Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays

by Parijat, Priyanka, Ponnam, Saraswathi, Attili, Seetharamaiah, Campbell, Kenneth S, El-Mezgueldi, Mohammed, Pfuhl, Mark, Kampourakis, Thomas
Published in Scientific reports

Hybrid Quinoline-Thiosemicarbazone Therapeutics as a New Treatment Opportunity for Alzheimer's Disease‒Synthesis, In Vitro Cholinesterase Inhibitory Potential and Computational Mod...

by Zaib, Sumera, Munir, Rubina, Younas, Muhammad Tayyab, Kausar, Naghmana, Ibrar, Aliya, Aqsa, Sehar, Shahid, Noorma, Asif, Tahira Tasneem, Alsaab, Hashem O, Khan, Imtiaz
Published in Molecules (Basel, Switzerland)

Simulating effects of biomarker enrichment on Alzheimer's disease prevention trials: Conceptual framework and example

by Leoutsakos, Jeannie-Marie S, Bartlett, Alexandra L, Forrester, Sarah N, Lyketsos, Constantine G
Published in Alzheimer's & dementia

Treatment of infantile-onset Pompe disease in a rat model with muscle-directed AAV gene therapy

by Muñoz, Sergio, Bertolin, Joan, Jimenez, Veronica, Jaén, Maria Luisa, Garcia, Miquel, Pujol, Anna, Vilà, Laia, Sacristan, Victor, Barbon, Elena, Ronzitti, Giuseppe, El Andari, Jihad, Tulalamba, Warut, Pham, Quang Hong, Ruberte, Jesus, VandenDriessche, Thierry, Chuah, Marinee K., Grimm, Dirk, Mingozzi, Federico, Bosch, Fatima
Published in Molecular metabolism (Germany)

KGDiff: towards explainable target-aware molecule generation with knowledge guidance

by Qian, Hao, Huang, Wenjing, Tu, Shikui, Xu, Lei
Published in Briefings in bioinformatics

Literature-Based Discovery Predicts Antihistamines Are a Promising Repurposed Adjuvant Therapy for Parkinson's Disease

by Tandra, Gabriella, Yoone, Amy, Mathew, Rhea, Wang, Minzhi, Hales, Chadwick M, Mitchell, Cassie S
Published in International journal of molecular sciences

Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis

by Hoefflin, Rouven, Lazarou, Adriana, Hess, Maria Elena, Reiser, Meike, Wehrle, Julius, Metzger, Patrick, Frey, Anna Verena, Becker, Heiko, Aumann, Konrad, Berner, Kai, Boeker, Martin, Buettner, Nico, Dierks, Christine, Duque-Afonso, Jesus, Eisenblaetter, Michel, Erbes, Thalia, Fritsch, Ralph, Ge, Isabell Xiang, Geißler, Anna-Lena, Grabbert, Markus, Heeg, Steffen, Heiland, Dieter Henrik, Hettmer, Simone, Kayser, Gian, Keller, Alexander, Kleiber, Anita, Kutilina, Alexandra, Mehmed, Leman, Meiss, Frank, Poxleitner, Philipp, Rawluk, Justyna, Ruf, Juri, Schäfer, Henning, Scherer, Florian, Shoumariyeh, Khalid, Tzschach, Andreas, Peters, Christoph, Brummer, Tilman, Werner, Martin, Duyster, Justus, Lassmann, Silke, Miething, Cornelius, Boerries, Melanie, Illert, Anna L, von Bubnoff, Nikolas
Published in Cancers

Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds

by Shi, Huahua, Zhao, Yan
Published in International journal of molecular sciences

Quantitative MRI Harmonization to Maximize Clinical Impact: The RIN-Neuroimaging Network

by Nigri, Anna, Ferraro, Stefania, Gandini Wheeler-Kingshott, Claudia A M, Tosetti, Michela, Redolfi, Alberto, Forloni, Gianluigi, D'Angelo, Egidio, Aquino, Domenico, Biagi, Laura, Bosco, Paolo, Carne, Irene, De Francesco, Silvia, Demichelis, Greta, Gianeri, Ruben, Lagana, Maria Marcella, Micotti, Edoardo, Napolitano, Antonio, Palesi, Fulvia, Pirastru, Alice, Savini, Giovanni, Alberici, Elisa, Amato, Carmelo, Arrigoni, Filippo, Baglio, Francesca, Bozzali, Marco, Castellano, Antonella, Cavaliere, Carlo, Contarino, Valeria Elisa, Ferrazzi, Giulio, Gaudino, Simona, Marino, Silvia, Manzo, Vittorio, Pavone, Luigi, Politi, Letterio S, Roccatagliata, Luca, Rognone, Elisa, Rossi, Andrea, Tonon, Caterina, Lodi, Raffaele, Tagliavini, Fabrizio, Bruzzone, Maria Grazia
Published in Frontiers in neurology

Bezlotoxumab: an emerging monoclonal antibody therapy for prevention of recurrent Clostridium difficile infection

by Navalkele, Bhagyashri D, Chopra, Teena
Published in Biologics

Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa

by Jong, Eric D, Hacibekiroglu, Sabiha, Guo, Lily, Sawula, Evan, Li, Biao, Li, Chengjin, Ho, Margaret T, Shoichet, Molly S, Wallace, Valerie A, Nagy, Andras
Published in Stem cell research & therapy

A self-binding immune complex vaccine elicits strong neutralizing responses against herpes simplex virus in mice

by Diamos, Andrew G, Pardhe, Mary D, Bergeman, Melissa H, Kamzina, Aigerim S, DiPalma, Michelle P, Aman, Sara, Chaves, Artemio, Lowe, Kenneth, Kilbourne, Jacquelyn, Hogue, Ian B, Mason, Hugh S
Published in Frontiers in immunology

Adherence to COVID-19 protective behaviours in India from May to December 2020: evidence from a nationally representative longitudinal survey

by Schaner, Simone, Theys, Natalie, Angrisani, Marco, Banerjee, Joyita, Khobragade, Pranali Yogiraj, Petrosyan, Sarah, Agarwal, Arunika, Chien, Sandy, Weerman, Bas, Chakrawarty, Avinash, Chatterjee, Prasun, Madaan, Nirupam, Bloom, David, Lee, Jinkook, Dey, Aparajit Ballav
Published in BMJ open

Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma

by Köksal, Hakan, Dillard, Pierre, Josefsson, Sarah E., Maggadottir, Solrun Melkorka, Pollmann, Sylvie, Fåne, Anne, Blaker, Yngvild Nuvin, Beiske, Klaus, Huse, Kanutte, Kolstad, Arne, Holte, Harald, Kvalheim, Gunnar, Smeland, Erlend B., Myklebust, June H., Inderberg, Else Marit, Wälchli, Sébastien
Published in Blood advances

Deconvoluting binding sites in amyloid nanofibrils using time-resolved spectroscopy

by Jiang, Bo, Umezaki, Utana, Augustine, Andrea, Jayasinghe-Arachchige, Vindi M, Serafim, Leonardo F, He, Zhi Mei Sonia, Wyss, Kevin M, Prabhakar, Rajeev, Martí, Angel A
Published in Chemical science (Cambridge)

bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements

by Yang, Jay, Tabuchi, Yudai, Katsuki, Riku, Taki, Masumi
Published in International journal of molecular sciences

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer

by Heo, Tae-Hwe, Wahler, Joseph, Suh, Nanjoo
Published in Oncotarget

Measuring what matters to rare disease patients - reflections on the work by the IRDiRC taskforce on patient-centered outcome measures

by Morel, Thomas, Cano, Stefan J
Published in Orphanet journal of rare diseases

Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load

by Eddins, Devon J., Yang, Junkai, Kosters, Astrid, Giacalone, Vincent D., Pechuan-Jorge, Ximo, Chandler, Joshua D., Eum, Jinyoung, Babcock, Benjamin R., Dobosh, Brian S., Hernández, Mindy R., Abdulkhader, Fathma, Collins, Genoah L., Orlova, Darya Y., Ramonell, Richard P., Sanz, Ignacio, Moussion, Christine, Eun-Hyung Lee, F., Tirouvanziam, Rabindra M., Ghosn, Eliver E. B.
Published in Blood advances

What Does the Pipeline Promise about Upcoming Biosimilar Antibodies in Oncology?

by Busse, Antonia, Lüftner, Diana
Published in Breast care (Basel, Switzerland)