, Guðbjartsson, Daníel F, van der Harst, Pim, Hyde, Craig L, Ingelsson, Erik, Jukema, J Wouter, Khaw, Kay-Tee, Kleber, Marcus E, Køber, Lars, Koekemoer, Andrea, Langenberg, Claudia, Lind, Lars, London, Barry, Lovering, Ruth C, Luan, Jian'an, Magnusson, Patrik, Mahajan, Anubha, Melander, Olle, Mordi, Ify R, Morgan, Thomas, Morris, Andrew D, Morris, Andrew P, Morrison, Alanna C, Nagle, Michael W, Niessner, Alexander, O'Donoghue, Michelle L, Owens, Anjali T, Palmer, Colin N A, Parry, Helen M, Portilla-Fernandez, Eliana, Psaty, Bruce M, Rice, Kenneth M, Ridker, Paul M, Romaine, Simon P R, Salo, Perttu, Salomaa, Veikko, Smith, Nicholas L, Stender, Steen, Stott, David J, Svensson, Per, Taylor, Kent D, Teumer, Alexander, Thorgeirsson, Guðmundur, Thorsteinsdottir, Unnur, Tyl, Benoit, Uitterlinden, Andre G, Veluchamy, Abirami, Völker, Uwe, Voors, Adriaan A, Wang, Xiaosong, Waterworth, Dawn, Weiss, Raul, Wiggins, Kerri L, Xing, Heming, Yerges-Armstrong, Laura M, Yu, Bing, Zannad, Faiez, Zhao, Jing Hua, Hemingway, Harry, Samani, Nilesh J, Malarstig, Anders, Asselbergs, Folkert W, Kuchenbaecker, Karoline, Lang, Chim C, Stefansson, Kari, Smith, J Gustav, Swerdlow, Daniel I, Lumbers, R Thomas
Published in Nature communications

Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

by Del-Toro, N, Duesbury, M, Koch, M, Perfetto, L, Shrivastava, A, Ochoa, D, Wagih, O, Piñero, J, Kotlyar, M, Pastrello, C, Beltrao, P, Furlong, L I, Jurisica, I, Hermjakob, H, Orchard, S, Porras, P
Published in Nature communications

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

by Cuomo, Anna S E, Seaton, Daniel D, McCarthy, Davis J, Martinez, Iker, Bonder, Marc Jan, Garcia-Bernardo, Jose, Amatya, Shradha, Madrigal, Pedro, Isaacson, Abigail, Buettner, Florian, Knights, Andrew, Natarajan, Kedar Nath, Vallier, Ludovic, Marioni, John C, Chhatriwala, Mariya, Stegle, Oliver
Published in Nature communications

Biological interpretation of genome-wide association studies using predicted gene functions

by Pers, Tune H, Karjalainen, Juha M, Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R, Yang, Jian, Lui, Julian C, Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K, Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S N, Hirschhorn, Joel N, Franke, Lude
Published in Nature communications

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

by Wessel, Jennifer, Willems, Sara M, Wang, Shuai, Dauriz, Marco, Hivert, Marie-France, Raghavan, Sridharan, Lipovich, Leonard, Fox, Keolu, Huffman, Jennifer E, An, Ping, Rasmussen-Torvik, Laura J, Ehm, Margaret G, Stančáková, Alena, Abrol, Ravinder, Besse, Céline, Boland, Anne, Fornage, Myriam, Freitag, Daniel F, Garcia, Melissa E, Guo, Xiuqing, Hara, Kazuo, Isaacs, Aaron, Layton, Jill C, Li, Man, Hua Zhao, Jing, Morrison, Alanna C, Peters, Marjolein J, Silveira, Angela, Southam, Lorraine, Stoiber, Marcus H, Taylor, Kent D, Allin, Kristine H, Amin, Najaf, Aponte, Jennifer L, Bihlmeyer, Nathan A, Boehnke, Michael, Chen, Yuning, Cheng, Ching-Yu, Correa, Adolfo, Czajkowski, Jacek, Dehghan, Abbas, Ehret, Georg B, Frånberg, Mattias, Giulianini, Franco, Goddard, 3rd, William A, Goel, Anuj, Hai, Yang, Hallmans, Göran, Jensen, Richard A, Jørgensen, Marit E, Jørgensen, Torben, Lee, I T, Lee, Wen-Jane, Leong, Aaron, Liu, Chunyu, Lindgren, Cecilia M, Malerba, Giovanni, Marouli, Eirini, Maruthur, Nisa M, McKean-Cowdin, Roberta, McLeod, Olga, Ntalla, Ioanna, Sennblad, Bengt, Smith, Jennifer A, Soranzo, Nicole, Stahl, Eli A, Tentolouris, Nikos, Javad, Sundas, Becker, Diane M, Bis, Joshua C, Brown, James B, Cupples, L Adrienne, Peloso, Gina M, Varma, Rohit, Boeing, Heiner, Bottinger, Erwin P, Deloukas, Panos, Ferrannini, Ele, Gudnason, Vilmundur, Hattersley, Andrew T, Hofman, Albert, Jansson, Jan-Håkan, Langenberg, Claudia, Launer, Lenore J, O'Donnell, Christopher J, Rich, Stephen S, Smith, Blair H, Uitterlinden, André G, Walker, Mark, Laakso, Markku, Chasman, Daniel I, Pedersen, Oluf, Psaty, Bruce M, Tai, E Shyong, Wareham, Nicholas J, Waterworth, Dawn M, Boerwinkle, Eric, Florez, Jose C, Dupuis, Josée, Scott, Robert A
Published in Nature communications

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

by Romagnoni, Alberto, Jégou, Simon, Van Steen, Kristel, Wainrib, Gilles, Hugot, Jean-Pierre
Published in Scientific reports

Genomics of cold adaptations in the Antarctic notothenioid fish radiation

by Bista, Iliana, Wood, Jonathan M D, Desvignes, Thomas, McCarthy, Shane A, Matschiner, Michael, Ning, Zemin, Tracey, Alan, Torrance, James, Sims, Ying, Chow, William, Smith, Michelle, Oliver, Karen, Haggerty, Leanne, Salzburger, Walter, Postlethwait, John H, Howe, Kerstin, Clark, Melody S, William Detrich, 3rd, H, Christina Cheng, C-H, Miska, Eric A, Durbin, Richard
Published in Nature communications

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

by Benyamin, Beben, Esko, Tonu, Ried, Janina S, Radhakrishnan, Aparna, Vermeulen, Sita H, Traglia, Michela, Gögele, Martin, Anderson, Denise, Broer, Linda, Podmore, Clara, Luan, Jian'an, Kutalik, Zoltan, Sanna, Serena, van der Meer, Peter, Tanaka, Toshiko, Wang, Fudi, Westra, Harm-Jan, Franke, Lude, Mihailov, Evelin, Milani, Lili, Hälldin, Jonas, Häldin, Jonas, Winkelmann, Juliane, Meitinger, Thomas, Thiery, Joachim, Peters, Annette, Waldenberger, Melanie, Rendon, Augusto, Jolley, Jennifer, Sambrook, Jennifer, Kiemeney, Lambertus A, Sweep, Fred C, Sala, Cinzia F, Schwienbacher, Christine, Pichler, Irene, Hui, Jennie, Demirkan, Ayse, Isaacs, Aaron, Amin, Najaf, Steri, Maristella, Waeber, Gérard, Verweij, Niek, Powell, Joseph E, Nyholt, Dale R, Heath, Andrew C, Madden, Pamela A F, Visscher, Peter M, Wright, Margaret J, Montgomery, Grant W, Martin, Nicholas G, Hernandez, Dena, Bandinelli, Stefania, van der Harst, Pim, Uda, Manuela, Vollenweider, Peter, Scott, Robert A, Langenberg, Claudia, Wareham, Nicholas J, van Duijn, Cornelia, Beilby, John, Pramstaller, Peter P, Hicks, Andrew A, Ouwehand, Willem H, Oexle, Konrad, Gieger, Christian, Metspalu, Andres, Camaschella, Clara, Toniolo, Daniela, Swinkels, Dorine W, Whitfield, John B
Published in Nature communications

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

by Postmus, Iris, Trompet, Stella, Deshmukh, Harshal A, Barnes, Michael R, Li, Xiaohui, Warren, Helen R, Chasman, Daniel I, Zhou, Kaixin, Arsenault, Benoit J, Donnelly, Louise A, Wiggins, Kerri L, Avery, Christy L, Griffin, Paula, Feng, QiPing, Taylor, Kent D, Li, Guo, Evans, Daniel S, Smith, Albert V, de Keyser, Catherine E, Johnson, Andrew D, de Craen, Anton J M, Stott, David J, Buckley, Brendan M, Ford, Ian, Westendorp, Rudi G J, Slagboom, P Eline, Sattar, Naveed, Munroe, Patricia B, Sever, Peter, Poulter, Neil, Stanton, Alice, Shields, Denis C, O'Brien, Eoin, Shaw-Hawkins, Sue, Chen, Y-D Ida, Nickerson, Deborah A, Smith, Joshua D, Dubé, Marie Pierre, Boekholdt, S Matthijs, Hovingh, G Kees, Kastelein, John J P, McKeigue, Paul M, Betteridge, John, Neil, Andrew, Durrington, Paul N, Doney, Alex, Carr, Fiona, Morris, Andrew, McCarthy, Mark I, Groop, Leif, Ahlqvist, Emma, Bis, Joshua C, Rice, Kenneth, Smith, Nicholas L, Whitsel, Eric A, Stürmer, Til, Boerwinkle, Eric, Ngwa, Julius S, O'Donnell, Christopher J, Vasan, Ramachandran S, Wei, Wei-Qi, Wilke, Russell A, Liu, Ching-Ti, Sun, Fangui, Guo, Xiuqing, Heckbert, Susan R, Post, Wendy, Sotoodehnia, Nona, Arnold, Alice M, Stafford, Jeanette M, Ding, Jingzhong, Herrington, David M, Kritchevsky, Stephen B, Eiriksdottir, Gudny, Launer, Leonore J, Harris, Tamara B, Chu, Audrey Y, Giulianini, Franco, MacFadyen, Jean G, Barratt, Bryan J, Nyberg, Fredrik, Stricker, Bruno H, Uitterlinden, André G, Hofman, Albert, Rivadeneira, Fernando, Emilsson, Valur, Franco, Oscar H, Ridker, Paul M, Gudnason, Vilmundur, Liu, Yongmei, Denny, Joshua C, Ballantyne, Christie M, Rotter, Jerome I, Adrienne Cupples, L, Psaty, Bruce M, Palmer, Colin N A, Tardif, Jean-Claude, Hitman, Graham, Krauss, Ronald M, Caulfield, Mark J
Published in Nature communications

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

by Yang, Jialiang, Huang, Tao, Petralia, Francesca, Long, Quan, Zhang, Bin, Argmann, Carmen, Zhao, Yong, Mobbs, Charles V, Schadt, Eric E, Zhu, Jun, Tu, Zhidong
Published in Scientific reports

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

by Takeuchi, Fumihiko, Akiyama, Masato, Matoba, Nana, Katsuya, Tomohiro, Nakatochi, Masahiro, Tabara, Yasuharu, Narita, Akira, Saw, Woei-Yuh, Moon, Sanghoon, Spracklen, Cassandra N, Chai, Jin-Fang, Kim, Young-Jin, Zhang, Liang, Wang, Chaolong, Li, Huaixing, Li, Honglan, Wu, Jer-Yuarn, Dorajoo, Rajkumar, Nierenberg, Jovia L, Wang, Ya Xing, He, Jing, Bennett, Derrick A, Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Rakugi, Hiromi, Nakashima, Eitaro, Isono, Masato, Shirota, Matsuyuki, Hozawa, Atsushi, Ichihara, Sahoko, Matsubara, Tatsuaki, Yamamoto, Ken, Kohara, Katsuhiko, Igase, Michiya, Han, Sohee, Gordon-Larsen, Penny, Huang, Wei, Lee, Nanette R, Adair, Linda S, Hwang, Mi Yeong, Lee, Juyoung, Chee, Miao Li, Sabanayagam, Charumathi, Zhao, Wanting, Liu, Jianjun, Reilly, Dermot F, Sun, Liang, Huo, Shaofeng, Edwards, Todd L, Long, Jirong, Chang, Li-Ching, Chen, Chien-Hsiun, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Kelly, Tanika N, Bin Wei, Wen, Xu, Liang, Cai, Hui, Xiang, Yong-Bing, Lin, Kuang, Clarke, Robert, Walters, Robin G, Millwood, Iona Y, Li, Liming, Chambers, John C, Kooner, Jaspal S, Elliott, Paul, van der Harst, Pim, Chen, Zhengming, Sasaki, Makoto, Shu, Xiao-Ou, Jonas, Jost B, He, Jiang, Heng, Chew-Kiat, Chen, Yuan-Tsong, Zheng, Wei, Lin, Xu, Teo, Yik-Ying, Tai, E-Shyong, Cheng, Ching-Yu, Wong, Tien Yin, Sim, Xueling, Mohlke, Karen L, Yamamoto, Masayuki, Kim, Bong-Jo, Miki, Tetsuro, Nabika, Toru, Yokota, Mitsuhiro, Kamatani, Yoichiro, Kubo, Michiaki, Kato, Norihiro
Published in Nature communications

High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

by Dhaubhadel, Sayera, Ganguly, Kumkum, Ribeiro, Ruy M, Cohn, Judith D, Hyman, James M, Hengartner, Nicolas W, Kolade, Beauty, Singley, Anna, Bhattacharya, Tanmoy, Finley, Patrick, Levin, Drew, Thelen, Haedi, Cho, Kelly, Costa, Lauren, Ho, Yuk-Lam, Justice, Amy C, Pestian, John, Santel, Daniel, Zamora-Resendiz, Rafael, Crivelli, Silvia, Tamang, Suzanne, Martins, Susana, Trafton, Jodie, Oslin, David W, Beckham, Jean C, Kimbrel, Nathan A, McMahon, Benjamin H
Published in Scientific reports

Differential methylation of the TRPA1 promoter in pain sensitivity

by Bell, J T, Loomis, A K, Butcher, L M, Gao, F, Zhang, B, Hyde, C L, Sun, J, Wu, H, Ward, K, Harris, J, Scollen, S, Davies, M N, Schalkwyk, L C, Mill, J, Williams, F M K, Li, N, Deloukas, P, Beck, S, McMahon, S B, Wang, J, John, S L, Spector, T D
Published in Nature communications

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

by Sivaramakrishnan, Manaswini, McCarthy, Kathleen D, Campagne, Sébastien, Huber, Sylwia, Meier, Sonja, Augustin, Angélique, Heckel, Tobias, Meistermann, Hélène, Hug, Melanie N, Birrer, Pascale, Moursy, Ahmed, Khawaja, Sarah, Schmucki, Roland, Berntenis, Nikos, Giroud, Nicolas, Golling, Sabrina, Tzouros, Manuel, Banfai, Balazs, Duran-Pacheco, Gonzalo, Lamerz, Jens, Hsiu Liu, Ying, Luebbers, Thomas, Ratni, Hasane, Ebeling, Martin, Cléry, Antoine, Paushkin, Sergey, Krainer, Adrian R, Allain, Frédéric H-T, Metzger, Friedrich
Published in Nature communications

Seasonal asthma in Melbourne, Australia, and some observations on the occurrence of thunderstorm asthma and its predictability

by Silver, Jeremy D, Sutherland, Michael F, Johnston, Fay H, Lampugnani, Edwin R, McCarthy, Michael A, Jacobs, Stephanie J, Pezza, Alexandre B, Newbigin, Edward J
Published in PloS one

Transmission dynamics of SARS-CoV-2 in a strictly-Orthodox Jewish community in the UK

by Waites, William, Pearson, Carl A B, Gaskell, Katherine M, House, Thomas, Pellis, Lorenzo, Johnson, Marina, Gould, Victoria, Hunt, Adam, Stone, Neil R H, Kasstan, Ben, Chantler, Tracey, Lal, Sham, Roberts, Chrissy H, Goldblatt, David, Marks, Michael, Eggo, Rosalind M
Published in Scientific reports

Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

by Kelly, M Ann, Rees, Simon D, Hydrie, M Zafar I, Shera, A Samad, Bellary, Srikanth, O'Hare, J Paul, Kumar, Sudhesh, Taheri, Shahrad, Basit, Abdul, Barnett, Anthony H
Published in PloS one

An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans

by Liu, Yutao, Garrett, Melanie E, Dennis, Michelle F, Green, Kimberly T, Ashley-Koch, Allison E, Hauser, Michael A, Beckham, Jean C, Kimbrel, Nathan A
Published in PloS one

Rare coding variants and X-linked loci associated with age at menarche

by Lunetta, Kathryn L, Day, Felix R, Sulem, Patrick, Ruth, Katherine S, Tung, Joyce Y, Hinds, David A, Esko, Tõnu, Elks, Cathy E, Altmaier, Elisabeth, He, Chunyan, Huffman, Jennifer E, Mihailov, Evelin, Porcu, Eleonora, Robino, Antonietta, Rose, Lynda M, Schick, Ursula M, Stolk, Lisette, Teumer, Alexander, Thompson, Deborah J, Traglia, Michela, Wang, Carol A, Yerges-Armstrong, Laura M, Antoniou, Antonis C, Barbieri, Caterina, Coviello, Andrea D, Cucca, Francesco, Demerath, Ellen W, Dunning, Alison M, Gandin, Ilaria, Grove, Megan L, Gudbjartsson, Daniel F, Hocking, Lynne J, Hofman, Albert, Huang, Jinyan, Jackson, Rebecca D, Karasik, David, Kriebel, Jennifer, Lange, Ethan M, Lange, Leslie A, Langenberg, Claudia, Li, Xin, Luan, Jian'an, Mägi, Reedik, Morrison, Alanna C, Padmanabhan, Sandosh, Pirie, Ailith, Polasek, Ozren, Porteous, David, Reiner, Alex P, Rivadeneira, Fernando, Rudan, Igor, Sala, Cinzia F, Schlessinger, David, Scott, Robert A, Stöckl, Doris, Visser, Jenny A, Völker, Uwe, Vozzi, Diego, Wilson, James G, Zygmunt, Marek, Boerwinkle, Eric, Buring, Julie E, Crisponi, Laura, Easton, Douglas F, Hayward, Caroline, Hu, Frank B, Liu, Simin, Metspalu, Andres, Pennell, Craig E, Ridker, Paul M, Strauch, Konstantin, Streeten, Elizabeth A, Toniolo, Daniela, Uitterlinden, André G, Ulivi, Sheila, Völzke, Henry, Wareham, Nicholas J, Wellons, Melissa, Franceschini, Nora, Chasman, Daniel I, Thorsteinsdottir, Unnur, Murray, Anna, Stefansson, Kari, Murabito, Joanne M, Ong, Ken K, Perry, John R B
Published in Nature communications

Barriers and enablers to deprescribing in long-term care: A qualitative investigation into the opinions of healthcare professionals in Ireland

by Heinrich, Clara H, McHugh, Sheena, McCarthy, Suzanne, Donovan, Maria D
Published in PloS one