Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

by Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W, Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Published in Nature communications

Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits

by Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V R, Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W, Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria
Published in Nature communications

A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates

by Tachmazidou, Ioanna, Dedoussis, George, Southam, Lorraine, Farmaki, Aliki-Eleni, Ritchie, Graham R S, Xifara, Dionysia K, Matchan, Angela, Hatzikotoulas, Konstantinos, Rayner, Nigel W, Chen, Yuan, Pollin, Toni I, O'Connell, Jeffrey R, Yerges-Armstrong, Laura M, Kiagiadaki, Chrysoula, Panoutsopoulou, Kalliope, Schwartzentruber, Jeremy, Moutsianas, Loukas, Tsafantakis, Emmanouil, Tyler-Smith, Chris, McVean, Gil, Xue, Yali, Zeggini, Eleftheria
Published in Nature communications

MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven

by Rantalainen, Mattias, Herrera, Blanca M, Nicholson, George, Bowden, Rory, Wills, Quin F, Min, Josine L, Neville, Matt J, Barrett, Amy, Allen, Maxine, Rayner, Nigel W, Fleckner, Jan, McCarthy, Mark I, Zondervan, Krina T, Karpe, Fredrik, Holmes, Chris C, Lindgren, Cecilia M
Published in PloS one

BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study

by Louwers, Yvonne V, Rayner, Nigel W, Herrera, Blanca M, Stolk, Lisette, Groves, Christopher J, Barber, Thomas M, Uitterlinden, Andre G, Franks, Stephen, Laven, Joop S E, McCarthy, Mark I
Published in PloS one

Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes

by Boraska, Vesna, Rayner, Nigel W, Groves, Christopher J, Frayling, Timothy M, Diakite, Mahamadou, Rockett, Kirk A, Kwiatkowski, Dominic P, Day-Williams, Aaron G, McCarthy, Mark I, Zeggini, Eleftheria
Published in BMC genetics

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants

by Panoutsopoulou, Kalliope, Hatzikotoulas, Konstantinos, Xifara, Dionysia Kiara, Colonna, Vincenza, Farmaki, Aliki-Eleni, Ritchie, Graham R S, Southam, Lorraine, Gilly, Arthur, Tachmazidou, Ioanna, Fatumo, Segun, Matchan, Angela, Rayner, Nigel W, Ntalla, Ioanna, Mezzavilla, Massimo, Chen, Yuan, Kiagiadaki, Chrysoula, Zengini, Eleni, Mamakou, Vasiliki, Athanasiadis, Antonis, Giannakopoulou, Margarita, Kariakli, Vassiliki-Eirini, Nsubuga, Rebecca N, Karabarinde, Alex, Sandhu, Manjinder, McVean, Gil, Tyler-Smith, Chris, Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria
Published in Nature communications

Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes

by Min, Josine L, Nicholson, George, Halgrimsdottir, Ingileif, Almstrup, Kristian, Petri, Andreas, Barrett, Amy, Travers, Mary, Rayner, Nigel W, Mägi, Reedik, Pettersson, Fredrik H, Broxholme, John, Neville, Matt J, Wills, Quin F, Cheeseman, Jane, Allen, Maxine, Holmes, Chris C, Spector, Tim D, Fleckner, Jan, McCarthy, Mark I, Karpe, Fredrik, Lindgren, Cecilia M, Zondervan, Krina T
Published in PLoS genetics

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

by Winkler, Thomas W, Feitosa, Mary F, Esko, Tõnu, Kilpeläinen, Tuomas O, Rüeger, Sina, Ferreira, Teresa, Absher, Devin, Bis, Joshua C, Fischer, Krista, Galesloot, Tessel E, Goel, Anuj, Gustafsson, Stefan, Haitjema, Saskia, Lahti, Jari, McKnight, Barbara, Monda, Keri L, Montasser, May E, Ryan, Kathy A, Scharnagl, Hubert, Sung, Yun Ju, van Setten, Jessica, van Vliet-Ostaptchouk, Jana V, Verweij, Niek, Zhao, Jing Hua, Andersson, Ehm A, Baldassarre, Damiano, Barlassina, Cristina, Campbell, Harry, Chen, Yii-Der Ida, Chines, Peter S, Claudi-Boehm, Simone, de Geus, Eco J C, Eury, Elodie, Friedrich, Nele, Grallert, Harald, Ham, Annelies C, Hansen, Torben, Hattersley, Andrew T, Hernandez, Dena, Hillege, Hans, Holmen, Oddgeir, Karaleftheri, Maria, Kinnunen, Leena, Kovacs, Peter, Kratzer, Wolfgang, Kuh, Diana, Kyriakou, Theodosios, Liu, Yan-Ping, Lyssenko, Valeriya, Männistö, Satu, Montgomery, Grant W, Morris, Andrew P, Ong, Ken K, Pilia, Maria G, Sanders, Alan R, Seufferlein, Thomas, Slagboom, P Eline, Stolk, Ronald P, Tsafantakis, Emmanouil, van der Most, Peter J, Völker, Uwe, Vonk, Judith M, Wennauer, Roman, Beilby, John, Boerwinkle, Eric, Bornstein, Stefan R, Chambers, John C, Farrall, Martin, Ford, Ian, Franke, Lude, Hofman, Albert, Hu, Frank, James, Alan L, Kajantie, Eero, Kivimaki, Mika, Maerz, Winfried, Martin, Nicholas G, Laakso, Markku, Melbye, Mads, Murray, Jeffrey C, Musk, Arthur W, Nieminen, Markku S, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Pasterkamp, Gerard, Pedersen, Oluf, Qi, Lu, Rauramaa, Rainer, Saltevo, Juha, Snieder, Harold, Spector, Tim D, Völzke, Henry, Wareham, Nicholas J, Assimes, Themistocles L, Berndt, Sonja I, Hunter, David J, van Duijn, Cornelia M, North, Kari E, Loos, Ruth J F
Published in PLoS genetics

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

by Scherag, André, Dina, Christian, Hinney, Anke, Vatin, Vincent, Scherag, Susann, Vogel, Carla I G, Müller, Timo D, Grallert, Harald, Wichmann, H-Erich, Balkau, Beverley, Heude, Barbara, Jarvelin, Marjo-Riitta, Hartikainen, Anna-Liisa, Levy-Marchal, Claire, Weill, Jacques, Delplanque, Jérôme, Körner, Antje, Kiess, Wieland, Kovacs, Peter, Rayner, Nigel W, Prokopenko, Inga, McCarthy, Mark I, Schäfer, Helmut, Jarick, Ivonne, Boeing, Heiner, Fisher, Eva, Reinehr, Thomas, Heinrich, Joachim, Rzehak, Peter, Berdel, Dietrich, Borte, Michael, Biebermann, Heike, Krude, Heiko, Rosskopf, Dieter, Rimmbach, Christian, Rief, Winfried, Fromme, Tobias, Klingenspor, Martin, Schürmann, Annette, Schulz, Nadja, Nöthen, Markus M, Mühleisen, Thomas W, Erbel, Raimund, Jöckel, Karl-Heinz, Moebus, Susanne, Boes, Tanja, Illig, Thomas, Froguel, Philippe, Hebebrand, Johannes, Meyre, David
Published in PLoS genetics

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

by Fall, Tove, Hägg, Sara, Ploner, Alexander, Fischer, Krista, Horikoshi, Momoko, Sarin, Antti-Pekka, Thorleifsson, Gudmar, Ladenvall, Claes, Kuningas, Maris, Draisma, Harmen H M, Ried, Janina S, van Zuydam, Natalie R, Huikari, Ville, Mangino, Massimo, Sonestedt, Emily, Nelson, Christopher P, Rivera, Natalia V, Shen, Huei-Yi, Havulinna, Aki S, Dehghan, Abbas, Donnelly, Louise A, Kaakinen, Marika, de Bruijn, Renée F A G, Ikram, M Arfan, Amin, Najaf, Balmforth, Anthony J, Braund, Peter S, Doney, Alexander S F, Döring, Angela, Elliott, Paul, Esko, Tõnu, Franco, Oscar H, Gretarsdottir, Solveig, Hartikainen, Anna-Liisa, Heikkilä, Kauko, Holm, Hilma, Hottenga, Jouke Jan, Hyppönen, Elina, Illig, Thomas, Isomaa, Bo, Karssen, Lennart C, Kettunen, Johannes, Kuulasmaa, Kari, Laatikainen, Tiina, Laitinen, Jaana, Läärä, Esa, Männistö, Satu, Pouta, Anneli, Rathmann, Wolfgang, Ruokonen, Aimo, Savolainen, Markku J, Sijbrands, Eric J G, Small, Kerrin S, Smit, Jan H, Steinthorsdottir, Valgerdur, Syvänen, Ann-Christine, Taanila, Anja, Tobin, Martin D, Uitterlinden, Andre G, Willems, Sara M, Willemsen, Gonneke, Witteman, Jacqueline, Perola, Markus, Virtamo, Jarmo, Kee, Frank, Tregouet, David-Alexandre, Amouyel, Philippe, Brambilla, Paolo, Hall, Alistair S, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Whitfield, John B, Jula, Antti, Knekt, Paul, van Duijn, Cornelia M, Penninx, Brenda W J H, Smith, George Davey, Samani, Nilesh J, Gieger, Christian, Wichmann, H Erich, Boomsma, Dorret I, de Geus, Eco J C, Tuomi, TiinaMaija, Power, Chris, Spector, Tim D, Lind, Lars, Orho-Melander, Marju, Järvelin, Marjo-Riitta, Salomaa, Veikko, Vartiainen, Erkki, Hofman, Albert, Ripatti, Samuli, Metspalu, Andres, Thorsteinsdottir, Unnur, Stefansson, Kari, McCarthy, Mark I, Ingelsson, Erik, Prokopenko, Inga
Published in PLoS medicine

A genome-wide association search for type 2 diabetes genes in African Americans

by Palmer, Nicholette D, Cooke, Jessica N, Bostrom, Meredith A, Ferrara, Assiamira, Ziegler, Julie T, Freedman, Barry I, Scott, Laura J, Morris, Andrew P, Thorleifsson, Gudmar, Ferreira, Teresa, Dupuis, Josée, Segrè, Ayellet V, van Hoek, Mandy, Bennett, Amanda J, Boström, Kristina Bengtsson, Couper, David J, Elliott, Katherine S, Elliott, Amanda L, Erdos, Michael R, Franklin, Christopher S, Ganser, Martha, Grarup, Niels, Guiducci, Candace, Kuusisto, Johanna, Lauritzen, Torsten, Lyssenko, Valeriya, Payne, Felicity, Prokopenko, Inga, Robertson, Neil R, Rocheleau, Ghislain, Roden, Michael, Saxena, Richa, Sigurdsson, Gunnar, Thorand, Barbara, Tichet, Jean, Weedon, Michael N, Hunter, David J, Hveem, Kristian, Pramstaller, Peter P, Sijbrands, Eric, Walker, Mark, Wareham, Nicholas J, Hattersley, Andrew T, Hu, Frank B, Pedersen, Oluf, Thorsteinsdottir, Unnur, Wilson, James F, van Duijn, Cornelia M, Altshuler, David, McCarthy, Mark I, Elliott, Paul, Dehghan, Abbas, Lajunen, Taina, Kanoni, Stavroula, Zabena, Carina, O'Connell, Jeffrey, Luan, Jian'an, Roccasecca, Rosa Maria, Bochud, Murielle, Clarke, Robert, Coin, Lachlan J M, Cooper, Matthew N, Crisponi, Laura, Frants, Rune, Galan, Pilar, Graessler, Jürgen, Grundy, Scott, Gwilliam, Rhian, Hartikainen, Anna-Liisa, Hercberg, Serge, Hicks, Andrew A, Hui, Jennie, Kovacs, Peter, Manning, Alisa K, McAteer, Jarred B, Melzer, David, Meyre, David, Naitza, Silvia, Orrù, Marco, Pattaro, Cristian, Peden, John F, Pichler, Irene, Psaty, Bruce M, Rayner, Nigel W, van Dijk, Ko Willems, Waeber, Gérard, Yarnell, John W G, Zethelius, Björn, Loos, Ruth J F, Smith, George Davey, Karpe, Fredrik, Serrano-Ríos, Manuel, Ebrahim, Shah, Pramstaller, Peter Paul, Wright, Alan F, Stumvoll, Michael, Hamsten, Anders, Buchanan, Thomas A, Peltonen, Leena, Mooser, Vincent
Published in PloS one

Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease

by Huertas-Vazquez, Adriana, Nelson, Christopher P, Guo, Xiuqing, Reinier, Kyndaron, Uy-Evanado, Audrey, Teodorescu, Carmen, Ayala, Jo, Jerger, Katherine, Chugh, Harpriya, Braund, Peter S, Deloukas, Panos, Hall, Alistair S, Balmforth, Anthony J, Jones, Michelle, Taylor, Kent D, Pulit, Sara L, Newton-Cheh, Christopher, Gunson, Karen, Jui, Jonathan, Rotter, Jerome I, Albert, Christine M, Samani, Nilesh J, Chugh, Sumeet S
Published in PloS one